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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 47 (1998), S. 269-289 
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Hyperbare Oxygenation ; Intensivtherapie ; Notfallmedizin ; Tauchmedizin ; Indikationen ; Key words Hyperbaric oxygen ; Emergency medicine ; Intensive care therapy ; Diving medicine ; Indications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Hyperbaric Oxygen (HBO) therapy is a kind of medical treatment in which a patient breathes 100% of oxygen inside a pressure chamber while the pressure of the chamber is increased to a point higher than sea level pressure. It is strongly based on clearly defined physical laws and physiological regularities. For the clinical use of HBO therapy, according to international recommendations, there are several commonly accepted indications in which HBO either is the only causative life-saving kind of treatment, or is an essential and oftenly decisive component of a comprehensive interdisciplinary intensive care therapy. Among potential adverse effects, barotrauma of the lungs and especially oxygen toxicity to the central nervous system have to be mentioned. Clinical use of HBO therefore requires special knowledge of its effects, risks, and adverse effects, a clear and distinct indication, and the ability and skills to keep complications under control by means of intensive care or emergency medical measures. The clinical use of hyperbaric oxygen with its interdisciplinary-like character of emergency medicine or intensive care therapy therefore should be an additional, most interesting field of activity for the anaesthesiologist.
    Notes: Zusammenfassung Hyperbare Oxygenation (HBO) ist eine medizinische Behandlungsform, bei der der Patient in einer Überdruckkammer Sauerstoff unter einem höheren Partialdruck atmet als dem Luftdruck auf Meereshöhe. Sie beruht streng auf klaren physikalischen Gesetzen und definierten physiologischen Gesetzmäßigkeiten. Nach internationalen Empfehlungen gibt es für die HBO-Therapie eine Reihe von allgemein anerkanntenen Indikationen, bei denen sie entweder die einzige kausal wirkende, lebensrettende Therapieform oder aber eine wesentliche, oftmals ausschlaggebende Therapiekomponente einer umfassenden, interdisziplinären Intensivtherapie darstellt. Unter den potentiellen Nebenwirkungen sind neben Barotraumen der Lunge vor allem die Möglichkeit einer zentral-nervösen Sauerstoffintoxikation besonders zu berücksichtigen. Die klinische Anwendung der HBO erfordert daher spezifische Kenntnisse ihrer Wirkungen, Nebenwirkungen und Risiken, eine gezielte und kritische Indikationsstellung sowie die Fähigkeiten und Fertigkeiten, auftretende Komplikationen mit intensiv- oder notfallmedizinischen Maßnahmen sicher zu beherrschen. Die klinische Anwendung der hyperbaren Oxygenation mit ihrem interdisziplinären, notfallmedizinischen oder intensivtherapeutischen Charakter sollte daher für den Anästhesisten ein zusätzliches, äußerst interessantes Betätigungsfeld sein können.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    The journal of membrane biology 151 (1996), S. 113-122 
    ISSN: 1432-1424
    Keywords: Key words: Patch clamp — Central nervous system — ATP — Ca2+— Glibenclamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract. We investigated the properties of single K+ channels in the soma membrane of embryonic leech ganglion cells using the patch-clamp technique. We compared these K+ channels with the K+ channels found previously in Retzius neurons of the adult leech. In ganglion cells of 9- to 15-day-old embryos we characterized eight different types of K+ channels with mean conductances of 21, 55, 84, 111, 122, 132, 149 and 223 pS. The 55 pS and 84 pS channels showed flickering and were active for less than 2 min after excising the patch. The 111 pS channel was an outward rectifier, and the open state probability (p o ) decreased in the inside-out configuration when the Ca2+ concentration was raised from pCa 7 to pCa 3. The 122 pS channel also showed outward rectification. This type of channel was activated after changing from the cell-attached to the inside-out configuration and it did not inactivate during more than 30 min. The p o was Ca2+- and voltage-insensitive. One hundred μm glibenclamide reversibly reduced p o . The 132 pS channel was an outward rectifier and was Ca2+-insensitive. The 149 pS channel inactivated in the inside-out configuration. The 149- and the 223 pS channel showed inward rectification. The 111 pS channel had similar properties to the Ca2+-dependent K+ channel and the 122 pS channel resembled the ATP-inhibited K+ channel found previously in Retzius neurons of the adult leech.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 35 (1988), S. 237-240 
    ISSN: 1432-1041
    Keywords: platelet activating factor (PAF) ; WEB 2086 ; platelet aggregation ; PAF-antagonist ; dose response ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary WEB 2086 is a novel PAF-acether antagonist, whose pharmacological action in man has only been preliminarily defined. Twelve healthy male volunteers received oral doses of 5, 30 and 90 mg and over the following 24 h inhibition of 5 × 10−8 M PAF-acether-induced platelet aggregation ex vivo was studied as an indicator of pharmacological activity. WEB 2086 inhibited PAF-acether-induced platelet aggregation in all the doses tested, with the maximum effect 1 to 2 h after administration. After 2 h 5- 30- and 90-mg doses caused, respectively, 87, 98 and 100% inhibition. The magnitude and duration of the inhibitory effect was dose-dependent, with a significant action still detectable 10 h after administration of all three doses, and 12 h after administration of the two highest doses (30 and 90 mg). The subjects did not complain of any significant adverse effect and all completed the study.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 38 (1990), S. S122 
    ISSN: 1432-1041
    Keywords: carvedilol ; propranolol ; coronary blood flow ; beta-blockade ; vasodilation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A total of 17 patients with angiographically proven coronary artery disease and at least one stenosis blocking ≥ 70% of the left anterior descending or circumflex artery were included in a double-blind, randomized study. They received either 5 mg carvedilol or 6 mg propranolol intravenously. Heart rate, aortic pressure, mean coronary sinus pressure and coronary flow (thermodilution) were measured and coronary resistance and the rate-pressure product were calculated before and 25 min after injection. Carvedilol significantly (P 〈 0.05) lowered the heart rate (mean, 76 to 69 beats/min), aortic pressure (mean, 153/80–135/72 mmHg), rate-pressure product (mean, 117–93 mmHg/min), and coronary flow (mean, 114–94 ml/min). Coronary resistance (mean, 0.97–1.07 mmHg × min/ml) and coronary flow related to the rate-pressure product (mean, 1.0–1.02 ml/mm Hg) showed no significant change after carvedilol treatment. Propranolol lowered the heart rate (mean, 76–64/min;P 〈 0.05) and rate-pressure product (mean, 109–96 mm. Hg/min; not significant). Aortic pressure (mean, 145/72–147/74 mmHg), coronary flow (mean 109–101 ml/min), coronary resistance (mean, 1.1–1.2 mmHg × min/ml), and coronary flow related to the rate-pressure product (mean,1.12–1.19 ml/mmHg) showed no significant change after propranolol administration. Following single application, carvedilol lowered the rate-pressure product more markedly than did propranolol on account of its acute blood-pressure-lowering effect. No differences in the hemodynamic effects of carvedilol and propranolol were found. Neither drug seems to influence the adaption of coronary flow to myocardial oxygen demand.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Chromatography A 142 (1977), S. 271-281 
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Chromatography A 142 (1977), S. 271-281 
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Phytochemistry 14 (1975), S. 417-422 
    ISSN: 0031-9422
    Keywords: IAA oxidase. ; Plant peroxidases ; degradation products ; flavonols ; isoelectric focusing ; isoenzymes
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Phytochemistry 14 (1975), S. 417-422 
    ISSN: 0031-9422
    Keywords: IAA oxidase ; Plant peroxidases ; degradation products ; flavonols ; isoelectric focusing ; isoenzymes
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
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    Unknown
    Berlin : Periodicals Archive Online (PAO)
    Kant-Studien. 45 (1953/1954) 33 
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