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  • 1
    Electronic Resource
    Electronic Resource
    Characterological traits of recovered patients with panic disorder and agoraphobia
    Amsterdam : Elsevier
    Journal of Affective Disorders 23 (1991), S. 113-117 
    Details
    ISSN: 0165-0327
    Keywords: Agoraphobia ; Anxiety disorders ; Panic ; Personality ; Prodromal symptoms
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-0327(91)90023-L
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  • 2
    Electronic Resource
    Electronic Resource
    Analysis of chlorpromazine in plasma: Effect of specimen storage
    Amsterdam : Elsevier
    Clinica Chimica Acta 109 (1981), S. 351-354 
    Details
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(81)90322-3
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  • 3
    Electronic Resource
    Electronic Resource
    Psycholinguistic and social psychological components of communication by and with the elderly
    Amsterdam : Elsevier
    Language and Communication 6 (1986), S. 1-24 
    Details
    ISSN: 0271-5309
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Linguistics and Literary Studies
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0271-5309(86)90002-9
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  • 4
    Electronic Resource
    Electronic Resource
    Chromosome aberrations and micronuclei in lymphocytes of workers exposed to low and medium levels of styrene (1992)
    Springer
    International archives of occupational and environmental health 64 (1992), S. 209-215 
    Details
    ISSN: 1432-1246
    Keywords: Chromosome aberrations ; Micronuclei ; Peripheral blood lymphocytes ; Styrene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the present study we analysed 19 workers exposed to styrene in two factories where polyester resins were used. Because of the different sizes of the pieces undergoing resin processing, the environmental styrene concentrations and urinary mandelic acid (MA) levels of the analysed subjects were quite different in the two plants examined. Cytogenetic monitoring was performed by analysis of chromosome aberrations (CAs) and micronuclei (Mn) in peripheral blood lymphocytes. Cytogenetic analysis revealed a significant increase in the percentage of aberrant cells and total aberrations in the group with higher styrene exposure (group 2) and no increase in the group with lower exposure (group 1), as compared with matched controls. Mn frequencies were not significantly increased in the two exposed populations. No correlations between length of exposure and CA or Mn frequency were found, and a weak correlation was found between exposure levels, measured as urinary MA, and Mn frequencies. Only 5 of the 12 exposed workers examined in group 2 had urinary MA levels higher than the limit recommended by the ACGIH in 1990–91 [1]. Significant increases in DNA damage are therefore already found at urinary MA levels lower than the internationally suggested exposure limits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00380911
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  • 5
    Electronic Resource
    Electronic Resource
    Otoneurological study in workers exposed to styrene in the fiberglass industry (1996)
    Springer
    International archives of occupational and environmental health 68 (1996), S. 219-223 
    Details
    ISSN: 1432-1246
    Keywords: Styrene ; Mandelic acid ; Phenylglyoxylic acid ; Vestibular tests ; Posturography ; Auditory brainstem responses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twenty workers exposed to styrene and acetone in small fiberglass factories were monitored for 8 h using passive dosimeters. Urine samples were collected at the end of the workshift and before the start of work on the next morning. The 8-h time-weighted average exposure values for styrene and acetone ranged from 14 to 416 mg/m3 and from 70 to 277 mg/m3, respectively. The sum of styrene metabolites, mandelic acid and phenylglyoxylic acid (MA + PGA), in the next-morning urine samples ranged from 81 to 943 mg/g creatinine. Different test sensitivity was identified in the otoneurological battery: it was low for audiometric tests and ABR, and relatively high for vestibular tests. The vestibular system seems partially sensitive to the toxic effects of styrene in the absence of clinical signs and symptoms. The actual exposure levels for styrene cannot be considered devoid of functional subclinical consequences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00381431
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  • 6
    Electronic Resource
    Electronic Resource
    Otoneurological study in workers exposed to styrene in the fiberglass industry (1996)
    Springer
    International archives of occupational and environmental health 68 (1996), S. 219-223 
    Details
    ISSN: 1432-1246
    Keywords: Key words Styrene ; Mandelic acid ; Phenylglyoxylic acid ; Vestibular tests ; Posturography ; Auditory brainstem responses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Twenty workers exposed to styrene and acetone in small fiberglass factories were monitored for 8 h using passive dosimeters. Urine samples were collected at the end of the workshift and before the start of work on the next morning. The 8-h time-weighted average exposure values for styrene and acetone ranged from 14 to 416 mg/m3 and from 70 to 277 mg/m3, respectively. The sum of styrene metabolites, mandelic acid and phenylglyoxylic acid (MA+PGA), in the next-morning urine samples ranged from 81 to 943 mg/g creatinine. Different test sensitivity was identified in the otoneurological battery: it was low for audiometric tests and ABR, and relatively high for vestibular tests. The vestibular system seems partially sensitive to the toxic effects of styrene in the absence of clinical signs and symptoms. The actual exposure levels for styrene cannot be considered devoid of functional subclinical consequences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00381431
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  • 7
    Electronic Resource
    Electronic Resource
    The validity of urinary metabolites as indicators of low exposures to toluene (1985)
    Springer
    International archives of occupational and environmental health 56 (1985), S. 135-145 
    Details
    ISSN: 1432-1246
    Keywords: Toluene ; Environmental monitoring ; Hippuric acid ; Orthocresol ; Biological monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Exposure to toluene was studied in a group of 14 subjects working in a printing industry, who were exposed to this solvent only. Environmental monitoring was carried out using personal samplers for the whole workshift over three consecutive days. Toluene TWA concentrations ranged from 37 to 229 mg/m3. At the end of the workshift on each day of investigation, urine samples were collected for the determination of hippuric acid and ortho-cresol. Hippuric acid was also determined for urine before the workshift and on the Saturday and Monday mornings after the end of exposure; hippuric acid was also determined in 16 controls over the same five-day period. At the end of the workshift, hippuricuria levels in exposed workers always turned out to be statistically different from pre-workshift levels and those of the controls. The end-of-workshift hippuricuria levels of exposed workers were significantly correlated with the mean daily environmental concentration (TWA): in the three days of comparative study, we found r = 0.63 (P 〈 0.05) on Day 1, r = 0.90 (P 〈 0.001) on Day 2, and r = 0.87 (P 〈 0.001) on Day 3. Orthocresol turned out to be correlated with daily exposure less significantly than hippuric acid: r = 0.49 (n.s.) on Day 1; r = 0.78 (P 〈 0.001) on Day 2, and r = 0.65 (P 〈 0.05) on Day 3. Using all available data (41 observations), a very significant correlation (P 〈 0.001) was found between the TWA and both metabolites (r = 0.80 for hippuric acid; r = 0.68 for o-cresol). The values of the two metabolites in the end-of-workshift urine samples (41 observations) also turned out to be well correlated (r = 0.70; P 〈 0.001). The authors conclude that hippuric acid is a valid test for evaluating even low exposures to toluene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00379385
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  • 8
    Electronic Resource
    Electronic Resource
    Ethylene oxide exposure (1986)
    Springer
    International archives of occupational and environmental health 58 (1986), S. 105-112 
    Details
    ISSN: 1432-1246
    Keywords: Ethylene oxide ; Alveolar air ; Blood biological monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Occupational exposure to ethylene oxide (ETO) was studied in ten workers employed in a hospital sterilizer unit by testing environmental air, alveolar air and blood during and at the end of the workshift. Alveolar (Ca) and blood (Cb) ETO concentrations were correlated with each other (r = 0.744, na = 36, P 〈 0.001) and both with the environmental (Ci) concentrations (r = 0.947, n = 144, P 〈 0.001; r = 0.827, n = 36, P 〈 0.001). The alveolar retention of ETO (1-Ca/Ci) was equal to 75–80% of the inhaled ETO. In comparison with a blood/air partition coefficient equal in vitro to 90 (SD = 20), the mean Cb/Ca ratio found in the exposed workers was equal to 12–17. During work the blood ETO concentration was, on average, three times the environmental ETO concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00380761
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  • 9
    Electronic Resource
    Electronic Resource
    Biological monitoring of workers exposed to styrene and acetone (1993)
    Springer
    International archives of occupational and environmental health 65 (1993), S. S107 
    Details
    ISSN: 1432-1246
    Keywords: Acetone ; Biological monitoring ; Fiberglass Industry ; Mandelic and phenylglyoxylic acids ; Styrene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-two workers exposed to styrene and acetone in two fiberglass industries were monitored on Monday and Thursday for 8 hours using passive dosimeters. Urine samples were collected at the end of the workshift and before the start of the work on the next morning (Tuesday and Friday). The charcoal disks of the passive dosimeters were analysed by gas-chromatography. Mandelic acid (MA) and phenylglyoxylic acid (PGA) were measured using a HPLC method; values were expressed in mg/g of creatinine. The 8-h TWA exposure values for styrene and acetone ranged respectively from 22 to 522 mg/m 3 and 40-1581 mg/m on Monday; 25–423 mg/m3 and 55–579 mg/m3 on Thursday. Styrene TWA exposure values significantly correlate with the sum of metabolites at the end of workday (r = 0.70 on Monday and r = 0.95 on Thursday) and also at the next morning (r = 0.86 on Tuesday and r = 0.85 on Friday). A styrene exposure level of 213 mg/m3 (ACGIH-TLV) was associated with an excretion of metabolites (MA+PGA) higher on Thursday (803 mg/g Great) than on Monday (570 mg/g creat). The same result was found on Friday (459 mg/g creat) compared with Tuesday (305 mg/g creat). Moreover our data show that the simultaneous exposure to acetone does not modify the excretion of MA. In conclusion the TLV of styrene is associated with different values of metabolites at the beginning and at the end of the work-week.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00381318
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  • 10
    Electronic Resource
    Electronic Resource
    High performance liquid chromatographic determination of methyl ethyl ketone in urine as its 3-methyl-2-benzothiazolinone hydrazone derivative (1995)
    Springer
    Chromatographia 40 (1995), S. 336-340 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Methyl ethyl ketone in urine ; Derivatization ; 3-Methyl-2-benzothiazolinone hydrazone ; Comparison with GC-MS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A HPLC method for the determination of methyl ethyl ketone (MEK) in urine after derivatization with 3-methyl-2-benzothiazolinone hydrazone is proposed. The calibration curve for the ketone was linear, ranging between 0.23–10 mg/L, with a detection limit of 0.025 mg/L. The results were compared to those obtained by GC-MS, coupled to the headspace technique. MEK derivatization and the derivative purification processes were verified with respect to the main variables such as reaction temperature, reagent concentration, probable interferences and enrichment phase. The method is simple and reliable and shows a good sensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02290366
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