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  • 1
    Electronic Resource
    Electronic Resource
    Plasmazellkolonien aus leukämischem Knochenmark in vitro (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 603-605 
    Details
    ISSN: 1432-1440
    Keywords: Agar culture ; colonies ; leukaemic bone marrow ; blasts ; plasma cells ; Agar-Kultur ; Kolonien ; Leukämisches Knochenmark ; Blasten ; Plasmazellen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Koloniezellen, die bei der Aussaat von mononukleären Blut- und Knochenmarkszellen von 42 Normalpersonen und 7 Leukämiepatienten in Agargel entstanden, wurden cytologisch und cytochemisch untersucht. Abweichend von der cytologischen Zusammensetzung normaler Kolonien konnten bei 3 Patienten mit akuter myeloischer Leukämie und bei einem Patienten mit Retikulose gemischte Kolonien von Blasten und Plasmazellen nachgewiesen werden.
    Notes: Summary Colonies which proliferated in agar culture from mononuclear blood and bone marrow cells of 42 normal persons and 7 patients with leukaemia have been investigated by means of cytological and cytochemical methods. In contrast to the cellular composition of normal colonies 3 patients with acute myeloid leukaemia and 1 patient with leukaemic reticulosis showed mixed colonies consisting of blasts and plasma cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468505
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  • 2
    Electronic Resource
    Electronic Resource
    Nukleinsäurebiosynthese normaler und leukämischer Blutzellen. Die Wirkung von Actinomycin D, Acridinfarbstoffen und verwandten Substanzen auf intakte Zellen und auf ein zellfreies System (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 783-784 
    Details
    ISSN: 1432-1440
    Keywords: Acridine dyes ; actinomycin D ; blood cells ; biosynthesis of nucleic acid ; RNA polymerases ; Acridinfarbstoffe ; Actinomycin D ; Blutzellen ; Nukleinsäurebiosynthese ; RNS-Polymerasen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Acridinfarbstoffe hemmen in gleichem Umfang wie Actinomycin D den Einbau von3H-Thymidin und3H-Uridin in intakten Zellen, inhibieren im Gegensatz zum Actinomycin D jedoch erst bei hundertfach höheren Konzentrationen die DNS-abhängige RNS-Polymerase im zellfreien System. Ferner wird in intakten Zellen bei Farbstoffeinwirkung eine Verminderung der intrazellulären Uridin- und Thymidinpools beobachtet. Es wird u.a. eine unspezifische Interaktion der Farbstoffe mit der Zellmembran diskutiert.
    Notes: Summary Acridine dyes inhibit the incorporation of3H-thymidine and3H-uridine in intact cells to the same extent as Actinomycin D. In contrast to Actinomycin D, RNA synthesis by DNA — dependent RNA polymerase in a cell-free system is inhibited at lo2 higher concentrations of acridine dyes, only. Possible differential effects on the cell membrane resulting in decreased intracellular pools of uridine and thymidine are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01614862
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  • 3
    Electronic Resource
    Electronic Resource
    Freie und matrizen-gebundene RNS-Polymerase in normalen und leukämischen Lymphocyten (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 235-237 
    Details
    ISSN: 1432-1440
    Keywords: DNA-dependent RNA-polymerase B ; Functional properties and regulation ; Leukemia ; DNS-abhängige RNS-Polymerase B ; Funktionelle Differenzierung und Regulation ; Leukaemie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es werden die spezifischen Aktivitäten von zwei funktionell unterschiedlichen Fraktionen der α-Amanitin-inhibierbaren DNS-abhängigen RNS-Polymerase in Zellkernen normaler menschlicher Lymphocyten (NL) sowie von Lymphocyten bei chronischer lymphatischer Leukämie (CLL) bestimmt. Die Aktivität der „freien“ RNS-Polymerase bei CLL beträgt 0,133 gegenüber 0,209 pMol (3H)-UMP/106 Zellen in normalen Lymphocyten. Die Aktivitäten der „gebundenen“ Enzyme liegen bei 0,139 (CLL) bzw. 0,132 pMol (3H)-UMP/106 Zellen (NL). Durch 400 ng/ml Rifamycin AF/013 wird das „freie“ Enzym in NL und CLL völlig inhibiiert, während das „gebundene“ Enzym noch 70% seiner Aktivität aufweist. Da „freie“ Enzym in CLL-Lymphocyten wird durch 1,0 ng/ml α-Amanitin zu 50% inhibitiert, während dieses Enzym in NL sowie die „gebundenen“ Enzyme in NL und CLL zu mehr als 90% inaktiviert werden.
    Notes: Summary Specific activities are determined of two functional fractions of α-amanitin sensitive DNA-dependent RNA polymerases in nuclei from human normal and chronic lymphocytic leukemia lymphocytes. Specific activity of “free” RNA polymerase in CLL corresponds to 0.133 pmoles (3H)-UMP/106 cells as compared to 0.209 in normals. Activities of the “engaged” enzymes are 0.139 in CLL and 0.132 in normals. “Free” enzymes in NL and CLL are completely inhibited by 400 ng/ml Rifamycin AF/013, while the “engaged” enzymes exhibit 70% of their original activity. 1.0 ng/ml α-amanitin suppress 50% of the activity of the “free” enzyme in CLL. The “free” enzyme in NL and the “engaged” enzymes in NL and CLL do not show any residual activity in the presence of 1.0 ng/ml α-amanitin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01469131
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  • 4
    Electronic Resource
    Electronic Resource
    Mögliche Prävention der Adriamycin-induzierten Kardiomyopathie durch Verapamil (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 1032-1037 
    Details
    ISSN: 1432-1440
    Keywords: Verapamil ; Adriamycin ; Cardiomyopathy ; Echocardiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An increased cytoplasmatic calcium levels seems to play an important role in the pathogenesis of Adriamycin (ADM)-induced cardiomyopathy. Experiments have shown that calcium channel blockers such as verapamil may prevent this type of cardiomyopathy in animals, but data are contradictory. In a clinical pilot trial, the left ventricular function of 22 patients undergoing ADM-chemotherapy in combination with verapamil was examined. M-mode echocardiograms were performed parallel to every chemotherapy course. Left ventricular function was determined by fractional shortening rate (FS) and peak fibre shortening velocity (Vcf max.). Three 40-mg doses of verapamil were given p.o./day continuously. Data of these patients were compared with a control group of 61 patients treated and checked equally without additional verapamil therapy. In the course of therapy parameters of left ventricular function remained almost constant in the verapamil group but decreased significantly in the control group. In the verapamil group FS changed by −0.05 FS %/100 mg ADM/m2, Vcf max. by +0.015 circ./s/ 100 mg ADM/m2 compared with −2.31 FS % and −0.33 circ./s in the control group (P 0.01 and 0.001, respectively). In the verapamil group no congestive heart failure occurred and no patient showed FS below 30%, whereas in the control group in 23% (14) of the cases ADM therapy had to be stopped because FS fell below 30%. One congestive heart failure was observed. These clinical results suggest that verapamil may be a useful drug for preventing ADM-induced cardiomyopathy but further investigations are necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711726
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  • 5
    Electronic Resource
    Electronic Resource
    DNS-abhängige RNS-Polymerasen in menschlichen Leukocyten (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 311-316 
    Details
    ISSN: 1432-1440
    Keywords: DNA-dependent RNA polymerases ; leukemia ; prognostic factors ; DNS-abhängige RNS-Polymerasen ; Leukämie ; prognostische Kriterien
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die spezifischen Aktivitäten der DNS-abhängigen RNS-Polymerasen A und B wurden in von exogener Matrizen-DNS abhängiger Form bei verschiedenen Hämoblastosen bestimmt. Die Aktivitätsbestimmungen erfolgten in Kernhomogenaten isolierter mononucleärer oder segmentkerniger Leukocyten. Eine signifikante Erhöhung der Polymeraseaktivitäten A und B fand sich in den Kernhomogenaten mononucleärer Zellen bei akuter myeloischer Leukämie, während diese bei chronisch-myeloischer Leukämie (signifikant) und chronisch-lymphatischer Leukämie (nicht signifikant) erniedrigt waren. Unter cytostatischer Therapie findet sich eine Angleichung der Polymeraseaktivitäten an den Normbereich. Hiermit ergeben sich möglicherweise neue Kriterien zur Verlaufsbeurteilung von Hämoblastosen unter einer Polychemotherapie.
    Notes: Summary Specific Activities of DNA-dependent RNA polymerases A and B have been determined in nuclei from leukocytes in acute and chronic leukemia. Enzyme activities, dependent on exogenous DNA template, were determined in homogenates of nuclei from isolated mononuclear cells or from isolated granulocytes. Activities of polymerases A and B have been found significantly elevated in homogenates of nuclei from mononuclear cells in acute myelocytic leukemia, while they were found subnormal in corresponding cell fractions from chronic myelocytic leukemia and chronic lymphatic leukemia. During cytostatic treatment polymerase activities were approaching normal values. The prognostic relevance of these data for the course of human leukemia is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01469057
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  • 6
    Electronic Resource
    Electronic Resource
    Terminal Ph1-positive monocytic crisis in chronic myeloid leukemia providing evidence for the promyelocytic origin of monocytes (1979)
    Springer
    Journal of molecular medicine 57 (1979), S. 237-242 
    Details
    ISSN: 1432-1440
    Keywords: Monozytopoiese ; Chronische myeloische Leukämie ; Monozytenkrise ; Promyelozyten ; Zytochemie ; Monocytopoiesis ; Chronic myeloid leukemia ; Monocytic crisis ; Promyelocytes ; Cytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A case of Ph1-positive chronic granulocytic leukemia is described in which a terminal monocytic crisis developed. The case still was Ph1-positive at the time of the monocyte crisis. Bone marrow smears contained promyelocytes and early granulocytes, but most of the cells belonged to the monocyte series as cytochemistry disclosed. No blast cells could be detected. Cytochemically, transitions between promyelocytes and promonocytes could be demonstrated. From these findings and those from the literature it is concluded that the monocytes of the terminal crisis in our case belonged to the leukemic cell strain and that these monocytes developed from non-specific promyelocytes like granulocytes. Our observation does not provide evidence for the existence of a separate monoblast which would implicate disparity of granulocytopoiesis and monocytopoiesis already at the level of undifferentiated blast cells. This, in turn, would be equal to a re-introduction of a modified polyphyletic theory of white blood cell formation.
    Notes: Zusammenfassung Es wird ein Fall von Ph1-positiver chronischer myeloischer Leukämie beschrieben, bei dem sich final eine Monozytenkrise entwickelte. Auch zum Zeitpunkt der Monozytenkrise war der Fall weiterhin Ph1-positiv. Präfinal enthielten die Knochenmarksausstriche Promyelozyten und andere Granulozytenvorstufen, jedoch gehörten die meisten der Knochenmarkszellen zur Monozytenreihe (Promonozyten und Monozyten), wie dies zytochemisch festgestellt werden konnte. Blasten waren in dem Knochenmark nicht enthalten. Zytochemisch konnten alle Über-gänge zwischen Promyelozyten und Promonozyten gefunden werden. Aus diesen Befunden und aus den Befunden der Literatur ergibt sich die Schlußfolgerung, daß die Monozyten der terminalen Krise leukämische Zellen darstellen und daß diese Monozyten sich aus unspezifischen Promyelozyten entwickelten. Unsere Beobachtung ergibt keinen Hinweis auf die Existenz eines eigenständigen Monoblasten, welche eine vollständige Trennung von Granulopoiese und Monozytopoiese bedeuten und einer modifizierten polyphyletischen Ableitung der weißen Blutzellen gleichkommen würde.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477492
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  • 7
    Electronic Resource
    Electronic Resource
    Untersuchung der DNS-abhängigen RNS-Polymerase aus menschlichen Leukocyten in einem einfachen zellfreien System (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 730-734 
    Details
    ISSN: 1432-1440
    Keywords: Leukocytes ; Leukemia ; RNA-polymerase ; RNA-metabolism ; Leukocyten ; Leukämie ; RNS-Polymerase ; RNS-Stoffwechsel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Lymphocyten und Leukocyten (Lymphocyten + Granulocyten) werden aus 10–40 ml heparinisiertem Venenblut isoliert, homogenisiert und 15 min bei 1000 g zentrifugiert. In dem aus Zellkernen und Kerntrümmern bestehenden Sediment lassen sich nach Resuspension ca. 70% der DNA-abhängigen RNS-Polymerase-Aktivität des Homogenats nachweisen. Die Reaktion ist von zugesetzter DNS und der Gegenwart aller vier Ribonucleosid-Triphosphate abhängig. Bei chronisch lymphatischer Leukämie, chronisch myeloischer Leukämie und Morbus Hodgkin findet sich unter diesen Bedingungen eine höhere spezifische Aktivität der DNS-abhängigen RNS-Polymerase als bei Normalpersonen.
    Notes: Summary Lymphocytes and leukocytes (lymphocytes + granulocytes), isolated from 10–40 ml of heparinized venous blood, are homogenized, and centrifuged for 15 min at 1000 g. The resuspended pellet, consisting of nuclei and nuclear debris, exhibits ca. 70% of the DNA-depenent RNA polymerase activity of the homogenate. The reaction depends on added DNA template and the presence of all four ribonucleoside triphosphates. In chronic lymphatic leukaemia, chronic myelocytic leukemia, and Hodgkin's disease, the activity of the DNA-dependent RNA polymerase is higher than in normal controls.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468365
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  • 8
    Electronic Resource
    Electronic Resource
    Hochmalignes B-Zell-Non-Hodgkin-Lymphom des Herzens: intravitale Diagnose durch transösophageale Echokardiographiegesteuerte Biopsie (1997)
    Springer
    Zeitschrift für Kardiologie 86 (1997), S. 848-856 
    Details
    ISSN: 1435-1285
    Keywords: Key words Non-Hdgkin-lymphoma – transesophageal echocardiography – right atrium septal biopsy – transesophageal echocardiography-guided right atrium septal biopsy ; Schlüsselwörter Non-Hodgkin-Lymphom – transösophageale Echokardiographie – Vorhofseptumbiopsie – TEE-gesteuerte Vorhofseptumbiopsie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We report about a 66-year old patient with Non-Q-wave infarction in coronary artery two-vessel disease. During an echo- and transesophageal multiplane echodardiography preoperatively before a coronary artery bypass surgery a right atrium septal tumor of unknown form was discovered. The computerized axial tomography (CAT) and nuclear magnetic resonance (NMR) scans did not demonstrate extracardiac pathologic findings. A transesophageal echocardiography-guided biopsy of the right atrial septum over the vena femoralis and the right atrium enabled intra vitam a very early diagnosis of high malignant B-cell Non-Hodgkin-lymphoma without the need for thoracotomy. The diagnosis was confirmed histopathologically and immunhistochemically and early treatment with cytostatic therapy could begin. To our knowledge the transesophageal echocardiography-guided biopsy has never been described in the worldwide literature.
    Notes: Zusammenfassung Wir berichten über einen 66jährigen Patienten mit nichttransmuralem Myokardinfarkt bei koronarer Zweigefäßerkrankung. Bei der Echo- und transösophagealen multiplanen Echokardiographie präoperativ vor dem herzchirurgischen Eingriff fand sich ein Tumor im Bereich des Vorhofseptums unbekannter Dignität. Die Computer- und Kernspintomographie ergaben keine extrakardialen pathologischen Befunde. Durch eine transösophageale Echokardiographie-gesteuerte Biopsie des Vorhofseptums über die Vena femoralis und den rechten Vorhof konnte sehr früh intra vitam die Diagnose eines hochmalignen B-Zell-Non-Hodgkin-Lymphoms ohne Thorakotomie gestellt werden. Histopathologisch und immunhistochemisch wurde die Diagnose gesichert. Frühzeitig wurde eine zytostatische Therapie eingeleitet. Die transösophageal-echokardiographisch gesteuerte Biopsie wurde weltweit unseres Wissens noch nicht beschrieben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003920050123
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  • 9
    Electronic Resource
    Electronic Resource
    Intermittent combination chemotherapy with chlorambucil and prednisone of low-grade malignant non-Hodgkin's lymphomas according to the Kiel classification (1979)
    Springer
    Journal of cancer research and clinical oncology 93 (1979), S. 189-194 
    Details
    ISSN: 1432-1335
    Keywords: Low-grade malignant non-Hodgkin's lymphomas ; Intermittent chlorambucil ; prednisone therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fourty-three of 61 patients suffering from low-grade malignant non-Hodgkin's lymphomas according to the Kiel classification were subjected to an intermittent combination chemotherapy, with chlorambucil and prednisone. In 12 of 35 evaluable patients a complete remission, in 14 of 35 a partial remission could be achieved The mean remission time of patients with a complete remission exceeds 16 months, that of patients with a partial remission amounts to more than 8 months. In 9 of 35 cases a remission could not be achieved. As 10 of the 12 patients in whom a complete remission could be obtained are alive, the median survival time in cases of complete remission cannot yet be determined. The hematological toxicity was very low, nausea and lack of appetite were observed in 9 of 35 patients. Three of 35 treated and evaluable patients died, viz., 1 patient with a centroblastic-centrocytic, lymphoma and 1 patient with a chronic lymphocytic leukemia died from the sequelae of progression during the chemotherapy, of second choice according to the COP regimen. The third patient with a centroblastic-centrocytic lymphoma died from the sequelae of an intrahepatic cholestatic icterus, also during the chemotherapy, of second choice according to the COP regimen. In the lastmentioned case, autopsy also confirmed, a continuous complete remission of the centroblastic-centrocytic lymphoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406577
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  • 10
    Electronic Resource
    Electronic Resource
    Cyclic induction chemotherapy with cyclophosphamide, vincristine, prednisone, and bleomycin of high-grade malignant non-Hodgkin's lymphomas according to the kiel classification (1979)
    Springer
    Journal of cancer research and clinical oncology 93 (1979), S. 93-98 
    Details
    ISSN: 1432-1335
    Keywords: High-grade malignant non-Hodgkin's Lymphomas ; Induction chemotherapy ; COP + bleomycin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seventeen of 22 patients suffering from high-grade malignant non-Hodgkin's lymphomas according to the Kiel classification were subjected to a cyclic induction chemotherapy with cyclophosphamide, vincristine, prednisone, and bleomycin. In 10 of 16 evaluable patients a complete remission, and in 3 of 16 a partial remission could be obtained. The mean remission time of patients with complete remission exceeds 13 months, that of patients with partial remission is 2.5 months. In 3 of 16 cases a remission could not be achieved. As 9 of the 10 patients in whom a complete remission could be obtained are alive, the median survival time in cases of complete remission is still unknown. The toxicity consisted especially in alopecia in 8 of 16 and in leukopenia in 9 of 16 patients. In one case pneumonia was observed, while a chronic bleomycin lung could not be clinically detected in any case. Four of 16 treated and evaluable patients died, 3 of 4 from tumor progression 1 of 4 from a pulmonary embolism following the opening of an abscess of the abdominal wall. In the last-mentioned case, autopsy also revealed a continuous complete remission of the non-Hodgkin's lymphoma. In 1 of the 4 patients who died, a bleomycin lung could be rendered likely by autopsy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00451444
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