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  • 1
    Electronic Resource
    Electronic Resource
    The A.D.E. Photo-Electric Integrator (1954)
    [s.l.] : Nature Publishing Group
    Nature 173 (1954), S. 1222-1223 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE instrument described in this article is capable of evaluating surface integrals of any function over a domain with any (possibly irregular) boundaries not containing poles of the function. It is necessary to prepare suitable photo-plate representations of the function, together with opaque ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1731222a0
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  • 2
    Electronic Resource
    Electronic Resource
    Dose dependent pharmacokinetics of prednisolone (1977)
    Springer
    European journal of clinical pharmacology 12 (1977), S. 213-219 
    Details
    ISSN: 1432-1041
    Keywords: Prednisolone pharmacokinetics ; intravenous dosing ; plasma clearance ; half-life ; volume of distribution ; plasma protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of prednisolone elimination have been studied in both arthritic patients and normal volunteers using tritiated prednisolone alone, and in conjunction with unlabelled prednisolone in doses of 0.15 mg·kg−1 and 0.3 mg·kg−1 body weight. With increasing dose there is prolongation of the plasma half-life and increase in the volume of distribution and plasma clearance of prednisolone. It is proposed that these changes in pharmacokinetic parameters may be associated with non-linear binding of the steroid to plasma proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609864
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  • 3
    Electronic Resource
    Electronic Resource
    A pharmacological and clinical comparison of prednisolone and betamethasone in rheumatoid arthritis (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 321-325 
    Details
    ISSN: 1432-1041
    Keywords: prednisolone ; betamethasone ; rheumatoid arthritis ; adrenal suppression ; chronic dosage ; anti-inflammatory activities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary 1. Two oral corticosteroids, prednisolone (8 mg/day) and betamethasone (1 mg/day) have been compared in terms of efficacy and adrenal suppressive activity when used in chronic oral dosage in rheumatoid arthritis. 2. 20 patients were entered to a single blind crossover study receiving each drug for a two-week period. Clinical and laboratory assessments were performed. 3. At this dosage there was no significant difference between any of the clinical parameters assessed for either drug though patient preference was 13 for prednisolone and 7 for betamethasone. 4. At this dosage adrenal suppression was not equivalent, being significantly more marked with betamethasone. 5. The results suggest that prednisolone is the drug of choice for chronic dosage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613613
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A phenylbutazone dose-finding study in rheumatoid arthritis (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 773-776 
    Details
    ISSN: 1432-1041
    Keywords: phenylbutazone ; rheumatoid arthritis ; dose ; oxyphenbutazone ; side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Different doses of phenylbutazone have been compared in a double blind study on 32 patients with rheumatoid arthritis in order to determine the minimum effective dose. Of 8 different dose levels studied (90 mg, 150 mg, 180 mg, 240 mg, 270 mg, 300 mg, 360 mg and 450 mg/day) the most efficacious was found to be 300 mg/day. Doses below this did not produce full benefit; no further improvement occurs with higher doses. Although 7/32 patients developed adverse reactions there was no relationship between these and the plasma levels of either phenylbutazone or oxyphenbutazone. An attempt was made to distinguish ‘responders’ from ‘non-responders’. We found no relationship between response and plasma levels of phenylbutazone or oxyphenbutazone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607086
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  • 5
    Electronic Resource
    Electronic Resource
    Caeruloplasmin concentration and oxidase activity in polyarthritis (1988)
    Springer
    Rheumatology international 8 (1988), S. 11-14 
    Details
    ISSN: 1437-160X
    Keywords: Caeruloplasmin concentration ; Oxidase activity ; Polyarthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Caeruloplasmin (Cp) concentration and oxidase activity have been shown to be elevated in rheumatoid arthritis (RA) and psoriatic arthritis, but normal in Reiter's syndrome, Behcet's syndrome and juvenile seronegative polyarthritis. Synovial fluid Cp was significantly depressed in comparison with serum Cp in RA. During second-line therapy in RA, Cp concentration and activity fell significantly (P〈0.001), but the change in Cp did not correlate with plasma viscosity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541344
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