Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Proton magnetic resonance spectroscopy of systemic lupus erythematosus involving the central nervous system (1995)
    Springer
    Journal of neurology 242 (1995), S. 522-528 
    Details
    ISSN: 1432-1459
    Keywords: Central nervous system ; Magnetic resonance spectroscopy ; Systemic lupus erythematosus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined 13 patients with neurological manifestations of systemic lupus erythematosus (SLE) based on previous and/or current neurological or psychotic episodes by magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (MRS) together with psychiatric and cognitive assessment. MRI was abnormal in 7 patients, showing high signal lesions in the white matter and/or cerebral atrophy. Proton MRS centred on white matter lesions in 5 patients showed a reduction in theN-acetyl aspartate creatine ratio compared with normal appearing white matter in the SLE group and in 10 healthy controls. This pattern of abnormality does not allow differentiation of SLE lesions from the chronic plaques occurring in multiple sclerosis. There was a very high incidence of current psychiatric morbidity in the SLE group, namely in 12 of the 13 patients. There was no correlation between the presence of current psychiatric involvement and/or cognitive dysfunction and abnormalities detected with MRI or MRS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00867424
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Correlation of magnetic resonance imaging parameters with clinical disability in multiple sclerosis: a preliminary study (1999)
    Springer
    Journal of neurology 246 (1999), S. 961-967 
    Details
    ISSN: 1432-1459
    Keywords: Key words Multi-parametric ; Multiple sclerosis ; Magnetic ; resonance imaging ; Lesion volume ; Clinico-radiological correlation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Magnetic resonance imaging (MRI) is frequently used to monitor new treatments in multiple sclerosis (MS), but its role is limited by the uncertain relationship between MRI parameters and clinical disability. A brain MRI study using nine MRI parameters was undertaken in 15 MS patients with a wide spectrum of disability to evaluate the relationship between each parameter and disability. A strong correlation was found between disability (measured using Kurtzke’s EDSS) and total lesion load on both proton density (PD; r = 0.79) and T1 (r = 0.71) weighted sequences. There was also a strong correlation of disability with average lesion magnetisation transfer ratio (MTR; r = –0.74) and calculated T1 (r = 0.71) but not with calculated T2 or the average signal intensity of lesions on the conventional T1-weighted, PD-weighted and heavily T2-weighted images. Thus, four parameters which measured either the extent of lesions (PD lesion load) or their pathological severity (MTR, calculated T1, hypointense T1-lesion load) were correlated significantly with disability. While this suggests that such parameters will be useful in treatment trial monitoring, further multi-parameter MRI studies, of larger cohorts and using a wider range of techniques, are indicated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050491
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The transverse magnetisation decay characteristics of longstanding lesions and normal-appearing white matter in multiple sclerosis (1997)
    Springer
    Journal of neurology 244 (1997), S. 125-130 
    Details
    ISSN: 1432-1459
    Keywords: Key words Multiple sclerosis ; Magnetic resonance imaging ; Axonal loss ; Disability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The characteristics of transverse magnetisation decay of 120 longstanding lesions and 40 regions of normal-appearing white matter have been analysed in 40 patients with multiple sclerosis (MS) and 10 normal controls. Fifty lesions showed a biexponential decay in which two water compartments – one probably intracellular, the other extracellular – could be defined. There was a higher frequency of biexponential lesions in patients with a primary progressive course but no significant difference between benign and secondary progressive groups. Seventy lesions showed a monoexponential decay, of which 31 showed a T2 of greater than 200 ms, implying that these lesions were predominantly composed of extracellular rather than intracellular water. The results imply that an expanded extracellular space within chronic MS brain lesions is a common finding at all levels of disability and disease course. In so far as an expanded extracellular space implies axonal loss, the results suggest that the latter occurs commonly in longstanding MS lesions. The lack of correlation with disability suggests a limited role for the technique in therapeutic monitoring.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050061
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Serial magnetisation transfer ratios in gadolinium-enhancing lesions in multiple sclerosis (1997)
    Springer
    Journal of neurology 244 (1997), S. 308-311 
    Details
    ISSN: 1432-1459
    Keywords: Key words Multiple sclerosis ; Magnetisation transfer ; Gadolinium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The magnetisation transfer (MT) ratio of eight multiple sclerosis lesions has been studied serially. Initially, when the lesions showed gadolinium enhancement, there was a marked reduction in their MT ratio compared with normal white matter. Follow-up a mean of 11 months later (range 3–23 months), when the lesions no longer enhanced, revealed a consistent and usually marked recovery of the MT ratios towards normal. The MT ratio is thought to reflect the structural integrity of tissues with an important contribution from myelin and axons. MT imaging is a promising tool for elucidating pathophysiology and monitoring treatment in multiple sclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050092
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Demonstration der Plaqueentwicklung bei multipler Sklerose mittels Magnetisation-Transfer-Ratio-Bildern und Protonenspektroskopie mit kurzer Echozeit (1997)
    Springer
    Der Nervenarzt 68 (1997), S. 996-1001 
    Details
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Multiple Sklerose ; Magnetresonanztomographie ; Protonenspektroskopie ; Magnetisation-Transfer ; Demyelinisierung ; Key words Magnetic resonance imaging ; Multiple sclerosis ; Proton spectroscopy ; Magnetisation transfer ; Demyelination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We investigated a patient with secondary progressive Multiple Sclerosis during an acute relapse and after 6 months using several Magnetic Resonance methods. Conventional Magnetic Resonance images demonstrated at the time of relapse a large gadolinium enhancing lesion. Using proton spectroscopy and Magnetisation Transfer images heterogeneous changes suggestive of oedematous swelling peripherally, and active myelin destruction centrally were demonstrated in the acute phase. After clinical recovery there was marked resolution of acute inflammatory Magnetic Resonance abnormalities and recovery of MR tissue parameters. In comparison with conventional Magnetic Resonance Imaging Magnetisation Transfer Imaging and Proton Spectroscopy provide improved characterisation of pathological changes in MS.
    Notes: Zusammenfassung Wir untersuchten eine Patientin mit sekundär progressiver multipler Sklerose während eines akuten Schubes und im Verlauf nach 6 Monaten mit verschiedenen Magnetresonanztechniken. In der konventionellen Bildgebung fand sich zeitgleich zur klinischen Verschlechterung eine ausgedehnte kontrastmittelanreichernde Läsion. Mittels der Protonenspektroskopie und Magnetisation-Transfer-Bildern konnten heterogene pathologische Veränderungen mit wahrscheinlich ödematösen Gewebeveränderungen in der Peripherie und Demyelinisierung im Zentrum der Läsion in der akuten Phase dargestellt werden. Mit dem Abklingen der akuten Symptomatik zeigte sich eine Rückbildung der akut entzündlichen Aktivität und eine Erholung der MR-Gewebeparameter. Im Vergleich zur konventionellen Magnetresonanztomographie bieten Magnetisation Transfer Bildgebung und Protonen Spektroskopie spezifischere Informationen bei der Darstellung pathologischer Gewebeveränderungen der multiplen Sklerose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050229
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    facet.materialart.
    Unknown
    Othryades (1845)
    London : Periodicals Archive Online (PAO)
    Bentley's miscellany. 18 (1845) 238 
    Details
    ISSN: 1751-8466
    Topics: Linguistics and Literary Studies
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:8727-1845-018-00-000076
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    facet.materialart.
    Unknown
    Othryades (1845)
    London : Periodicals Archive Online (PAO)
    Bentley's miscellany. 18 (1845) 238 
    Details
    ISSN: 1751-8466
    Topics: Linguistics and Literary Studies
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:8727-1845-018-00-000076
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Benign and secondary progressive multiple sclerosis: a preliminary quantitative MRI study (1994)
    Springer
    Journal of neurology 241 (1994), S. 246-251 
    Details
    ISSN: 1432-1459
    Keywords: Quantitative MRI ; Disability ; Multiple sclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a preliminary study, we compared by means of quantitative magnetic resonance imaging (MRI) methods (1) the T2 values and the decay characteristics of chronic brain lesions, (2) the T2 values of normal-appearing frontal white matter (NAWM) and (3) brain lesion volumes in patients with benign and secondary progressive multiple sclerosis (MS) in order to evaluate the mechanisms underlying the development of disability. Eleven clinically definite MS patients with either benign MS (n = 5) or secondary progressive MS (n = 6) were studied. Fifty-two chronic lesions (identified by comparison with MRI scans obtained at least 12 months previously) were identified. The mean T2 of large lesions (cross-sectional area greater than 41 mm2) and of the NAWM was similar in both clinical groups. However, small lesions had higher mean T2 values (P 〈 0.01) in the benign group, probably at least in part because of partial volume effects. Analysis of large lesions revealed biexponential T2 relaxation in 6 of 8 “secondary progressive” and in 2 of 16 “benign” lesions, perhaps indicating a greater degree of axonal loss in large lesions of patients with secondary progressive MS. Patients with secondary progressive MS had higher (although not significant) total and infratentorial lesion loads than those of the benign group. These preliminary findings suggest, but do not establish, that variations in the extent, site and pathological nature of lesions may all contribute to different patterns of disease evolution in MS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00863776
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Proton magnetic resonance spectroscopy in a pathologically confirmed acute demyelinating lesion (1997)
    Springer
    Journal of neurology 244 (1997), S. 204-207 
    Details
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050074
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Lesion discrimination in optic neuritis using high-resolution fat-suppressed fast spin-echo MRI (1996)
    Springer
    Neuroradiology 38 (1996), S. 317-321 
    Details
    ISSN: 1432-1920
    Keywords: Key words Magnetic resonance imaging ; Fast spin-echo ; STIR ; Fat suppression ; Optic neuritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fast spin-echo (FSE) is a new sequence with acquisition times currently down to one-sixteenth of those obtained with conventional spin-echo sequences, which allows high-resolution (512 × 512 matrix) images to be acquired in an acceptable time. We compared the higher resolution of FSE with the medium resolution of a short inversion-time inversion-recovery (STIR) sequence in depicting the optic nerves of healthy controls and patients with optic neuritis. Optic nerve MRI examinations were performed in 18 patients with optic neuritis and 10 normal controls. Two sequences were obtained coronally: fat-suppressed FSE (FSE TR 3250 ms/TEef 68 ms, echo-train length 16, 4 excitations, 24 cm rectangular field of view, 3 mm interleaved contiguous slices, in-plane resolution 0.5 × 0.5 mm) and STIR (TR 2000 ms/TE 50 ms/TI 175 ms, in-plane resolution 0.8 × 0.8 mm, slice thickness 5 mm). FSE demonstrated much more anatomical detail than STIR, e. g. distinction of optic nerve and sheath. Lesions were seen in 20 of 21 symptomatic nerves using FSE and in 18 of 21 using STIR. Nerve swelling or partial cross-sectional lesions of the optic nerve were each seen only on FSE in 3 cases. Fat-suppressed FSE imaging of the optic nerve improves anatomical definition and increases lesion detection in optic neuritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00596577
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...