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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Analytica Chimica Acta 97 (1978), S. 269-274 
    ISSN: 0003-2670
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2307
    Keywords: Purkinje fibres ; Transitional cells ; Working myocardium ; Global ischaemia ; Ultrastructure ; Contraction state
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Contraction bands usually occur in the intramural working myocardium following post-ischaemic reperfusion. In the subendocardium, however, they are found during ischaemia. Thus, we ascertained the contraction states of Purkinje fibres, transitional cells, subendocardial and intramural parts of the working myocardium during 30 min global ischaemia at 25° C. The effects with and without myocardial protection were compared. At the onset of pure ischaemia contraction bands are completely lacking in all cell types. During pure ischaemia contraction bands are found in all subendocardial cell types but not in the intramural working myocardium. A peak of pathological contraction states is found in the intramural working myocardium at the onset (0 min), in the subendocardial working myocardium at 10 min, in the transitional cells and Purkinje fibres at 30 min of pure ischaemia. Histidine-, tryptophan-, ketoglutarate-enriched (HTK) cardioplegia prevents contraction bands completely at the onset of ischaemia and prevents both contraction bands and pathological contraction states during ischaemia almost completely. Striking differences in the physiological contraction states are seen only in the working myocardium: HTK cardioplegia brings about dominance of relaxation during ischaemia. These findings may be due mainly to the effects of global ischaemia on the one hand and to catecholamines, calcium and oxygen on the other.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2307
    Keywords: Purkinje fibres ; Ischaemia tolerance ; Qualitative and quantitative ultrastructure ; Cardioplegia ; Arrhythmias
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary During open heart surgery, reperfusion-induced arrhythmias arising after short periods of ischaemia may originate from subendocardial Purkinje fibres. We investigated the ultrastructure of these fibres during 30 min of global ischaemia at 25° C. The effects both with myocardial protection (HTK cardioplegia) and without it (pure ischaemia) were compared qualitatively and morphometrically. After 30 min pure ischaemia overcontraction of sarcomeres, hypercontraction and contraction bands, together with considerable changes in organelles, predominate over cellular oedema. In Purkinje fibres, both cellular and mitochondrial swelling were significantly increased within this 30-min time period from the onset of pure ischaemia. In contrast, following HTK cardioplegia and 30 min ischaemia, cellular and mitochondrial swelling remain moderate and over-contractions are almost entirely lacking. This means that despite remarkable differences between pure ischaemia and HTK cardioplegia in the degree of protection attained it is clear that, compared with the working myocardium, subendocardial Purkinje fibres do not display a higher resistance to early global ischaemia. Further investigations of this sensitivity of Purkinje fibres to global ischaemia and certain drugs may bring about new insights into myocardial protection and pharmacotherapy of arrhythmias.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 254 (1993), S. 1444-1446 
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Untersuchungen aus Fruchtwasser ergaben im I. Trimenon eine hohe Konzentration von IL2, TNF und den löslichen Rezeptoren IL2Rs und CD14s. Bei Wehen ohne Amnioninfektion waren die Zytokine IL6 und IL8 zusammen mit den Eikosaiden PGE2, PGF2, THXB2 und LTB4 erhöht. Der enge Zusammenhang zwischen Gestationsalter und Lymphokinprofil, löslichen immunozytären Rezeptoren und Eikosanoiden verweist auf eine vom Gestationsalter und Wehen unabhängige Interaktion zwischen Gravidität und Immunregulation.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 254 (1993), S. 822-823 
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Die Image-zytophotometrische DNA-Analyse gibt auch retrospektiv im Paraffinschnitt Informationen über das biologische Wachstumsverhalten von Mammakarzinomen, was einen Vorteil gegenüber dem nur am Gefrierschnitt nachweisbaren Ki 67 darstellt. Eine c-neu-Überexpression ist gehäuft mit einem tetraploiden Chromosomensatz assoziert.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2072
    Keywords: Tricyclic antidepressant ; Side-effects ; Heart rate variation ; Pupillary function ; Salivation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cholinergic functions were studied in ten nondepressed healthy volunteers who were treated with 50 mg clomipramine daily for 3 weeks and subsequently with 100 mg daily for a further 3 weeks. Impairments in heart rate variation (HRV) at rest and standing, of the pupillary light response and of salivation were related to serum levels of clomipramine. Since reduction of HRV is closely related to dose (r=−0.83, P〈10−2) and is a better predictor of serum levels than the other measures examined, it is suggested that the easy obtainable function test of HRV at standing can be used as an estimate of over-all cholinergic dysfunction during treatment with tricyclic antidepressants.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 330 (1988), S. 158-158 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 281 (1976), S. 215-219 
    ISSN: 1618-2650
    Keywords: Best. von Arsen(III), Zinn(II) ; Potentiometrische Titration ; adsorptionspolarisierte Elektroden
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Möglichkeit der analytischen Verwendung adsorptionspolarisierter Elektroden (APE) bei Redoxtitrationen wird untersucht. Beispiele für die erfolgreiche Anwendung werden gezeigt. Notwendig zur Ausbildung eines scharfen Peaks im Titrationsendpunkt ist die Ausbildung einer spezifischen Adsorptionsschicht der zu bestimmenden Ionen. Störungen durch Adsorptionsverdrängung, Katalysator- und Fremdioneneinflüsse sowie irreversible Adsorption werden an Beispielen besprochen.
    Notes: Abstract The application of Adsorption-Polarised Electrodes (APE) to redox titrations is investigated. Examples for successful use are presented. The formation of a specific adsorbed layer of ions to be determined is necessary to indicate the endpoint by a sharp peak. Examples will be discussed, where the titration is interfered by adsorption displacement, influences of catalysators and other ions or irreversible adsorption.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 284 (1977), S. 263-266 
    ISSN: 1618-2650
    Keywords: Best. von Palladium mit Jodid ; Potentiometrische Titration ; adsorptionspolarisierte Elektroden
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Adsorptionspolarisierte Elektroden (APE) sind geeignet, die potentiometrische Titration geringer Mengen von Palladium mit Jodid, z.B. zur Bestimmung in Katalysatoren, zu indizieren. Die besten Resultate erhält man mit einer Meßkette bestehend aus einem palladiniertem Pt-Blech, das gegen ein Pt-Blech geschaltet wird. Die Titration wird durchgeführt in salzsaurer Lösung bei ca. pH 2 oder in schwefelsaurer Lösung, wobei sie weitgehend unabhängig von der Säurekonzentration abläuft. Der Äquivalenzpunkt wird durch einen scharfen, positiven Potentialpeak angezeigt. Für die Bestimmung von 50 μg Pd beträgt die relative Standardabweichung 1% (n = 15).
    Notes: Abstract Adsorption-polarised electrodes (APE) have been found to be suitable to indicate the endpoint of the titration of small amounts of palladium with iodide, e.g. palladium in catalysts. The best results can be obtained by the use of an electrode system consisting of a palladised Pt-foil coupled with a counter electrode made of a Pt-foil. The titration is possible in a hydrochloric acid solution (pH 2) or in a sulphuric acid solution where the results are independent of the acid concentration. The equivalence point is indicated by a sharp peak at positive potential. For the determination of 50 μg of Pd the relative standard deviation is 1 % (n = 15).
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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