Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    [15N]Methacetin urine test: A method to study the development of hepatic detoxification capacity (1990)
    Springer
    European journal of pediatrics 149 (1990), S. 393-395 
    Details
    ISSN: 1432-1076
    Keywords: Age dependence ; Detoxification capacity ; Liver-Stable isotopes ; 15N urine test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The [15N]methacetin urine test was used to study human O-demethylase activities to characterize the maturation of hepatic detoxification capacity. The study involved 43 healthy subjects aged 1 day−47 years. The urinary15N elimination rates were measured following oral administrations of an aqueous [15N]methacetin solution. Age-dependent normal values of hepatic drug elimination capacity were established. Parameters were the15N elimination half-life and cumulative elimination of the15N dose as a percentage over a 9 h period. The maximum elimination rate (% dose/h) and peak time can give additional information. The15N method is a simple, noninvasive and non-radioactive liver function test avoiding disadvantages of14C and13C breath tests. The [15N]methacetin test is suitable and useful in studying the hepatic development at birth and pathological changes of the microsomal detoxification capacity in early childhood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02009656
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Influence of intrauterine growth retardation on parameters of liver function in low birth weight infants (1990)
    Springer
    European journal of pediatrics 149 (1990), S. 396-398 
    Details
    ISSN: 1432-1076
    Keywords: Low birth weight infants ; Small-for-gestationalage ; Liver functions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To establish nutritional management of low birthweight infants according to their individual metabolic situation, hepatocellular partial function was studied in 13 appropriate (AGA) and 11 small-for-gestational-age (SGA) low birthweight (LBW) infants during the first weeks of postnatal life. The concentrations of total bile acids and of alpha-amino-nitrogen in serum, the renal excretion of urea and ammonia and the renal excretion of15N after enteral administration of 3 mg15N-labeled methacetin/kg were measured. In comparison to AGA infants, SGA infants had elevated serum concentrations of total bile acids and of alpha-amino-nitrogen, decreased excretion of urea, increased excretion of ammonia in urine, and lower urinary15N-excretion after enteral administration of15N-labeled methacetin. The data suggest that hepato-cellular functions are influenced by intrauterine growth retardation resulting in a reduced metabolic capacity in SGA infants. The metabolic differences between SGA and AGA infants should be considered in the nutritional management of LBW infants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02009657
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Isotopenverdunnungsanalyse mit stabilen isotopen-II - Monomeren-bestimmung im polycaproamid mit epsilon-caprolactam-[15N]
    Amsterdam : Elsevier
    Talanta 13 (1966), S. 1329-1334 
    Details
    ISSN: 0039-9140
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0039-9140(66)80222-9
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Nuclear medicine liver function tests for pregnant women and children 1. Breath tests with 14C-methacetin and 13C-methacetin (1985)
    Springer
    European journal of nuclear medicine 10 (1985), S. 129-133 
    Details
    ISSN: 1619-7089
    Keywords: carbon-13, carbon-14 ; children ; diagnostic techniques ; diseases ; double labelling ; drugs ; isotope applications ; liver ; function tests ; metabolism ; pregnant women ; synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Stable isotopes, such as 13C, should be substituted for the long-lived radionuclide 14C in the 14C breath test when doing liver function tests in children and pregnant women. For comparison 13C, 15N-methacetin and 14C-methacetin were synthesized as suitable diagnostic agents. Methods are described for the measurement of 14C and 13C in the breath. After oral administration of labelled methacetin to healthy subjects and patients with liver diseases a good correspondence between 13C- and 14C-measurements in the same subject on the one hand, and a good discrimination between controls and patients on the other hand were shown. Findings with regard to 14C measurements in urine are discussed supporting the supposed advantage of 13C-methacetin over 14C-methacetin application.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252720
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Nuclear medicine liver-function tests for pregnant women and children (1985)
    Springer
    European journal of nuclear medicine 11 (1985), S. 58-61 
    Details
    ISSN: 1619-7089
    Keywords: Children ; Diagnostic techniques ; Diseases ; Drugs ; Function tests ; Isotope applications ; Liver ; Metabolism ; Nitrogen-15 ; Pregnant women ; Stable isotopes ; Urine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A simple, non-invasive, non-radioactive liverfunction test is proposed. After an oral dose of 3 mg 15N-methacetin per kilogram body mass, the kinetics of 15N excretion via urine were characterized by the quotient of the amounts of 15N excreted in two successive urine samples (Q value). The stable nitrogen isotope 15N was found to be an excellent and easily detectable indicator of the sum of all methacetin metabolites present in urine. Alterations in the nature or ratio of methacetin metabolites due to liver diseases could not be found. From the investigation of 11 men, 3 pregnant women and 15 children, a clear difference was observed in Q values of healthy persons and patients suffering from liver-cell-activity diseases. The discriminating power of our new liver-function test is shown to be equivalent to that of the 14CO2 breath test.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252133
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Isotopieeffekte bei Autoxydationen. II. Konstitution und kinetischer Wasserstoffisotopieeffekt bei der Autoxydation am tertiären Kohlenstoffatom (1968)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 37 (1968), S. 206-213 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die strukturell nahe verwandten Kohlenwasserstoffe Cumol, Phenylcyclohexan und Phenyleyclopentan sowie ihre α-D-Derivate wurden in einer modifizierten FRIEDEL-CRAFTS-Reaktion synthetisiert und der durch Co-Stearat katalysierten Autoxydation unterworfen. Aus den maximalen Autoxydationsgeschwindigkeiten wurden folgende primäre kinetische Brutto-Isotopieeffekte bei 61 °C bestimmt: Es wird versucht, den Gang der Isotopieeffekte innerhalb der quasihomologen Reihe mit der Annahme unterschiedlicher energetischer Verhältnisse im Übergangszustand der Reaktionen zu deuten.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19680370313
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Modelluntersuchungen zur oxydativen und thermischen Stabilität von DicarbonsäureesterölenVorgetragen auf dem 10. Internationalen Symposium über Schmierstoffe und Schmierstoffanwendung, Halle/Saale, 1968. (1969)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 311 (1969), S. 677-683 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Durch die Bestimmung der Deuterium-Isotopieeffekte bei der Oxydation von Adipinsäure-di-n-amylester und der in der Alkoholkomponente D-substituierten Analoga Adipinsäure-di-n-amylester-[α-D2],-[β-D2],-[γ-D2] und -[α,β-D4] wurde gefunden, daß sich die Reaktivitäten der Methylengruppen der Alkoholkomponente gegenüber einem oxydativen Angriff nicht beträchtlich unterscheiden und in der Reihe α 〉 β 〉 γ abnehmen.Durch eine Abschätzung der Isotopieeffekte bei der thermischen Zersetzungsreaktion aus den Zersetzungstemperaturen der Verbindung konnte nachgewiesen werden, daß der rein thermische Angriff im Gegensatz zum oxydativen Angriff praktisch nur an der Methylengruppe in β-Stellung der Alkoholkomponente erfolgt. Dies steht in Übereinstimmung mit dem nach anderen Methoden bestimmten Reaktionsmechanismus der thermischen Zersetzung von Esterölen.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19693110420
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...