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  • 1
    Electronic Resource
    Electronic Resource
    The immunosuppressive effect of streptozotocin-induced diabetes in rats (1986)
    Springer
    Research in experimental medicine 186 (1986), S. 455-462 
    Details
    ISSN: 1433-8580
    Keywords: Experimental diabetes ; Immunosuppression ; Rat ; Heart transplantation ; Streptozotocin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Streptozotocin-diabetic isogenous Brown-Norway (BN) rats received heterotopic Wistar-Furth (WF × BN) F1 heart transplants. The functional graft survival time after different duration of diabetes and during insulin-treated diabetes was recorded. Some diabetic rats were challenged with sheep red cells, and their spleens were used in PHA stimulation and plaqueforming assays. Prolongation in heart transplant survival was found to be independent of the duration of diabetes. The prolongation disappeared promptly when insulin was administered to the diabetic rats. A depression of cellular immunoresponsiveness as measured by PHA stimulation assay was recorded during diabetes. Valid results were not obtained in the plaque-forming assay.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852199
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cytomegalovirus infection in orthotopic liver transplantation (1989)
    Springer
    Transplant international 2 (1989), S. 96-101 
    Details
    ISSN: 1432-2277
    Keywords: Liver transplantation, and cytomegalovirus infection ; Cytomegalovirus infection, in liver transplantation ; Gancyclovir, for cytomegalovirus infection, in liver transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We retrospectively studied 175 orthotopic liver transplants in 151 patients. Of the 151 patients, 59 (39.1%) were diagnosed as having cytomegalovirus (CMV) infection. The rate of infection in patients treated for rejection was 48.8% as compared to 26.2% in patients without rejection (P〈0.01). Antirejection therapy was associated with culture-positive cases in 33 out of 43 patients as compared to 9 out of 16 patients who had CMV antibody titer elevations. Patients were treated with gancyclovir if they had simultaneous positive cultures from multiple sites and were seriously ill. Eighteen of the 19 patients thus treated had side effects, one of which was serious (bone marrow hypoplasia). Cultures became negative in 15 out of 17 (88%) of the surviving patients. Patient survival was similar to our overall survival rate of 87%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02459327
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The influence of dose interval on the immunosuppressive potency of methylprednisolone: an experimental organ transplant study in isogenous rats (1990)
    Springer
    Transplant international 3 (1990), S. 23-25 
    Details
    ISSN: 1432-2277
    Keywords: Heart transplantation, experimental, rat ; Prednisolone, in experimental heart transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Groups of isogenous Brown-Norway rats received heterotopic heart transplants from (Brown-Norway/Wistar Furth)xF1 hybrid rats. Methylprednisolone was administered IV in a daily dose of 5–40 mg/kg, using a dose interval of 24, 12, or 0 h (continuous infusion). Continuous infusion proved to be superior when small daily doses were used and then caused a more than threefold increase in graft survival. High daily doses created a substantial mortality with all dose intervals. Moreover, the equipment used for continuous drug administrations was unreliable beyond 4 weeks of infusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00333198
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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