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  • 1
    Electronic Resource
    Electronic Resource
    Neoplastic cells in the cerebrospinal fluid in intravascular lymphomatosis (2000)
    Springer
    Journal of neurology 247 (2000), S. 656-658 
    Details
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007809
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  • 2
    Electronic Resource
    Electronic Resource
    Reference electrodes based on conducting polymers (2000)
    Springer
    Fresenius' journal of analytical chemistry 367 (2000), S. 340-342 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Several attempts to produce conducting polymer based all-solid-state reference electrodes are presented. Open circuit potential of conducting polymers is redox sensitive and Donan equilibrium dependent. Therefore, more sophisticated constructions are necessary. Most promising were bilayers composed of conducting polymers with different ion-exchanger properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160000387
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  • 3
    Electronic Resource
    Electronic Resource
    Vulvodynie (2000)
    Springer
    Der Hautarzt 51 (2000), S. 147-151 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Vulvodynie ; Klinische Subtypen ; Dermatosen der Vulva ; Differentialdiagnose ; Key words Vulvodynia ; Clinical subtypes ; Vulvar dermatoses ; Differential diagnoses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Vulvodynia is a complex syndrome of chronic vulvar pain. It is divided into several subtypes: 1. cyclic vulvovaginitis (pain occurs after coitus), 2. vulvar vestibulitis syndrome (pain mainly with intercourse), 3. dysaesthetic vulvodynia (psychosomatic; diagnosis of exclusion), 4. vulvar dermatoses (e.g. pemphigus vulgaris, contact dermatitis). Additional causes have been described in single cases. Though vulvodynia is often accompanied by psychological distress, somatic causes have to be considered in each case.
    Notes: Zusammenfassung Der Begriff Vulvodynie beschreibt chronische Schmerzzustände des äußeren weiblichen Genitales. Klinisch werden verschiedene Subtypen unterschieden: 1. Zyklische Vulvovaginitis mit postkoitalem Beschwerdemaximum und fraglicher Assoziation mit Candida albicans. 2. Vulvavestibulitis mit umschriebener Schmerzhaftigkeit des Introitus durch Entzündung der dortigen Drüsenausführungsgänge mit koitalem Beschwerdemaximum. 3. Essentielle Vulvodynie als funktionelles Beschwerdebild ohne erkennbare somatische Ursache. 4. Dermatosen der Vulva unterschiedlicher Genese, wobei Autoimmunerkrankungen (z.B. Pemphigus vulgaris) und Kontaktdermatitiden von besonderer Bedeutung sind. Zusätzlich kommen verschiedene meist kasuistisch dargestellte seltene Ursachen in Betracht. Somatoforme Störungen oder psychische Alterationen können die Differentialdiagnose einer somatischen Ursache der Vulvodynie (z.B. Kontaktdermatitis) verschleiern. Ein interdisziplinäres Vorgehen ist in jedem Fall sinnvoll.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050051095
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  • 4
    Electronic Resource
    Electronic Resource
    Teratogenicity of arotinoids (retinoids) in vivo and in vitro (1990)
    Springer
    Archives of toxicology 64 (1990), S. 616-622 
    Details
    ISSN: 1432-0738
    Keywords: Teratogenicity in vivo ; Teratogenicity in vitro ; Retinoids ; Arotinoids ; Micromass culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of structural modifications on the arotinoid molecule, a new class of retinoids, on their teratogenicity in mice was studied. Animals were treated on days 8 and 9 of gestation, the most susceptible stages to retinoid-induced malformations in rodents. The teratogenic potency of the 13 arotinoids tested varied over a dose range of more than five orders of magnitude. Next, we tested whether the quantitative differences in the teratogenicity of these arotinoids correlates with their activity in high density (micromass) cultures of rat embryonic limb bud and midbrain cells. There was a good quantitative correlation between the in vivo teratogenicity and the in vitro activity in limb bud cells but no correlation was found in midbrain cells. Thus, the limb bud cell culture system may be useful for a preliminary testing to select non-teratogenic retinoids. For the risk assessment in humans, however, the in vitro results should be verified in animals studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01974689
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  • 5
    Electronic Resource
    Electronic Resource
    Degradation of 3,9-dimethoxypterocarpan and medicarpin by Fusarium fungi (1981)
    Springer
    Archives of microbiology 130 (1981), S. 381-384 
    Details
    ISSN: 1432-072X
    Keywords: O-demethylation ; Pterocarpans ; Isoflavans ; Fusarium ; Gibberella ; Phytoalexins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Fusarium sporotrichioides and Gibberella saubinetti O-demethylate 3,9-dimethoxypterocarpan to 3-methoxy-9-hydroxypterocarpan and then 3,9-dihydroxypterocarpan. F. anguioides Sherb., F. avenaceum and F. graminearum convert the same substrate to a mixture of 3-methoxy-9-hydroxypterocarpan and 3-hydroxy-9-methoxypterocarpan. Induction of pterocarpan degradation by pisatin in F. avenaceum leads to preferential conversion of 3,9-dimethoxypterocarpan to 3-hydroxy-9-methoxypterocarpan (medicarpin) and the isoflavan vestitol. The data are discussed with respect to phytoalexin degradation by phytopathogenic Fusarium fungi.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414604
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  • 6
    Electronic Resource
    Electronic Resource
    Circulating haematopoietic progenitors during treatment of renal anaemia with recombinant human erythropoietin (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 43-48 
    Details
    ISSN: 1432-1076
    Keywords: Chronic renal failure Erythropoietin ; Haematopoietic progenitors ; Haemodialysis Interleukin 3
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of recombinant human erythropoietin (rhEPO) and interleukin 3 (IL3) on circulating haematopoietic progenitors consisting mainly of immature burst-forming-units-erythrocytes (BFU-E), was investigated in ten paediatric patients treated by regular haemodialysis. During a 30-week study rhEPO treatment resulted in a rise of median haemoglobin levels from 6.7 g/dl to 〉10 g/dl in all patients. Before initiating rhEPO treatment the number of circulating BFU-E in chronic renal failure patients responded to grading doses of rhEPO in vitro similar to that in control children; however, the dose-response curves were not predictive for the in vivo response to rhEPO. After an initial rise in five patients BFU-E numbers declined by week 30 of rhEPO treatment. BFU-E numbers decreased to 35% of pretreatment values. The number of granulocyte-macrophage colony forming cells (GM-CFC) also decreased during rhEPO treatment. Addition of IL3 to the culture medium containing saturating concentrations of granulocyte-macrophage colony stimulating factor did not stimulate BFU-E numbers of patients before rhEPO treatment or those of controls. However, 2 weeks after start of rhEPO treatment IL3 increased the growth of patient's BFU-E in vitro to 220% of pretreatment levels, followed by a gradual decrease of stimulation until the end of observation. These findings indicate that: (1) long-term recruitment of circulating haematopoietic progenitors during rhEPO treatment is low in children with renal anaemia; (2) rhEPO sensitivity of circulating BFU-E is not predictive for the in vivo response; (3) rhEPO treatment results in enhanced sensitivity of BFU-E to IL3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02000786
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  • 7
    Electronic Resource
    Electronic Resource
    Circulating haematopoietic progenitors during treatment of renal anaemia with recombinant human erythropoietin (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 43-48 
    Details
    ISSN: 1432-1076
    Keywords: Key words: Chronic renal failure – Erythropoietin – Haematopoietic progenitors – Haemodialysis – Interleukin 3
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The effect of recombinant human erythropoietin (rhEPO) and interleukin 3 (IL3) on circulating haematopoietic progenitors consisting mainly of immature burst-forming-units-erythrocytes (BFU-E), was investigated in ten paediatric patients treated by regular haemodialysis. During a 30-week study rhEPO treatment resulted in a rise of median haemoglobin levels from 6.7 g/dl to 〉10 g/dl in all patients. Before initiating rhEPO treatment the number of circulating BFU-E in chronic renal failure patients responded to grading doses of rhEPO in vitro similar to that in control children; however, the dose-response curves were not predictive for the in vivo response to rhEPO. After an initial rise in five patients BFU-E numbers declined by week 30 of rhEPO treatment. BFU-E numbers decreased to 35% of pretreatment values. The number of granulocyte-macrophage colony forming cells (GM-CFC) also decreased during rhEPO treatment. Addition of IL3 to the culture medium containing saturating concentrations of granulocyte-macrophage colony stimulating factor did not stimulate BFU-E numbers of patients before rhEPO treatment or those of controls. However, 2 weeks after start of rhEPO treatment IL3 increased the growth of patient's BFU-E in vitro to 220% of pretreatment levels, followed by a gradual decrease of stimulation until the end of observation. These findings indicate that: (1) long-term recruitment of circulating haematopoietic progenitors during rhEPO treatment is low in children with renal anaemia; (2) rhEPO sensitivity of circulating BFU-E is not predictive for the in vivo response; (3) rhEPO treatment results in enhanced sensitivity of BFU-E to IL3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02000786
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    A method for easy isolation of promoter fragments from promoter-probe libraries of filamentous fungi (1995)
    Springer
    Current genetics 28 (1995), S. 190-196 
    Details
    ISSN: 1432-0983
    Keywords: Promoter ; Fungi ; Fusarium ; Transformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Two genomic fragments capable of driving the expression of the hygromycin B resistance gene (hph) were isolated from the phytopathogenic ascomycete Gibberella pulicaris (anamorph Fusarium sambucinum) using a “promoter-probe library” strategy. Two libraries consisting of random, 0.5–2.0-kb fragments of genomic DNA inserted 5′ of a promoterless hph gene were constructed and used for transformation of G. pulicaris. Both libraries transformed G. pulicaris at a low frequency. Transformants tolerated up to 800 μg/ml of hygromycin B, while untransformed colonies were inhibited completely by 50 μg/ml of the antibiotic. Plasmids were re-isolated from transformants by simply digesting, the genomic DNA with KpnI, which cuts once in the polylinker 5′ to the insert, and transforming E. coli with the re-ligated DNA. The recovered plasmids transformed G. pulicaris with a frequency of up to 4.4 transformants/μg of DNA. Both promoter fragments were sequenced and found to contain TATA and CAAT boxes as well as CT-rich sequences. This method makes it possible to easily isolate many fragments with promoter activity from filamentous fungi, and should facilitate the investigation of the promoter structures necessary for the expression of fungal genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315787
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  • 9
    Electronic Resource
    Electronic Resource
    The fungal acl1 and acl2 genes encode two polypeptides with homology to the N- and C-terminal parts of the animal ATP citrate lyase polypeptide (2000)
    Springer
    Current genetics 37 (2000), S. 189-193 
    Details
    ISSN: 1432-0983
    Keywords: Keywords ATP citrate lyase ; Filamentous fungi ; Gene cluster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract ATP citrate lyase (ACL) catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols. In this paper, we show for the first time that in filamentous fungi two different subunits of ACL are encoded by two separate genes. This is in contrast to animals where ACL is encoded by a single gene. Data are presented on acl genes from the filamentous fungi Sordaria macrospora and Gibberella pulicaris. In S. macrospora, both genes, acl1 and acl2, are clustered within a region of 10 kb and are divergently transcribed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002940050518
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  • 10
    Electronic Resource
    Electronic Resource
    Organochlorine and mecury concetrations in eggs of grey plovers (Pluvialis squatarola) breeding in the Lena Dlta, north-east Sibveria, 1997 (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Polar research 19 (2000), S. 0 
    Details
    ISSN: 1751-8369
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geography , Geosciences
    Notes: Seven eggs from four clutches of grey plovers (Pluvialis squatarola) breeding in the Lena Delta, Sakha Republic, Yakutia, in 1997 were analysed for persistent organochlorines and mercury. Contamination levels were low and within the same range as found in eggs from waders (Charadriiformes) breeding in north-west Europe. One exception was ?HCH, averaging 99.2 ng g−1 fresh egg mass, a level about ten times higher than in wader eggs from north-west Europe. β-HCH accounted for 98% of the total HCH concentration. There are indications that the pesticide levels may reflect former local use. ∑PCB level (57.0 ng g−1, 62 congeners) and mercury concentration (68.7 ng g−1) can be considered low.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1751-8369.2000.tb00348.x
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