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  • 1
    Electronic Resource
    Electronic Resource
    Argyrophilic and endocrine cells in breast cancer (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 9 (1985), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1985.tb02806.x
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  • 2
    Electronic Resource
    Electronic Resource
    The nature of breast dense core granules: chromogranin reactivity (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 20 (1992), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ultrastructural immunoreactivity for chromogranin with the LK2H10 antibody was examined in nine cases of breast carcinoma and one example of normal resting breast. These tissues were selected for study on the basis of argyrophilia or LK2H10 immunostaining by light microscopy. In two cases, positive reactivity with the chromogranin antibody was seen in breast neuroendocrine-like dense core granules. In a further six cases chromogranin reactivity was not seen in similar granules that showed the neuroendocrine properties of ultrastructural argyrophilia and uranaffinity. Inability to exhibit the full complement of neuroendocrine characteristics in breast carcinomas contrasts with the facility to demonstrate them in tissues of usual neuroendocrine differentiation. Furthermore, in two mucoid carcinomas and one example of normal resting breast ultrastructural cytoplasmic LK2H10 reactivity was evident, which was not localized to dense core granules, although these were present in two of the cases. Our findings demonstrate the heterogeneity of breast dense core granules and discourage acceptance of such characteristics as evidence of histogenesis of these carcinomas from a neuroendocrine cell type in breast tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1992.tb00939.x
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  • 3
    Electronic Resource
    Electronic Resource
    The nature of breast dense core granules: uranaffin reactivity (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 11 (1987), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In this study breast tissue that contained ultrastructural dense core granules has been examined from 24 patients. The possible neuroendocrine characteristics of the granules were studied using the uranaffin reaction and an ultrastructural argyrophil stain. The tissue included 15 breast carcinomas and nine benign samples. Two types of breast dense core granules can be distinguished on the basis of intracellular distribution patterns and histochemical reactivity. Type I dense core granules are the most common and they were found subluminally distributed in non-pathological tissues and benign lesions as well as carcinomas. They were uranaffin-negative and are unlikely to be of endocrine nature. Type II dense core granules were found only in four carcinomas, where they occurred abundantly throughout the cytoplasm. These granules were uranaffin-positive and argyrophilic and thus exhibited characteristics consistent with neuroendocrine structure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1987.tb01855.x
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  • 4
    Electronic Resource
    Electronic Resource
    An ultrastructural study of mucoid carcinoma of the breast: variability of cytoplasmic features (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 10 (1986), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The ultrastructural characteristics of 14 cases of mucoid carcinoma of the breast, with different histological appearances, have been examined. Thirteen of the tumours were observed to consist of two populations of tumour cells, one showing secretory changes while the other group showed no evidence of activity. In one tumour only synthetically active cells were observed. Ultrastructurally, six different types of cytoplasmic granules, comprising typical mucin plus glycoprotein or proteincontaining granules, were identified within the synthetically active tumour cells. The number of types of granules and the relative proportion of the various granules varied between tumours with only mucin granules present in all tumours. It would appear that synthetic pathways are activated in certain tumours which result in protein/glycoprotein granules associated with the argyrophilia observed histologically. In addition, the tumours varied with respect to luminal differentiation, presence of intracytoplasmic lumina, intracytoplasmic mucin pools, lipid droplets, ciliated cells and areas of calcification. The marked heterogeneity of the ultrastructural features of the mucoid carcinoma of the breast prevents the tumours from being readily divided into distinct subgroups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1986.tb02566.x
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  • 5
    Electronic Resource
    Electronic Resource
    Histological changes in breast tissue that characterize recent pregnancy (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 15 (1989), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1989.tb01593.x
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of undoped GaAs spacers on the characteristics of GaAs-(Al,Ga)As-GaAs single barrier structures (1989)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 65 (1989), S. 1183-1188 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The effects of undoped spacer layers on the electrical properties of single barrier heterostructures (both alloy and superlattice) have been investigated by measuring incremental slope resistance over the bias range −400 to +400 mV and at convenient temperature intervals between 70 and 290 K. The zero bias slope resistance, Rs(0), and the effective barrier heights increase with spacer thickness. Also, the low-temperature slope resistances, Rs(V), decrease exponentially with the magnitude of the bias, V, while the effective barrier heights, deduced from high-temperature measurements, decrease approximately linearly. This suggests that the decrease in Rs(V) with bias is due simply to the voltage-induced decrease in effective barrier height. Rs(0) varies exponentially with zero bias effective barrier height for both alloy and superlattice barriers and this is consistent with the Γ electrons dominating the current transport through the barriers. All of our Rs(V) curves are asymmetric and, using Airy function calculations, we have modeled curves similar to the experimental ones by assuming different doping levels for the two doped GaAs layers on either side of the barriers. This is possibly due to Si migration into the "undoped'' barrier or the spacer layer closest to the substrate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.343061
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  • 7
    Electronic Resource
    Electronic Resource
    Influence of oral contraceptives on normal human breast epithelial proliferation
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 28 (1987), S. 4 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(87)91112-5
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  • 8
    Electronic Resource
    Electronic Resource
    Proliferative and secretory activity in the pregnant and lactating human breast (1988)
    Springer
    Virchows Archiv 413 (1988), S. 189-196 
    Details
    ISSN: 1432-2307
    Keywords: Breast ; Human ; Pregnancy ; Proliferation ; Secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this study the proliferative and secretory activity of human pregnant and lactating breast has been examined. 17 cases of pregnant tissue were obtained, comprising 9 from first trimester, 6 from the second and 2 from the third, together with 3 cases of lactating breast. Proliferation, measured by 3H thymidine autoradiography, gave a constant Thymidine labelling index of approximately 6% during the first 20 weeks, with a reduction by 50% thereafter. Levels of 0.2% were seen during lactation. Morphological assessment showed a high frequency of both mitosis and apoptosis throughout gestation. Although mitotic frequency did reduce with time, values were more variable than thymidine labelling. The reduction in thymidine uptake halfway through pregnancy coincided with generalised morphological lactational differentiation and the major immunocytochemical expression of alpha-lactalbumin. However, cytoplasmic expression of the secretory component of IgA was generalised and marked even during the first trimester and was closely related to increased proliferation and general synthetic cellular activity. These and other observations support a complex relationship of autocrine and paracrine factors in addition to the customary endocrine ones for breast regulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00718610
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  • 9
    Electronic Resource
    Electronic Resource
    The ultrastructure of Rhesus monkey prostate (1977)
    Springer
    Urological research 5 (1977), S. 175-183 
    Details
    ISSN: 1434-0879
    Keywords: Monkey ; Prostate ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An ultrastructural study of immature and mature rhesus monkey prostate is described and a comparison is made with human tissue. The immature gland consists of largely undifferentiated epithelium showing little or no secretory activity. The mature gland exhibits the general characteristics of prostates of the other species studied. Columnar epithelial cells and undifferentiated basal cells are observed. The two lobes of the gland show several differences, the caudal lobe being rich in secretory granules, with the cranial lobe consisting of taller vacuolated cells. The description provides a basis for comparison with ultrastructural changes produced during in vivo and in vitro experimentation and with characteristics of normal and diseased human prostate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00263734
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  • 10
    Electronic Resource
    Electronic Resource
    The effect of orally administered cadmium on the ultrastructure of the rat prostate (1982)
    Springer
    Urological research 10 (1982), S. 123-130 
    Details
    ISSN: 1434-0879
    Keywords: Prostate ; Cadmium ; Ultrastructure ; Testosterone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of cadmium and nickel chloride, administered in drinking water at 5 and 50 ppm, on the rat prostate are described. Zinc concentrations in the two lobes of the gland were unaffected by the metals and no consistent changes were observed at the subcellular level by X-ray microanalysis. The ultrastructural appearance of the prostate gland in rats of varying ages was unaltered following cadmium administration at those levels, while plasma testosterone concentrations did not differ significantly in cadmium treated animals. Low levels of cadmium (5 ppm) were accumulated by the ventral lobe of the prostate, although the metal was not detectable subcellularly. The results are discussed in relation to human prostatic carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00255954
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