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  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical differentiation of eosinophilic heart diseases using antibodies against eosinophil activation markers (2005)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 46 (2005), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims : Eosinophilic heart syndromes are rare in Western countries and include endocarditis parietalis fibroplastica (EPF) and hypersensitivity myocarditis (HM). There are striking differences in natural history and morphological findings. Since diagnosis can be difficult when analysing small myocardial biopsies lacking the characteristic histological features, we studied a set of immunohistochemical markers in order to characterize the activation status of the infiltrating eosinophils to distinguish between these two entities.Methods and results : This study is based on the investigation of seven explanted hearts and one left ventricular specimen collected during implantation of a left ventricular assist device from a total of seven patients with HM. Also investigated were three right and three left ventricular specimens from five patients with EPF. We used antibodies (Ab) against EG1, and EG2, CD44, and CD69 which have been described as markers to distinguish between resting and activated eosinophils. The EG1 to EG2 ratio of eosinophils and the immunoreactivity against CD44 showed no differences between the two entities. However, eosinophils in the EPF were completely negative for CD69, whereas eosinophils reacted positively within the HM group.Conclusion : The immunohistochemical investigation of eosinophilic heart diseases using antibodies against CD69 can be a useful tool to distinguish between hypersensitivity myocarditis and endocarditis parietalis fibroplastica.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.2005.01999.x
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  • 2
    Electronic Resource
    Electronic Resource
    Electron microscopic stereology of capillary endothelial cells and cardiomyocytes in artificially arrested canine hearts (1999)
    Springer
    Medical electron microscopy 32 (1999), S. 151-160 
    Details
    ISSN: 1437-773X
    Keywords: Key words Heart ; Ultrastructure ; Capillaries ; Endothelium ; Stereology ; Cardioplegic solutions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In open heart surgery and transplantation, sufficient structural preservation of the myocardium immediately following cardioplegic arrest is a precondition for overcoming ischemia and for resumption of postischemic function. Therefore, we compared the protective effect of three clinically applied cardioplegic solutions with fibrillating and beating hearts using structural criteria. Left ventricular samples were taken from (1) beating, or (2) fibrillating or arrested hearts following coronary perfu-sion with (3) St. Thomas' Hospital solution, (4) histidine tryptophane ketoglutalate (HTK) (Custodiol), or (5) University of Wisconsin (UW) solution and fixed by immersion. Ultrastructural differences in the swelling of capillary endothelial cells and myocytes were quantitatively evaluated using stereological methods. Endothelial cells were somewhat more swollen after St. Thomas perfusion than those in beating and fibrillating hearts. HTK-arrested hearts showed significantly lower values for cellular edema than beating hearts. UW perfusion resulted in the (significantly) lowest degree of endothelial cell edema. Edematous changes in myocytes were significantly greater in St. Thomas-arrested hearts than in UW- or HTK-arrested hearts. Cardiomyocyte edema in beating and fibrillating hearts was comparable to that in St. Thomas-perfused hearts. Thus, the stereol-ogical analysis revealed significant differences between cardioplegic solutions in structural preservation of myocardial ultrastructure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007950050022
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  • 3
    Electronic Resource
    Electronic Resource
    The ultrastructural effects of global ischaemia on Purkinje fibres compared with working myocardium: A qualitative and morphometric investigation on the canine heart (1991)
    Springer
    Virchows Archiv 418 (1991), S. 17-25 
    Details
    ISSN: 1432-2307
    Keywords: Purkinje fibres ; Ischaemia tolerance ; Qualitative and quantitative ultrastructure ; Cardioplegia ; Arrhythmias
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary During open heart surgery, reperfusion-induced arrhythmias arising after short periods of ischaemia may originate from subendocardial Purkinje fibres. We investigated the ultrastructure of these fibres during 30 min of global ischaemia at 25° C. The effects both with myocardial protection (HTK cardioplegia) and without it (pure ischaemia) were compared qualitatively and morphometrically. After 30 min pure ischaemia overcontraction of sarcomeres, hypercontraction and contraction bands, together with considerable changes in organelles, predominate over cellular oedema. In Purkinje fibres, both cellular and mitochondrial swelling were significantly increased within this 30-min time period from the onset of pure ischaemia. In contrast, following HTK cardioplegia and 30 min ischaemia, cellular and mitochondrial swelling remain moderate and over-contractions are almost entirely lacking. This means that despite remarkable differences between pure ischaemia and HTK cardioplegia in the degree of protection attained it is clear that, compared with the working myocardium, subendocardial Purkinje fibres do not display a higher resistance to early global ischaemia. Further investigations of this sensitivity of Purkinje fibres to global ischaemia and certain drugs may bring about new insights into myocardial protection and pharmacotherapy of arrhythmias.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01600240
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  • 4
    Electronic Resource
    Electronic Resource
    Aspergillus endocarditis, myocarditis and pericarditis complicating necrotizing fasciitis (1996)
    Springer
    Virchows Archiv 429 (1996), S. 177-180 
    Details
    ISSN: 1432-2307
    Keywords: Necrotizing fasciitis ; Endocarditis ; Myocarditis ; Epicarditis ; Aspergillus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A patient with Aspergillus endocarditis, myocarditis and pericarditis is described. A 55-year-old man developed necrotizing fasciitis of the lower abdominal wall, pelvis and right thigh. Despite aggressive surgical débridement and antibiotic coverage, the patient died of multisystem organ failure. Autopsy revealed Aspergillus thromboulcerative endocarditis, myocarditis and pericarditis, acute necrotizing fungal bronchopneumonia and mycotic dissemination to brain, kidney and thyroid gland. A review of the literature showed that in the absence of open-heart surgery Aspergillus endocarditis and myocarditis are very uncommon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00192441
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  • 5
    Electronic Resource
    Electronic Resource
    Gedeckte Aortenruptur im thorakoabdominellen Übergangsbereich bei Sarkoidose (2000)
    Springer
    Gefässchirurgie 5 (2000), S. 192-195 
    Details
    ISSN: 1434-3932
    Keywords: Schlüsselwörter Sarkoidose ; Aorta ; Aneurysma spurium ; Keywords Sarcoidosis ; Aorta ; False aneurysm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract  Spontaneous rupture und false aneurysms of the non-arteriosclerotic aorta are rare. We report on a 53-year-old patient with false aneurysm due to covered rupture of the thoraco abdominal aorta following sarcoidosis initially repaired by semicircumferential aortic end-to-end anastomosis. After 6 months local recurrence occurred and the afflicted aorta was replaced by autologous arterial graft, transferring the right iliac artery as aortic patch. The iliac reconstruction was performed by PTFE interposition. There was no specific therapy for sarcoidosis. At 1 year follow-up there was no recurrence and the patient is free of symptoms.
    Notes: Zusammenfassung Spontane Rupturen und falsche Aneurysmen der nicht degenerativ veränderten Aorta sind selten. Wir berichten über einen 53-jährigen Patienten mit sarkoidose- induzierter Ruptur der Aorta im thorakoabdominellen Übergangsbereich. Die Primärversorgung erfolgte durch semizirkumferentielle End-zu-End-Anastomose der Aorta. Nach 6 Monaten zeigte sich ein lokales Rezidiv, es erfolgte der Ersatz der erkrankten Aorta durch autologen arteriellen Transfer der A. iliaca communis (AIC) von rechts als aortale Patchplastik. Die Strombahn der rechten Beckenachse wurde durch ein PTFE-Interponat wiederhergestellt. Eine spezifische Therapie der Sarkoidose wurde nicht durchgeführt. Nach 1 Jahr ist der Patient rezidiv- und krankheitsfrei.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00010593
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