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  • 1
    Electronic Resource
    Electronic Resource
    Hepatic involvement in hypereosinophilic syndrome: value of portal venous phase imaging (1998)
    Springer
    Abdominal imaging 23 (1998), S. 154-157 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Liver, hypereosinophilic syndrome—Liver, utrasonography—Liver, CT—Liver, MRI.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. US, portal venous phase CT, and MRI-CSE (MRI with conventional spin-echo sequence) findings in three cases of hepatic involvement in hypereosinophilic syndrome are presented. These showed varied imaging findings, but portal venous phase CT showed multiple, poorly marginated, and hypodense hepatic lesions in all three cases. The result suggested that portal venous phase CT is the optimal method for depicting hepatic involvement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900310
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  • 2
    Electronic Resource
    Electronic Resource
    Intestinal tuberculosis with abdominal complications: radiologic and pathologic features (1999)
    Springer
    Abdominal imaging 24 (1999), S. 32-38 
    Details
    ISSN: 1432-0509
    Keywords: Enteritis—Intestines, diseases—Intestines, infection—Intestines, perforation—Intestines, stenosis or obstruction.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: To investigate radiologic and pathological features of intestinal tuberculosis with abdominal complications. Methods: Twenty-two patients with 23 surgically proven complications (nine intestinal obstructions, eight perforations, three fistulae, and three intestinal bleeds) were analyzed. Medical records, radiologic studies, and pathologic examinations were reviewed with special emphasis on searching for the common features in each group of complication. Results: The most important single feature in seven of the nine patients with intestinal obstruction was the presence of stricture. In the remaining two patients, bowel adhesion was a primary cause of obstruction. In eight patients with intestinal perforation, both obstruction and ulcerations in the dilated proximal loop were the important features in six, and multiple deep ulcerations without obstruction was a primary cause in the remaining two. The common features in three patients with fistulae were focal or multiple strictures, severe adhesions, and fibrotic bowel wall. Intestinal bleeding originated from diffuse mucosal ulcerations. The abdominal complications occurred during antituberculous therapy in 10 of the 22 patients. Conclusion: Understanding the radiologic and pathologic features of intestinal tuberculosis with complications help in making an appropriate clinical decision for the treatment strategy. Close observation is necessary, especially in those patients who are acutely ill during antituberculous medical therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900436
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  • 3
    Electronic Resource
    Electronic Resource
    Colonic wall thickening in cirrhotic patients: CT features and its clinical significance (1999)
    Springer
    Abdominal imaging 24 (1999), S. 125-128 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Gastrointestinal edema—Edema cirrhosis—Colon edema—CT.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: To evaluate the computed tomographic (CT) features of colonic wall thickening in cirrhotic patients and to determine their prognostic value. Methods: We retrospectively reviewed 28 cirrhotic patients with colonic wall thickening (≥10 mm) on CT. Twenty-six of the 28 patients had hepatocellular carcinoma. The severity of hepatic dysfunction was determined by using the Child–Pugh classification. We analyzed the patterns of bowel wall thickening and degree of portal hypertension on CT and the survival periods after initial CT detection of colonic wall thickening. Results: The involved segment of the colon was diffusely thickened with either scalloped or nodular circumferential configuration. In all patients, the thickened colonic wall enhanced poorly. Although the ascending colon was involved in all patients, the transverse (n= 14) or descending (n= 5) colon was also simultaneously involved. Most patients exhibited an advanced stage of portal hypertension on CT. The median survival period of 25 patients who expired was 34 days, and 21 patients (84%) expired within 3 months. Conclusions: Colonic wall thickening on CT can be used as one of the indicators of poor prognosis in cirrhotic patients. Advanced liver cirrhosis with significantly severe dysfunction is the likely cause of mortality. Therefore, a less aggressive therapeutic approach is recommended if hepatocellular carcinoma is coexistent in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900459
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  • 4
    Electronic Resource
    Electronic Resource
    Use of methylcellulose in small bowel follow-through examination: comparison with conventional series in normal subjects (1998)
    Springer
    Abdominal imaging 23 (1998), S. 281-285 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Intestines, radiography—Small intestine, gastrointestinal examination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: To evaluate and optimize a modified small bowel follow-through examination (SBFT) by using an oral administration of a large amount (600 mL) of methylcellulose after taking a small amount of barium. Methods: Ninety-nine normal subjects underwent modified SBFT with an oral administration of 600 mL of 0.5% methylcellulose after taking 100 mL of 120% or 100, 150, or 200 mL of 70% w/v barium. The transradiancy and distensibility of the bowel and the transit time were compared with those of 39 other normal subjects who underwent conventional SBFT with 500 mL of 70% w/v barium. Results: Except for two subjects who developed diarrhea immediately after examination, no patients complained of acute symptoms, such as abdominal pain or vomiting. Modified SBFT was much superior to conventional series for obtaining good bowel transradiancy and rapid transit time (range = 37–49 min), but bowel distention was not significantly improved. The use of 150 mL of 70% w/v barium was better than the other three modified techniques for achieving good bowel transradiancy, rapid transit time, and less occurrence of flocculation. Conclusion: Modified SBFT is a simple method for easily improving the image quality in terms of bowel transradiancy and transit time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900340
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  • 5
    Electronic Resource
    Electronic Resource
    Nodular regenerative hyperplasia of the liver in Budd–Chiari syndrome: CT and MR features (2000)
    Springer
    Abdominal imaging 25 (2000), S. 255-258 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Hepatic veins, thrombosis—Liver neoplasms—Liver neoplasms, CT—Liver neoplasms, MR.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report the imaging findings of spiral computed tomography (CT), magnetic resonance (MR) imaging, and MR angiography in a patient with nodular regenerative hyperplasia of the liver associated with Budd–Chiari syndrome. Spiral CT showed multiple enhancing nodules during the hepatic arterial and portal venous phases. MR images showed multiple hyperintense nodules on T1-weighted images and hypointense or isointense nodules on T2-weighted images. MR angiography showed thrombotic occlusion of three hepatic veins, suggesting Budd–Chiari syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002610000027
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  • 6
    Electronic Resource
    Electronic Resource
    Structure–effect relationships of amiodarone analogues on the inhibition of thyroxine deiodination (2000)
    Springer
    European journal of clinical pharmacology 55 (2000), S. 807-814 
    Details
    ISSN: 1432-1041
    Keywords: Key words Amiodarone analogues ; 5′-T4 deiodinase ; Deiodination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objectives: Amiodarone (AMI) has proven to be a potent anti-arrhythmic compound. Due to the structural similarity between AMI and thyroid hormone, it is possible that the drug could inhibit the activity of the 5′-thyroxine-deiodinase. Methods: AMI analogues resulting from (1) dealkylation, (2) deiodination and (3) deamination were synthesised and used as inhibitors in an in vitro biotransformation reaction of thyroxine (T4) to 3,3′,5′-triiodothyronine (T3). Using high-performance liquid chromatography and ultraviolet detection for quantifying T3, it was found that the 5′-T4 deiodinase type I was involved in the reaction. On separate occasions, AMI or an AMI analogue was added to the reaction as an inhibitor. Results: All studied AMI analogues inhibited 5′-T4 deiodination competitively (K i value range 25–360 μM). In the concentration range of 1–1000 μM, AMI and its N-desethylated, deiodinated analogues inhibited 5′-T4 deiodination very weakly. AMI analogues with a hydroxyl group at the 4-position were strong inhibitors. Moreover, diiodo-AMI analogues inhibited 5′-T4 deiodination more strongly than their corresponding monoiodo- or deiodinated derivatives. Conclusion: It is likely that the degraded products of AMI could be responsible for thyroid dysfunction toxicosis in AMI therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050701
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  • 7
    Electronic Resource
    Electronic Resource
    The antiarrhythmic effects of controlled release disopyramide phosphate and long acting propranolol in patients with ventricular arrhythmias (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 729-734 
    Details
    ISSN: 1432-1041
    Keywords: disopyramide ; cardiac arrhythmias ; propranolol ; slow release formulations ; plasma levels ; 24-hour ECG monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The antiarrhythmic effect of slow-release disopyramide phosphate (DR) 300 mg twice daily and of long-acting propranolol (PR) 1 × 160 mg daily was compared in a randomized cross-over study in patients with premature ventricular beats (PVB). 12 patients with PVB (Lown Classes II–V) were given: placebo I for 3 days, DR or PR for 7 days, placebo II for 5 days and PR or DR for 7 days. During each study phase Holter-ECG recordings were taken over a period of 24h. With DR 6 patients showed a positive qualitative effect, improving by at least one Lown class, whereas only 2 patients did so with PR. With DR reduction of PVB〉80% occurred in 7 patients, and with PR in 2 patients. In all patients with any reduction in PVB, the median decrease was 85% with DR and 59% with PR. The overall results suggest that the antiarrhythmic effect of disopyramide phosphate in the slow-release preparation is at least satisfactory and comparable to that of disopyramide phosphate in the standard capsule formulation given in the usual and more complicated regime of four divided doses. The antiarrhythmic effect of PR in the recommended dose as given was not convincing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542510
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  • 8
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and metabolism of quinidine in extensive and poor metabolisers of sparteine (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 69-72 
    Details
    ISSN: 1432-1041
    Keywords: quinidine ; sparteine ; pharmacokinetics ; drug oxidation ; polymorphism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics and metabolism of quinidine were investigated in extensive and poor metabolisers of sparteine. No differences in plasma clearance, terminal half life, volume of distribution or cumulative urinary excretion of quinidine, 3-hydroxyquinidine and quinidine-N-oxide were observed between phenotypes. Thus, it is unlikely that quinidine metabolism is controlled by the sparteine/debrisoquine gene locus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00870989
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  • 9
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of midazolam in patients recovering from cardiac surgery (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 161-166 
    Details
    ISSN: 1432-1041
    Keywords: midazolam ; benzodiazepine ; pharmacokinetics ; biotransformation ; surgery ; prolonged recovery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of midazolam has been studied in patients recovering from cardiac surgery, who required sedation for postoperative mechanical ventilation. Twelve males (mean age 64.5 years) with severe heart disease received an infusion of midazolam 15 mg·h−1 for 4 h, starting 1 to 3 h post surgery. Multiple blood samples were collected from each patient during the infusion and up to 48–93 h after it. The pharmacokinetic parameters of midazolam were determined using both moment analysis and the program NONMEM. The average terminal half-life was 10.6 h. The prolonged elimination was mainly due to a decrease in its metabolic clearance (0.25 l·min−1). The maintenance infusion dose of midazolam in such patients should be reduced. The time to recovery after stopping an infusion depends upon the amount of drug in the body at that time and a simulation of the plasma concentrations after various infusion regimens suggests that recovery will be delayed after prolonged (〉48 h) administration of midazolam to these patients. However, after shorter infusions (〈12 h), redistribution of the drug away from the site of action was still occurring and recovery would be expected to be relatively rapid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558225
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  • 10
    Electronic Resource
    Electronic Resource
    Nonlinear kinetics of propafenone metabolites in healthy man (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 509-513 
    Details
    ISSN: 1432-1041
    Keywords: Propafenone ; metabolism ; non-linear pharmacokinetics ; 5-hydroxypropafenone ; N-depropylpropafenone ; saturable biliary excretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary. The pharmacokinetics of oral and i. v. propafenone and its major metabolites have been investigated in 8 healthy subjects. The total body clearance of propafenone was 963 ml/min, the terminal half-life 198 min and its absolute bioavailability was 15.5%. The two active metabolites (5-hydroxypropafenone and N-depropylpropafenone) showed non-linear kinetics in that both the dose-corrected area under the serum concentration-time curve and the amount excreted in the urine were larger after oral dosing. This resulted in considerably higher serum concentrations of the metabolites despite comparable serum concentrations of the parent compound. Thus, the concentration-effect relationship in the same patient may differ after oral and intravenous doses if concentrations of the active metabolite(s) are not taken into consideration. Although the mechanism of the nonlinearity is not clear, the data indicate that it may be due to saturable biliary excretion of the metabolites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02336693
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