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  • 1
    Electronic Resource
    Electronic Resource
    Cardiac slowing and respiratory arrest in preterm infants (1976)
    Springer
    European journal of pediatrics 122 (1976), S. 257-261 
    Details
    ISSN: 1432-1076
    Keywords: Preterm infants ; Bradycardia ; Apneic spells ; Active sleep ; Neuronal inhibition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Changes in respiration and heart rate during sleep states have been recorded by a polygraphic device in healthy preterm infants. Cardiac slowing/bradycardia often coincide with respiratory arrest/apnea. Bradycardia starts early during apneic spells. The incidence of respiratory arrest and cardiac slowing and their simultaneous occurrence is significantly increased by the active or REM sleep state. The physiologic, inhibitory mechanisms of active sleep suggest a neurogenic etiology of episodes of cardiac slowing/bradycardia and/or respiratory arrest/apnea in prematures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00481505
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Sleep induced PO2-changes in preterm infants (1980)
    Springer
    European journal of pediatrics 134 (1980), S. 153-154 
    Details
    ISSN: 1432-1076
    Keywords: Transcutaneous PO2 ; Sleep states ; Apneas ; Preterm infants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In seven healthy preterm infants the transcutaneous PO2 was measured during different sleep states. The tcPO2 is lower during active sleep than during quiet sleep and shows a higher variability in active sleep. The incidence of apneic spells, which occur predominantly during active sleep, was not found to be correlated to tcPO2 levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01846036
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Infant sleep apnea profile: preterm vs. term infants (1985)
    Springer
    European journal of pediatrics 143 (1985), S. 261-268 
    Details
    ISSN: 1432-1076
    Keywords: Apnea ; Sleep state ; Polygraphic monitoring ; Preterms ; SIDS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract By means of polygraphic sleep recording, the sleep apnea profile with respect to the number and duration of inactive, obstructive and mixed apneic episodes as well as periodic breathing has been investigated in infants born preterm at 40, 52 and 64 weeks conceptional age and compared to that of term infants. At 40 weeks preterm infants showed significantly more apnea and periodic breathing compared to term infants. The difference was essentially due to obstructive and mixed apnea in non-REM sleep. There was a sharp decrease in all apneic variables—inactive, obstructive and mixed apnea as well as of periodic breathing—at 52 weeks conceptional age in infants that were previously preterm. Both groups exhibited a rather identical sleep apnea profile at 64 weeks. Two prospectively studied infants in the preterm group later became SIDS victims. One of them might have been identified as being at risk on the basis of his apnea profile compared to the normative data now available.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442298
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A familial progressive neurodegenerative disease with 2-oxoglutaric aciduria (1982)
    Springer
    European journal of pediatrics 138 (1982), S. 32-37 
    Details
    ISSN: 1432-1076
    Keywords: Neurometabolic disease ; Organic aciduria ; 2-oxoglutarate dehydrogenase deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A boy and a girl born to a consanguineous Tunisian couple are suffering from a slowly progressive nervous disorder. Initially they both had normal psychomotor development with acquisition of gait and speech. First symptoms in the boy were athetoid movements during the second year of life. He later lost all motor and language skills and developed muscular rigidity and intention tremor. At the age of five years, he was completely bedridden while he appeared mentally much less affected. His younger sister followed a similar course. The major specific abnormality detected was a strikingly elevated excretion of 2-oxoglutaric acid, which was identified by gas liquid chromatography, mass spectrometry, and enzymatic analysis. 2-oxoglutarate dehydrogenase activity in homogenates of cultured skin fibroblasts was reduced to about 25% of control values in both children. Although the pathogenetic mechanisms leading to brain damage remain obscure, the finding strongly suggest an autosomal recessive neurometabolic disease with predominant involvement of the extrapyramidal system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442325
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Sleep and aminophylline treatment of apnea in preterm infants (1978)
    Springer
    European journal of pediatrics 128 (1978), S. 145-149 
    Details
    ISSN: 1432-1076
    Keywords: Active sleep ; Apnea ; Aminophylline ; Preterm infants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of short-term aminophylline treatment on sleep behaviour was studied in six preterms infants with recurrent apnea. The incidence of apnea, respiratory pauses, and bradycardias which were closely related to the phases of active sleep, decreased during aminophylline treatment. However, the amount of active sleep remained unaffected. The mode of action of aminophylline is discussed in view of the previously proposed neurophysiological concept of apnea of prematurity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00444299
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  • 6
    Electronic Resource
    Electronic Resource
    5-Methoxyuridine, a new modified constituent in tRNAs of bacillaceae
    Amsterdam : Elsevier
    FEBS Letters 70 (1976), S. 37-42 
    Details
    ISSN: 0014-5793
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(76)80721-1
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  • 7
    Electronic Resource
    Electronic Resource
    Tetrapyrrole biosynthesis from 4,5-dioxovaleric acid inRhodopseudomonas spheroides (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 168-169 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Porphyrin biosynthesis from 4,5-dioxovaleric acid was studied in cell suspensions ofR. spheroides. The experiments show that 4,5-dioxovaleric acid is a far precursor of porphyrins through δ amino laevulinic acid formation in a transamination reaction involving also 1-alanine. It differs radically from the classical δ aminolaevulinic acid synthesis using glycine and succinyl CoA as substrates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01920591
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  • 8
    Electronic Resource
    Electronic Resource
    Anticholinerges Syndrom nach Ingestion von Tee aus Engelstrompetenblüten (2000)
    Springer
    Monatsschrift Kinderheilkunde 148 (2000), S. 18-22 
    Details
    ISSN: 1433-0474
    Keywords: Schlüsselwörter ; Zentrales anticholinerges Syndrom ; Engelstrompete ; Datura suaveolens ; Skopolaminvergiftung ; Alkaloidintoxikation ; Key words ; Central anticholinergic syndrome ; Angel’s trumpet ; Datura suaveolens ; Scopolamine-poisoning ; Alkaloid-intoxication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Reports of accidental alkaloid-intoxications with plants of the nightshade family, in particular Datura-species are well known in pediatric care. The intentional abuse as a hallucinogenic drug in adolescents became more frequent in recent years. Two patients, a 14- resp. 16-year old boy were admitted to the intensive care units of our hospitals because of a severe central anticholinergic syndrome after ingestion of tea from Angel’s Trumpet blossoms for experimental reasons. Patient’s history in the first somnolent patient was not available at the time of admission, a routine immunological drug screening of the patient’s urine had been negative. Discussion: Prominent central nervous symptoms as unconsciousness or hallucinations in adolescents without further explanation should suggest a special toxicological analysis for tropan-alcaloids e.g. scopolamine because of increasing abuse of plants containing the drug.
    Notes: Zusammenfassung Akzidentelle Intoxikationen von Nachtschattengewächsen bei Kindern sind bereits häufiger beschrieben worden. In jüngster Zeit nimmt der bewußte Mißbrauch insbesondere von Daturaarten als Rauschmittel bei Heranwachsenden deutlich zu. Wir berichten über 2 14 bzw. 16jährige Jugendliche, die aus Experimentierfreudigkeit einen Tee aus Engelstrompetenblüten getrunken hatten und sich wegen eines ausgeprägten zentralen anticholinergen Syndroms auf unseren Intensivstationen behandeln lassen mußten. Im ersten Fall, einem somnolenten Patienten, war zunächst keine Anamnese verfügbar, ein immunologisches Drogen-Screening im Urin blieb ohne richtungsweisendes Ergebnis. Diskussion: Auch bei im Vordergrund stehender Bewußtseinstrübung oder paranoid-halluzinatorischen Symptomen sollte insbesondere bei Jugendlichen an eine Ingestion von Tropanalkaloiden bzw. eine Skopolaminintoxikation durch Ziergewächse wie Engelstrompete oder Stechapfel gedacht und gezielt danach gesucht werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050004
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