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  • 1
    Electronic Resource
    Electronic Resource
    Influence of cyproterone acetate on sexual differentiation of male guinea pigs (1972)
    Springer
    Anatomy and embryology 137 (1972), S. 200-220 
    Details
    ISSN: 1432-0568
    Keywords: Guinea pig ; Antiandrogen cyproterone acetate ; Sexual differentiation external and internal ; Feminization ; Virilization/masculinization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pregnant guinea pigs were treated with cyproterone acetate from the 15th to the 40th day p.c. The dosage was 50, 75 and 100 mg/kg/day. On the 46th day p.c. the internal and external genitalia of untreated female and male foetuses and of male foetuses from treated mothers were prepared and histologically examined. Some fetuses, whose mothers had been treated from the 25th to the 45th day p.c. with a daily dose of 50 mg/kg cyproterone acetate, were allowed to grow up and an adult male animal was dissected. Neither the differentiation of the gonads, the descent of the testes nor the regression of the Müllerian ducts could be influenced by cyproterone acetate. The Wolffian ducts and the seminal vesicles regularly showed signs of a clear regression. In isolated cases their development was completely inhibited by the antiandrogen. The size of the prostate and the bulbo-urethral gland was much reduced in comparison to those of male control animals. However, it was not possible to induce complete regression of these gland complexes. The course of the urethra in the region of the pelvis and phallus and the anatomical form of the external genital organs of male guinea pig fetuses showed clear signs of feminization under the influence of cyproterone acetate. The formation of a vagina could not be induced. It was possible to evaluate the influence of endogenous androgens on critical phases of intrauterine sexual differentiation for the guinea pig. The possibility that cyproterone acetate also has an inherent androgenic effect and the probable existence of species-specific androgens and organ-specific androgen receptors were also discussed. Since the differentiation of the gonads, the descent of the testes and the regression of the Müllerian ducts cannot be influenced by cyproterone acetate administration even several days before the start of the histologically detectable differentiation of these tissues, the results again lead to the assumption that, apart from androgens, at least one other sexual inductor exists which is responsible for the complete sexual differentiation of the genital organs to the male or female type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00538791
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and endocrine effects of terguride in healthy subjects (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 609-615 
    Details
    ISSN: 1432-1041
    Keywords: Terguride ; partial dopamine agonist ; pharmacokinetics ; endocrine effects ; pituitary hormones ; 6β-OH cortisol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma levels of the partial dopamine agonist, terguride, were measured by RIA in healthy volunteers after a single i. v. dose of 50 μg and on the first and seventh day of an oral treatment with 250 μg, 500 μg and 750 μg b. d. Basal and releasing hormone (TRH, GHRH, CRF, LHRH) — stimulated pituitary hormone secretion (PRL, TSH, GH, FSH, LH) and cortisol were also determined by RIA. Following the i. v. injection, plasma terguride levels declined biphasically, with half-lives of 0.2 and 1.5 h; total clearance was 17 ml·min−1·kg−1. the oral bioavailability of terguride over all doses was about 20%. Basal and TRH-stimulated prolactin levels were dose-dependently depressed, but the secretion of other hormones remained unaffected. Tolerance of terguride was excellent and there was no negative effect on performance or mood, nor on mixed-function oxygenase activity, assessed as urinary 6β-OH cortisol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00278591
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and pharmacodynamics in man of the dopamine antagonist ergot derivative, bromerguride (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 165-168 
    Details
    ISSN: 1432-1041
    Keywords: bromerguride ; dopamine antagonist ; pharmacokinetics ; pharmacodynamics ; prolactin level ; side-effects ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma levels and urinary excretion of the dopamine antagonist, bromerguride, were measured by radioimmunoassay in healthy male volunteers given 50 µg i.v. and oral doses of 1 and 2 mg. Plasma prolactin was also measured by radioimmunoassay. Following i.v. injection, the concentration of bromerguride declined biphasically, with half-lives of 7 min and 1.2h. The total clearance was 32 ml·min−1·kg−1 and the apparent volume of distribution was 3.6 l/kg. The bioavailability of oral bromerguride was 29% after 1 mg and 25% after 2 mg. The drug was almost totally metabolized and less than 0.05% of the dose was excreted in urine in 24 h after oral administration. Plasma prolactin levels were increased in a dose-dependent manner for about 8 h. Side-effects were minimal, mainly being tiredness and headache in some of the volunteers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00606653
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  • 4
    Electronic Resource
    Electronic Resource
    Application of layer systems for optical components
    Amsterdam : Elsevier
    Vacuum 37 (1987), S. 193 
    Details
    ISSN: 0042-207X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0042-207X(87)90136-9
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  • 5
    Electronic Resource
    Electronic Resource
    Evidence for prolonged recovery of dopaminergic transmission after detoxification in alcoholics with poor treatment outcome (1995)
    Springer
    Journal of neural transmission 102 (1995), S. 149-157 
    Details
    ISSN: 1435-1463
    Keywords: Dopamine receptors ; Growth Hormone ; alcoholism ; dopamine ; relapse ; neuroadaption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It has been hypothesized that dysfunction of dopaminergic neurotransmission is involved in the pathogenesis of alcohol addiction. Therefore, peripheral dopamine levels, sensitivity of central dopamine receptors (apomorphine-induced Growth Hormone (GH) secretion), and the inhibitory efficacy of G-proteins on adenylyl cyclase activity (as an indicator for dopamine D2-receptor coupled second messenger mechanisms) were measured in 45 alcohol-dependent patients before and after detoxification and in 10 healthy controls. The time needed to adjust to abstinence conditions differed between patients with good and poor treatment outcome. In subsequent abstainers, effects of alcohol withdrawal were already found during the first 24 hours of abstinence (normalisation of GH response, increases in dopamine levels and the inhibitory efficacy of G-proteins). During the next 7 days of abstinence, no more significant changes were observed in the assessed variables. In subsequent relapsers, no significant effect of acute ethanol withdrawal on the same measures was found. However, at day 8 of abstinence, increases in apomorphine-induced GH secretion (towards normalisation), in dopamine plasma levels, and in the inhibitory efficacy of G-proteins (towards above-normal levels) were observed. This retarded adjustment of dopaminergic signal transduction seems to reflect the relapse risk of treatment non-responders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01276510
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  • 6
    Electronic Resource
    Electronic Resource
    Inhibition of prolactin secretion by histidyl-proline-diketopiperazine (1978)
    [s.l.] : Nature Publishing Group
    Nature 274 (1978), S. 174-175 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Although the rapid inactivation and metabolisation of TRH has been reported by several investigators (for review see ref. 8) so far the mechanisms underlying the fragmentation have not been fully elucidated. To investigate the enzymatic degradation of TRH, [3H-His]TRH was incubated with a number of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/274174a0
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  • 7
    Electronic Resource
    Electronic Resource
    84. Bringt die synchrone abdomino-perineale Rectumexstirpation wesentliche Vorteile? (1985)
    Springer
    Langenbeck's archives of surgery 366 (1985), S. 439-442 
    Details
    ISSN: 1435-2451
    Keywords: Synchronous rectum excision ; Low rectum cancer ; Incontinence excision of rectum ; Synchrone Rectumexstirpation ; Tiefsitzendes Rectumcarcinom ; Inkontinenzresektion des Rectums
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Vom 01. 01. 74 bis 31. 12. 84 wurden 421 Patienten mit einem Rectosigmoid-Carcinom operiert. 269 Patienten (=63,8%) wurden kontinent reseziert. Bei 103 Patienten wurde das Rectum entfernt, wobei 17mal der schlieBmuskeltragende Anteil des Anorectums belassen wurde. Bei 86 Patienten (=20,4%) wurde die einzeitige abdomino-perineale Rectumexstirpation (42mal metachron und 44mal synchron) durchgeführt. Durch das synchrone Vorgehen konnte die Operationszeit um durchschnittlich 34 min verkürzt und die Mortalität von 19,0 auf 9% gesenkt werden.
    Notes: Summary From January lth, 1974 through December, 31th, 1984 a total of 421 patients with cancer of the rectosigmoid was operated upon. 269 patients (63.8%) underwent operations in which continence was maintained. In 17 of the cases the rectum was removed and the sphincter muscle was left intact. In 86 cases (=20.4%) a combined abdominoperineal rectum excision was performed (42X metachronous and 44X synchronous) in one session. The operating time involved in the synchronous method is on the average 34 min shorter than in metachronous. The mortality was reduced from 19% to 9%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01836683
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