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  • 1
    Electronic Resource
    Electronic Resource
    Cost-effectiveness of adjuvant chemotherapy with cyclophosphamide + methotrexate + fluorouracil in patients with node-positive breast cancer (1997)
    Springer
    European journal of clinical pharmacology 51 (1997), S. 427-427 
    Details
    ISSN: 1432-1041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050225
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  • 2
    Electronic Resource
    Electronic Resource
    Changes of mitochondrial cytochrome c oxidase and FoF1 ATP synthase subunits in rat cerebral cortex during aging (1995)
    Springer
    Neurochemical research 20 (1995), S. 1465-1470 
    Details
    ISSN: 1573-6903
    Keywords: Cytochrome c oxidase ; FoF1 ATP synthase ; aging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The contents of subunits I, II/III, and IV of cytochrome c oxidase and of subunits α, β and γ of FoF1 ATP synthase in inner mitochondrial membrane proteins purified from cerebral cortex of rat at 2, 6, 12, 18, 24, and 26 months of age were analyzed by western blot. Age-related changes in the content of subunits, either of mitochondrial or nuclear origin, were observed. All the cytochrome c oxidase (COX) subunits examined showed an age-related increase from 2-month-old rats up to 24 months with a decrease at the oldest age (26 months). The same pattern of age-dependent changes was observed for γ ATP synthase, while the α and β subunits increased progressively up to 26 months.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00970595
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  • 3
    Electronic Resource
    Electronic Resource
    Cost-effectiveness of adjuvant chemotherapy with cyclophosphamide + methotrexate + fluorouracil in patients with node-positive breast cancer (1996)
    Springer
    European journal of clinical pharmacology 51 (1996), S. 111-116 
    Details
    ISSN: 1432-1041
    Keywords: Key words Adjuvant chemotherapy ; Breast cancer; pharmacoeconomics ; cost-effectiveness analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Background: The analysis of published survival curves can be used as the basis for incremental cost-effectiveness analyses in which two treatments are compared with each other in terms of cost per life year saved. In patients with node-positive breast cancer adjuvant chemotherapy with cyclophosphamide + methotrexate + fluorouracil has been reported to improve survival in comparison with patients who are not given this treatment. Methods: To assess the pharmacoeconomic profile of this adjuvant chemotherapeutic regimen in terms of cost per life-year gained, we conducted an incremental cost-effectiveness analysis in which the Gompertz model was used to calculate the lifetime estimate of the patient-years gained by treated subjects compared to controls. Results: Using data from a published, controlled long-term trial involving 207 patients treated with cyclophosphamide + methotrexate + fluorouracil and 179 controls, we estimated that this adjuvant chemotherapy improved life expectancy by 357 patient-years per 100 subjects. Direct costs, which were almost exclusively related to the administration of chemotherapy, were estimated to be US $159,516 per 100 patients. On the basis of these data, adjuvant chemotherapy was found to imply an incremental cost of US $447 per life-year saved. Conclusions: The cost-effectiveness ratio of adjuvant chemotherapy with cyclophosphamide + methotrexate + fluorouracil in patients with node-positive breast cancer seems to be particularly favourable in comparison with estimates of cost per life-year saved previously calculated for other types of pharmacological intervention.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050169
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  • 4
    Electronic Resource
    Electronic Resource
    Regulation of Cytochrome c Oxidase and FoF1-ATPase Subunits Expression in Rat Brain During Aging (1998)
    Springer
    Neurochemical research 23 (1998), S. 55-61 
    Details
    ISSN: 1573-6903
    Keywords: Cytochrome c oxidase ; F0F1-ATP synthase ; mRNA ; aging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the present study we analyzed the age-dependent changes of mRNA levels for cytochrome c oxidase and F0F1-ATP synthase subunits in rat cerebral cortex and cerebellum. To establish whether the regulation of expression is transcriptional or post-transcriptional, the results were compared to those related to protein subunits levels, of the same enzymatic complexes, previously observed. The different patterns of age-related changes of mRNA subunits, in particular the lower increments, compared with those related to protein subunits, indicate that post-transcriptional mechanisms of regulation might be involved in the coordinated expression of the various subunits of each complex. Northern blotting analyses of RNA from the cerebellum of rats at the various ages, showed also differences in age-dependent patterns of transcription between cerebral cortex and cerebellum. Moreover, the major age-dependent changes of mitochondrial-encoded subunits, compared with the nuclear-encoded ones, previously observed at proteins level, occur also during transcription.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022449403619
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  • 5
    Electronic Resource
    Electronic Resource
    Clinical application of the Mullen and Foster method for individualizing phenytoin dosage (1984)
    Springer
    Neurological sciences 5 (1984), S. 195-200 
    Details
    ISSN: 1590-3478
    Keywords: Anticonvulsants ; phenytoin ; pharmacokinetics ; Michaelis-Menten kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Il metodo di Mullen e Foster è stato applicato al fine di individualizzare la posologia della fenitoina in 24 pazienti epilettici. Le caratteristiche di precisione ed affidabilità del metodo sono state valutate confrontando le concentrazioni plasmatiche previste con quelle misurate sperimentalmente. La differenza percentuale tra valori e misurati della concentrazione plasmatica di fenitoina è risultata inferiore al 15 per cento in 22 casi su 35 (63 per cento), compresa tra il 15 e il 25 per cento in 8 casi su 35 (23 per cento), superiore al 25 per cento in 6 casi su 35 (17 per cento).
    Notes: Abstract The Mullen and Foster method was prospectively applied for individualizing phenytoin dosage in 24 epileptic patients. Accuracy and reliability of the method were assessed by comparing predicted and measured values of plasma phenytoin steady-state concentration. The absolute difference between predicted and measured phenytoin levels was less than 15 percent in 22 of 35 cases (63 percent), between 15 and 25 percent in 8 of 35 cases (23 percent) and more than 25 percent in 6 of 35 cases (17 percent).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02043223
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    Paper (German National Licenses)
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