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  • 1
    Electronic Resource
    Electronic Resource
    Pravastatin treatment in combined hyperlipidaemia (1994)
    Springer
    European journal of clinical pharmacology 46 (1994), S. 221-224 
    Details
    ISSN: 1432-1041
    Keywords: Pravastatin ; Combined hyperlipidaemia ; LDL ; cholesterol ; triglycerides ; adverse effects ; LDL size
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Combined hyperlipidaemia and the presence of small and dense LDL particles in the circulation are associated with an increased risk of myocardial infarction. The effect of pravastatin on plasma lipoproteins and on LDL size has been evaluated in a single-blind, randomised, placebo-controlled study in 24 patients with combined hyperlipidaemia; 12 patients on pravastatin and 12 on placebo. After 16 weeks on pravastatin, plasma total (−15%) and LDL (−23%) cholesterol and apo B (−13%) levels were significantly reduced and apo AI (+6%) had increased. LDL size (measured by gradient gel electrophoresis) had not changed. No adverse effect was observed. The study suggests that, in combined hyperlipidaemia, LDL size is not affected by variation in LDL receptor activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00192552
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Levels and physicochemical properties of lipoprotein subclasses in moderate hypertriglyceridemia
    Amsterdam : Elsevier
    Clinica Chimica Acta 219 (1993), S. 57-65 
    Details
    ISSN: 0009-8981
    Keywords: Apoproteins ; Atherosclerosis ; Cholesterol ; Lipoproteins ; Triglycerides
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(93)90197-C
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Lipids and diabetic nephropathy: hypertension, microalbuminuria and lipids in type 2 diabetic patients (1992)
    Springer
    Acta diabetologica 29 (1992), S. 231-233 
    Details
    ISSN: 1432-5233
    Keywords: Atherosclerosis ; Cholesterol ; Hypertension Risk factors ; Triglycerides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hypertension and microalbuminuria are predictors of cardiovascular mortality in type 2 (non-insulin-dependent) diabetes independently of other conventional risk factors. The presence of high triglyceride levels with small and/or dense low density lipoprotein particles is associated with cardiovascular disease. The aim of this study was to analyse the plasma lipids, Na+/Li+ countertransport (a genetic marker of hypertension) and microalbuminuria in type 2 diabetic patients. Plasma lipids were determined in 15 normotensive normoalbuminuric (H−M−), 32 hypertensive normoalbuminuric (H+M−) and 22 hypertensive microalbuminuric (H+M+) type 2 diabetic patients and in 20 sex-and age-matched non-diabetic subjects. Plasma cholesterol was significantly higher in H+M+ patients than in controls (226±38 vs 192±38 mg/dl, mean ±SD). Plasma triglycerides were significantly higher in H+M+ patients than in either controls or H−M− patients (192±117 vs 104±59 and 115±52 respectively). The Na+/Li+ countertransport activity in red blood cells was significantly higher in H+M− and H+M+ patients than in controls, and in the type 2 diabetic patients it was directly related to plasma triglycerides (r=0.53,P〈0.0001) and inversely to high density lipoprotein (HDL) cholesterol (r=−0.43,P〈0.0001). Microalbuminuria, hypertension and elevated Na+/Li+ countertransport activity are thus associated with high triglyceride and low HDL cholesterol levels in type 2 diabetic patients. This atherogenic lipoprotein pattern might at least partially explain the association of microalbuminuria with cardiovascular disease in type 2 diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00573494
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  • 4
    Electronic Resource
    Electronic Resource
    Lipoprotein compositional abnormalities in type 1 (insulin-dependent) diabetic patients (1993)
    Springer
    Acta diabetologica 30 (1993), S. 11-16 
    Details
    ISSN: 1432-5233
    Keywords: Apoproteins ; Atherosclerosis ; Cholesterol ; Lipoproteins ; Triglycerides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Patients with type 1 (insulin-dependent) diabetes mellitus in good metabolic control usually have normal plasma lipid levels yet they have an increased incidence of vascular complications. Abnormalities in the distribution and composition of lipoprotein subfractions might in part be responsible for the macroangiopathy seen in type 1 diabetes mellitus. The plasma lipids, lipoproteins and apolipoproteins were studied in 9 type 1 diabetic patients during conventional insulin therapy and in 14 healthy controls. Plasma lipoproteins were analysed by ultracentrifugation in a zonal rotor to evaluate their concentrations and flotation properties and for compositional analysis. In diabetic patients the mean glycosylated haemoglobin (HbA1c) was 9.44±1.02% and the plasma lipid concentrations were not significantly different from healthy controls. The very low density lipoprotein (VLDL) subclass cholesterol concentrations were no different in diabetic patients and control subjects, but the VLDL cholesterol/triglyceride ratio was significantly lower in diabetic patients than in control subjects (0.34±0.05 vs 0.85±0.14; p〈0.05). The flotation rate of LDL2, the major component of low density lipoprotein (LDL) was lower in the diabetic patients compared with the control subjects. The cholesterol concentrations of intermediate density lipoprotein and LDL3, the minor component of LDL, were significantly higher (0.17±0.03 and 0.83±0.14 mmol/l respectively) in diabetic patients than in control subjects (0.05±0.02 and 0.24±0.08 mmol/l). The flotation properties and cholesterol concentrations of the high density lipoprotein (HDL) subclass, and the protein-lipid composition of LDL2, HDL2 and HDL3, were no different in diabetic patients and control subjects. Diabetic patients had lower apoprotein AII and higher CII and E levels than control subjects. the plasma lipoproteins in type 1 diabetes mellitus are characterized by increased intermediate density lipoprotein and LDL3 concentrations and by abnormal LDL2 flotation properties. These lipoprotein abnormalities might have a role in atherogenesis in type 1 diabetic patients since similar alterations were associated in some recent epidemiological studies with an increased incidence of cardiovascular disease in non-diabetic patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00572867
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    Paper (German National Licenses)
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