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  • 1
    Electronic Resource
    Electronic Resource
    Levels of serum-soluble receptor for interleukin-2 in patients with colorectal cancer (1998)
    Springer
    Surgery today 28 (1998), S. 1115-1117 
    Details
    ISSN: 1436-2813
    Keywords: interleukin-2 receptor ; colorectal cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The preoperative levels of serum-soluble receptor for interleukin-2 (IL-2R) were determined by an enzyme-linked immunosorbent assay in 38 patients undergoing surgery for colorectal cancer and 98 healthy controls. The levels of serum-soluble IL-2R in the patients with colorectal cancer were significantly higher than those in the normal controls (P〈0.05). Markedly elevated levels of serum-soluble IL-2R were recognized in patients with stage IV cancer, those with Dukes' stage D cancer, and those with liver metastasis. Moreover, the prognosis of patients with low levels of IL-2R (〈531 U/ml) was significantly better than that of those with high levels (P〈0.05). These findings demonstrate that an elevated concentration of soluble IL-2R might be a useful indicator of liver metastasis and poor prognosis in patients with colorectal carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02483977
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  • 2
    Electronic Resource
    Electronic Resource
    Long-term survival of 5 years following initial surgery for gastric cancer and simultaneous disseminated peritoneal metastasis: Report of a case (1995)
    Springer
    Surgery today 25 (1995), S. 959-961 
    Details
    ISSN: 1436-2813
    Keywords: gastric cancer ; peritoneal metastasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report herein the rare case of a patient who survived for 5 years and 10 months after commencing treatment for gastric cancer with simultaneous disseminated peritoneal metastasis. A 45-year-old man was diagnosed as having advanced gastric cancer following the discovery of numerous nodules in the peritoneal cavity at laparotomy. The patient was treated by palliative gastrectomy and continuous hyperthermic peritoneal perfusion (CHPP) immediately after surgery on November 11, 1987. Postoperatively, he underwent radiofrequency (RF) hyperthermia with intraperitoneal cisplatin a total of seven times. He continued on a combination of uracil and tegafur (UFT) administered orally with a protein-bound β-d-glucan extracted from the mycelia ofCariolus versicolor(PSK). Long-term survival was achieved following the initial palliative gastrectomy despite simultaneous disseminated peritoneal metastasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00312381
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  • 3
    Electronic Resource
    Electronic Resource
    Prophylactic portal infusion chemotherapy as adjuvant therapy for the prevention of metachronous liver metastasis in colorectal cancer (1995)
    Springer
    Surgery today 25 (1995), S. 211-216 
    Details
    ISSN: 1436-2813
    Keywords: liver metastasis ; portal infusion chemotherapy ; colorectal cancer ; DNA index ; DNA ploidy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The DNA ploidy and DNA indices (DI) of 414 patients with colorectal cancer were analyzed, and the incidence of patients with metachronous liver metastasis was found to be significantly higher in those with aneuploid tumors and a DI above 1.5 than in those with aneuploid tumors and a DI below 1.4, or in those with diploid tumors and a DI equal to 1.0. Next, to confirm the effectiveness of administering prophylactic portal infusion chemotherapy (PPIC) as adjuvant therapy for the prevention of metachronous liver metastasis in colorectal cancer, a randomized controlled trial of PPIC was performed on 110 consecutive patients with primary colorectal cancer who had undergone curative resection. Although the incidence of patients with metachronous liver metastasis in the two study groups was not significantly different at 3.3% in the PPIC group and 10.3% in the control group, the incidence in the patients with aneuploidy and a DI above 1.5 was significantly lower in the PPIC group than in the control group. These findings suggest that colorectal cancer with aneuploidy and a DI above 1.5 may have a strong tendency to metastasize to the liver, and that prophylactic portal infusion chemotherapy may be effective for preventing metachronous liver metastasis in such patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311529
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  • 4
    Electronic Resource
    Electronic Resource
    The argyrophilic nucleolar organizer region (Ag-NOR) score in invasive ductal carcinoma of the pancreas (1997)
    Springer
    Surgery today 27 (1997), S. 414-419 
    Details
    ISSN: 1436-2813
    Keywords: invasive ; pancreatic ; ductal ; carcinoma ; argyrophilic nucleolar organizer region (Ag-NOR)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The biological malignancy of pancreatic carcinoma was evaluated by determining the score of the argyrophilic nucleolar organizer region (Ag-NOR) in resected specimens, and comparing it with the various clinicopathological factors and long-term results of 38 patients who underwent surgical resection for invasive ductal carcinoma of the pancreas between 1977 and 1992, in whom the Ag-NOR could be stained. The Ag-NOR analysis of pancreatic carcinomas from the 38 patients resulted in a mean Ag-NOR score of 3.82±0.62, which was significantly (P〈0.01) higher than the mean score of 1.72±0.28 observed in normal pancreatic tissues obtained from 20 of these patients. The mean Ag-NOR score significantly increased in patients with anterior capsular infiltration (s) (P〈0.01), posterior tissue infiltration (rp) (P〈0.01), and lymph node metastasis (n) (P〈0.05) compared to those without these factors. The rate of curability A or B was only 13.0% in patients with a high Ag-NOR score of ≧3.80 in comparison to 66.7% in those with a low Ag-NOR score of 〈3.80. The 3-year survival rate was significantly (P〈0.05) higher in the low Ag-NOR score group than in the high Ag-NOR score group. These results suggest that the Ag-NOR score can serve as an indicator of the biological malignancy of pancreatic carcinoma, and of the patients' prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02385704
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  • 5
    Electronic Resource
    Electronic Resource
    Clinicopathological value of immunohistochemical detection of occult involvement in pT3N0 gastric cancer (1999)
    Springer
    Gastric cancer 2 (1999), S. 95-100 
    Details
    ISSN: 1436-3305
    Keywords: Key words: gastric neoplasm ; microinvolvement ; micrometastasis ; cytokeratin ; immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Background. In cases of pT3 gastric cancer, even when standard histological staining reveals no evidence of metastases in the regional lymph nodes, patients still may die of postoperative recurrence of the tumor. An attempt was made in the present study to explain the unfavorable outcome of such patients by investigating the presence of occult cancer cells in lymph nodes by immunostaining of cytokeratin. Methods. We examined 2310 lymph nodes that had been removed from 83 patients with stage II gastric cancer (pT3, N0, M0). Two consecutive sections of 4 μm thick were prepared for simultaneous staining with hematoxylin and eosin and immunostaining with the CAM 5.2 monoclonal antibody against cytokeratin, respectively. Results. Evidence of occult involvement was found in 299 of 2310 (13%) lymph nodes and in 54 of 83 (65%) patients with pT3 gastric cancer. An analysis of survival demonstrated the limited 5-year survival of patients with occult involvement in their resected lymph nodes, as compared with that of patients without involvement (P 〈 0.01). Moreover, the patients in whom group 2 lymph nodes had occult cancer cells had a significantly poorer prognosis than those in whom occult involvement was limited to group 1 lymph nodes (P 〈 0.05). Conclusions. The accuracy of predictions of prognosis of patients with pT3 gastric cancer should be greatly enhanced if cytokeratin-specific immunostaining is performed in conjunction with routine histopathological examination of lymph nodes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101200050030
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  • 6
    Electronic Resource
    Electronic Resource
    Postoperative long term chemotherapy for advanced gastric cancer (1976)
    Springer
    Surgery today 6 (1976), S. 54-59 
    Details
    ISSN: 1436-2813
    Keywords: Gastric cancer ; Postoperative long term cancer chemotherapy (PLCC) ; Mitomycin-C ; Futraful ; PS-K
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A postoperative long term chemotherapy was carried out against stage IV gastric cancer with Mitomycin-C, Futraful and a plant polysaccharide, PS-K. The 2-year survival rate was 15 per cent in patients who received an intraoperative Mitomycin-C alone, while it increased to 34 per cent in those receiving the anticancer agents for a prolonged period. The postoperative long term chemotherapy is assumed to be an effective means of improving the therapeutical results of gastric cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02468887
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  • 7
    Electronic Resource
    Electronic Resource
    Metastatic involvement of the stomach from breast cancer (1973)
    Springer
    Surgery today 3 (1973), S. 98-105 
    Details
    ISSN: 1436-2813
    Keywords: breast cancer ; gastric metastasis ; successful surgical hormone therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A patient with metastatic lesions of the stomach from the breast cancer was reported, in whom the gastric trouble appeared in the early stage of the disease. The patient had had a quiescent period of over nine years after the successful hormonal therapy, until when she began to get worse again. At autopsy extensive multinodular metastases were found in the both lungs, liver, spleen and many other organs except the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02468942
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  • 8
    Electronic Resource
    Electronic Resource
    Apoptosis as a Prognostic Factor in Colorectal Carcinoma (1998)
    Springer
    Surgery today 28 (1998), S. 145-150 
    Details
    ISSN: 1436-2813
    Keywords: Key Words: colorectal carcinoma ; apoptosis ; Ki-67 ; p53 ; prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: P 〈 0.05); in tumors showing evidence of moderate differentiation than in well-differentiated tumors (P 〈 0.05); and in tumors with venous invasion or lymph node metastasis than in those without these features (P 〈 0.05). Moreover, the subgroup of patients with a low AI of 〈4.1 had a significantly poorer survival rate than the subgroup with a high AI in tumors at Dukes stage C, the 5-year survival rates being 33% vs 68% (P 〈 0.05; Cox-Mantel). Our findings suggest that less apoptosis might result in a greater progression of colorectal carcinoma, and that the rate of apoptosis might be an indicator of the degree of malignancy. Thus it would appear that the frequency of apoptosis in tumor cells could be a useful prognostic factor in colorectal carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005950050096
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  • 9
    Electronic Resource
    Electronic Resource
    Postoperative delirium following gastrointestinal surgery in elderly patients (1997)
    Springer
    Surgery today 27 (1997), S. 107-111 
    Details
    ISSN: 1436-2813
    Keywords: postoperative delirium ; geriatric surgery ; cognitive impairment ; sleep cycle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Postoperative delirium is a common complication which can interfere with the surgical treatment and recovery of elderly patients, and is likely to prolong their hospitalization. Unfortunately, there is as yet no completely effective pre- and/or post operative technique of patient care to reduce or prevent postoperative delirium. In this study, 36 patients aged over 70 years undergoing gastrointestinal operations were assessed to examine the relationships between the preoperative cognitive state, the postoperative sleep cycle, and the occurrence of postoperative delirium. All patients were evaluated preoperatively using the revised version of Hasegawa's dementia scale (HDS-R). We correlated those test results and assessed the sleep-wakefulness disturbance postoperatively, to obtain a clinical DMS-III diagnosis of postoperative delirium. The incidence of postoperative delirium was 17% (6/36). The patients who developed postoperative delirium demonstrated preoperative cognitive impairment, and had a short sleep period during the night and a long sleep period during the day. Postoperatively, these results suggest that HDS-R is a useful method of evaluating preoperative cognition in elderly patients. Considering that sleep deficiency is likely to predispose elderly patients to postoperative delirium, techniques to prevent sleep deprivation may be of considerable value in minimizing the incidence of postoperative delirium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02385897
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  • 10
    Electronic Resource
    Electronic Resource
    Micrometastasis in lymph nodes of mucosal gastric cancer (2000)
    Springer
    Gastric cancer 3 (2000), S. 91-96 
    Details
    ISSN: 1436-3305
    Keywords: Key words Mucosal gastric cancer ; Micrometastasis ; Cytokeratin ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. Endoscopic mucosal resection is frequently used in the treatment of mucosal gastric cancer. Micrometastasis in the lymph nodes of mucosal gastric cancer remains unclear. Methods. We examined 2526 lymph nodes from 84 patients with mucosal gastric cancer. Two consecutive sections were prepared, for simultaneous staining with hematoxylin and eosin and immunostaining with CAM 5.2 monoclonal antibody against cytokeratin (CK), respectively. A clinicopathological comparison was made between patients with and without lymph node involvement. Results. Lymph node involvement was detected in 45 of 2526 (1.8%) lymph nodes. The incidence of nodal involvement was significantly increased, from 1.2% (1/84 patients) with hematoxylin and eosin staining, to 19% (16/84 patients) with CK immunostaining. Although no significant difference was found, micrometastasis to lymph nodes was more frequently detected in tumors larger than 1.0 cm (15/72 patients, 21%) than in those less than or equal to 1.0 cm (1/12 patients; 8%, P = 0.307). However, discrete CK-positive cancer cells or clusters of CK-positive cancer cells were detected only in tumors larger than 2 cm. Conclusion. Because mucosal gastric cancer of more than 1.0 cm in superficial diameter may indicate a risk of micrometastasis to lymph nodes, endoscopic mucosal resection is not recommended for these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00011702
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