Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Selective vulnerability in the gerbil hippocampus following transient ischemia (1984)
    Springer
    Acta neuropathologica 62 (1984), S. 201-208 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral ischemia ; Selective vulnerability ; Hippocampus ; Cell death ; Gerbils
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Following brief ischemia, the Mongolian gerbil is reported to develop unusual hippocampal cell injury (Brain Res 239:57–69, 1982). To further clarify this hippocampal vulnerability, gerbils were subjected to ischemia for 3, 5, 10, 20, and 30 min by bilateral occlusion of the common carotid arteries. They were perfusion-fixed after varying intervals of survival time ranging from 3 h up to 7 days. Following brief ischemia (5–10min), about 90% of the animals developed typical hippocampal damage. The lesion was present throughout the extent of the dorsal hippocampus, whereas damage outside the hippocampus was not observed. Each sector of the hippocampus showed different types of cell reaction to ischemia. Ischemic cell change was seen in scattered CA4 neurons, and reactive change was found in CA2, whereas CA1 pyramidal cells developed a strikingly slow cell death process. Ischemia for 3 min did not produce hippocampal lesion in most cases. Following prolonged ischemia (20–30min), brain injury had a wide variety in its extent and distribution. These results revealed that the gerbil brief ischemia model can serve as an excellent, reliable model to study the long-known hippocampal selective vulnerability to ischemia. Delayed neuronal death in CA1 pyramidal cells was confirmed after varying degrees of ischemic insult. These findings demonstrated that the pathology of neuronal injury following brief ischemia was by no means uniform nor simple.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691853
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Delayed neuronal death in the rat hippocampus following transient forebrain ischemia (1984)
    Springer
    Acta neuropathologica 64 (1984), S. 139-147 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral ischemia ; Cell death ; Endoplasmic reticulum ; Hippocampus ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An unusual, slowly progressing neuronal damage has been reported to occur in the gerbil hippocampus following ischemia (Kirino 1982). Delayed neuronal death following ischemia has also been noticed in the rat four-vessel occlusion model (Pulsinelli et al. 1982). By light microscopy this slow neuronal injury in the rat was not different from the previously known neuronal ischemic cell change. This report lead us to the question as to whether neurons in the rat hippocampus are damaged rapidly following an initial latent period or deteriorate slowly and progressively until they display overt changes. To clarify this point, observation was done on the hippocampal CA1 sector of the rat following ischemia. Rats were subjected to four-vessel occlusion, and those which developed ischemic symptoms were perfusion-fixed. Although the change appeared very slowly and lacked microvacuolation of the cytoplasm, neuronal alteration was practically not different from classical ischemic cell change. By electron microscopy, however, the change was detectable when the neurons still appeared intact by light microscopy. An increase in the membranous organelles and deposition of dark substances were the initial manifestations. It seemed that the CA1 neurons deteriorated very slowly and progressively, and that they retained partial viability in the initial phase of the change. In spite of the difference in light-microscopic findings, the mechanisms underlying delayed neuronal death in the rat and gerbil hippocampus seemed to be identical.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00695577
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The effects of 5-minute ischemia in mongolian gerbils: I. Blood-brain barrier, cerebral blood flow, and local cerebral glucose utilization changes (1983)
    Springer
    Acta neuropathologica 60 (1983), S. 207-216 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral ischemia ; Blood-brain barrier ; Cerebral blood flow ; Glucose utilization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Changes in morphology, behavior of the blood-brain barrier (BBB), regional cerebral blood flow (rCBF), and local cerebral glucose utilization (LCGU) were assessed and correlated in Mongolian gerbils following 5 min cerebral ischemia, produced by bilateral clamping of the common carotid arteries. The morphological changes were confined to the hippocampus and revealed a conspicuously delayed destruction of the CA1 neurons, occurring after 3 days. Following release of carotid occlusions, there were two separate openings of the BBB. One, occurring shortly after recirculation, was associated with focal hyperemia in the cerebral cortex, hippocampus and basal ganglia; the second opening was observed after several days and was associated with severe neuronal destruction in the CA1 sector. Correlation of quantitative and qualitative rCBF assays with14C-deoxyglucose autoradiographic observations indicated an uncoupling between blood flow and glucose metabolism, observed in the hippocampus at 10 min after recirculation. The described changes provide a further insight into the post-ischemic events which determine the outcome of ischemic injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691868
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Fine structural nature of delayed neuronal death following ischemia in the gerbil hippocampus (1984)
    Springer
    Acta neuropathologica 62 (1984), S. 209-218 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral ischemia ; Cell death ; Hippocampus ; Endoplasmic reticulum ; Ribosomes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An unusual, delayed neuronal death (DND) has been noticed in the hippocampus of the Mongolian gerbil following brief ischemia (Kirino 1982). On day 1 following 5–10min of ischemia, light microscopy showed the CA1 pyramidal cells unchanged. On day 2, the cells showed massive growth of membranous cytoplasmic organelles instead of overt cellular disintegration. These neurons were destroyed extensively by day 4 after ischemic insult. Following longer ischemia (20–30min), however, the changes in the CA1 pyramidal cells appeared faster and resembled the wellcharacterized ischemic cell change (ICC). To further clarify the differences between ICC and DND, gerbils were submitted to transient 5–30min ischemia. They were perfusion-fixed following a given survival period and then processed for electron microscopy. Following transient ischemia, specimens showed slow cell changes with growth of cisterns of the endoplasmic reticulum (ER). In some CA1 neurons, the cytoplasm was shrunken and darkly stained, but they also displayed accumulation of ER cisterns. Occasionally, the CA1 cells demonstrated highly shrunken dark perikarya, no different than in ICC. These results indicate that DND seems to be the typical disease process of the CA1 sector and that a severer insult makes the change faster and more similar to ICC. ICC seems to occur when the CA1 pyramidal cells are damaged so severely that they cannot react with proliferous activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691854
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Primary large choroid plexus papillomas in the cerebellopontine angle: Radiological manifestations and surgical management (1995)
    Springer
    Acta neurochirurgica 135 (1995), S. 144-149 
    Details
    ISSN: 0942-0940
    Keywords: Cerebellopontine angle ; choroid plexus papilloma ; lateral-suboccipital approach ; magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two cases of primary choroid plexus papilloma originating in the cerebellopontine angle (CPA) are reported. Both papillomas were encapsulated and strongly adhering to a choroid plexus tuft protruding from the foramen of Luschka. Successful removal of the tumour was achieved in each case. Surgical strategy, neuroradiological manifestations, and the differential diagnosis are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02187759
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    A Case of pituitary somatotroph adenoma with concomitant secretion of growth hormone, prolactin, and adrenocorticotropic hormone — an adenoma derived from primordial stem cell, studied by immunohistochemistry, in situ hybridization, and cell culture (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 1002-1007 
    Details
    ISSN: 0942-0940
    Keywords: Adrenocorticotropic hormone ; hypersecretion ; plurihormonal primordial stem cell ; Somatotroph adenoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Somatotroph adenomas often secrete prolactin (PRL) besides growth hormone (GH) and are sometimes immunostained for other anterior pituitary hormones or their subunits, such as thyroid-stimulating hormone (TSH) β-subunit and glycoprotein hormone α-subunit (αSU). However, Somatotroph adenomas showing hypersecretion of adrenocorticotropic hormone (ACTH) are extremely rare. There have been, to our knowledge, only five published reports on Somatotroph adenomas accompanied by excessive ACTH secretion. Here we report a case of intracavernously invading Somatotroph macro-adenoma with high serum GH, PRL, and ACTH levels. We examined the case using immunohistochemistry (IHC), in situ hybridization (ISH), and cell culture, and confirmed GH, PRL, and ACTH, as well as αSU, production, and the expression of Pit-1 protein by the adenoma, which is known as a transcriptional factor for GH, PRL, and TSH, not for ACTH. Therefore, the presence of unknown transcriptional factor other than Pit-1, common to GH, PRL, and ACTH, may be speculated to be expressed in this adenoma. In our previous study, we had found plurihormonal mRNA expression, especially for ACTH, the β-subunit of follicle-stimulating hormone and luteinizing hormone in some Somatotroph adenomas, using non-radio-isotopic ISH, and suggested that these adenomas might be derived from plurihormonal primordial stem cells. Our present case is significant from the viewpoint of histogenesis of pituitary adenomas, because it further supports the cell origin of Somatotroph adenomas from plurihormonal primordial stem cells, and moreover it suggests the presence of unknown transcriptional factor other than Pit-1, common to GH, PRL, and ACTH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411291
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Recurrent trigeminal neuralgia caused by an inserted prosthesis: Report of two cases (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 1307-1310 
    Details
    ISSN: 0942-0940
    Keywords: Recurrent trigeminal neuralgia ; prosthesis ; vascular transposition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report two cases of recurrent trigeminal neuralgia caused by an inserted prosthesis. Teflon material or polyurethane sponge inserted between the trigeminal nerve and the superior cerebellar artery became hardened and compressed the trigeminal nerve 17 months (Teflon) and 9 years (polyurethane sponge) respectively after the initial surgery. On the basis of these cases, it is suggested that actual decompression of the trigeminal nerve is important in surgery for trigeminal neuralgia, and that the prosthesis should not touch the trigeminal nerve.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411060
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Dumbbell Type Jugular Foramen Meningioma Extending Both into the Posterior Cranial Fossa and into the Parapharyngeal Space: Report of 2 Cases with Vascular Reconstruction (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 323-331 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Jugular foramen; meningioma; carotid ligation; cerebral revascularisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two cases with huge dumbbell type jugular foramen meningioma with extension into the parapharyngeal space are reported. A well co-ordinated surgical strategy for total resection to this high risk tumour with neurosurgeons, otolaryngologists and plastic surgeons is mandatory to minimise operative complications. Both of our patients presented with a cervical mass and lower cranial nerve palsies, and had huge dumbbell type masses extending from the posterior cranial fossa through the jugular foramen to the parapharyngeal space, encasing the cervical internal carotid artery. Gross total resection of the tumours was successfully achieved by basically a 2-stage operation. In the first stage, posterior fossa tumours were removed by the transjugular approach, combined with the petrosal approach in one case. In the second stage, cervical tumours were removed along with the cervical carotid artery by the transcervical and/or transmandibular approach, followed by vascular reconstruction from the ipsilateral carotid artery to the middle cerebral artery using saphenous vein graft. From these experiences, we recommend this 2-stage operation for large dumbbell type meningiomas extending to the infratemporal/parapharyngeal space. The intracranial tumour is removed at the first operation. The extracranial portion is resected at the second, and if necessary, the involved cervical carotid artery is resected and simultaneous revascularisation using saphenous vein graft is performed with a vascularised free muscle graft. This strategy could maximise the functional preservation on the one hand, and minimise the surgical risk, such as postoperative infection, on the other.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050105
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Radiation-Induced Aneurysm and Moyamoya Vessels Presenting with Subarachnoid Haemorrhage (2000)
    Springer
    Acta neurochirurgica 142 (2000), S. 139-143 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Moyamoya; optic glioma; radiation therapy; subarachnoid haemorrhage.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ A rare case of a ruptured internal carotid artery (ICA) aneurysm, with ICA stenosis and moyamoya vessels, was diagnosed in a young female patient after radiotherapy for optic glioma. Retrospective analysis revealed that an extraordinarily high dose of radiation (110 Gy) had been delivered to the area around the ICA in two therapeutic sessions. Clipping and wrapping of the aneurysm were performed and the patient made a good recovery. A review of the literature suggested that rupture of radiation-induced aneurysms is a rare event, but may be fatal. Considerable care must therefore be taken when delivering high-dose radiation to cerebral arteries. We suggest that the incidence of radiation-induced moyamoya vessels is higher in younger patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050016
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Pure Intracranial Vagal Neurinoma (2000)
    Springer
    Acta neurochirurgica 142 (2000), S. 479-480 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050461
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...