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  • 1
    Electronic Resource
    Electronic Resource
    Elevated cytokine levels in tracheobronchial aspirate fluids from ventilator treated neonates with bronchopulmonary dysplasia (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 112-116 
    Details
    ISSN: 1432-1076
    Keywords: Key words Bronchopulmonary ; dysplasia ; Tracheobronchial aspirate ; Interleukins ; Cytokines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Bronchopulmonary dysplasia (BPD) is a chronic lung disease often occurring in ventilator-treated very low birth weight infants. The aetiology of BPD is multifactorial and pulmonary immaturity, high oxygen concentrations, peak inspiratory pressure levels and large tidal volumes during prolonged mechanical ventilation are important factors. We measured in tracheobronchial aspirate fluid (TAF) the concentrations of the pro-inflammatory cytokines tumour necrosis factor α, interleukin-1β (IL-1β), IL-6, IL-8, and IL-1 receptor antagonist in infants requiring artificial ventilation for BPD (n = 17) or respiratory distress syndrome (RDS) (n = 15) or postoperatively after surgery (n = 15). The median levels of all studied cytokines in TAF were higher in infants with BPD without local or systemic corticosteroid treatment compared to the median TAF levels of BPD neonates treated with corticosteroids (P = 0.06–P 〈 0.01). The neonates with BPD not treated with corticosteroids also showed higher levels of the five studied cytokines in TAF compared to infants on short-time ventilator treatment (P 〈 0.01–P 〈 0.001) and compared to neonates with RDS (P = 0.07–P 〈 0.001). The corticosteroid treated neonates with BPD had TAF cytokine levels approaching those of the control neonates. Conclusion Tumour necrosis factors α, IL-1β, IL6, IL8 and IL1ra were markedly elevated in tracheobronchial aspirate fluids from neonates with bronchopulmonary dysplasia. Corticoid treatment seemed to reduce these levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050386
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  • 2
    Electronic Resource
    Electronic Resource
    Elevated cytokine levels in tracheobronchial aspirate fluids from ventilator treated neonates with bronchopulmonary dysplasia (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 112-116 
    Details
    ISSN: 1432-1076
    Keywords: Bronchopulmonary dysplasia ; Tracheobronchial aspirate ; Interleukins ; Cytokines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Abstract Bronchopulmonary dysplasia (BPD) is a chronic lung disease often occurring in ventilator-treated very low birth weight infants. The aetiology of BPD is multifactorial and pulmonary immaturity, high oxygen concentrations, peak inspiratory pressure levels and large tidal volumes during prolonged mechanical ventilation are important factors. We measured in tracheobronchial aspirate fluid (TAF) the concentrations of the pro-inflammatory cytokines tumour necrosis factor α, interleukin-1β (IL-1β), IL-6, IL-8, and IL-1 receptor antagonist in infants requiring artificial ventilation for BPD (n=17) or respiratory distress syndrome (RDS) (n=15) or postoperatively after surgery (n=15). The median levels of all studied cytokines in TAF were higher in infants with BPD without local or systemic corticosteroid, treatment compared to the median TAF levels of BPD neonates treated with corticosteroids (P=0.06−P〈0.01). The neonates with BPD not treated with corticosteroids also showed higher levels of the five studied cytokines in TAF compared to infants on short-time ventilator treatment (P〈0.01−P〈0.001) and compared to neonates with RDS (P=0.07−P〈0.001). The corticosteroid treated neonates with BPD had TAF cytokine levels approaching those of the control neonates. Conclusion Tumour necrosis factors α, IL-1β, IL6, IL8 and IL 1 ra were markedly elevated in tracheobronchial aspirate fluids from neonates with bronchopulmonary dysplasia. Corticoid treatment seemed to reduce these levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02075762
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  • 3
    Electronic Resource
    Electronic Resource
    Use of labetalol in hypertensive patients during discontinuation of clonidine therapy (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 237-240 
    Details
    ISSN: 1432-1041
    Keywords: labetalol ; clonidine ; hypertension ; adverse effects ; plasma catecholamines ; plasma cAMP ; withdrawal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Eleven hypertensive patients in whom clonidine therapy had to be discontinued, were treated prophylactically with labetalol, in order to avoid a possible hypertensive crisis. Most of the known side effects, which are consistent with the withdrawal phenomenon were observed, e.g. tremor, insomnia and apprehension, but headaches and flushing did not occur. Blood pressure levels remained unchanged, despite up to a 20-fold increase in plasma catecholamines. The lack of change in serial measurements of plasma cyclic AMP level appears to indicate that adequate adrenergic blockade was induced by labetalol. Since labetalol is a potent anti-hypertensive drug, and is also effective in avoiding a possible hypertensive crisis due to withdrawal of clonidine, we propose to use it as the drug of choice whenever discontinuation of clonidine therapy is indicated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00618771
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  • 4
    Electronic Resource
    Electronic Resource
    Non-radioactively labelled DNA probes for the detection of periodontopathogenic Prevotella and Porphyromonas species (1993)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 6 (1993), S. 0 
    Details
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Abstract Dioxigenin-labelled synthetic DNA probes directed against the 16S rRNA were used for the direct detection of the periodontopathogenic bacteria Prevotella intermedia and Porphyromonas gingivalis in subgingival plaque by applying a DNA-RNA dot-blot hybridization procedure. The test was evaluated with 134 plaque samples from 26 patients with adult periodontitis or rapidly progressive periodontitis. The lower limit of detection was 104–105 bacteria/specimen. A semiquantitative assessment of the two species in each sample and in the corresponding periodontal site was achieved by this technique. It is possible to examine 80–90 samples within two days with low material costs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-695X.1993.tb00313.x
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  • 5
    Electronic Resource
    Electronic Resource
    Urine interleukin-6 and interleukin-8 in children with acute pyelonephritis, in relation to DMSA scintigraphy in the acute phase and at 1-year follow-up (1994)
    Springer
    Pediatric radiology 24 (1994), S. 513-515 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between urine interleukin-6 (IL-6) and interleukin-8 (IL-8)/creatinine quotients and99mTc-dimercaptosuccinic acid (DMSA) scintigraphy, performed within 10 days of acute first-time pyelonephritis and after 1 year, was studied in 41 children. The urine IL-6 and IL-8/creatinine quotients were also related to the urineN-acetyl-β-D-glucosaminidase (NAG) and albumin/creatinine quotients. Presence of DMSA uptake defects, reflecting local inflammation, in children in the acute phase of pyelonephritis, were associated with elevated urine IL-6/creatinine quotients (median 27 pg/μmol); in children without DMSA changes there was no increase in quotients (median non-detectable) (P〈0.05). Persistent DMSA changes at the 1-year follow-up, probably reflecting renal scarring, were only seen in children with increased urine IL-6/creatinine quotients in the acute phase (P〈0.01). No correlation was found between urine IL-8 and DMSA uptake defects. Vesicoureteral reflux (VUR) at 6–8 weeks did not correlate with the urine cytokine levels in the acute phase. The urine excretion of NAG and albumin, reflecting renal dysfunction, was associated with values of both urine IL-6 and IL-8/creatinine quotients, but not with DMSA defects or VUR. Thus, the initial urine IL-6/creatinine quotients might be used as an indicator of risk for persistent renal damage in acute pyelonephritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02015016
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  • 6
    Electronic Resource
    Electronic Resource
    Occurrence of P-fimbriatedEscherichia coli in patients with bacteremia (1985)
    Springer
    European journal of clinical microbiology & infectious diseases 4 (1985), S. 566-569 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The case history of 88 patients with blood cultures positive forEscherichia coli and evidence of systemic disease was reviewed, and theEscherichia coli blood isolates tested for P-fimbriation. Fifty-five strains (63 %) were P-fimbriated. Patients with a positive urine culture had a higher incidence of P-fimbriatedEscherichia coli strains (53/75, 71 %) than patients with a negative urine culture (2/13, 15%). Patients with no predisposing factors, such as instrumentation of the urinary tract or a chronic disease, had a significantly higher frequency of P-fimbriated strains (31/36, 86%) compared to patients without such underlying factors (p 〈 0.01). There was no significant difference in clinical parameters or in frequency of P-fimbriated strains between patients with one positive blood culture and those with two or more positive cultures. The high incidence of P-fimbriatedEscherichia coli strains in these patients is thought to depend on the ability of such bacteria to cause acute pyelonephritis, which in many cases precedesEscherichia coli bacteremia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02013396
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  • 7
    Electronic Resource
    Electronic Resource
    Production of cytotoxic necrotizing factor, verocytotoxin and haemolysin by pyelonephritogenicEscherichia coli (1990)
    Springer
    European journal of clinical microbiology & infectious diseases 9 (1990), S. 762-767 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two hundred and thirty-two strains ofEscherichia coli isolated from children with non-obstructive acute pyelonephritis (n=65), women with non-obstructive acute pyelonephritis (n=63) and the faecal flora of healthy children (n=33) and adults (n=71) were examined for cytotoxic necrotizing factor production, haemolysin synthesis, verocytotoxin production and expression of mannose-resistant haemagglutination of human erythrocytes. Forty-eight per cent of the pyelonephritogenicEscherichia coli strains produced cytotoxic necrotizing factor and 61 % produced haemolysin compared to 25 % and 27 % of faecal control strains (p〈0.001 and p〈0.001 respectively). Cytotoxic necrotizing factor production did not occur among the non-haemolyticEscherichia coli strains which confirms the close association between these two toxic factors. The bacterial phenotypes producing both haemolysin and cytotoxic necrotizing factor, and the phenotype expressing both these toxic factors and mannose-resistant haemagglutination occurred significantly more often in pyelonephritogenic strains than in faecal isolates (p〈0.001). Haemolytic strains without the ability to produce cytotoxic necrotizing factor were more common in faecal isolates than in uropathogenic strains (p=0.05). Strains lacking the ability to synthesize both these toxins were also over-represented in faecal isolates (p〈0.01).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02184691
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  • 8
    Electronic Resource
    Electronic Resource
    Immunoglobulin G antibodies toPseudomonas aeruginosa lipopolysaccharides and exotoxin A in patients with cystic fibrosis or bacteremia (1993)
    Springer
    European journal of clinical microbiology & infectious diseases 12 (1993), S. 430-436 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract IgG antibodies to ninePseudomonas aeruginosa lipopolysaccharides (LPS) and exotoxin A in sera from 11 patients with bacteremia and 51 patients with cystic fibrosis (CF) were analyzed. The methods used were enzyme immunoassay (EIA) and immunoblotting. Nine of the 11 bacteremic patients were infected with strains expressing an LPS serotype identical to one of the test antigens. In sera from six of these nine patients, antibody homologous to the serotype of the infecting strain was observed. An antibody response to heterologousPseudomonas aeruginosa LPS antigens was observed in nine patients. Eight of the bacteremic patients mounted an antibody response to exotoxin A. Thirty-five CF patients chronically colonized withPseudomonas aeruginosa possessed significantly higher levels of antibody to all of the test antigens than 16 patients with intermittent or no colonization (p〈0.001). For exotoxin A and serotype 3 the sensitivity was 91 % and 94 %, and the specificity 94 % and 88 % respectively. When the results for exotoxin A and serotype 3 were combined, the sensitivity was 91 % while the specificity was 81 %. The pronounced antibody response to heterologous LPS antigens, as measured by the EIA and immunoblot, suggests expression of a common antigen determinant. A simplified serological assay utilizing exotoxin A and serotype 3 as test antigens may be useful for detectingPseudomonas aeruginosa infections in patients with CF and chronic colonization and in bacteremic patients from whom cultures are not available.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967437
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  • 9
    Electronic Resource
    Electronic Resource
    Incidence of aerobactin-positiveEscherichia coli strains in patients with symptomatic urinary tract infection (1988)
    Springer
    European journal of clinical microbiology & infectious diseases 7 (1988), S. 630-634 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A total of 323Escherichia coli strains from children with primary acute non-obstructive pyelonephritis (n=144) or cystitis (n=56) and from adults with acute non-obstructive pyelonephritis (n=66) or cystitis (n=57) were examined for presence of the aerobactin-mediated iron uptake system and expression of P-fimbriae. Overall, pyelonephritogenicEscherichia coli strains were significantly more often aerobactin-positive (72 %) than cystitis strains (42 %) (p〈0.001). Seventy-three percent of the isolates from children with acute pyelonephritis were aerobactin-positive compared to 54 % of the cystitis strains (p〈0.05). PyelonephritogenicEscherichia coli strains from adults were also significantly more often aerobactin-positive (70 %) than cystitis strains (30 %) (p〈0.001). The cystitis strains from children were more often aerobactin-positive than cystitis strains from adult patients (p〈0.05). There was a significant correlation between presence of the aerobactin-mediated iron uptake system and expression of P-fimbriae in all strains (p〈0.001).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964240
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  • 10
    Electronic Resource
    Electronic Resource
    Studies in chemical ionization mass spectrometry: VFor part IV, see Ref. 1. - localization of homoconjugated triene and tetraene units in aliphatic compounds (1982)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 17 (1982), S. 161-164 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The homoconjugated triene (‘linolenic acid unsaturation’) and tetraene (‘arachidonic acid unsaturation’) pattern can be readily recognized and localized in aliphatic compounds by chemical ionization (NO) mass spectrometry. This method may be used for the screening of biological material, especially in food analysis.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210170403
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