ISSN:
1432-1955
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Two field studies were carried out to confirm the efficacy of doramectin in cattle and pigs in Europe. A total of 40 cattle harbouring naturally acquired infections of gastrointestinal nematodes, includingOstertagia spp.,Oesophagostomum spp.,Cooperia spp.,Haemonchus spp.,Nematodirus spp. andTrichuris spp., were allocated to a treated or a control group (20 animals/group), and 100 harbouring naturally acquired infections of gastrointestinal nematodes and lungworms, includingOesophagostomum spp.,Metastrongylus spp.,Ascaris suum andTrichuris suis, were allocated to either a treated (60 pigs) or a control (40 pigs) group. Animals in the treated groups received an injection of doramectin at 200 μg/kg (1 ml/50 kg) for cattle or 300 μg/kg (1 ml/33 kg) for swine. Animals in the control groups received saline at 1 ml/50 kg for cattle or 1 ml/33 kg for swine. The cattle were injected by the subcutaneous route in the lateral mid-line of the neck and the pigs were injected intramuscularly in the neck. Faecal egg counts were determined for all animals on days −7, 0, 7, 14 and 21 of the studies, where day 0 was the day of treatment. The mean daily weight gain of doramectin-treated animals was significantly higher than that of the control animals over the 21 days of the studies (P〈0.0007 for cattle andP=0.0001 for swine). At 21 days after treatment, the mean faecal egg counts of the doramectin-treated animals were significantly lower than those of the control animals and were reduced by 100% as compared with pretreatment levels. No adverse reaction to treatment was observed in any animal during either study. It is concluded that doramectin is highly efficacious in the treatment of mixed infections of gastrointestinal nematodes and lungworms in both cattle and pigs.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00932246
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