ISSN:
1432-2307
Keywords:
Tumour necrosis factor
;
Interleukin 6
;
Biphasic tumour
;
Sarcomatoid tumour
;
Lung carcinoma
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We established a clonal cell line, HAT.MC8, derived from a human pulmonary large cell carcinoma with sarcomatoid features. This cell line was successfully maintained in a protein-free medium and exhibited sarcomatoid fibroblastic features in vitro. The cells constitutively produced a large amount of interleukin 6 (IL-6) in vitro. Tumour necrosis factor α (TNF-α) not only stimulated HAT.MC8 cells to produce IL-6, but also induced a morphological change from sarcomatoid fibroblastic to epithelial features. Although this change was related to actin and zonula adherens, there was no evidence that E-cadherin participated in the change. Interleukin 1β (IL-1β) had a stimulatory effect on IL-6 production by HAT.MC8 cells, but no influence on the morphology of the cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00190557
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