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  • 1
    ISSN: 1432-0428
    Keywords: Diabetes ; neuropathy ; microangiopathy ; heterogeneity ; morphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Clinical, electrophysiological and ultrastractural morphometric observations were made in 5 diabetic non-neuropathic patients, 5 diabetic patients with mild neuropathy and 11 diabetic patients with severe neuropathy. Capillary abnormalities were assessed in simultaneous nerve, muscle and skin biopsies and compared with results from 6 age-matched, non-diabetic control subjects. Nerve capillaries demonstrated markedly greater pathology than skin and muscle capillaries. Endoneurial capillary density was significantly reduced in severely neuropathic diabetic patients (p〈0.01) when compared with control subjects. Capillary basement membrane (p〈0.002), endothelial cell (p〈0.003) and total diffusion barrier (endothelial cell, pericyte, basement membrane) (p〈0.001) thickness were significantly increased, and oxygen diffusing capacity was significantly reduced (p〈0.001) in the nerves of patients with severe diabetic neuropathy when compared to control subjects. Endothelial cell profile number and luminal perimeter were significantly increased in asymptomatic (p〈0.01), (p〈0.05) and severely neuropathic (p〈0.001), (p〈0.05) diabetic patients respectively. However, endothelial cell outer perimeter, a measure of capillary size, showed no significant increase in diabetic patients when compared with control subjects. An association was observed between neurophysiological and neuropathological measures of neuropathic severity. There was no significant correlation between the duration of diabetes and HbA1 levels with capillary pathology or with neuropathic severity. Very few abnormalities of muscle and skin correlated with neuropathic severity. However, all measures of nerve capillary pathology correlated significantly with neurophysiological and neuropathological measures of neuropathic severity.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Electrical engineering 30 (1936), S. 430-445 
    ISSN: 1432-0487
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Zusammenfassung Man kann beim Gleichrichterverfahren Glimmlichtgleichrichter an Stelle der Elektronenröhren anwenden, wenn man gleichzeitig die zu den Gleichrichtern parallele KapazitätC k sehr klein macht und den Anfang der Mikroamperemeterskala verschiebt. Demzufolge nimmt die Genauigkeit des Verfahrens zwar ein wenig ab, aber die Meßeinrichtung vereinfacht sich sehr (die Heizbatterien fallen fort).
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Electrical engineering 28 (1934), S. 8-15 
    ISSN: 1432-0487
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Zusammenfassung Die Gleichrichtermethode wird prinzipiell zur Messung der Maximalwerte der Spannungskurven, die blo\ zwei Scheitelwerte in einer Periode aufweisen, angewendet. Die Spannungskurven, die dieser Bedingung nicht entsprechen, kommen aber in der Praxis manchmal vor. In diesem Falle wird die Messung der Scheitelspannung mit einem Fehler belastet. Eine praktische Methode der Bestimmung dieses Fehlers existiert unseres Wissens noch nicht. Die anderen hier vorkommenden Fehler, die ihre Ursache in der Unvollkommenheit der Anordnung der Elemente haben, können nach dem Verfahren von H. König bestimmt werden, das jedoch keinen allgemeinen Charakter hat und ziemlich umstÄndlich ist. Es ist besser die obere Grenze des dabei begangenen Fehlers auf die hier nÄher beschriebene einfache Weise zu bestimmen. Au\erdem kann die Messung mit anderen Fehlern belastet werden, deren Ursache in der mangelhaften Ausführung der Me\anordnung liegt (schlechte Kontakte, Sprühen der Zuleitung usw.). Solche Fehlerquellen sollen sorgfÄltig geprüft und beseitigt werden. Bei der kapazitiven Spannungsmessung empfiehlt es sich, die dunkelglühenden Elektronenröhren als Gleichrichter zu verwenden. Man kann dann eine Zusatzbatterie vermeiden, die sonst zur Trennung der Arbeit der Gleichrichter nötig ist. Unter diesen Bedingungen kann die Gleichrichtermethode der Messung der Scheitelwerte der Hochspannung als eine sehr praktische und genaue Me\methode, auch in Fabriklaboratorien, betrachtet werden.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0428
    Keywords: Diabetic neuropathy ; sural nerve ; nerve blood flow ; epineurial vessel photography ; fluorescein angiography ; arterio-venous shunting ; vasa nervorum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary New techniques of sural nerve photography and fluorescein angiography which are able to provide an index of nerve blood flow have been developed. Under local anaesthetic, 3 cm of sural nerve was exposed at the ankle using an operating microscope. Without disturbing the epineurium, vessels were identified and photographed at a standard magnification (× 30). These were independently graded by an ophthalmologist not otherwise involved with the study. Fluorescein angiography was then carried out on the exposed nerve. The fluorescein appearance time and intensity of fluorescence were quantified, using computer analysis of digitised images. Thirteen subjects with chronic sensory motor neuropathy, five non-neuropathic diabetic and nine normal control subjects were studied. The mean epineurial vessel pathology score of the neuropathic group was significantly higher than the combined normal control and non-neuropathic diabetic groups (p 〈0.01). Direct epineurial arteriovenous shunting was observed in six neuropathic and one non-neuropathic diabetic patients and not in any of the normal control subjects. The nerve fluorescein appearance time was significantly delayed in subjects with chronic sensory motor neuropathy (51.5 ± 12 s) compared to both normal (34.7 ± 9 s, p 〈0.01) and non-neuropathic diabetic subjects (33.4 ± 11 s, p 〈0.025). The mean intensity of fluorescence at 96, 252 and 576 s, was significantly lower in subjects with chronic sensory motor neuropathy compared with both of the other groups (p 〈0.05). The epineurial vessel pathology score was significantly related to reduced sural (p 〈0.01) and peroneal (p 〈0.001) nerve conduction velocities, elevated vibration (p 〈0.01) and thermal (p 〈0.001) perception and the severity of retinopathy (p 〈0.002). The fluorescein appearance time was significantly related to reduced sural sensory (p 〈0.02) conduction velocity, elevated vibration (p 〈0.01) perception and epineurial vessel (p 〈0.002) pathology score, but it failed to relate to peroneal motor (p = 0.06) conduction velocity, thermal (p = 0.1) perception and the severity of retinopathy (p = 0.3). Intensity of fluorescence was significantly related to fluorescein appearance time (at 96 s, p 〈0.001; at 576 s, p 〈0.05) but did not relate to measures of neuropathic severity. These techniques have enabled us to observe that epineurial vessel anatomy is abnormal and that nerve blood flow is impaired in subjects with chronic sensory motor neuropathy. In addition epineurial arterio-venous shunting may be a feature of diabetic neuropathy. These techniques may further be applied to study nerve blood flow in early diabetic neuropathy.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0428
    Keywords: Insulin neuritis ; diabetic neuropathy ; sural nerve ; nerve blood flow ; arterio-venous shunting ; nerve ; hypoxia ; new vessel formation ; fluorescein angiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Insulin neuritis, or painful neuropathy following rapid improvement in glycaemic control, is well recognised but its aetiology is unclear. An understanding of the processes involved in the genesis of acute painful neuropathy of rapid glycaemic control may give an insight into the early pathogenetic factors leading to diabetic nerve damage in general. We have identified five subjects with insulin neuritis including one who developed severe autonomic neuropathy following treatment with insulin. Subjects underwent: 1) assessment of neuropathic symptom and deficit scores; 2) quantitative sensory and electro-physiological studies and 3) sural nerve epineurial vessel photography and fluorescein angiography in vivo. The sural nerve photographs were independently graded by an ophthalmologist. All subjects with insulin neuritis presented with severe sensory symptoms but clinical examination and electrophysiological tests were normal except in the subject with the severe autonomic neuropathy in whom all the tests were abnormal. On nerve photography, there was an abundance of epineurial nutrient vessels although these showed severe abnormalities including arteriolar attenuation, tortuosity and arterio-venous shunting in all subjects. Proliferating neural ‘new vessels’ which bear striking similarities to those found in the retina and that were more leaky to fluorescein than normal vessels, were observed in three subjects. Venous distension and/or tortuosity was also observed in three subjects and this was most marked in the subject with severe autonomic neuropathy. This study shows that epineurial nutrient vessel anatomy is abnormal in subjects with acute painful neuropathy of rapid glycaemic control, a condition previously thought to be purely metabolic in origin. The presence of epineurial arterio-venous shunting and a fine network of vessels resembling the new vessels of the retina, may lead to a ‘steal’ effect rendering the endoneurium ischaemic. This process may be important in the genesis of neuropathic pain, and further supports the importance of vascular factors in the pathogenesis of diabetic neuropathy.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0428
    Keywords: Keywords Insulin neuritis ; diabetic neuropathy ; sural nerve ; nerve blood flow ; arterio-venous shunting ; nerve ; hypoxia ; new vessel formation ; fluorescein angiography.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Insulin neuritis, or painful neuropathy following rapid improvement in glycaemic control, is well recognised but its aetiology is unclear. An understanding of the processes involved in the genesis of acute painful neuropathy of rapid glycaemic control may give an insight into the early pathogenetic factors leading to diabetic nerve damage in general. We have identified five subjects with insulin neuritis including one who developed severe autonomic neuropathy following treatment with insulin. Subjects underwent: 1) assessment of neuropathic symptom and deficit scores; 2) quantitative sensory and electrophysiological studies and 3) sural nerve epineurial vessel photography and fluorescein angiography in vivo. The sural nerve photographs were independently graded by an ophthalmologist. All subjects with insulin neuritis presented with severe sensory symptoms but clinical examination and electrophysiological tests were normal except in the subject with the severe autonomic neuropathy in whom all the tests were abnormal. On nerve photography, there was an abundance of epineurial nutrient vessels although these showed severe abnormalities including arteriolar attenuation, tortuosity and arterio-venous shunting in all subjects. Proliferating neural ’new vessels' which bear striking similarities to those found in the retina and that were more leaky to fluorescein than normal vessels, were observed in three subjects. Venous distension and/or tortuosity was also observed in three subjects and this was most marked in the subject with severe autonomic neuropathy. This study shows that epineurial nutrient vessel anatomy is abnormal in subjects with acute painful neuropathy of rapid glycaemic control, a condition previously thought to be purely metabolic in origin. The presence of epineurial arterio-venous shunting and a fine network of vessels resembling the new vessels of the retina, may lead to a ’steal' effect rendering the endoneurium ischaemic. This process may be important in the genesis of neuropathic pain, and further supports the importance of vascular factors in the pathogenesis of diabetic neuropathy. [Diabetologia (1996) 39: 329–335]
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0428
    Keywords: Keywords Diabetic neuropathy ; spectrophotometry ; sural nerve ; nerve blood flow ; oxygen saturation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Experimental studies have shown that abnormalities of nerve microcirculation are important factors in the pathogenesis of diabetic neuropathy but there have been few clinical studies. We have applied microlightguide spectrophotometry to measure intravascular oxygen saturation (HbO2%) and blood flow in human sural nerve. Methods. We studied ten patients with mild-moderate sensory motor diabetic neuropathy, nine patients without neuropathy and nine control subjects. We took 300 measurements of oxygen saturation under direct visual control through a 1.9 mm rigid endoscope over three regions of the nerve. Spectrophotometric measurements of nerve fluorescence were taken after an intravenous injection of sodium fluorescein and the rate of increase in nerve fluorescence (rise time) was used as an indicator of nerve blood flow. Results. Nerve oxygen saturation was reduced in patients with neuropathy compared with control subjects (67.1 ± 2.2 % vs 76.7 ± 2.1 %, p = 0.006). Fluorescein rise time was prolonged in patients with neuropathy compared with the control group (48.5 ± 7.0 s vs 14.0 ± 3.1 s, p = 0.001) suggesting impaired nerve blood flow. There was a correlation between rise time, nerve oxygen saturation, glycaemic control and sural nerve sensory conduction velocity (p 〈 0.01). Conclusion/interpretation. The combination of microlight-guide spectrophotometry and micro-endoscopy provides a valuable minimally invasive technique for clinical investigation of nerve microcirculation. We have shown reduced nerve oxygenation and impaired blood flow in diabetic neuropathy and these findings strongly support a central role of microvascular disease in the pathogenesis of diabetic neuropathy. [Diabetologia (1999) 42: 737–742]
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Electrical engineering 30 (1936), S. 276-280 
    ISSN: 1432-0487
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Zusammenfassung Gezeigt wurde, daß man das Verfahren von König so abandern kann, daß es leichter zu benutzen ist. Zu diesem Zwecke muß man an Stelle der Zusatzbatterie einen Kondensator einschalten. Für die Praxis wird am besten die am Kondensator auftretende SpannungV mit einem elektrostatischen Voltmeter gemessen. Damit die zeitliche Zunahme der SpannungV langsam genug vor sich geht, muß die KapazitätC 0 des Kondensators etwa 150 μF betragen.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Electrical engineering 31 (1937), S. 186-191 
    ISSN: 1432-0487
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Zusammenfassung Es wurde experimentell bewiesen, daß eine geeignete Leitung (konstanter Wellenwiderstand, keine Glimmentladung), eine einmalig hindurchgehende Wanderwelle nicht merklich verzerrt, auch wenn die Leitungslänge 75 m beträgt. Man konnte also klarstellen, daß die zu Beginn des Durchbruchs auftretende Abrundung der Durchschlagskurve eine physikalische Realität ist. Es hat sich ferner bei Untersuchung der vom statischen Durchschlag herrührenden Wanderwelle gezeigt, daß der Spannungsverlauf an der Funkenstrecke, wenn der Durchschlag durch Lichtanstoßen bei kleinerer als bei statischer Spannung erfolgt, derselbe ist wie bei statischer Spannung. Besonders vorteilhaft erwies sich die benutzte Meßanordnung, wenn man parallel der zu untersuchenden Funkenstrecke sehr kleine oder sehr große Kapazität schaltete. Eine Veränderung der Steilheit ergab sich dabei nicht und dies steht im Einklang mit der Toeplerschen Theorie über die Funkenkonstante. Es wurde wiederum die sehr große Reproduzierbarkeit der Durchschlagskurve (bis zu 50 kV) nachgewiesen.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 118 (1992), S. 98-102 
    ISSN: 0942-0940
    Keywords: Aged population ; head injury ; GCS ; GOS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 136 patients older than 70 years, admitted to our neurosurgical ward directly after head trauma, were analysed. 40% of them were admitted with low GCS, below 9 points, and showed a mortality of 85%. 45 patients had intracranial mass lesions — the commonest was subdural haematoma, with a low incidence of epidural haematomas. In patients admitted with GCS above 12, mortality was 20%, mainly due to pneumonia. Satisfactory results were achieved in 30% of trauma victims. From patients with intracranial space occupying lesions and GCS below 9 points on admission practically all died, despite aggresive surgical treatment and intensive care. Thus, especially in departments with limited resources, therapy can be limited, or even no therapy may be introduced in this group. Surgical treatment can be limited only to patients who are conscious on admission. In patients with non-surgical lesions, low GCS — below 9 points — leads to mortality of 80%, and in this group we propose aggresive intensive care for 24 hours and the limitation of further “maximal” therapy only to those, who significantly improve within this period of time. If the patient has a non-surgical lesion and is conscious after trauma, aggresive treatment of extracranial complication is the most important, because brain injury can usually be well tolerated by these patients. If pneumonia or heart complications do not occur this group of old patients often have a good prognosis.
    Type of Medium: Electronic Resource
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