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  • 1
    Electronic Resource
    Electronic Resource
    Nuclear medicine liver function tests for pregnant women and children 1. Breath tests with 14C-methacetin and 13C-methacetin (1985)
    Springer
    European journal of nuclear medicine 10 (1985), S. 129-133 
    Details
    ISSN: 1619-7089
    Keywords: carbon-13, carbon-14 ; children ; diagnostic techniques ; diseases ; double labelling ; drugs ; isotope applications ; liver ; function tests ; metabolism ; pregnant women ; synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Stable isotopes, such as 13C, should be substituted for the long-lived radionuclide 14C in the 14C breath test when doing liver function tests in children and pregnant women. For comparison 13C, 15N-methacetin and 14C-methacetin were synthesized as suitable diagnostic agents. Methods are described for the measurement of 14C and 13C in the breath. After oral administration of labelled methacetin to healthy subjects and patients with liver diseases a good correspondence between 13C- and 14C-measurements in the same subject on the one hand, and a good discrimination between controls and patients on the other hand were shown. Findings with regard to 14C measurements in urine are discussed supporting the supposed advantage of 13C-methacetin over 14C-methacetin application.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252720
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  • 2
    Electronic Resource
    Electronic Resource
    A liver-function test using 15N-labelled ammonium chloride (1985)
    Springer
    European journal of nuclear medicine 11 (1985), S. 62-64 
    Details
    ISSN: 1619-7089
    Keywords: Ammonia ; Diagnosis ; Emission spectroscopy ; Isotope application ; Liver ; Nitrogen-15 ; Tracer technique ; Urea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Malfunction of the liver involves disturbances of urea synthesis and ammonia detoxification. These phenomena became apparent, especially during ammonia loading of patients. The functional state of the liver can be assessed by oral administration of 15NH4Cl and subsequent analysis of 15N-urea and 15N-ammonia in urine by emission spectrometry. Clinical tests based on the ratio of the excess abundances (see Appendix) of 15N-ammonia to 15N-urea excreted in urine 3 h after oral administration gave values for patients with liver disease which differed significantly from those for healthy subjects. Absorption disturbances, which often accompany liver diseases, do not influence the effectiveness of the method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252134
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  • 3
    Electronic Resource
    Electronic Resource
    Nuclear medicine liver-function tests for pregnant women and children (1985)
    Springer
    European journal of nuclear medicine 11 (1985), S. 58-61 
    Details
    ISSN: 1619-7089
    Keywords: Children ; Diagnostic techniques ; Diseases ; Drugs ; Function tests ; Isotope applications ; Liver ; Metabolism ; Nitrogen-15 ; Pregnant women ; Stable isotopes ; Urine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A simple, non-invasive, non-radioactive liverfunction test is proposed. After an oral dose of 3 mg 15N-methacetin per kilogram body mass, the kinetics of 15N excretion via urine were characterized by the quotient of the amounts of 15N excreted in two successive urine samples (Q value). The stable nitrogen isotope 15N was found to be an excellent and easily detectable indicator of the sum of all methacetin metabolites present in urine. Alterations in the nature or ratio of methacetin metabolites due to liver diseases could not be found. From the investigation of 11 men, 3 pregnant women and 15 children, a clear difference was observed in Q values of healthy persons and patients suffering from liver-cell-activity diseases. The discriminating power of our new liver-function test is shown to be equivalent to that of the 14CO2 breath test.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252133
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  • 4
    Electronic Resource
    Electronic Resource
    Cytokinin-induzierte de novo-Synthese der Nitratreductase in Embryonen von Agrostemma githago (1972)
    Springer
    Planta 108 (1972), S. 333-337 
    Details
    ISSN: 1432-2048
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Nitrate reductase can be induced in isolated embryos of Agrostemma githago by treatment with cytokinin. By labeling proteins with H2 18O and subsequent isopycnic density gradient centrifugation it was proved that the benzyladenine induction of nitrate reductase is caused by a de-novo synthesis of the enzyme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00389310
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  • 5
    Electronic Resource
    Electronic Resource
    Ω-Diazofettsäureester. II. Eigenzerfall, katalytischer und photolytischer Zerfall der Ω-DiazofettsäureesterProfessor Dr. Leopold Wolf zum 70. Geburtstag gewidmet (1966)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 34 (1966), S. 55-63 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Stabilität der ω-Diazofettsäureester ist abhängig von der Kettenlänge. Der Eigenzerfall gehorcht einer Kinetik I. Ordnung, β-Diazopropionester zerfällt am schnellsten. Hauptprodukte sind die Azine von ω-Formylfettsäureestern. Dagegen entstehen beim Cu-katalysierten Zerfall ungesättigte Ester mit endständiger Doppelbindung als Hauptprodukte, beim photolytischen Zerfall Dicarbonsäureester mit mittelständiger Doppelbindung. Das Produktverhältnis wird durch die Anwesenheit von Cyclohexen nicht beeinflußt.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19660340107
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  • 6
    Electronic Resource
    Electronic Resource
    Ω-Diazofettsäureester. III. Reaktionen der Ω-Diazofettsäureester mit Säuren und Säurechloriden (1966)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 34 (1966), S. 262-271 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ω-Diazofettsäureester werden durch wäßrige Halogenwasserstoffsäuren zu den entsprechenden ω-Halogenfettsäureestern zersetzt, mit verd. H2SO4 entstehen hauptsächlich ω-Hydroxyfettsäureester. Die durch Einwirkung von Benzoylchlorid in Gegenwart von Triäthylamin leicht erhältlichen ω-Benzoyl-diazofettsäureester ermöglichen die Synthese einiger auf anderen Wegen schwierig oder nicht herstellbarer Verbindungen und sind außerdem der Wolffschen Umlagerung zugänglich.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19660340505
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  • 7
    Electronic Resource
    Electronic Resource
    Ω-Diazofettsäureester. IV. Reaktionen der Ω-Diazofettsäureester mit Carbonylverbindungen (1966)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 34 (1966), S. 272-282 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ω-Diazofettsäureester reagieren mit aromatischen und heteroaromatischen Aldehyden in guten Ausbeuten zu ω-Acyl-fettsäureestern, mit Cycloketonen unter Ringerweiterung zu den homologen ω-[Cycloalkanon-2-yl-]-fettsäureestern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19660340506
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  • 8
    Electronic Resource
    Electronic Resource
    ω-Diazofettsäureester. V. Reaktionen der ω-Diazofettsäureester mit Acetylenen (1967)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 35 (1967), S. 105-109 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ω-Diazofettsäureester lagern sich an die Dreifachbindungen von Acetylendicarbonester, Propiolsäureester, Phenylpropiolsäureester und Phenylpropargylaldehyddimethylacetal unter Bildung der entsprechend substituierten Pyrazole an.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19670350116
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  • 9
    Electronic Resource
    Electronic Resource
    ω-Diazofettsäureester. VI. Reaktionen der ω-Diazofettsäureester mit Olefinen (1967)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 36 (1967), S. 73-81 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ω-Diazofettsäureester lagern sich an die Doppelbindungen von Acrylsäureäthylester, Zimtsäuremethylester, Fumarsäuredimethylester, Maleinsäuredimethylester, N-Phenyl-maleinimid, Mesaconsäuredimethylester, Naphthochinon-(1,4) und Benzochinon-(1,4) unter Bildung der entsprechend substituierten Pyrazoline an. Diese können durch Brom zu den entsprechenden Pyrazolen dehydriert werden und ergeben bei der Pyrolyse je nach Art der Substituenten ungesättigte Ester, Cyclopropanderivate oder bicyclische Lactame.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19670360108
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  • 10
    Electronic Resource
    Electronic Resource
    ω-Diazofettsäureester. VII. Addition der ω-Diazofettsäureester an Heterodoppelbindungen (1967)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 36 (1967), S. 82-85 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ω-Diazofettsäureester lagern sich an die Doppelbindungen von Di-(α-naphthyl)-carbodiimid, Phenylisothiocyanat, Benzoylisothiocyanat und Azodicarbonsäureester unter Bildung der entsprechend substituierten Triazole, Thiadiazole und Oxadiazoline an.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19670360109
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