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  • 1
    ISSN: 1569-8041
    Keywords: antiangiogenesis ; apoptosis ; cell differentiation ; lung cancer ; spontaneous remission
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Spontaneous remission of cancer (SR) is defined as a complete or partial, temporary or permanent disappearance of all or at least some relevant parameters of a soundly diagnosed malignant disease without any medical treatment or with treatment that is considered inadequate to produce the resulting regression. We report the case of a 61-year-old man who presented with extensive metatastic disease five months after pneumonectomy for poorly differentiated large cell and polymorphic lung cancer. A vast metastatic tumour mass of the abdominal wall was confirmed histolologically and there was clinical and radiographic evidence of liver and lung metastases. Eight months later, the patient was operated on for a hernia, which had developed in the inguinal biopsy scar and the surgeon confirmed complete clinical SR of the abdominal wall metastases. Again five months later there was no longer any radiologic evidence of liver and lung metastases. Complete remission has persisted more than five years. Histology of the primary and of the abdominal metastases were reviewed by several independent pathologists. SR is an extremly rare event in lung cancer. This is the first documented case of clinically evident visceral metastases of a bronchiogenic adenocarcinoma developing after complete resection of the primary and then showing complete SR. The epidemiology of SR is reviewed and possible mechanisms involved in SR are discussed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 254 (1993), S. 748-749 
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Non-Hodgkin-Lymphom ; Nierenbefall ; Ferritin ; Tumormarker ; Histiozyten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Bei einem 46jährigen Patienten mit Funktionsminderung der linken Niere und sonographischer Größenzunahme wurde bioptisch ein Rezidiv eines hochmaligen Non-Hodgkin-Lymphoms festgestellt. Zeitlich koinzident mit dem einseitigen Nierenfunktionsverlust wurde ein Anstieg des Serum-Ferritins von 2356 µg/l auf 6254 µg/l als Korrelat der Lymphomprogredienz beobachtet (Serum-Eisen, Transferrin und Transferrinsättigung normal). In der immunhistologischen Untersuchung der Nierenbiopsie zeigten die Lymphomzellen ein negatives Resultat bezüglich der Ferritin-Färbung. Ein positiver Ferritin-Nachweis gelang jedoch in histiozytären Zellen. Vereinzelte Angaben in der Literatur deuten darauf hin, daß die Synthese von Ferritin in den Histiozyten im Rahmen einer Neoexpression durch Lymphomzellen induziert werden kann.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of plastic surgery 13 (1990), S. 16-21 
    ISSN: 1435-0130
    Keywords: Silicone gel implants ; Constrictive capsular fibrosis ; Oxygen-derived free radicals ; Superoxide dismutase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Constrictive capsular fibrosis is the most common complication following silicone gel implants. In experiments in animals, the influence of superoxide dismutase on experimentally produced capsular tissue was investigated. Superoxide dismutase reduces the thickness of the connective tissue by approximately 50%. A relaxation of the connective tissue was also regularly observed. The superoxide dismutase is established as a drug. As it is very tolerable and has a low rate of side effects, its application in the treatment of fresh constrictive capsular fibrosis in humans is conceivable.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 353 (1980), S. 47-55 
    ISSN: 1435-2451
    Keywords: Benign fibrous histiocytoma ; Lung neoplasm ; Coin Lesion ; Differential diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Multiple Rundherde in beiden Lungen einer 45jährigen Frau erwiesen sich als benigne fibröse Histiocytome. Die Geschwülste wurden reseziert, 2Jahre später war die Patientin rezidivfrei. Die Tumoren waren überwiegend fibroblastisch ausdifferenziert, enthielten aber auch Histiocyten, Xanthomzellen, Lymphocyten, Plasmazellen und Riesenzellen. Zellen und Fasern zeigten die charakteristische wagenradähnliche Anordnung (≫storiform pattern≪〈). Benignefibröse Histiocytomeder Lunge sollten durch den kleinstmöglichen Eingriff entfernt werden, da sie weder rezidivieren noch metastasieren. Dies scheint die erste Mitteilung über multipel und synchron auftretende benigne fibröse Histiocytome beider Lungen zu sein.
    Notes: Summary Multiple benign fibrous histiocytomas in both lungs of a 45-year-old woman are described. The tumors were found incidentally on routine roentgenograms. The lesions were resected, with no recurrence after two years. The tumors were predominantly fibroblastic and included histiocytes, xanthomatous cells, lymphocytes, plasma cells, and giant cells. Cells and fibers had a characteristic storiform pattern. Because of their absolutely benign biological behavior, resection of benign fibrous histiocytomas should be minimal. This appears to be the first reported case of multiple benign fibrous histiocytomas in both lungs.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 355 (1981), S. 620-621 
    ISSN: 1435-2451
    Keywords: Soft tissue tumors ; Incidence ; Grading and classification ; Weichgewebstumoren ; Häufigkeit ; Graduierung und Klassifizierung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Weichgewebstumoren machten ca. 2,8 % unseres gesamten chirurgischen Einsendungsmaterials aus. Am häufigsten fanden sich dabei Tumoren des Fett- und Bindegewebes. Bei den letzteren sind die agrressive Fibromatose und die noduläre Fasciitis von besonderem klinisch-pathologischem Interesse. Durch eine kombinierte Beurteilung der histologischen Graduierung und der histogenetischen Klassifizierung kann das TNM/G-System angewandt werden, woraus sich auch eine Stadieneinteilung ergibt. Die Unterscheidung von geringem und hohem Malignitätsgrad ist die Voraussetzung einer optimalen Therapie von Sarkomen.
    Notes: Summary Soft tissue tumors showed an overall incidence of 2.8% in our surgical material. Most frequently found were tumors of fatty or connective tissues. In the latter, aggressive fibromatosis and nodular fasciitis are of special clinical-pathological interest. By combined consideration of a histological grading and histogenetic classification the TNM/G-system can be applied with consecutive staging. Distinction between low- or highgrade malignancy is a prerequisite for an optimal therapy.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 859-859 
    ISSN: 1435-2451
    Keywords: Primary retroperitoneal tumors ; Operative treatment ; Prognosis ; Primär retroperitoneale Tumoren ; Operative Behandlung ; Prognose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Seit 1945 wurden 184 Patienten mit einem primären Tumor behandelt. Die histologische Differenzierung zeigte eine grosse Vielfalt. Bei der Diagnostik sind Sonographie und CT von hohem Stellenwert. 63 (30%) wurden palliativ operiert und 65 (36%) waren inoperabel. 112 Patienten erhielten eine nachfolgende Radiatio oder Chemotherapie. Die Prognose ist ausgesprochen schlecht. Die mediane Überlebenszeit betrug 8 Monate.
    Notes: Summary Since 1945, 184 patients have been treated for primary retroperitoneal tumors. The histological classification showed great variety. Sonography and CT are of particular value in making the diagnosis. Sixty-three (34%) had complete tumor excision; 28 required resection of adjacent organs; 56 (30%) underwent partial excision of the tumor; 65 (36%) were inoperable. Irradiation and/or chemotherapy was administered to 112 patients. The prognosis is very poor: the median survival rate was 8 months.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 355 (1981), S. 564-564 
    ISSN: 1435-2451
    Keywords: Fibrous sarcomas ; Liposarcomas ; Surgical pathology ; Fibröse Sarkome ; Liposarkome ; Klinische Pathologie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 55% aller malignen Weichgewebsgeschwülste unseres Materials (1478 benigne und 322 maligne Weichteiltumoren) betreffen fibröse und lipomatöse Sarkome (i.e. Liposarkom, malignes fibröses Histiocytom, Fibrosarkom, Dermatofibrosarcoma protuberans). Zahlenmäßig führen Liposarkome (19,9%), es folgen Histiocytome (12,7 %), Fibrosarkome (11,5 %) und Dermatofibrosarkome (10,9 %). Sowohl auf die Tumormorphe einschließlich der prognostisch günstigen myxoiden Varianten, als auch auf Alters- und Lokalisationsverteilung sowie Rezidivhäufigkeit wurde detailliert eingegangen.
    Notes: Summary In our material (1478 benign tumors, 322 malignant ones) 55% of the malignant soft tissue tumors were made up by sarcomas of the fibrous and adipose tissue. In order of frequency, we found among these neoplasms liposarcoma (19.9%), malignant fibrous histiocytoma (12.7%), fibrosarcoma (11.5%), and dermatofibrosarcoma protuberans (10.9%).The morphological pictures were demonstrated, especially myxoid subtypes with favorable prognosis. In addition the distribution of age, the anatomical location, and the account of recurrences were reported.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 358 (1982), S. 567-567 
    ISSN: 1435-2451
    Keywords: Thermography ; Biocompatibility ; Monometal niobium ; Thermografie ; Biokompatibilität ; Monometall Niob
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei histologischen Implantatbettuntersuchungen konnten deutliche Fremdkörperreaktio-nen bei Stahlimplantaten nachgewiesen werden. Das bioinerte Monometall Niob zeigte keine Fremdkörperreaktionen im Implantatbett. Diese geringere Stoffwechselsteigerung in der Implantatumgebung konnte durch die Thermografie nachgewiesen werden. Es zeigten sich signifikant niedrigere Temperaturen bei Niobimplantaten. Die besondere Gewebeverträglichkeit des Niob konnte somit auch thermografisch objektiviert werden.
    Notes: Summary Distinct foreign body reactions to steel implants could be proved in the histological examination of implantation beds. The bioinert momometal niobium did not show any foreign-body reaction in the implantation bed. The slight increase of metabolic activity in the implantation area could be demonstrated thermographically as significantly lower temperatures were found for niobium implantations. Thus, special tissue compatibility could also be objectified by thermography.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 366 (1985), S. 565-567 
    ISSN: 1435-2451
    Keywords: Nonocclusive mesenteric infarction ; Hypoxic venous ; Nichtocclusive ischämische Enteropathie ; Hypoxie venöser Rigor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Als prädisponierend für eine nichtocclusive ischämische Enteropathie (NOD) gilt ein low-cardiac-output-Syndrom. Meist entwickelt sich die NOD unter dem Bild eines paralytischen Ileus. Die Laborparameter sind uncharakteristisch. Im Mesentericogramm imponiert bei enggestellten Arterien ein extrem verzögerter venöser Abstrom. Dies kann erklart werden durch einen hypoxischen Rigor der Darmmuskulatur und der Venolen im low-flow-state. Dieser Rigor bedingt schließlich eine venoläre Thrombose. Dem Rigor kann durch Zufuhr energiereicher Substrate entgegengewirkt werden.
    Notes: Summary The cause for a nonocclusive ischemic enteropathy seems to be a low cardiac output syndrome. There are often signs of a paralytic intestinal obstruction. Parameters of the blood chemistry offer no conclusive data. The angiogram of the mesenteric vessels demonstrates extensive arterial vasoconstriction as well as an obstructed venous outflow. Experimental findings disclose that this venous obstruction may be a result of an ischemic contracture in the course of a low flow state. This rigor initiates finally a thrombosis of the venoles. The rigor can be of ectually mastered by energy-rich compounds.
    Type of Medium: Electronic Resource
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