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  • 1
    Electronic Resource
    Electronic Resource
    An interleukin-8 (IL-8) cDNA clone identifies a frequent HindIII polymorphism (1993)
    Springer
    Human genetics 〈Berlin〉 91 (1993), S. 298-298 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract An interleukin-8 cDNA probe detects a biallelic HindIII polymorphism. This frequent restriction fragment length polymorphism (RFLP) provides a new genetic marker for the long arm of chromosome 4.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218279
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  • 2
    Electronic Resource
    Electronic Resource
    A myeloblastin/proteinase-3 cDNA clone identifies a BglII and a PvuII restriction fragment length polymorphism (1993)
    Springer
    Human genetics 〈Berlin〉 92 (1993), S. 525-525 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A myeloblastin/proteinase-3 (MBN/PR-3) cDNA probe detects two bi-allelic (BglII, PvuII) DNA polymorphisms. These restriction fragment length polymorphisms provide new genetic markers on chromosome 19.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00216465
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of isosorbide-5-nitrate during haemodialysis and peritoneal dialysis (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 503-505 
    Details
    ISSN: 1432-1041
    Keywords: isosorbide-5-nitrate ; renal failure ; haemodialysis ; peritoneal dialysis ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of isosorbide-5-nitrate (IS-5-N) was studied in ten patients on haemodialysis (HD) after a single oral dose of 20 mg IS-5-N, and in six patients on continuous ambulatory peritoneal dialysis (CAPD) after repeated oral doses of 3×20 mg IS-5-N. There was significant removal of IS-5-N from blood during HD; Cmax decreased by about 20%, AUC(0–8 h) by 30% and t1/2 by about 20% from 4.3 to 3.4 h, and plasma clearance was increased by 81 ml/min. No important loss of IS-5-N was observed in patients on CAPD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637678
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  • 4
    Electronic Resource
    Electronic Resource
    Extending Shelf-Life of Fresh Wet Red Hake and Salmon Using CO2-O2 Modified Atmosphere and Potassium Sorbate Ice at 1°C (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 47 (1982), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The ability to safely extend the shelf-life of fish would open up the possibility of shipping fresh wet fish by boat. Red hake and salmon can be successfully held for almost 1 month and still be sensorally acceptable. A 60% carbon dioxide:20% oxygen:20% nitrogen-modified atmosphere with a 1% potassium sorbate ice was most satisfactory. CO2 did not lower the pH of the fish. Low temperature (1°C) and presence of both oxygen and potassium sorbate served as protection against botulism development. The presence of oxygen, even with salmon, did not lead to rancidity (TBA) problems. The Torrymeter can be used to monitor red hake quality. Work incorporating potassium sorbate dips before modified atmosphere storage with or without potassium sorbate ice is needed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1982.tb07619.x
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  • 5
    Electronic Resource
    Electronic Resource
    Interactive response of herbivores, soils and vegetation to annual burning in a South African savanna (2005)
    Melbourne, Australia : Blackwell Science Pty
    Austral ecology 30 (2005), S. 0 
    Details
    ISSN: 1442-9993
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract  Despite decades of research, the primary factors determining savanna structure remain elusive – a conundrum termed ‘the savanna problem’. After 47 years of annual burning in Terminalia woodland and Acacia/Combretum savanna on sandy, granite-derived soils in the southern Kruger National Park, South Africa, a dense cover of trees and shrubs persists on some burnt plots and is largely absent from others. We postulated that intense browsing pressure by antelope and other herbivores prevents recruitment of trees in burnt plots and that herbivores concentrate on plots that are richest in nutrients. Herbivore abundance did not show a relationship with soil macronutrients and we consequently investigated micronutrient status. The reduction in tree cover as a result of annual burning was positively correlated with mass of herbivores (15–1500 kg) (r 2 = 0.61, n = 8). This index of herbivore abundance was in turn positively correlated with total Zn (r 2 = 0.64, n = 8). Other indices of herbivore abundance showed significant relationships with total clay content and total Mn. We suggest that herbivores concentrate on sites with greater clay content (possibly due to a greater availability of micronutrients), and that tree cover can remain relatively dense under a regime of annual burning if browsing pressure is not intense. The long-term burn experiments in the Kruger National Park savanna provide a platform for unravelling the savanna problem. Determining possible interactions between soil properties, herbivory and fire is a step in this direction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1442-9993.2005.01487.x
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of goat pastoralism on ecosystem carbon storage in semiarid thicket, Eastern Cape, South Africa (2005)
    Melbourne, Australia : Blackwell Science Pty
    Austral ecology 30 (2005), S. 0 
    Details
    ISSN: 1442-9993
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract  Intensive pastoralism with goats transforms semiarid thicket in the Eastern Cape, South Africa from a dense vegetation of tall shrubs to an open landscape dominated by ephemeral grasses and forbs. Approx. 800 000 ha of thicket (which prior to the introduction of goats had a closed canopy and a Portulacaria afra Jacq. component) have been transformed in this manner. Ecosystem C storage in intact thicket and loss of C due to transformation were quantified. Carbon storage in intact thicket was surprisingly high for a semiarid region, with an average of 76 t C ha−1 in living biomass and surface litter and 133 t C ha−1 in soils to a depth of 30 cm. Exceptional C accumulation in thicket may be a result of P. afra dominance. This succulent shrub switches between C3 and CAM photosynthesis, produces large quantities of leaf litter (approx. 450 g m−2 year−1) and shades the soil densely. Transformed thicket had approx. 35% less soil C to a depth of 10 cm and approx. 75% less biomass C than intact thicket. Restoration of transformed thicket landscapes could consequently recoup more than 80 t C ha−1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1442-9993.2005.01523.x
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  • 7
    Electronic Resource
    Electronic Resource
    Continuous 5-day infusion of ifosfamide with mesna in inoperable pancreatic cancer patients: a phase II study (1991)
    Springer
    Journal of cancer research and clinical oncology 117 (1991), S. S135 
    Details
    ISSN: 1432-1335
    Keywords: Ifosfamide ; Continuous infusion ; Pancreas ; Cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Phase II studies on ifosfamide and mesna in pancreatic cancer have mostly been inconclusive. In all of these studies ifosfamide was administered as an i.v. bolus or by short infusions. Since dose fractionation of ifosfamide over several days increases its therapeutic index, we chose to maximize the dose fractioning by selecting a continuous-infusion schedule (1.75 g/m2 on days 1–5 every 21–28 days, with mesna 60%–100% of the ifosfamide dose up to 12 h after ifosfamide). Since 1987 29 patients (performance status ≦ 2) with advanced inoperable adenocarcinoma of the pancreas were studied (8 women and 21 men; median age 58 years: 36–73 years). A total of 25 patients are evaluable for response (1 ineligible; 3 inevaluable: 2 early deaths due to disseminated intravascular coagulation, 1 refusal). One female patient with a complete response on computed tomography scan (after five cycles) but residual liver metastases on surgical exploration survived for 473 days. Three male patients with partial response survived for 205, 335 and 355 days. Six more patients with minor response (3) or no change (3) but significant decrease of tumour marker CA 19-9 had a median survival of 213 days (106–243). Responders seemed to benefit in terms of pain relief and general wellbeing. The median overall survival of all patients was 148 days (21–473). Haematotoxicity was rarely dose-limiting [median nadirs: white blood cells=2.1×109/l (0.45–6.4), Hb=10.7g/dl (7.5–13), platelets=137×109/l (21–411)]. Nausea and vomiting were mild with prophylactic oral metoclopramide. No central nervous system toxicity or urotoxicity was observed. Alopecia was seen in all patients who had received at least two cycles. Continuous infusion of ifosfamide was generally well tolerated and useful for palliation in 10 of 25 patients. A higher dose intensity is recommended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01613218
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  • 8
    Electronic Resource
    Electronic Resource
    Factors associated with transfusion requirements during treatment for acute myelogenous leukemia (1993)
    Springer
    Annals of hematology 67 (1993), S. 153-160 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Supportive care is a prerequisite for intensive chemotherapy in leukemic patients. Little has been published about quantitative aspects of red blood cell and platelet transfusions. We evaluated transfusion requirements and factors associated with observed differences in 206 patients undergoing initial induction consolidation chemotherapy for newly diagnosed acute myelogenous leukemia. All patients were treated during a 5-year period in 12 hospitals on a common protocol of the Swiss Study Group for Clinical Cancer Research (SAKK). Protocol 30/85 comprises a double induction and one course of consolidation. Of 206 registered patients, 199 were evaluable; 118 of 199 (59%) patients entered completed all three cycles of chemotherapy. These 118 patients received a median (range) of 18 (3–44) units of red blood cells and 12 (2–61) platelet transfusions during 112 (70–129) days of hospitalization. Patients with a hemoglobin 〉10g/l, platelets 〉100×109/l, and white blood cell counts 〈5×109/l at diagnosis received fewer transfusions than patients with less favorable blood counts during the first cycle of chemotherapy (p〈0.05). Patients with FAB subtype M3 received more platelet transfusions during the first cycle. Female patients received more platelet transfusions than male patients. In multivariate analyses the participating center was the most important single factor associated with the number of red cell and platelet concentrates given per patient and cycle (p〈0.05), the number of days in hospital (p〈0.05), and the risk of premature withdrawal from the study. These data define factors associated with transfusion requirements in patients treated for newly diagnosed AML. They include severity and subtype of disease at diagnosis, age and sex of the patients, and the participating institution. Results suggest that medical decision-making varies from center to center. The participating institution is strongly associated with differences in transfusion requirements, hospitalization time, and premature withdrawal from study. Leukemia trials tend to focus on the prospective evaluation of chemotherapy or growth factors. Our results suggest that other variables, such as management strategies, should be included for prospective analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01695861
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  • 9
    Electronic Resource
    Electronic Resource
    Intensive induction and consolidation chemotherapy in a young woman with acute myeloid leukemia and severe chronic renal failure (1996)
    Springer
    Annals of hematology 72 (1996), S. 327-328 
    Details
    ISSN: 1432-0584
    Keywords: Key words Acute myeloblastic leukemia ; Intensive chemotherapy ; Renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A young woman with acute myeloblastic leukemia was successfully treated with three cycles of intensive induction/consolidation chemotherapy in the presence of severe chronic renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050180
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  • 10
    Electronic Resource
    Electronic Resource
    MTS1 expression and prognosis in acute myeloid leukemia (1997)
    Springer
    Annals of hematology 75 (1997), S. 141-144 
    Details
    ISSN: 1432-0584
    Keywords: Key words MTS1 ; p16 ; Tumor suppressor gene ; Leukemia ; Prognostic factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  MTS1, a tumor supressor gene located on chromosome 9p21, has been shown to be altered in a number of human tumor cell lines, primary solid tumors, and leukemias. In this study we found low expression of MTS1 in lymphocytes from seven of nine healthy donors, but in none of eight granulocyte samples from the same controls, suggesting a physiological role of MTS1 in peripheral blood cells capable of proliferation, but not in end-stage differentiated cells. We detected MTS1 mRNA expression in 38 of 57 patients (66%) with acute myelogenous leukemia (AML) treated in a standardized clinical protocol. No deletion of the MTS1 gene was found in any of the AML samples tested. There was no significant association between expression of MTS1 and response to therapy, progression-free, or overall survival. Except for a negative correlation between MTS1 level and leukocyte count at diagnosis (p=0.03), there was also no association with any of the known prognostic parameters in AML. We conclude that MTS1 shows a significantly higher expression in leukemic than in normal peripheral blood cells, that deletion of MTS1 is not a frequent event in AML, and that its expression is not significantly correlated with outcome of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050331
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