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  • 1
    ISSN: 1432-1440
    Keywords: Nitroprussid ; Zyamid ; Entgiftung ; Thiosulfat ; Nitroprusside ; Cyanide ; Detoxification ; Thiosulfate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A 42-year old patient received a continuous infusion of sodium nitroprusside (SNP) at a dosage rate of 600 µg/min for approximately four days. On the third day of treatment a dangerous high level of cyanide was measured in the blood. When an additional continuous infusion of sodium thiosulphate at five times the molar concentration of the SNP was given, this cyanide level dropped over a period of 7 h to one-seventh of its initial value. The thiosulphate did not reduce the effectiveness of the SNP in lowering the blood pressure.
    Notes: Zusammenfassung Ein 42jähriger Patient bekam etwa 4 Tage lang Natriumnitroprussid (NNP) mit einem Dosisstrom von 600 µg/min infundiert. Am dritten Behandlungstag wurde ein gefährlich erhöhter Zyanidspiegel im Blut gemessen. Unter der zusätzlichen Infusion von Natriumthiosulfat in 5fachem molaren Überschuß sank dieser Spiegel in 7 h auf 1/7 des Ausgangswertes. Das Thiosulfat beeinträchtigte die blutdrucksenkende Wirkung des NNP nicht.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 14 (1935), S. 1584-1585 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 17 (1938), S. 840-843 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European food research and technology 124 (1964), S. 138-148 
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European food research and technology 124 (1964), S. 376-380 
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Kardiologie 89 (2000), S. 606-611 
    ISSN: 1435-1285
    Keywords: Key words Adult congenital cardiac disease ; contraception ; birth control ; pregnancy ; Schlüsselwörter Angeborene Herzfehler ; Erwachsene mit angeborenen Herzfehlern ; Kontrazeption ; Schwangerschaft
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Zahl der Frauen, die mit einem angeborenen Herzfehler das Erwachsenenalter erreicht, nimmt zu. Leider existieren zu den verschiedenen kontrazeptiven Möglichkeiten und ihren Risiken speziell für diese Patientinnen keine prospektiven Daten. Die meisten Frauen mit angeborenen Herzfehlern können gefahrlos orale Kontrazeptiva anwenden, besonders die modernen niedrig-dosierten Präparate. Hoch-Risikopatientinnen sind solche Patientinnen, die ein erhöhtes Risiko für thrombembolische Komplikationen aufweisen (besonders bei Zyanose, pulmonaler Hypertonie, Eisenmenger-Reaktion, Herzrhythmus-Störungen), die zu Flüssigkeitsretention neigen (vor allem bei eingeschränkter Ventrikelfunktion und Herzinsuffizienz), eine arterielle Hypertonie haben (z.B. Aortenisthmusstenosen), ein erhöhtes Endokarditis-Risiko aufweisen oder bei denen Lipidstoffwechselstörungen vorliegen. Orale Kontrazeptiva sollten bei Frauen mit erhöhtem thromboembolischen Risiko vermieden werden. Intrauterin-Pessare (IUP) haben keine metabolischen Effekte und nur ein geringes Endokarditis-Risiko, besonders neue gestagenhaltige Pessare. Subdermale Gestagen-Implantate (Norplant, Implanon) werden im Ausland bereits erfolgreich verwendet und könnten in den kommenden Jahren in Deutschland auch bei Patientinnen mit angeborenen Herzfehlern breitere Anwendung finden. Barrieremethoden sind nebenwirkungsarm, haben aber besonders bei jungen Patientinnen hohe Versagerquoten, was bei Patientinnen für die eine Schwangerschaft kontraindiziert ist (z.B. Eisenmenger-Reaktion) inakzeptabel ist. In diesen Fällen ist weiterhin eine Tubensterilisation anzuraten. Die nachfolgende Übersicht stellt die heute möglichen Verfahren der Kontrazeption vor, wobei speziell auf deren Wirkungen und potentielle Risiken für Frauen mit angeborenen Herzfehlern eingegangen wird.
    Notes: Summary The number of women with congenital cardiac disease, who mature into adulthood is increasing. Unfortunately, there are no prospective data published about the relative risk of different forms of contraception for these patients. Most women with congenital cardiac disease can safely use oral contracetives, especially low-estrogen combination or progestin-only preparations, with the exception of those, who are at particular risk because of thrombembolic complications (especially in cyanosis, pulmonary hypertension, Eisenmenger reaction, rhythm disturbances), fluid retention (especially in reduced ventricular function and congestive heart failure), arterial hypertension (important in coarctation), infectious complications (endocarditis) or hyperlipidemia. Oral contraceptives should be avoided in patients at increased risk for thrombembolic events. Intrauterine devices are very effective, have no metabolic side effects and merely cary a small risk of endocarditis. Newer devices containing progesterone only may put the patients at a still smaller risk. Contraceptive subdermal implants (e.g. levonorgestrel) are used with good results in the United States for patients with contraindications to estrogen-containing oral contraceptives and may well become more widely accepted in patients in Germany in the coming years. Barrier methods can be used, but have a higher failure rate, which may be inacceptable in patients at risk (e.g. Eisenmenger‘s). Especially in Eisenmenger‘s, permanent sterilisation should be advised.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Monatshefte für Chemie 104 (1973), S. 1315-1324 
    ISSN: 1434-4475
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The pK-values of the first and second degree of dissociation of 2.2′-dihydroxy-5-methyl-3′.5′-dinitro-diphenylmethane, 2.2′-dihydroxy-5-methyl-5′-nitro-diphenylmethane and 2.2′-dihydroxy-5.5′-dimethyl-3′-nitro-diphenylmethane were determined in aqueous solution at 25°C spectrophotometrically. Comparing the observed pK-values with those of 2-methyl-4.6-dinitrophenol, 2-methyl-4-nitrophenol, 2.4-dimethyl-6-nitro-phenol and 2.4-dimethylphenol, we found a decrease of the values of pK 1 and an increase of pK 2. We explain this by the formation of an intramolecular hydrogen bridge which stabilizes the anion of the half dissociated form. This assumption is supported by the UV spectra.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Monatshefte für Chemie 105 (1974), S. 501-509 
    ISSN: 1434-4475
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The pK-values of the first and second degree of dissociation of 2.3′-dihydroxy-6′-methyl-3.5-dinitro-diphenylmethane, 2.3′-dihydroxy-6′-methyl-5-nitro-diphenylmethane, 2.3′-dihydroxy-5.6′-dimethyl-3-nitro-diphenylmethane, 2.4′-dihydroxy-3′. 5′-dimethyl-3.5-dinitro-diphenylmethane, 2.4′-dihydroxy-3′. 5′-dimethyl-5-nitro-diphenylmethane and 2.4′-dihydroxy-3′.5.5′-trimethyl-3-nitrodiphenylmethane were determined in aqueous solution at 25°C by the spectrophotometric method. The observed pK-values are compared with those of 2-methyl-4.6-dinitro-phenol, 2-methyl-4-nitrophenol, 2.4-dimethyl-6-nitrophenol, 3.4-dimethylphenol and 2.4.6-trimethylphenol which serve as model compounds for the single phenolic units.
    Type of Medium: Electronic Resource
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