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  • 1
    Electronic Resource
    Electronic Resource
    Cytochrome c used as a model system to probe the structural properties of benthic mucilage (1998)
    Springer
    Marine biology 131 (1998), S. 33-39 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Benthic mucilage, whether native or artificially fragmented to microscopic dimensions by ultrasonic treatment, was mixed with cytochrome c, which was used as a 12 000 Da polycationic model compound. Cytochrome c binding profiles proved to depend on the aggregation state of the mucilage. The native mucus matrix binds cytochrome c quasi hyperbolically with an apparent affinity constant K = 1 × 106  M −1. As shown by chemical modification of both the mucilage and cytochrome c, the binding expression is dependent on the availability of both the positive charges on the cytochrome c surface and the negative charges within the mucus matrix. The extent of binding is sensitive to the ionic strength of the medium. The ultrasonic-stabilized mucus fragments display a peculiar binding profile, with an apparent low affinity, abruptly entering into a high affinity binding region. The results suggest that, depending on the mucus to polycation ratio, a polymeric reticulus builds up. This reticulus can accommodate molecules of at least 12 000 Da molecular weight. The results are also discussed with respect to biological implications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002270050293
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  • 2
    Electronic Resource
    Electronic Resource
    Four years of treatment with lamivudine: clinical and virological evaluations in HBe antigen-negative chronic hepatitis B (2004)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 20 (2004), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim : To evaluate the clinical and virological impact of the prolonged use of lamivudine in 94 patients with HBe antigen-negative chronic hepatitis B.Methods : Initial virological and biochemical responses were obtained in 84 (89%) and in 83 (88%) patients respectively.Results : The virological response peaked within the first 12 months, but diminished to 39% at 48 months because of drug resistance. Overall a virological breakthrough developed in 44 patients (52.4%). After virological breakthrough, the actuarial probability of maintaining biochemical remission diminished to 15% at 24 months and 0% at 29 months. There was no response in 10.6%. Polymerase gene mutations were observed in 82.5% of virological breakthroughs but also in 75% of the non-responders. Overall 7.4% of patients developed a hepatocellular carcinoma.Conclusion : Almost 90% of patients responded initially to lamivudine but the emergence of drug resistance progressively reduced the rate of virological remission to 39% at the fourth year of therapy. YMDD mutants explained the 75% of lamivudine resistances and were also selected very early in non-responders. Although the biochemical response is invariably lost within 29 months of the YMDD mutant's duration, the clinical outcome was benign despite severe postvirological breakthrough hepatitic flares in about 12% of cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2004.02073.x
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  • 3
    Electronic Resource
    Electronic Resource
    Selective inactivation of catalase during protoporphyrin induced photohemolysis of human red blood cells (1978)
    Springer
    Cellular and molecular life sciences 34 (1978), S. 181-182 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The level of some enzymatic activities in red blood cells before and after photohemolysis induced by protoporphyrin IX was studied. A 30% decrease in catalase activity was found both in normal erythrocytes and those from patients affected by favism. Other proteins though present in larger amounts inside the erythrocytes are not affected by the photohemolytic process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01944663
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  • 4
    Electronic Resource
    Electronic Resource
    Role of oxygen radicals scavenging enzymes in the protoporphyrin induced photohemolysis (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 1445-1447 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Inhibition of superoxide dismutase by diethyldithiocarbamate or cyanide increases the rate of red blood cells lysis after irradiation in the presence of protoporphyrin IX. Catalase activity, which is decreased during the photohemolytic process, appears to be not essential for the lytic event. No relationship between catalase activity and hemolysis rate was found. Superoxide dismutase appears to prevent only in part catalase inactivation by singlet oxygen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01962774
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  • 5
    Electronic Resource
    Electronic Resource
    Ultrastructural appearance of chondroblastoma (1994)
    Springer
    International orthopaedics 18 (1994), S. 389-392 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs ont comparé les aspects ultrastructuraux de deux chondroblastomes, au microscope électronique à balayage et au microscope électronique à transmission, afin d'évaluer l'histogénèse de la lésion. Les cellules basales, polyédriques et amassées, avec une matrice péricellulaire peu abondante, présentent un réticulum endoplasmique peu développé et des systèmes de Golgi souvent dilatés et multiples. Les cellules qui présentent la différenciation chondroîde la plus marquée sont réunies dans des groupes isogènes, montrant des inclusions de glycogène et de lipides dans le cytoplasme, de nombreuses mitochondries renflées et, en surface, des vésicules de sécrétion provenant d'un réticulum endoplasmique bien développé. On observe, tout prés de la cellule tumorale, des bouquets de cristaux en contact direct avec les fibres collagènes de la matrice. La présence de cellules basales indifférenciées qui prolifèrent et se différencient en tissu cartilagineux distingue cette néoplasie des autres (chondrome, chondrosarcome mésenchymal et fibrome chondromyxoïde) et permet de la classer parmi les lésions d'origine chondroïde.
    Notes: Summary The ultrastructural appearance of two chondroblastoma were examined by scanning and transmission electron microscopy. The polygonal basal cells, with a scanty pericellular matrix, show a poorly developed endoplasmic reticulum and many Golgi bodies. The highly differentiated chondroid cells are assembled in isogenous clusters and show intracytoplasmic inclusions of glycogen and lipids, numerous mitochondria and superficial secretion vesicles arising from a well developed rough endoplasmic reticulum. Clusters of crystals, in close contact with the matrix collagen fibres, are found near to the tumour cells. These ultrastructural characteristics, together with the basal undifferentiated cells that proliferate and differentiate into cartilaginous tissue, distinguish this neoplasm from chondroma, mesenchymal chondrosarcoma and chondromyxoid fibroma and confirm its chondroid origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00187088
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  • 6
    Electronic Resource
    Electronic Resource
    Pregnancy and delivery in young woman affected by isthmic coarctation of the aorta (2000)
    Springer
    Archives of gynecology and obstetrics 263 (2000), S. 145-147 
    Details
    ISSN: 1432-0711
    Keywords: Key words Pregnancy ; Delivery ; Aortic coarctation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Coarctation of aorta is a rare cause of hypertension in pregnancy and the case material reported in literature is limited without a univocal line of clinical conduct. A case association between isthmic coarctation of the aorta and pregnancy in a 17 year-old primigravida woman is described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007472
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  • 7
    Electronic Resource
    Electronic Resource
    Quantitative analysis of osteolytic versus osteoclastic activity in various experimental osteoporoses. 1. Disuse osteoporosis (1976)
    Springer
    Calcified tissue international 22 (1976), S. 242-246 
    Details
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02064073
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  • 8
    Electronic Resource
    Electronic Resource
    Valutazione dei dati aerosporologici ottenuti in due diverse stazioni di rilevamento di una stessa città (1987)
    Springer
    Aerobiologia 3 (1987), S. 73-77 
    Details
    ISSN: 1573-3025
    Keywords: Aerobiological data ; Mould allergy ; Dati aerobiologici ; Allergia da miceti
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Summary Mould spores at two different places in Cagliari from February to April 1987 have been studied using Petri dishes containing “Potato dextrose agar”. The change of the numerical consistence of the isolations in two different places has been observed. 6702 mycetical colonies, belonging to 15 different genera, have been isolated; 6 of them mostly prevailing. On the basis of the amount and variety of isolated species, the Authors think that mould air-spores are not a negligible risk factor allergic disease.
    Notes: Riassunto Nel presente lavoro vengono riportati gli studi quantitativi e qualitativi delle spore micetiche presenti in due diverse zone della città di Cagliari. I rilevamenti sono stati effettuati nei mesi di Febbraio, Marzo ed Aprile del 1987 utilizzando capsule di Petri contenenti “Potato dextrose agar” più antibiotico. Sono state osservate differenze significative nella frequenza delle spore delle due zone considerate. Nel corso dell'intera ricerca abbiamo isolato 6702 colonie filamentose appartenenti a 15 generi diversi; 6 generi sono stati repertati costantemente. Sulla base della quantità e varietà delle specie micetiche identificate, gli Autori ritengono che le spore aerodiffuse possono costituire un fattore di rischio non trascurabile.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02449997
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  • 9
    Electronic Resource
    Electronic Resource
    Identification of S-carboxymethyl-thiopyruvate as the product of oxidative deamination of S-carboxymethyl-cysteine (1974)
    Springer
    Molecular and cellular biochemistry 3 (1974), S. 3-7 
    Details
    ISSN: 1573-4919
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary Bromopyruvic acid and thioglycolic acid react to form carboxymethylthiopyruvic acid, which was then isolated as the 2,4-dinitrophenylhydrazone. Chromatographic and spectral properties of the compound have been investigated. Using this as a reference standard, it has been possible to demonstrate that carboxymethylthiopyruvate is the main product of the oxidative deamination of carboxymethylcysteine, D-isomer, catalyzed by D-aspartate oxidase. It has been demonstrated moreover that carboxymethylcysteine, L-isomer, may be a substrate for snake venom L-aminoacid oxidase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01660071
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