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  • 1
    Electronic Resource
    Electronic Resource
    Acral-lentiginous naevus of plantar skin (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 27 (1995), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In a consecutive series of 165 plantar naevi, a group of 36 benign naevi with sufficiently distinctive histopathological features to justify their classification as a special entity, here designated acral-lentiginous naevus, was identified. The main morphological features distinguishing the acral-lentiginous naevi from other acral non-lentiginous naevi are: elongation of rete ridges, continuous proliferation of melanocytes at the dermo-epidermal junction, presence of single scattered melanocytes, or less commonly small clusters, within the upper epidermis, poor or absent lateral circumscription, melanocytes with abundant pale cytoplasm and round to oval, sometimes hyperchromatic, nuclei and prominent nucleoli present at the dermo-epidermal junction. Some histological features of acral-lentiginous naevi are similar to those of dysplastic naevi; however, anastomosing rete ridges, cytological atypia and well-formed lamellar fibroplasia are absent. The histopathological criteria to distinguish these naevi from melanoma are: the lack of pagetoid lateral spread, the absence of mitotic activity in the deep dermal component and the evidence of dermal naevocytic differentiation. The identification of this benign acral naevus, that we have identified as the benign counterpart of acral lentiginous melanoma, is important in order to avoid misdiagnoses and consequent under- or over-treatment of doubtful pigmented lesions of acral skin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1995.tb00326.x
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  • 2
    Electronic Resource
    Electronic Resource
    A gene homologous to the reg gene is expressed in the human pancreas
    Amsterdam : Elsevier
    FEBS Letters 327 (1993), S. 289-293 
    Details
    ISSN: 0014-5793
    Keywords: Lithostathine ; Pancreas ; reg gene
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(93)81006-L
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Recent developments in high current liquid metal ion sources for space propulsion
    Amsterdam : Elsevier
    Vacuum 34 (1984), S. 43-46 
    Details
    ISSN: 0042-207X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0042-207X(84)90105-2
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Local expression of monocyte chemoattractant protein-1 (MCP-1) in idiopathic inflammatory myopathies (1999)
    Springer
    Acta neuropathologica 97 (1999), S. 642-648 
    Details
    ISSN: 1432-0533
    Keywords: Key words Inflammatory myopathies ; MCP-1 ; Chemokine ; Immune response ; In situ hybridization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The idiopathic inflammatory myopathies (IIM), including dermatomyositis (DM), polymyositis (PM), and inclusion body myositis (IBM), are a group of autoimmune diseases characterized by the recruitment of lymphocytes and monocytes to the site of affection. The mechanism for recruitment of these cells likely involves chemokines. The monocyte chemoattractant protein-1 (MCP-1), a chemoattractant to T lymphocytes and monocytes, may play an important role in the pathogenesis of IIM. Frozen muscular tissues were obtained from eight cases of DM, five PM, and four IBM. We investigated the MCP-1 expression by the reverse transcription -PCR technique, immunohistochemistry and in situ hybridization. MCP-1 mRNA was markedly expressed in all the IIM cases. Greater amounts of MCP-1 mRNA were observed in DM, and in situ hybridization showed MCP-1 mRNA accumulation in perivascular mononuclear cells. Immunohistochemistry showed MCP-1 expression in vessels (endothelial cells and walls of veins and arteries) in all IIM cases. Very few mononuclear cells in DM perivascular infiltrates expressed MCP-1, whereas in PM and IBM, it was strongly expressed by mononuclear cells partially invading non-necrotic muscle fibers. These findings suggest that MCP-1 can contribute to the inflammatory response by attracting monocytes and T lymphocytes to sites of cell-mediated immune injury. The morphological characteristics and distribution of positive cells indicate that macrophages, lymphocytes, and endothelial cells previously reported to produce MCP-1, contribute to its production in IIM lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010051041
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  • 5
    Electronic Resource
    Electronic Resource
    Clinical application of the Mullen and Foster method for individualizing phenytoin dosage (1984)
    Springer
    Neurological sciences 5 (1984), S. 195-200 
    Details
    ISSN: 1590-3478
    Keywords: Anticonvulsants ; phenytoin ; pharmacokinetics ; Michaelis-Menten kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Il metodo di Mullen e Foster è stato applicato al fine di individualizzare la posologia della fenitoina in 24 pazienti epilettici. Le caratteristiche di precisione ed affidabilità del metodo sono state valutate confrontando le concentrazioni plasmatiche previste con quelle misurate sperimentalmente. La differenza percentuale tra valori e misurati della concentrazione plasmatica di fenitoina è risultata inferiore al 15 per cento in 22 casi su 35 (63 per cento), compresa tra il 15 e il 25 per cento in 8 casi su 35 (23 per cento), superiore al 25 per cento in 6 casi su 35 (17 per cento).
    Notes: Abstract The Mullen and Foster method was prospectively applied for individualizing phenytoin dosage in 24 epileptic patients. Accuracy and reliability of the method were assessed by comparing predicted and measured values of plasma phenytoin steady-state concentration. The absolute difference between predicted and measured phenytoin levels was less than 15 percent in 22 of 35 cases (63 percent), between 15 and 25 percent in 8 of 35 cases (23 percent) and more than 25 percent in 6 of 35 cases (17 percent).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02043223
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    Paper (German National Licenses)
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