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  • 1
    Electronic Resource
    Electronic Resource
    Simple devices in differentiating the effects of buprenorphine and fentanyl in healthy volunteers (1987)
    Springer
    European journal of clinical pharmacology 31 (1987), S. 673-676 
    Details
    ISSN: 1432-1041
    Keywords: buprenorphine ; fentanyl ; critical flicker fusion threshold-test ; Maddox wing readings ; visual analoque scale scores ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have tested the usefulness of the critical flicker fusion threshold-test (CFF), Maddox wing readings (MW), and visual analoque scale scores (VAS) in a double-blind, random-order study designed to evaluate the clinical effects of two different kinds of opiates, buprenorphine and fentanyl in comparison with those of placebo. The results were compared with the so-called postanaesthetic recovery score (PARS). In 7 healthy volunteers MW and VAS differentiated the effects of buprenorphine 7.5 µg/kg i.v. from those of fentanyl 2.5 µg/kg i.v. and placebo. CFF was very insensitive in this respect and PARS completely useless. Our results show that, in addition to the known usefulness of VAS, MW is also able to differentiate the effects of these opiates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541294
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of valine, leucine, isoleucine, and a balanced amino acid solution on the seizure threshold to picrotoxin in rats
    Amsterdam : Elsevier
    Pharmacology, Biochemistry and Behavior 48 (1994), S. 101-103 
    Details
    ISSN: 0091-3057
    Keywords: Branched-chain amino acids ; GABA-receptor complex ; Nutritional pharmacology ; Proconvulsant drugs
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0091-3057(94)90504-5
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Lung compliance during laparoscopic surgery in paediatric patients (1998)
    Oxford, UK : Blackwell Science Ltd
    Pediatric anesthesia 8 (1998), S. 0 
    Details
    ISSN: 1460-9592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Insufflation of CO2 and positioning of patients induces changes in cardiovascular and respiratory function during laparoscopic procedures. This study was initiated to assess respiratory mechanics such as lung compliance and peak airway pressure (PIP) during laparoscopic surgery in paediatric patients. Ten consecutive patients (age 1–15 years) scheduled for laparoscopic procedure were included in this open prospective single-group study. Anaesthesia was induced and maintained with intravenous infusions of propofol and alfentanil. Vecuronium was administered to maintain muscle relaxation. Head down tilt induced a mean decrease of 17% in lung compliance, which was further decreased by 27% from the baseline during insufflation of intraabdominal CO2 (intraabdominal pressure 12 mmHg). Coincidently, PIP increased by 19% and 32% from the baseline during Trendelenburg position and peritoneal insufflation. Lung compliance and PIP returned to their respective baseline values after removal of CO2 from the peritoneal cavity. Endtidal CO2 increased from a baseline value of 4.3 kPa to 5.4 kPa (33–42 mmHg) during surgery when ventilator settings were not altered. We conclude that insufflation of CO2 induces significant increases in peak airway pressure with simultaneous decreases in lung compliance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9592.1998.00699.x
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    Paper (German National Licenses)
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