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  • 1
    Electronic Resource
    Electronic Resource
    Protection of islet allografts transplanted together with Fas ligand expressing testicular allografts (1998)
    Springer
    Diabetologia 41 (1998), S. 315-321 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Fas ; Fas ligand ; islet transplantation ; testicular tissue ; apoptosis ; composite graft.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fas ligand (FasL) is highly expressed in testicular tissues and thought to be responsible for protection from allograft rejection by inducing apoptosis of anti-graft activated T cells. FasL-expressing islets have been shown to induce a granulocyte-mediated inflammatory reaction. We investigated whether a graft can be protected from alloimmune responses by manipulating the Fas/FasL-system. We transplanted allogeneic islets under the kidney capsule of streptozotocin-induced diabetic mice together with testicular tissue. Significant prolongation of survival of C3H islet allograft was observed in C57BL/6 (B6) recipients transplanted with C3H testicular tissue, but not in those transplanted with C3H-gld testicular tissue expressing non-functional FasL. No significant prolongation was observed in B6-lpr recipients expressing non-functional Fas. Immunohistochemical staining of C3H testicular tissue in the composite graft showed a high expression of FasL, but not that of the C3H-gld testicular tissue. In situ terminal deoxynucleotidyl transferase-mediated dUDP-biotin catalysed DNA nick-end labelling (TUNEL) staining of a composite graft of C3H islet and testicular tissue in B6 recipients demonstrated extensive apoptosis of infiltrating mononuclear cells around the graft. The protective effect of C3H testicular tissue was abrogated when anti-FasL monoclonal antibody was administered i. p. postoperatively. Our results suggest that FasL-positive testicular allografts protect composite islet allografts and indicate that manipulation of Fas/FasL mediated apoptosis is a suitable strategy for controlling rejection of islet allografts. [Diabetologia (1998) 41: 315–321]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050909
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  • 2
    Electronic Resource
    Electronic Resource
    Serum soluble Fas/APO-1 is increased in patients with primary Sjögren's syndrome (1998)
    Springer
    Clinical rheumatology 17 (1998), S. 496-499 
    Details
    ISSN: 1434-9949
    Keywords: Autoimmune disease ; Enzyme-linked immunosorbent assay ; Sjögren's syndrome ; Soluble Fas/APO-1 protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the study was to elucidate the involvement of Fas antigen in human autoimmune disease, by analysing serum levels of soluble Fas/APO-1 protein in patients with various autoimmune diseases, including system lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), polymyositis/dermatomyositis (PM/DM), Behçet's syndrome and Sjögren's syndrome (SjS). The levels of soluble Fas/APO-1 in sera were quantitated by a sandwich enzymelinked immunosorbent assay. Soluble Fas/APO-1 levels were significantly increased in serum from patients with primary Sjögren's syndrome (1° SjS) compared with control subjects. However, no significant differences in soluble Fas/APO-1 levels were noted in patients with secondary Sjögren's syndrome (2° SjS) nor in patients with any of the other autoimmune diseases. The soluble Fas/APO-1 level in 1° SjS patients with extraglandular diseases was significantly higher than that in patients without extraglandular diseases. These results suggest that soluble Fas/APO-1 protein may play an important role in the pathogenesis of 1° SS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01451286
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    Paper (German National Licenses)
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