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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Allergy 59 (2004), S. 0 
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  The basophil activation test (BAT), which relies on flow cytometric quantitation of the allergen-induced up-regulation of the granule-associated marker CD63 in peripheral blood basophils, has been suggested to be a useful approach in detecting responsiveness to allergens. The purpose of this study was to establish the usefulness of the BAT with regard to the clinical history and current diagnostic tools in Hymenoptera venom allergy using a prospective study design.Methods:  Fifty-seven consecutive patients allergic to Hymenoptera venom as defined by a systemic reaction after an insect sting, and 30 age- and sex-matched control subjects with a negative history were included. The degree and nature of sensitization was confirmed by skin testing, specific immunoglobulin E (IgE), serum tryptase levels and BAT. In the nonallergic control group only analysis of specific IgE and BAT were performed. Correlation of BAT, skin test and specific IgE, respectively, with the clinical history in the allergic group was termed as sensitivity and in the control group as specificity.Results:  Twenty one of 23 (91.3%) bee venom allergic patients and 29 of 34 (85.3%) patients allergic to wasp and hornet venom tested positive in BAT. The overall sensitivity of BAT, specific IgE and skin tests were 87.7, 91.2 and 93.0%, respectively. The overall specificities were 86.7% for BAT and 66.7% for specific IgE. No correlation between the severity of clinical symptoms and the magnitude of basophil activation was observed.Conclusion:  The BAT seems to be an appropriate method to identify patients allergic to bee or wasp venom with a comparable sensitivity to standard diagnostic regimens. The higher specificity of BAT as compared with specific IgE makes this test a useful tool in the diagnosis of Hymenoptera venom allergy.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 18 (2004), S. 0 
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Akustikusneurinom ; Stereotaktische Radiochirurgie ; γ-Knife ; Hirnnervenfunktion ; Key words Acoustic neurinoma ; Stereotactic radiosurgery ; Gamma Knife ; Cranial nerve preservation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary From April 1992 to July 1998 stereotactic radiosurgery (Gamma Knife) was used to treat 1382 patients; 181 had acoustic neurinomas and were followed up, 44 of them for at least 4 years (48–75 months, median 60). With no mortality control of growth tumor was achieved in all cases but one. It was possible to preserve useful hearing in more than half of the patients (60%). In two patients complications due to the radiation with enlargement of the cystic component were observed. One patient needed additional microsurgical decompression. Three patients suffered transient incomplete facial palsy (one permanent, HBI III), and two patients complained of mild trigeminal neuropathy. One suffered from hydrocephalus and a shunting procedure was necessary. The neurological state improved in 23 patients (52%); five complained of new or worsened deficits. Radiosurgery is an effective alternative treatment for acoustic neurinomas with exceptionally low mortality and morbidity. With respect to preserving cranial nerve function the results are just as good as those of microsurgical resection. Short duration of hospitalization and quick return to normal activities make radiosurgery quite cost effective.
    Notes: Zusammenfassung Von April 1992 bis Ende Juli 1998 wurden an der Universitätsklinik für Neurochirugie in Graz 1382 Patienten mittels stereotaktischer Radiochirurgie (γ-Knife) behandelt. 181 Patienten hatten Akustikusneurinome; 44 sind nun mindestens 4 Jahre beobachtet worden (48–75, Median 60 Monate). Bei fehlender Mortalität fand sich nur in einem Fall Tumorwachstum. Das präoperativ vorhandene „gebrauchsfähige” Gehör blieb in mehr als der Hälfte der Patienten erhalten (60%); 2 Patienten mit zystischen Anteilen wiesen als Bestrahlungsfolge eine Vergrößerung auf, ein Patient mußte nachoperiert werden; 3 Fazialisparesen und 2 Trigeminusschädigungen traten transient auf, eine Fazialisparese (HBI III) persistierte. Ein Patient entwickelte einen Hydrozephalus und wurde geshuntet. Der neurologische Befund hatte sich bei 23 Patienten (52%) gebessert, 5 Patienten klagten über neu auftretende bzw. verschlechterte Defizite (11%). Die Radiochirurgie ist eine wirkungsvolle alternative Behandlungsform für Akustikusneurinome mit fehlender Mortalität und niedriger Morbidität. Eine 2tägige Krankenhausaufenthaltsdauer und eine sofortige Rückkehr zu den normalen Aktivitäten des täglichen Lebens machen die Behandlung auch hinsichtlich der Kosten vorteilhaft.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 141 (1999), S. 811-818 
    ISSN: 0942-0940
    Keywords: Keywords: Gamma knife; stereotactic radiosurgery; glomus jugulare tumour; paragangliomas.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  The aim of this clinical study was to determine the tumour control rate, clinical outcome and complication rate following gamma knife treatment for glomus jugulare tumours. Between May 1992 and May 1998, 13 patients with glomus tumours underwent stereotactic radiosurgical treatment in our department. The age of these patients ranged from 21 to 80 years. The male : female ratio was 2 : 11. Six patients had primary open surgery for partial removal or recurrent growth and subsequent radiosurgical therapy. Radiosurgery was performed as primary treatment in 7 cases. The median tumour volume was 6,4 cm3 (range: 4,6–13,7 cm3). The median marginal dose applied to an average isodose volume of 50% (30–50%) was 13,5 Gy (12–20 Gy). In 10 patients, a total of 48 MRI and CT follow-up scans were available. The remaining three patients have been excluded from the postradiosurgical evaluation since the observation time (t〈12 months) was too short or patients were lost to follow up. The median interval from Gamma Knife treatment to the last radiological follow-up was 37,6 months (5–68 months). In 4 patients (40%) decreased tumour volumes were observed and in 6 cases (60%) the tumour size remained unchanged. Neurological follow-up examinations revealed improved clinical status in 5 patients (50%), a stable neurological status in 5 patients (50%) and no complications occurred. According to our preliminary experience Gamma Knife radiosurgery represents an effective treatment option for glomus jugulare tumours.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0942-0940
    Keywords: Keywords: Acoustic neuroma; cranial nerve preservation; Gamma Knife; stereotactic radiosurgery; vestibular schwannoma.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ From April 1992 till December 1998 stereotactic radiosurgery (Gamma Knife) was applied to 192 patients with vestibular schwannomas. 56 of them had radiosurgery as primary treatment modality and were followed-up for at least 4 years (48–80 months, median 62).  Without fatal complications, control of tumour growth was achieved in all but three cases, useful hearing being preserved in more than one half of the patients (62%). The neurological state improved in 30 patients (54%). Irradiation-associated adverse effects (18%) comprised neurological signs (incomplete facial palsy, four cases (two recovered completely), and mild trigeminal neuropathy, three cases, respectively) and morphological changes (three patients) marked by an enlargement of pre-existing cystic components calling for additional surgical treatment: Microsurgical decompression was performed in two cases, the third patient underwent a shunting procedure because of hydrocephalus formation.  Based on the present data, radiosurgery represents an effective treatment for vestibular schwannomas associated with an exceptionally low mortality rate and a good quality of life. With respect to the preservation of cranial nerve function, results are comparable to microsurgical resection. A short duration of hospitalization and a quick return to normal activities constitute further advantages and contribute to cost effectiveness in public health care.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 142 (2000), S. 601-602 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1420-9039
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für angewandte Mathematik und Physik 32 (1981), S. 121-124 
    ISSN: 1420-9039
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Computing 33 (1984), S. 349-352 
    ISSN: 1436-5057
    Keywords: 65F10 ; 15A09 ; 92A07 ; Image reconstruction ; linear equations ; iterative methods ; generalized inverses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Die Konvergenz des ART-Algorithmus, ein iteratives Verfahren zur Lösung linearer Gleichungssysteme, wird bewiesen. Bei geeigneter Wahl der Relaxationsparameter konvergiert der Algorithmus selbst im Falle inkonsistenter Systeme, und zwar gegen eine Kleinste-Quadrate-Lösung.
    Notes: Abstract The ART algorithm, an iterative technique for solving large systems of linear equations, is shown to converge even for inconsistent systems, provided the relaxation parameters are chosen appropriately. The limit is a weighted least squares solution.
    Type of Medium: Electronic Resource
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