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  • 1
    Electronic Resource
    Electronic Resource
    Computer simulation of kinetics of gelation by addition polymerization in a solvent (1984)
    s.l. : American Chemical Society
    Macromolecules 17 (1984), S. 998-1004 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00135a004
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  • 2
    Electronic Resource
    Electronic Resource
    Left or right transaxillary approach in lower extremity arteriography for severe occlusive vascular disease (1987)
    Springer
    Surgical and radiologic anatomy 9 (1987), S. 315-317 
    Details
    ISSN: 1279-8517
    Keywords: Angiography ; Technology ; Aortic arch
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé A partir d'une étude anatomique de 46 spécimens, les angles du tronc artériel brachio-céphalique droit et de l'artère sous-clavière gauche par rapport à la tangente à la crosse de l'aorte sont mesurés de façon à déterminer quelle voie permet l'accès le plus facile et le plus rapide à l'aorte descendante lors des angiographies des membres inférieurs en cas d'artériopathie sévère. L'étude montre que les angles moyens (77.1±16.0 degrés pour le tronc brachio-céphalique, 77.7±16.3 degrés pour l'artère sous-clavière gauche) ne sont pas significativement différents. Comme l'abord axillaire droit comporte plus de risques qui ne peuvent être contre-balancés que par un accès plus rapide, nous concluons que chez les patients de tous âges, le côté gauche droit être la voie d'accès de première intention.
    Notes: Summary In an anatomic study of 46 specimens, the angle of the brachiocephalic trunk and the left subclavian artery to the tangent of the aortic arch was measured in an effort to decide which route offers the quickest access to the descending aorta in lower extremity angiography for severe occlusive vascular diseases. The study shows that the average angles (77.1±16.0 degrees for the brachiocephalic trunk/77.7±16.3 degrees for the left subclavian artery) are not significantly different. Since the right axillary approach incurs other risks that could only be compensated by significantly quicker access, i.e. shorter maneuvering time in the aortic arch we conclude that in patients of all ages the left side should be the access route of choice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02105303
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  • 3
    Electronic Resource
    Electronic Resource
    Über die Blutkonzentrationen der Leukozyten und Thrombozyten bei Eisenmangel (1967)
    Springer
    Annals of hematology 14 (1967), S. 267-272 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Leucopenia was frequently found in iron deficiency anemias; there was no correlation between the numbers of leucocytes and the values of hemoglobin or serum iron values. The thrombocyte count was changed only in few cases. The changes in blood cells are interpreted as a manifestation of a general reduction in iron-containing enzyme systems, particularly leading to damages in tissues with a high cellular turnover and a great demand of energy.
    Notes: Zusammenfassung Bei Eisenmangelanämien wurden gehäuft Leukopenien nachgewiesen, wobei keine Korrelation der Leukozytenzahlen mit den Hämoglobin- bzw. Serumeisenwerten bestand. Die Thrombozytenzahlen erwiesen sich nur in wenigen Fällen verändert. Die Blutzellveränderungen werden als Ausdruck einer allgemeinen Verminderung eisenhaltiger Fermentsysteme gewertet, die zu Schädigungen insbesondere von Geweben mit hohem Zellumsatz und großem Energiebedarf führen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01632155
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  • 4
    Electronic Resource
    Electronic Resource
    An action of adenosine 3′,5′-monophosphate on glucose metabolism of rabbit brain slices (1970)
    Springer
    Cellular and molecular life sciences 26 (1970), S. 133-134 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Der Einfluss von Adenosin-3′, 5′- monophosphat (AMP) auf den Glukosestoffwechsel von Grosshirnrindenschnitten des Kaninchens wurde untersucht. 0.1 bis 1mM AMP pro Liter Incubationslösung stimulieren die Atmung der Schnitte. Die aerobe Glykolyse der Schnitte wird durch 0,5 bis 1 mM AMP anfänglich stark gesteigert und nach ca. 30 min völlig gehemmt. 0.1 mM AMP hemmt die Glykolyse lediglich.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01895535
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  • 5
    Electronic Resource
    Electronic Resource
    Über das Auftreten von Phenolischen, auf Grund der Millonschen Reaktion Erfassbaren Harnsubstanzen (1932)
    Springer
    Journal of molecular medicine 11 (1932), S. 1231-1231 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01766039
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Der Einfluß großer parenteraler Vitamin B12-Gaben auf den im Alter erhöhten Kernsegmentierungsgrad der Granulocyten (1962)
    Springer
    Journal of molecular medicine 40 (1962), S. 266-266 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Da die beobachtete Übersegmentierung des Kernes neutrophiler Granulocyten nach einer einmaligen hochdosierten Vitamin B12-Gabe nur vorübergehend zurückgebildet wird (unter gleichzeitiger Vermehrung der Zahl der stabkernigen Leukocyten), wird die Kernveränderung nicht auf das Vorliegen eines Vitamin B12-Mangels bei alten Menschen zurückgeführt, sondern als altersabhängig angesehen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477112
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  • 7
    Electronic Resource
    Electronic Resource
    Intracranial germ-cell tumours — treatment results and residuals (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 230-236 
    Details
    ISSN: 1432-1076
    Keywords: Intracranial germ-cell tumours ; Childhood ; Residuals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract There is only sparse information about the development of children after successful treatment for intracranial germ-cell tumours. Between January 1981 and June 1992, 26 children with intracranial germ-cell tumours were treated in the University Hospital Hamburg-Eppendorf. We report on treatment results, long standing residuals and the “quality of life” of these patients. The long-term event-free survival was 88% for the germinomas and 43% for the malignant teratomas. Of the patients 58% had no relevant functional neurological deficits and 37% had mild impairment. Only 1 patient with metastatic disease was severely handicapped. Six patients showed neuro-endocrine dysfunction. All of them had suprasellar/hypothalamic lesions and all received successful substitution therapy. As to neuropsychological functions, 53% of the patients had no or only mild disturbances. The most affected function was speed of information processing. Of the children 69% were able to proceed with their education at the same level as before therapy. The overall self-assessment revealed good results in 75% of the patients. Conclusion After surgical removal and radiation therapy long-term survival of intracranial germinomas amounts to 88%. Despite craniospinal axis radiation severe residuals are rare and a good quality of life is common. In malignant teratomas treatment regimens including chemotherapy are much less successful.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01953944
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  • 8
    Electronic Resource
    Electronic Resource
    Pineal region tumours of childhood (1987)
    Springer
    European journal of pediatrics 146 (1987), S. 233-245 
    Details
    ISSN: 1432-1076
    Keywords: Germinoma ; Teratoma ; Pineocytoma ; Pinealoblastoma ; Astrocytoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In Germany, the relative frequency of pineal region tumours seems to be much higher than hitherto assumed. At the University Hospital Hamburg, from 1980–1985 17 children with pineal region tumours were encountered amongst 102 children with CNS tumours. Two-cell-type germinoma is the most frequent pineal region tumour. Cerebrospinal fluid cytology is highly successful in identifying this germ cell tumour. Surgical removal has become a reasonably safe procedure in the treatment of pineal region tumours and was successful in all 10 cases so treated. In addition, our patients with two-cell-type germinomas received craniospinal axis radiation. All children, treated by both surgical removal and craniospinal exis radiation are so far relapse-free and are functioning on a pretreatment level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00716466
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of trospium chloride on gastrointestinal motility in humans (1993)
    Springer
    European journal of clinical pharmacology 44 (1993), S. 219-223 
    Details
    ISSN: 1432-1041
    Keywords: Trospium chloride ; Gastrointestinal motor function ; gall bladder contraction ; gastric emptying ; gastrooesophageal reflux ; orocaecal transit time ; Oesophageal pH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The aim of this double-blind, placebo-controlled, cross-over study was to investigate the effect of trospium chloride on gall bladder contraction, gastric emptying of a liquid meal, gastrooesophageal reflux, and orocaecal transit time in healthy subjects. Gall bladder contraction was examined by ultrasonography before and after stimulation with two raw eggs. Gastric emptying was evaluated by an intubation technique and by sonography. To determine gastrooesophageal reflux and orocaecal transit time, 24-hour pH metry and a hydrogen breath test were used. The gall bladder ejection fractions were significantly lower after oral treatment with both 4×10 mg and 4×20 mg trospium compared to placebo, but no difference was seen between the two doses of drug. Gastric emptying of a liquid meal was significantly delayed after intake of 4×15 mg trospium, whilst the time course of the intragastric volume determined by ultrasound did not differ from that after placebo, suggesting an antisecretory effect of trospium on gastric secretion. The fractional time of oesophageal pH〈4 as a percentage of the entire 24-hour investigation period was significantly increased by treatment with trospium 3×15 mg per day. The orocaecal transit time of 10 g lactulose was significantly prolonged. Provided that the observed effects on gall bladder contraction, gastric emptying, and orocaecal transit time are reproduced in disease states, trospium should be regarded as a potentially useful antispasmodic agent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00271361
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  • 10
    Electronic Resource
    Electronic Resource
    Über die Verträglichkeit verschiedener Cytostatica bei intracranieller Anwendung (1965)
    Springer
    Acta neurochirurgica 12 (1965), S. 554-586 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The electroencephalograms of rabbits were investigated following the intracranial extracerebral application of different cytotoxic agents (ENDOXANR, TRENIMONR, Tetra-Ethylenimino-Benzochinon and MITOMENR). ENDOXAN caused only slight electroencephalographic changes, without appreciable clinical symptoms. TRENIMON, Tetra-Ethylenimino-Benzochinon and MITOMEN resulted in pronounced changes of the brain wave picture, recognisable especially as a change in reaction to photic stimulation. Clinically these agents caused epileptic attacks, disturbances of equilibrium or paralyses. The three last named preparations appear to be so toxic that for local intracranial application, only ENDOXAN — of those agents investigated — seems suitable.
    Abstract: Résumé L'électro-encéphalogramme du lapin a été étudié lors d'injections intracraniennes et extracérébrales de différents cytostatiques (ENDOXANR, TRENIMONR, Tétra-Aethylentmino-Benzochinon et MITOMENR). L'Endoxan ne produisit que des troubles minimes de l'électro-encéphalogramme sans symptômes cliniques manifestes. Trenimon, Tétra-Aethyleninimo-Benzochinon et Mitomen par contre provoquèrent des perturbations nettes du tracé électro-encéphalographique concernant surtout la réplique aux excitations lumineuses. Au point de vue clinique ces animaux présentèrent des épisodes convulsifs, des troubles de l'équilibre et des paralysies. La toxicité de ces derniers médicaments semble tellement importante que parmi les cytostatiques étudiés, seul l'Endoxan entre en ligne de compte pour l'application locale intracranienne.
    Notes: Zusammenfassung An Kaninchen wurden Untersuchungen des Elektroencephalogramms bei intracranieller extracerebraler Verabreichung verschiedener Cytostatica (ENDOXANR, TRENIMONR, Tetra-Aethylenimino-Benzochinon und MITOMENR) durchgeführt. ENDOXAN verursachte nur geringe elektroencephalographische Veränderungen ohne faßbare klinische Symptome. TRENIMON, Tetra-Aethylenimino-Benzochinon und MITOMEN hatte markante Störungen des Hirnstrombildes zur Folge, kenntlich besonders an Änderungen der Lichtreizbeantwortung. Klinisch kam es hier zu Krampfanfällen, Gleichgewichtsstörungen oder Lähmungen. Die Toxizität der letztgenannten Präparate erscheint so groß, daß für lokale, intracranielle Anwendung von den untersuchten Medikamenten nur das ENDOXAN in Frage kommt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405803
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