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  • 1
    Electronic Resource
    Electronic Resource
    A DR3-related DXα gene polymorphism strongly associates with insulin-dependent diabetes mellitus (1986)
    Springer
    Immunogenetics 23 (1986), S. 47-51 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract HLA-DQα and HLA-DXα gene polymorphisms were analyzed by Southern blot techniques in 78 Caucasoid insulin-dependent diabetes mellitus (IDDM) subjects and 55 control subjects. Five restriction fragment length polymorphisms of the HLA-DQ α gene correlated with HLA-DR typing. Two allelic DX α-related gene fragments, of 2.1 kb (U) and 1.9 kb (L) in size were identified. Genotype frequencies in the IDDM group for UU, UL, and LL were 54%, 38.5%, and 7.5%, respectively, whereas the corresponding frequencies in the control group were 24%,40%, and 36% (P 〈 0.00005 for differences in genotype frequencies). The U allele was associated particularly with IDDM patients who were DR3, with healthy controls who were DR3, as well as with IDDM patients who were not DR3. Thus, if this DX α U allele is not the DR3-associated IDDM susceptibility gene, it is the closest marker hitherto studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00376521
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Reversible tetraplegia due to polyneuropathy in a diabetic patient with hyperosmolar non-ketotic coma (1999)
    Springer
    Intensive care medicine 25 (1999), S. 1437-1439 
    Details
    ISSN: 1432-1238
    Keywords: Key words Critical illness ; Diabetes ; Sepsis ; Neuromuscular disease ; Neuropathies ; Motor and sensory ; Electromyography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Critical illness polyneuromypathy has not previously been reported as a complication of diabetic coma. We describe a patient with hyperosmolar non-ketotic coma (HONK) complicating gram-negative sepsis in whom persistent coma and profound tetraplegia caused considerable concern. Although, initially, it was feared that the patient had suffered a central neurological complication such as stroke or cerebral oedema, a diagnosis of critical illness motor syndrome (CIMS) was subsequently confirmed neurophysiologically. Profound limb weakness associated with HONK is not necessarily due to a catastrophic cerebral event, rather it may be a result of CIMS, which has an excellent prognosis for full neurological recovery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340051095
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Hormonal modulation of hepatic plasma membrane lactate transport in cultured rat hepatocytes (1990)
    Springer
    Bioscience reports 10 (1990), S. 573-577 
    Details
    ISSN: 1573-4935
    Keywords: lactate transport ; gluconeogenesis ; cultured hepatocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Hormonal modulation of hepatic plasma membrane lactate transport was studied in primary cultures of isolated hepatocytes from fed rats to examine the mechanism for the known enhancement of lactate transport in starvation and diabetes. Total cellular lactate entry was increased by 14% in the presence of dexamethasone; this was accounted for by an approximately 40% increase in the carrier-mediated component of entry with no effect on diffusion. A trend of similar magnitude was evident with glucagon. The effects of dexamethasone and glucagon on lactate transport constitute an additional potential mechanism for enhancement of gluconeogenesis by these hormones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01116618
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  • 4
    Electronic Resource
    Electronic Resource
    Carrier-mediated lactate entry into isolated hepatocytes from fed and starved rats: Zonal distribution and temperature dependence (1995)
    Springer
    Bioscience reports 15 (1995), S. 99-109 
    Details
    ISSN: 1573-4935
    Keywords: lactate transport ; hepatic heterogeneity ; temperature dependence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract We examined the possibility of quantitative differences in lactate entry into periportal and perivenous hepatocytes under different nutritional states. The rate of14C-L(+)-lactate uptake was determined after 15-second incubations with freshly isolated zonally separated hepatocytes using a centrifuge stop technique at 37 °C and 4 °C, in the presence or absence of either differing amounts of unlabelled lactate or of a hepatocyte lactate transport inhibitor,α-cyano-3-hydroxycinnamate. Total entry as well as carrier mediated entry of14C-L(+)-lactate into the isolated cell populations was found to be similar in periportal and perivenous hepatocytes, irrespective of the nutritional state of the animal. Periportal and perivenous hepatocytes showed a greater tendency to transport lactate when isolated from starved animals, in agreement with previously reported data from non-zonally separated isolated hepatocytes. The activity of the hepatocyte plasma-membrane lactate transporter was diminished between fourfold and eightfold in transport studies conducted at 4 °C; similar results were obtained in unseparated and zonally separated suspensions. Temperature dependence of the hepatocyte transporter is markedly less than that reported for the erythrocyte transporter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01200144
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  • 5
    Electronic Resource
    Electronic Resource
    The mechanism of inhibition of ureogenesis by acidosis (1984)
    Springer
    Bioscience reports 4 (1984), S. 819-825 
    Details
    ISSN: 1573-4935
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract In perfused rat liver a decrease of cytosol pH, determined with pH-sensitive microelectrodes7 from 7.2 to 6.85 is associated with a 50% fall in ureogenesis from ammonium chloride. In isolated rat hepatocytes the fall in ureogenesis due to acidosis is associated with decrease in the mitochondrial and cytosolic concentration of citrulline. Limitation of carbamoyl phosphate synthesis and thus citrulline supply could be responsible for the inhibition of ureogenesis observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01138163
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    Paper (German National Licenses)
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