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  • 1
    Electronic Resource
    Electronic Resource
    Association of body mass index with respiratory symptoms and atopy: results from the European Community Respiratory Health Survey (2002)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 32 (2002), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background There are several reports showing that obese adults report more respiratory symptoms suggestive of asthma than those who are not obese.Objective To determine the association of body mass index with respiratory symptoms and atopy in young adultsMethod Information collected from 15 454 participants in the European Community Respiratory Health Survey, a multicentre cross-sectional survey of young adults, was analysed to determine the association of body mass index with respiratory symptoms and atopy.Results Men and women with a body mass index of greater than 30 were at an increased risk of wheeze with shortness of breath compared with those with a body mass of 20–24.99 (OR in men 1.85, 95% confidence interval 1.41–2.42; OR in women 2.03, 95% confidence interval 1.59–2.58). Similar associations were observed for other symptoms suggestive of asthma. Body mass index was not associated with ‘hayfever or nasal allergies’, specific IgE to house dust mite, grass or cat or with total IgE in men or women.Conclusion Reported associations of body mass index with symptoms suggestive of asthma are unlikely to be explained by a higher risk of atopy in the obese. Alternative explanations must be sought.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2002.01380.x
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  • 2
    Electronic Resource
    Electronic Resource
    The association of family size with atopy and atopic disease (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 27 (1997), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Studies in children have shown that family size is negatively associated with atopy and atopic disease.Objective To describe the association of family size with atopy and atopic disease in young adults.Methods A randomly selected sample of 1159 men and women aged 20–44 years provided information on respiratory symptoms, hay fever and eczema. Blood samples were taken for assessment of total IgE and specific IgE to house dust mite, grass, cat, Cladosporium and birch. The association of family size and birth order with respiratory symptoms, atopy and total IgE was assessed by multiple logistic and linear regression.Results There was a negative association between family size and the reporting of ‘wheeze with breathlessness’ (adjusted odds ratio for an increase of one sibling 0.85; 95% confidence interval 0.75–0.98), ‘wheeze without a cold’ (adjusted odds ratio for an increase of one sibling 0.85; 95% confidence interva l0.75–0.98) and ‘asthma attacks’ in the last 12 months (adjusted odds ratio for an increase of one sibling 0.77; 95% confidence interval 0.61–0.97), current ‘hayfever and nasal allergies’ (adjusted odds ratio for an increase of one sibling 0.84; 95% confidence interval 0.75–0.94) and sensitization to grass (adjusted odds ratio for an increase of one sibling 0.87; 95% confidence interval 0.76–0.99). Birth order was negatively associated with ‘hayfever and nasal allergies’ only. A decreased risk of sensitization to grass in those from large families did not fully explain the negative association between family size and hayfever. No statistically significant (P 〉 0.05) association of family size or birth order with the reporting of other respiratory symptoms, eczema, sensitization to the other allergens or total IgE was observed.Conclusion There is a negative association between family size and some symptoms suggestive of asthma, ‘hayfever and nasal allergies’ and sensitization to grass in young adults. There is no consistent, significant association between family size and eczema, total IgE or sensitization to other allergens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1997.tb00701.x
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  • 3
    Electronic Resource
    Electronic Resource
    Intra-operative patient-controlled sedation (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 47 (1992), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Propofol and midazolam were compared for intra-operative patient-controlled sedation in 40 Asa 1 day patients undergoing surgical extraction of third molar teeth under local anaesthesia. All patients initially received 0.7 ng.kg−1 fentanyl. Patients in the propofol group self-administered 20 mg (2 ml over 6 s) bolus doses of propofol; successful demands averaged 8.0 (SD 4.4) and unsuccessful demands (during the 1 min lockout period) 2.8 (SD 4.1). The midazolam group self-administered 0.5 mg (2 ml over 6 s) bolus doses and averaged 14.0 (SD 6.3) and 17.6 (SD 19.8) successful and unsuccessful demands respectively. Postoperative memory, measured with delayed free recall, and postoperative mental performance, measured with the frequency accrual speed test index, were both significantly less impaired in the propofol group. Although there was no significant difference in patient satisfaction, measured postoperatively, propofol was judged the more suitable agent for patient-controlled sedation, because of its more rapid response to fluctuating intra-operative requirements, superior recovery characteristics and beneficial effect on mood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1992.tb02216.x
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  • 4
    Electronic Resource
    Electronic Resource
    Systemic air embolism during laser bronchoscopy (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 43 (1988), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report a case of massive, fatal, systemic gas embolism which occurred during the course of laser bronchoscopic resection of a bronchial carcinoma. The clinical features of systemic air embolism are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1988.tb05604.x
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  • 5
    Electronic Resource
    Electronic Resource
    Maternal atopy and changes in parity (2005)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 35 (2005), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Atopic women tend to have fewer children, although atopy may favour conception.Objective To assess whether atopy is associated with the number of new births and whether changes in parity are associated with a change in atopy in a cohort of young women.Methods Women had atopy (defined as the presence of serum-specific IgE against common aeroallergens) measured in the European Community Respiratory Health Study during the years 1991–92 (n=4580). About 9 years later, 2844 (62.1%) were recontacted and 2414 (52.7%) had atopy measured again.Results Atopic women had fewer children at baseline than non-atopic women but the association disappeared at the end of the follow-up. Atopy tended to increase parity during the follow-up, but in a non-statistically significant way (relative risk=1.08; 0.86–1.35, after adjusting for number of children at baseline, age, length of follow-up, education or social class). Prevalence of atopy during the follow-up changed by the same magnitude whatever the birth cohort and the change in the number of children (P for interaction 〉0.7).Conclusion Atopic women did not have a significantly higher fertility rate but they may postpone having their first child compared with non-atopic women. We are unable to confirm the hypothesis that atopy in women may decrease with successive pregnancies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2005.02300.x
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  • 6
    Electronic Resource
    Electronic Resource
    Promoting safer sex among HIV-positive youth with haemophilia: theory, intervention, and outcome (2003)
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 9 (2003), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  The goal of the project was to develop and evaluate theory-based interventions designed to change sexual behaviour and promote safer sex practices of HIV seropositive young men and adolescents with haemophilia to prevent transmission to sexual partners and offspring. Safer sex was defined as abstinence, consistent condom use, or ‘outercourse’ (intimate, non-intercourse sexual behaviour). This project utilized the Transtheoretical Model developed by Prochaska and DiClemente, which describes behaviour change as an incremental, stage-based process. The 1-year intervention protocol consisted of two individual sessions and two peer-centred activities. One hundred and four adolescents, residing in 22 states, participated. Pre- and post-intervention evaluations were conducted to measure stage progression for participants. The number who were in the action or maintenance stage of change for safer sex was significantly greater at post-test than at pre-test (79 vs. 62%, P 〈 0.0001). Participants also reported an increased use of outercourse. In addition, significant increases in self-efficacy and knowledge regarding safer sex were demonstrated. Following these stage-based interventions, participants were significantly more likely to be engaging in safer sex behaviours than they were previously. These intervention activities can be adapted for use with other adolescent populations and for other behaviour change goals in adolescents with haemophilia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2516.2003.00722.x
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  • 7
    Electronic Resource
    Electronic Resource
    The electrical properties of metal-sandwiched Langmuir–Blodgett multilayers and monolayers of a redox-active organic molecular compound (1992)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 71 (1992), S. 756-768 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Both ac and dc conduction processes through thin Langmuir–Blodgett (LB) films of the dodecyloxyphenylurethane of 2-bromo-5 (2'-hydroxyethoxy) tetracyanoquinodimethan (DDOP-C-TCNQ, a redox-active molecule) sandwiched between dissimilar metal (Pt and Mg) electrodes have been studied. The dc conduction changed from a linear I/V characteristic for the lowest applied voltages (±20 mV) to a symmetric nonlinear characteristic obeying a ln I∝V1/4 dependence for voltages up to ±1.5 V, in as-prepared samples. For larger positive voltages, a large increase in current was observed with the dependence changing to a ln I∝V3 law, a dependence not reported previously for metal/LB film/metal systems. For increased negative voltages, the ln I∝V1/4 was again observed. For low applied ac fields, the conductance was found to follow a ωn law with a value of n close to 0.8. The effect of heat annealing the samples was also studied with significant differences in the observed changes in conductance between bilayer and monolayer structures. Emphasis was placed on understanding the conduction process through the single DDOP-C-BHTCNQ layer film. For the monolayer device, hysteresis is observed in the positive bias, and both as-prepared and annealed samples exhibit ln I∝V3 behavior. Such behavior was not observed for the corresponding negative voltages, indicating rectification across a distance approximated by the length of an individual molecule. Possible models of the three-dimensional arrays for both monolayer and multilayer metal/LB film/Mg structures are presented. The weight of existing experimental results does not support the Aviram–Ratner "molecular rectifier'' concept for presently known Pt/LB monolayer/Mg devices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.351340
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  • 8
    Electronic Resource
    Electronic Resource
    Fabrication and investigation of asymmetric current-voltage characteristics of a metal/Langmuir–Blodgett monolayer/metal structure (1990)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 56 (1990), S. 1916-1918 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Metal/Langmuir–Blodgett monolayer/metal devices, where the monolayer consists of the dodecyloxyphenylcarbamate of 2-bromo, 5(2'-hydroxyethoxy) tetracyanoquinodimethan, a donor-σ-acceptor molecular system, have been constructed, and dc current-voltage (I-V) characteristics of these devices were recorded at room temperature. For biases of ±20 mV, the I-V characteristics are linear, changing to a nonlinear form for higher voltages. This nonlinear characteristic exhibited a ln(I)∝V1/4 dependence for both positive and negative voltages up to ±1 V. For positive voltages 〉+2.0 V for as-prepared devices and 〉+1.5 V for annealed devices, a ln(I)∝V3 dependence was observed, revealing a very large increase in current for small voltage changes. Such behavior was not observed for corresponding negative voltages, indicating rectification across a distance approximated by the length of an individual molecule.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.103043
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  • 9
    Electronic Resource
    Electronic Resource
    Viability and recovery from degranulation of isolated rat peritoneal mast cells
    Amsterdam : Elsevier
    Experimental Cell Research 168 (1987), S. 63-78 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(87)90416-2
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  • 10
    Electronic Resource
    Electronic Resource
    Femoral artery pressure monitoring (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 32 (1977), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1977.tb09982.x
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