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  • 1
    Electronic Resource
    Electronic Resource
    Pravastatin treatment in combined hyperlipidaemia (1994)
    Springer
    European journal of clinical pharmacology 46 (1994), S. 221-224 
    Details
    ISSN: 1432-1041
    Keywords: Pravastatin ; Combined hyperlipidaemia ; LDL ; cholesterol ; triglycerides ; adverse effects ; LDL size
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Combined hyperlipidaemia and the presence of small and dense LDL particles in the circulation are associated with an increased risk of myocardial infarction. The effect of pravastatin on plasma lipoproteins and on LDL size has been evaluated in a single-blind, randomised, placebo-controlled study in 24 patients with combined hyperlipidaemia; 12 patients on pravastatin and 12 on placebo. After 16 weeks on pravastatin, plasma total (−15%) and LDL (−23%) cholesterol and apo B (−13%) levels were significantly reduced and apo AI (+6%) had increased. LDL size (measured by gradient gel electrophoresis) had not changed. No adverse effect was observed. The study suggests that, in combined hyperlipidaemia, LDL size is not affected by variation in LDL receptor activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00192552
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Comparison of lipoprotein(a) assay methods in serum and in a plasminogen-free fraction
    Amsterdam : Elsevier
    Clinica Chimica Acta 218 (1993), S. 83-95 
    Details
    ISSN: 0009-8981
    Keywords: Lipoprotein(a) ; Lp(a) assays ; Plasminogen
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(93)90224-R
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Analbuminaemia: a natural model of metabolic compensatory systems (1987)
    Springer
    Journal of inherited metabolic disease 10 (1987), S. 317-329 
    Details
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Important clinical signs are usually not present in analbuminaemia, a congenital condition inherited as an autosomal recessive trait, but several biochemical alterations in proteins, cholesterol, phospholipids and plasma beta lipoproteins have been observed. We studied two sibs, R.U. and R.R., with this disease and observed a striking increase in the variables mentioned above as well as a high LDL fraction with concomitant increase in apo B; increases in HDL3 and apo A-I and A-II levels were also observed. The lipoproteins, however, were not altered in morphology but showed a slight increase in lipid/protein ratio. Post-heparin lipolytic activity was normal in the male patient and reduced in the female while LCAT enzyme activity instead was increased in both. Fatty acids bound to phospholipids and serum cholesterol were mostly monounsaturated. Free fatty acid concentration was normal and they appeared mostly bound to the LDL and HDL3 fractions, which are increased in this disease and appear to replace albumin in one of its main carrier functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01799973
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    Paper (German National Licenses)
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