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  • 1
    ISSN: 1432-0533
    Keywords: Tumourettes of the neurohypophysis ; Granular cell tumours ; Sialomucopolysaccharides ; Neuraminidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The granular cell tumourettes of the posterior lobe of the pituitary possess neuraminic acid containing carbohydrate. After removal of neuraminic acid with neuraminidase and exposure to FITC (Fluorescein isothiocyanate) labelled peanut agglutinin (Arachis hypogaea) (PNA), intracellular receptor structures could be demonstrated. The significance of the findings is discussed.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Keywords: Thomsen-Friedenreich Antigen ; Erdnußagglutinin ; Neuraminidase ; Autoradiographie ; Fluorescenzmikroskop ie ; Thomsen-Friedenreich antigen ; Peanut agglutinin ; Neuraminidase ; Autoradiography ; Fluorescence microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary 1. Three different methods are described for the visualisation of the Thomsen-Friedenreich (TF) antigen on cell suspensions, formalin-fixed and paraffin embedded or frozen tissue sections: a) Rosette formation with chicken and sheep erythrocytes. b) Fluorescence-microscopy with fluorescein labelled peanut agglutinin. c) Autoradiography with3H-labelled peanut agglutinin. 2. The TF antigen was shown, as far as presently investigated, to be exposed on various blood cells, glomerula of the kidney and normal mammary gland after neuraminidase treatment. Mammary gland was also shown to possess TF receptors without prior treatment with neuraminidase. 3. The exposure of this cryptantigen can be brought about by bacterial or viral neuraminidase and is followed by an antigen/antibody reaction, which can lead to possible pathological consequences.
    Notes: Zusammenfassung 1. Drei verschiedene Methoden zur Darstellung von sog. Thomsen-Friedenreich (TF)-Antigenen in Zellsuspensionen, an Formalin-fixiertem und in Paraffin eingebettetem Gewebe sowie in Gefrierschnitten werden beschrieben: a) Rosetten-Bildung mit Hühner- und Schaferythrocyten. b) Fluorescenzmikroskopie mit Fluorescein-markiertem Erdnußagglutinin. c) Autoradiographie mit3H-markiertem Erdnußagglutinin. 2. Nach Neuraminidasebehandlung konnten TF-Antigene — soweit bisher untersucht — auf verschiedenen Blutzellen, in Nierenglomerula und in normalem Brustdrüsengewebe nachgewiesen werden. Ein Teil derartiger Antigene lag im Brustdrüsenparenchym auch bereits als freie Rezeptoren vor, d. h. waren nicht von Neuraminsäure bedeckt. 3. Die Freilegung dieser Kryptantigene kann im Rahmen von Infektionen durch bakterielle und virale Neuraminidase erfolgen. Dabei kommt es zu einer Antigen/Antikörper Reaktion mit unter Umständen klinisch relevanten Folgen.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 57 (1979), S. 533-533 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 66 (1995), S. 130-138 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Analysis of Doppler-shifted Balmer-α line emission from the Tokamak Fusion Test Reactor's (TFTR) neutral beam injection systems has revealed that the line shape, which is a direct measure of the velocity distribution function, is well approximated by the sum of two Gaussians, or, alternatively, by a Lorentzian. For the sum of two Gaussians, the wide-divergence part of the distribution contains 40% of the beam power and has a divergence five times that of the narrow part. Assuming a narrow 1/e-divergence of 1.3° (based on fits to the beam shape on the calorimeter), the wide part has a divergence of 6.9°. The entire line shape is also well approximated by a Lorentzian with a half-maximum divergence of 0.9°. Up to now, most fusion neutral beam modelers have assumed a single Gaussian velocity distribution, at the extraction plane, in each direction perpendicular to beam propagation. This predicts a beam transmission efficiency from the ion source to the calorimeter of 97%. Waterflow calorimetry data, however, yield a transmission efficiency of ∼75%, a value in rough agreement with predictions of the two Gaussian or Lorentzian models presented here. The broad wing of the two Gaussian distribution also accurately predicts the loss in the neutralizer. An additional factor in determining the power density at the surface of beam absorbers is the angle at which the particles arrive. Angles are different for particles emitted from different locations on the ion source. To treat this situation, the average angle of incidence is calculated. For beam loss at the exit of the neutralizer, the average angle of incidence is 2.2°, rather than the 4.95° subtended by the center of the ion source. This average angle of incidence is found to be a function of beam divergence. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 64 (1993), S. 2729-2736 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Tokamak Fusion Test Reactor (TFTR) deuterium neutral beams have been operated unintentionally with significant quantities of extracted water ions. Water has been observed with an optical multichannel analyzer. These leaks were thermally induced with the contamination level increasing linearly with pulse length. Up to 6% of the beam current was attributed to water ions, corresponding to an instantaneous value of 12% at the end of a 1.5 s pulse. A similar contamination is observed during initial operation of ion sources exposed to air. Operation of new ion sources typically produces a contamination level of ∼2%, with cleanup to undetectable levels in 50–100 beam pulses. Approximately 90% of the water extracted from ion sources with water leaks was deuterated, implying that there is the potential for tritiated water production during TFTR's forthcoming DT operation. It is concluded that isotope exchange in the plasma generator takes place rapidly, most likely as the result of surface catalysis. The primary concern is with O implanted into beam absorbers recombining with tritium, and the subsequent retention of T2O on cryopanels.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Determination of two critical neutral beam parameters, power and divergence, are affected by the reflection of a fraction of the incident energy from the surface of the measuring calorimeter. On the TFTR Neutral Beam Test Stand, greater than 30% of the incident power directed at the target chamber calorimeter was unaccounted for. Most of this loss is believed due to reflection from the surface of the flat calorimeter, which was struck at a near grazing incidence (12°). Beamline calorimeters, of a "V''-shape design, while retaining the beam power, also suffer from reflection effects. Reflection, in this latter case, artificially peaks the power toward the apex of the "V,'' complicating the fitting technique, and increasing the power density on axis by 10%–20%; an effect of import to future beamline designers. Agreement is found between measured and expected divergence values, even with 24% of the incident energy reflected.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: 195 tritium ion source shots were injected into Tokamak Fusion Test Reactor (TFTR) high power plasmas during December 1993–March 1994. In addition, four highly diagnosed pulses were fired into the calorimeter. Analysis of the Doppler shifted Tα emission of the beam in the neutralizer has revealed that the extracted ion compositions for deuterium and tritium are indistinguishable: 0.72±0.04 D+; 0.22±0.02 D+2; 0.07±0.01 D+3 compared to 0.72±0.04 T+; 0.23±0.02 T+2; 0.05±0.01 T+3. The resultant tritium full-energy neutral fraction is higher than for deuterium due to the increased neutralization efficiency at lower velocity. To conserve tritium, it was used only for injection and a few calorimeter test shots, never for ion source conditioning. When used, the gas species were switched to tritium only for the shot in question. This resulted in an approximately 2% deuterium contamination of the tritium beam and vice versa for the first deuterium pulse following tritium. Data from the calorimeter shots indicate that tritium contamination of the deuterium beam cleans up in five to six beam pulses, and is reduced to immeasurable quantities prior to deuterium beam injection. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: TFTR long pulse ion sources have been operated with gas fed only into the neutralizer. Gas for the plasma generator entered through the accelerator rather than directly into the arc chamber. This modification has been proposed for tritium beam operation to locate control electronics at ground potential and to simplify tritium plumbing. Source operation with this configuration and with the nominal gas system that feeds gas into both the ion source and the center of the neutralizer are compared. Comparison is based upon accelerator grid currents, beam composition, and neutral power delivered to the calorimeter. Charge exchange in the accelerator can be a significant loss mechanism in both systems at high throughput. A suitable operating point with the proposed system was found that requires 30% less gas than used presently. The extracted D+, D+2, and D+3 fractions of the beam were found to be a function of the gas throughput; at similar throughputs, the two gas feed systems produced similar extracted ion fractions. Operation at the proposed gas efficient point results in a small reduction (relative to the old high throughput mode) in the extracted D+ fraction of the beam from 77% to 71%, with concomitant changes in the D+2 fraction from 18% to 26%, and 6% to 3% for D+3. The injected power is unchanged, ∼2.2 MW at 95 kV.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of medicinal chemistry 25 (1982), S. 952-956 
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pharmacokinetics and tissue distribution of a lipophilic analogue of cisplatin, cis-bis-N-decyl-iminodiacetato-1,2-diaminocyclohexane platinum (II) (N-decyl-IDP), were studied after the i.v. administration of the free drug in suspension in phosphate-buffered saline (F-N-decyl-IDP) and encapsulated in multilamellar liposomes comprising dimyristoyl phosphatidylcholine and dimyristol phosphatidylglycerol at a molar ratio of 7:3 (L-N-decyl-IDP). The encapsulation efficiency and stability at 14 days of L-N-decyl-IDP were greater than 95%. The blood clearance of both forms of the drug fit a two-compartment model. The peak blood level of elemental platinum for L-N-decyl-IDP was fourfold higher than for the free drug (24.2 versus 6.1 μg/ml). In consequence, a fourfold difference in the volumes of distribution was observed (176 ml/kg for L-N-decyl-IDP versus 608 ml/kg for F-N-decyl-IDP). Liposome encapsulation reduced the drug clearance by threefold; therefore, the CXT of L-N-decyl-IDP was threefold higher than that of F-N-decyl-IDP (1308 μg platinum/ml per min versus 395 μg platinum/ml per min). Tissue platinum levels were significantly increased by liposome encapsulation in the lung (33 versus 3.6 μg/g), spleen (38.3 μg/g versus none detected), and liver (16.2 versus 11.7 μg/g), and unchanged in the kidneys. Although only F-N-decyl-IDP resulted in detectable levels of platinum in the small bowel (70.5 μg/g), the stool excretion was similar for both forms of the drug. The organ distribution changes secondary to liposome encapsulation may result in an increased antitumor activity of N-decyl-IDP in tumors involving the lung, spleen, and liver, and avoidance of gastrointestinal toxicity.
    Type of Medium: Electronic Resource
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