Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1432-1076
    Keywords: Neurometabolic disease ; Organic aciduria ; 2-oxoglutarate dehydrogenase deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A boy and a girl born to a consanguineous Tunisian couple are suffering from a slowly progressive nervous disorder. Initially they both had normal psychomotor development with acquisition of gait and speech. First symptoms in the boy were athetoid movements during the second year of life. He later lost all motor and language skills and developed muscular rigidity and intention tremor. At the age of five years, he was completely bedridden while he appeared mentally much less affected. His younger sister followed a similar course. The major specific abnormality detected was a strikingly elevated excretion of 2-oxoglutaric acid, which was identified by gas liquid chromatography, mass spectrometry, and enzymatic analysis. 2-oxoglutarate dehydrogenase activity in homogenates of cultured skin fibroblasts was reduced to about 25% of control values in both children. Although the pathogenetic mechanisms leading to brain damage remain obscure, the finding strongly suggest an autosomal recessive neurometabolic disease with predominant involvement of the extrapyramidal system.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-1076
    Keywords: Mitochondrial myopathy ; Lactic acidosis ; Respiratory chain ; Succinate cytochrome-c-oxidoreductase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A male infant had severe muscular hypotonia from birth. Recurrent vomiting with dehydration and severe metabolic acidosis complicated the course. Elevated lactate (up to 12.3 mmol/l; n〈2), pyruvate (0.4 mmol/l; n〈0.05) and alanine levels were found in serum with an abnormal lactate/pyruvate ratio (〉30; n〈15). In urine the concentrations of lactate, pyruvate, alanine and of several intermediates of the citric acid cycle were increased. In muscle, numerous disseminated “ragged red fibres” were found by light microscopy; muscle fibres were found to contain subsarcolemmal aggregates of mitochondria, lipid droplets and glycogen by electromicroscopical methods. More-over, mitochondria with a typical circular arrangement of cristae were noticed. In liver homogenates normal activities of pyruvate carboxylase and pyruvate dehydrogenase complex were found; in liver mitochondria also succinate-cytochrome-c-oxidoreductase activity was normal. However, in muscle no succinate-cytochrome-c-oxidoreductase activity was detectable. The patient became increasingly lethargic and died because of sepsis at 5 months of age.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1432-1076
    Keywords: Phenylketonuria ; Carnitine ; Iron ; Ferritin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A previous observation of decreased serum carnitine concentrations in phenylketonuria (PKU) was investigated in 169 patients either on a strict diet (n=107; median: 8.1 years) or off diet (n=62; median: 15.0 years). Fifty-seven metabolically healthy children (median: 8.5 years) served as controls. PKU patients on a strict diet and older than 2 years had significantly lower serum carnitine concentrations (19.4±5.4 μmol/l) than those off diet (29.6±6.7 μmol/l). PKU patients on diet also had significantly lower concentrations of haemoglobin and serum ferritin than those off diet. A linear correlation existed between total serum carnitine and ferritin concentrations up to 40 μg/l (r=0.52;P〈0.01). As iron is an essential cofactor of carnitine synthesis we conclude that reduced endogenous carnitine synthesis due to an inadequate availability of iron may be a major cause of low serum carnitine concentrations. The low carnitine content of the strict and highly protein-reduced diet additionally contributes to a decrease in the serum carnitine concentration. Our results show that a further optimization of the PKU diet increasing either iron availability or carnitine intake should be considered.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Oxford : Blackwell Science Ltd
    Anaesthesia 52 (1997), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Antiphospholipid syndrome is a paradoxical disease state with in vitro prolongation of activated partial thromboplastin time and a strong predilection for in vivo thrombosis. The syndrome can be associated with systemic lupus erythematosus or lupus-like diseases or may be primary, presenting with thrombotic phenomena in young patients with no risk factors for thrombosis. We present two cases seen in two different settings in the hospital.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 227 (1980), S. 650-653 
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach Vergleich mit den bisherigen Untersuchungsmethoden zur Gewinnung zytologischer Ausstriche im menschlichen Nasensekret wird die neue Methode geschildert. Hierbei wird nach Zentrifugation menschlichen Nasensekrets das Sediment ausgestrichen. Durch vorherige Auszählung der Gesamtzellzahl in der Zellkammer ist nach Differenzierung im Zellausstrich eine quantitative Bestimmung der einzelnen Zellarten im Nasensekret möglich.
    Notes: Summary Cytological examination of the nasal mucosa has been performed in normal persons by a new introduced technique. Thereby native secreta are centrifuged and after determination of the total cell-number a smear is made. By the new method a quantitative and qualitative determination of cell-number and cell-differentiation in the nasal smears is possible.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 235 (1982), S. 626-628 
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ausgehend von den guten Erfahrungen mit lösungsmittel-getrockneter Dura, erprobten wir in den vergangenen 2 Jahren an der Universitäts-HNO-Klinik München die Anwendung von lösungsmittel-getrockneter Fascia lata. Fascia lata ist elastischer, weicher und viel anschmiegsamer als die relativ starre Dura. Insgesamt wandten wir lösungsmittel-getrocknete Fascia lata bei 116 Patienten an: 53 frontobasale Frakturen mit Rhinoliquorrhoe, 42 Tympanoplastiken, 8 Septumperforationen, 12 Orbitabodenfrakturen, 1 Zügelplastik. Zur Fixation der Fascia lata wurde Human-Fibrinkleber verwandt. Die lösungsmittel-getrocknete Fascia lata heilte bei allen Patienten komplikationslos ein, ebensogut wie körpereigene Fascia lata.
    Notes: Summary After our good experiences with dehydrated solvent-dried human dura we applied during the last 2 years dehydrated solvent-dried fascia lata in our clinic. Fascia lata is more flexible in comparison to the stiff dura. In 116 cases we got experiences with the new dehydrated solvent-dried human fascia lata: 53 patients with frontobasal fractures and rhinoliquorrhoea, 42 patients with tympanoplasties, 8 patients with septum perforations, 12 patients with blow out fractures, 1 patient with facial paralysis. Fascia lata was fixated by human fibrin glue. The human solvent dried dehydrated fascia lata showed the same results as autologous fascia lata.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Surgical endoscopy and other interventional techniques 14 (2000), S. 56-58 
    ISSN: 1432-2218
    Keywords: Key words: Laparoscopic surgery — Peptic ulcer — Perforted duodenal ulcer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Medical treatment of peptic ulcer is highly successful, and the eradication of Helicobacter pylori (H. pylori) reduces ulcer recurrence. However, the incidence of perforated duodenal ulcer and its associated mortality have not been reduced by modern methods of therapy. Laparoscopic simple closure and omental plug by suturing, fibrin glue, and stapler have been successful. Methods: Over a 1-year period (1996–97), 21 patients with perforated duodenal ulcer were operated on in our hospital by laparoscopic simple closure and omental patch. The mean age was 36.4 ± 11.8 years (range, 18–61). Twenty patients were male (93.7%). The mean duration of pain was 9.1 ± 11.7 hs (range, 2–48). Three patients had a previous history of duodenal ulcer (14.3%), and another three (14.3%) patients had a history of nonsteroidal antiinflammatory drug (NSAID) intake. Erect chest radiograph showed that 19 patients had air under the diaphragm (90.5%). Sixteen patients (76.2%) had frank pus in the abdomen, and five patients had a minimal peritoneal reaction (23.8%). Results: The mean operative time was 71.6 ± 24.6 mins (range, 40–120), and the mean hospital stay was 5.2 ± 1.6 days (range, 3–9). The mean time to resume oral fluids was 3.1 ± 0.8 days (range, 2–4). Only one patient was reoperated due to leakage identified by gastrographin swallow. Conclusions: This procedure is safe and efficient; however, further study of its long-term effectiveness and comparability to existing therapy is still needed.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 223 (1979), S. 442-443 
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A new method to get pure nasal secretions is introduced. In comparison to the other methods, who are described in the literature, by this method it is possible to get qualitative and quantitative estimable amounts of nasal secretions. The advantage of this method is discussed. First results are reported about protein concentration and diskelectrophoretic separations of the nasal secretions.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 231 (1981), S. 792-794 
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary By a new technique it is possible to obtain nasal mucus in native form. By immunoencymatic methods simultaneously the IgE levels in nasal mucus and in serum were determined in 100 patients with allergic disorders in the upper respiratory tract. All patients with positive skin reaction and positive provocation test showed an IgE level 10–70 times above normal. In contrast 30% false negative results were obtained with IgE determination in serum. The IgE level is only 2–10 times over normal in serum with patients with positive skin test. The IgE concentration in nasal mucus can be related to the protein content determined by UV-spectroscopy. With this technique the reliability of accuracy of the IgE level in nasal mucus is increased.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of inherited metabolic disease 5 (1982), S. 29-30 
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...