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  • 1
    Electronic Resource
    Electronic Resource
    Experiments on the efficacy and toxicity of locoregional chemotherapy of liver tumors with 5-fluoro-2′-deoxyuridine (FUDR) and 5-fluorouracil (5-FU) in an animal model (1986)
    Springer
    Journal of cancer research and clinical oncology 111 (1986), S. 42-46 
    Details
    ISSN: 1432-1335
    Keywords: Locoregional chemotherapy ; Neoplasms of the liver ; Experimental rat tumors ; Fluorinated pyrimidines ; Bone marrow depression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary For the investigation of locoregional chemotherapy of liver neoplasms we developed a standardized animal model in the rat. Continuous infusion therapy or repeated bolus injections of FUDR or 5-FU were given via the hepatic artery, the portal vein or the vena cava in tumor-bearing animals. The efficacy of the treatment was determined by measuring the tumor volume 3 weeks after tumor cell implantation. For the evaluation of the local and systemic toxicity serum GOT, GPT, and total bilirubin were determined. DNA single strand breaks were assessed in isolated liver and bone marrow cells. Inhibition of colony formation of bone marrow stem cells was determined by CFU-C and CFU-S bioassay. A significant reduction of tumor growth was observed only after continuous infusion of FUDR via the hepatic artery. Systemic toxicity was lowest in this group for both compounds while the local liver toxicity was only slightly elevated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402774
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Feasible model for locoregional and systemic longterm administration of drugs and concomitant blood sampling in Sprague-Dawley rats (1987)
    Springer
    Journal of cancer research and clinical oncology 113 (1987), S. 27-30 
    Details
    ISSN: 1432-1335
    Keywords: Locoregional drug administration ; Blood sammpling ; Rat model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This methodological study describes three surgical prodedures for locoregional and systemic drug administration, which are based on a similar experimental design. Cannulation of the arterial and portal access to the liver in comparison to the general venous system, and arterial access to the large intestine through a permanently implantable system, suitable for serial bolus injections and infusions in unrestrained rats, is presented (experiment I). Furthermore, an infusion system for longterm administration (experiment II) and a method for blood sampling during locoregional or systemic infusion procedures (experiment III) have been developed. The positioning and free flow of the catheters were checked by means of scintigraphy, administration of fluorescein under UV light and angiography in animals of experimental series I. After 7 days, no obstruction was detected. On day 15 and 30 following implantation 73.3% and 58.3% of the animals, respectively, showed unimpeded flow through the catheter system. The methods described here were well tolerated by the animals without alteration of their general condition and are currently in use in a series of chemotherapeutic and pharmacokinetic investigations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00389963
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    310. Ein EDV-gestütztes Dokumentationssystem für die Onkologie (1987)
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 930-930 
    Details
    ISSN: 1435-2451
    Keywords: Documentation ; Oncology ; Personal Computer ; EDV ; Dokumentation Onkologie ; Personal-Computer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Personal-Computer erlauben neue Wege der klinischen Dokumentation. Das vorgestellte Programm ermöglicht in Verbindung mit dem kommerziellen Datenbanksystem dBase III eine Datenerfassung mit simultanen Plausibilitätskontrollen direkt am Bildschirm. Tumorlokalisation, histologischer Befund, TNM-Klassifikation und durchgeführte Operationen werden automatisch codiert und zusammen mit den weiteren Basisdaten gespeichert. Eine Dokumentation der Nachsorgeuntersuchungen ist ebenfalls vorgesehen und kann beliebig fortgeschrieben werden. Die Daten sind jederzeit für eigene statistische Auswertungen verfügbar und können anonymisiert an ein überregionales Krebsregister transferiert werden.
    Notes: Summary Personal computers make possible new methods of clinical documentation. In connection with the commercial data bank system, dBase III, the program presented permits the recording of data with simultaneous plausibility control right at the work station. Tumor localization, histological findings, TNM classification and the operations performed are coded automatically and stored with the other basic data. There is also a provision for documenting the follow-up examinations, which can be continued at well. The data can be used at any time to carry out your own statistical evaluations and can be transferred anonymously to a centralized cancer registry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01298095
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    Paper (German National Licenses)
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