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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 52 (1930), S. 2668-2681 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 15 (1979), S. 319-322 
    ISSN: 1432-1041
    Keywords: warfarin ; anticoagulation ; age ; sex ; weight
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In 228 ambulatory patients receiving treatment with warfarin, there was a progressive decline in the dose required to produce an equivalent degree of anticoagulant control with increasing age from the third decade onwards. However, the relationship between age and dose was significant only in patients receiving warfarin after episodes of venous thromboembolism or because of coronary artery disease. Patient weight was also related to warfarin requirements, although it was less important a determinant than age.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 25 (1983), S. 547-551 
    ISSN: 1432-1041
    Keywords: astemizole ; histamine weal and flare ; urticaria ; pruritus ; antihistamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of astemizole on the weal and flare response to intradermal histamine has been studied in normal volunteers after single dosing, and in patients with urticaria and pruritus after chronic dosing with the drug. Single doses of astemizole (40 mg) in normal volunteers significantly reduced histamine weal and flare at 24 and 48 h (p〈0.001). Before treatment, there was a significantly greater response to intradermal histamine in patients with urticaria than pruritus (p〈0.05). Chronic dosing with astemizole produced significant reduction in histamine-induced weal and flare in both patient groups which did not show evidence of tachyphalaxis over the period of the study. The effect of astemizole on histamine-induced weal and flare was accompanied by a significant increase in the rate of weal and flare disappearance in both patients (weal p〈0.002, flare p〈0.05) and volunteers (weal p〈0.02, flare p〈0.005); but there was no change in the rate of weal formation. The effects of astemizole on weal and flare kinetics may be a function of its high level of H1 antagonist activity.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 21 (1981), S. 257-258 
    ISSN: 1432-1041
    Keywords: debrisoquine ; psoriasis ; chronic discoid psoriasis ; 4-hydroxylation ; microsomal oxidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary 1. The 4-hydroxylation of debrisoquine was measured in 42 patients with chronic discoid psoriasis. 2. The proportion of poor metabolisers (4.8%) and the median metabolic ratio (0.5) in psoriatics were similar to that reported previously in a healthy British population. 3. We conclude that the abnormality of microsomal mono-oxygenase activity which we have found in the skin and other tissues of psoriatics is not due to a generalised (non-specific) impairment of microsomal oxidation and may be enzyme specific.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 25 (1983), S. 567-568 
    ISSN: 1432-1041
    Keywords: astemizole ; ethanol ; antihistamine ; pharmacodynamics ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of astemizole (10 mg daily for 7 days) on the kinetics and CNS depressant activity of ethanol have been examined in a double-blind cross-over study agonist placebo in 7 volunteers. There was no significant change in the elimination rate or AUC of the plasma ethanol concentration-time curve after astemizole. Central nervous system effects of ethanol as monitored by visual analogues of sedation, visual discrimination, pursuit rotor and reaction time were also unaffected by astemizole pretreatment.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Annales geophysicae 15 (1997), S. 1548-1556 
    ISSN: 0992-7689
    Keywords: Auroral ionosphere ; Magnetosphere-ionosphere interactions ; MHD waves and instabilities HF Dopplre ; ULF Waves
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract A quantitative study of observations of the ionospheric signatures of magnetospheric ultra low frequency (ULF) waves by a high-latitude (geographic: 69.6°N 19.2°E) high-frequency Doppler sounder has been undertaken. The signatures, which are clearly correlated with pulsations in ground magnetometer data, exhibit periods in the range 100–400 s and have azimuthal wave numbers in the range 3–8. They are interpreted here as local field line resonances. Phase information provided by O- and X-mode Doppler data support the view that these are associated with field line resonances having large azimuthal scale sizes. The relative phases and amplitudes of the signatures in the Doppler and ground magnetometer data are compared with a model for the generation of Doppler signatures from incident ULF waves. The outcome suggests that the dominant mechanism involved in producing the Doppler signature is the vertical component of an E × B bulk motion of the local plasma caused by the electric field perturbation of the ULF wave.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0992-7689
    Keywords: Ionosphere (active experiments) ; Radio science (instruments and techniques) ; Space plasma physics (instruments and techniques)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract SPEAR is a new polar cap HF radar facility which is to be deployed on Svalbard. The principal capabilities of SPEAR will include the generation of artificial plasma irregularities, operation as an ‘all-sky’ HF radar, the excitation of ULF waves, and remote sounding of the magnetosphere. Operation of SPEAR in conjunction with the multitude of other instruments on Svalbard, including the EISCAT Svalbard radar, and the overlap of its extensive field-of-view with that of several of the HF radars in the SuperDARN network, will enable in-depth diagnosis of many geophysical and plasma phenomena associated with the cusp region and the substorm expansion phase. Moreover, its ability to produce artificial radar aurora will provide a means for the other instruments to undertake polar cap plasma physics experiments in a controlled manner. Another potential use of the facility is in ‚field-line tagging’ experiments, for coordinated ground-satellite experiments. Here the scientific objectives of SPEAR are detailed, along with the proposed technical specifications of the system.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 172 (1953), S. 77-78 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We have now investigated the electrical conductivity and thermoelectric potential of coprecipitated chromium oxide - alumina (Cr2O3-Al2O3) catalysts. The test specimens take the form of a small disk 1 mm. thick and 9*5 mm. in diameter, made by compression of the catalyst into a glass cell after ...
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0888-7543
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Soil use and management 14 (1998), S. 0 
    ISSN: 1475-2743
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract. Phosphorus budgets have been compiled for two contrasting grassland farming systems in the UK; intensive dairy farming and extensive hill sheep production. Balance sheets of inputs, recycling of P through the soil–plant–animal pathway and outputs are presented to determine the potential rate of P accumulation in the two systems. A typical 57 ha intensive dairy farm with 129 lactating cows imports 2.48t P via fertilizer, bedding and concentrates, plus a small amount from the atmosphere, of which 0.98t are exported in milk, calves and transfer from soil to the aquatic environment. Therefore 1.5t of P are retained within the farm each year, which equates to an accumulation rate of 26 kg/ha in the plant-soil system. This surplus occurs despite a fertilizer input of only 16 kg/ha. However, a large proportion of P, equivalent to 27 kg/ha, is imported in feed concentrates.For the typical 841 ha hill sheep farm supporting 694 Blackface ewes, P inputs and outputs are 0.66 and 0.42 t/yr, respectively. Therefore, approximately 0.24t P are retained within the farm, which is equivalent to an accumulation rate of 0.28 kg/ha per yr. In comparison to the small annual inputs and outputs of P on the hill farm, much P, 2.48t, is recycled through the plant-soil and plant-animal-soil pathways on the hill sheep farm. For both farming systems there is a net input of P, although the rate of accumulation is ten times greater for the dairy farm where the annual retention of P represents 60% of the total P inputs, compared with 36% on the hill sheep farm.
    Type of Medium: Electronic Resource
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