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  • 1
    Electronic Resource
    Electronic Resource
    Über Abbauprodukte des Inter-alpha-Trypsininhibitors im Serum (1977)
    Springer
    Journal of molecular medicine 55 (1977), S. 343-345 
    Details
    ISSN: 1432-1440
    Keywords: Inter-alpha-trypsin inhibitor ; Inflammation ; Nephropathy ; Inter-alpha-Trypsininhibitor ; Entzündung ; Nephropathie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei der Freisetzung des säurestabilen Serum-Trypsin-Plasmin-Inhibitors aus dem Inter-alpha-Trypsininhibitor in vivo, entstehen zusätzlich säurelabile Abbauprodukte, die immunologisch bestimmt werden können. Das Hauptabbauprodukt wird im Gegensatz zum säurestabilen Inhibitor nicht durch die Niere ausgeschieden. Dieses Produkt häuft sich im Serum bei verschiedenen Erkrankungen an. Die erhöhte Konzentration dieses Abbauprodukts gestattet auch in den Fällen einen erhöhten Umsatz nachzuweisen, bei denen die Bestimmung des intakten Inter-alpha-Trypsininhibitors oder des filtrierbaren Derivates keinen solchen Nachweis zuläßt.
    Notes: Summary Simultaneous to the liberation of the acid stable trypsin-plasmin-inhibitor from the inter-alpha-trypsininhibitor in vivo, acid labile degradation products are set free. The main product can be estimated by immunological methods. This product is not excreted by the kidney in contrast to the acid stable inhibitor. The product accumulates in serum in different diseases. An increased concentration of this product indicates also an increased turn-over of the inter-alpha-trypsin inhibitor in the case when the concentration of the intact inter-alpha-trypsin inhibitor or of the filtrable derivative are within normal range.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01488113
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  • 2
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1979)
    Springer
    Journal of molecular medicine 57 (1979), S. 911-912 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477031
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  • 3
    Electronic Resource
    Electronic Resource
    Über Abbauprodukte des Inter-alpha-Trypsininhibitors im Serum (1977)
    Springer
    Journal of molecular medicine 55 (1977), S. 337-342 
    Details
    ISSN: 1432-1440
    Keywords: Inter-alpha-trypsin inhibitor ; Inflammation ; Nephropathy ; Inter-alpha-Trypsininhibitor ; Entzündung ; Nephropathie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der humorale Inter-alpha-Trypsin-inhibitor ist als Prekursor des säurestabilen Serum-trypsin-plasmin-inhibitors zu definieren. Dieser Inhibitor wird glomerulär filtriert, die Serumkonzentration steigt bei Nephropathien stark an. An Hand einer neuen Bestimmungsmethode für den Prekursor konnte festgestellt werden, daß bei entzündlichen Erkrankungen trotz normaler Ausscheidung des säurestabilen Abbauprodukts ein Abfall der Prekursorkonzentration einen gesteigerten Inter-alpha-trypsininhibitor Umsatz anzeigt. Die Ergebnisse belegen, daß die Niere sicher das Hauptabbauorgan für den Prekursor ist, da bei Nephropathien ein Anstieg der Prekursorkonzentration gefunden wird. Trotz eingeschränktem Abbau ist jedoch parallel dazu eine Zunahme der Inhibitorkonzentration zu beobachten. Dies ist nur zu erklären, wenn angenommen wird, daß der Abbau des Inter-alpha-trypsininhibitors im Organismus ein ubiquitärer Vorgang ist.
    Notes: Summary The humoral inter-alpha-trypsin inhibitor is to define as precursor of the acid stable trypsin-plasmin-inhibitor in the serum. The inhibitor is filtrated by the glomerulum and excreted in the urine. The serum level of the inhibitor is increased in nephropathy. Using a new assay for the intact precursor it was found that during inflammation the decreased precursor level indicates an increased turnover, though the glomerular filtration of the acid-stable inhibitor is within normal range. The increase of the precursor level during nephropathy indicates that the kidney is the main degradation organe for the inter-alpha-trypsin inhibitor. Nevertheless, an increase of the acid-stable inhibitor is to be seen. This fact is only to explain if it is assumed that the inter-alpha-trypsin inhibitor is permanently degraded everywhere in the organism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01488112
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  • 4
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1980)
    Springer
    Journal of molecular medicine 58 (1980), S. 541-542 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477074
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  • 5
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1979)
    Springer
    Journal of molecular medicine 57 (1979), S. 1303-1304 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01492987
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  • 6
    Electronic Resource
    Electronic Resource
    Inhibition by interferon of SV40 tumor antigen formation in cells injected with SV40 cRNA transcribed in vitro
    Amsterdam : Elsevier
    FEBS Letters 39 (1974), S. 249-251 
    Details
    ISSN: 0014-5793
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(74)80122-5
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  • 7
    Electronic Resource
    Electronic Resource
    Book review (1992)
    Springer
    Infection 20 (1992), S. 370-370 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01710689
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  • 8
    Electronic Resource
    Electronic Resource
    Die schwer therapierbare infektiöse Endokarditis: Drei Fallberichte (1980)
    Springer
    Infection 8 (1980), S. S466 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Three cases of infective endocarditis with associated therapy problems are reported. In one case the infectous agent was unknown, in the other two cases aStreptococcus viridans strain sensitive to penicillin G (MIC〈0.1 µg/ml) was isolated. The patients were initially treated with penicillin G, but due to either penicillin allergy or lack of clinical response, therapy was changed to either cefotaxime alone or in combination with either tobramycin or mezlocillin. With this therapy the infective and inflammatory processes were brought under control. The initial lack of response was possibly due to an insufficient concentration of the antibiotic in the target area. Although these therapy regimes with cefotaxime, tobramycin and mezlocillin cannot be generally recommended in the treatment of endocarditis, they can be used with success in cases which have not responded.
    Notes: Zusammenfassung Es wird über drei Fälle mit schwer therapierbarer infektiöser Endokarditis berichtet. Der Erreger war einmal unbekannt, in den beiden anderen Fällen konnte ein gegen Penizillin G empfindlicherStreptococcus viridans mit MHK〈0,1 µg/ml nachgewiesen werden. Die Patienten wurden initial mit Penizillin G behandelt. Wegen Penizillin-Allergie oder fehlendem klinischem Erfolg wurde auf Cefotaxim oder Cefotaxim und Tobramycin oder Cefotaxim und Mezlocillin umgestellt. Das infektiös-entzündliche Bild konnte so in allen Fällen beherrscht werden. Die primäre klinische Resistenz ist möglicherweise durch mangelhafte Antibiotikakonzentration am Zielort zu erklären. Die genannten Therapieschemata mit Cefotaxim, Tobramycin und Mezlocillin können nicht als generelle Empfehlung zur Endokarditisbehandlung dienen. Ein solcher Behandlungsversuch bei therapieresistenter Endokarditis kann jedoch erfolgreich sein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01639423
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  • 9
    Electronic Resource
    Electronic Resource
    Endokarditis-Prophylaxe 1998 – was ist gesichert (1998)
    Springer
    Zeitschrift für Kardiologie 87 (1998), S. 663-666 
    Details
    ISSN: 1435-1285
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003920050224
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  • 10
    Electronic Resource
    Electronic Resource
    Experimental evidence that polyoma-specific tumour antigen is a virus-coded protein (1975)
    [s.l.] : Nature Publishing Group
    Nature 258 (1975), S. 756-758 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] PV DNA I was used as template for the Escherichia coli DNA-dependent RNA polymerase. After transcription viral DNA was thoroughly removed by exhaustive DNase treatment (M.G. and A.G., unpublished). To prevent any contamination with viral DNA, the cRNA preparation was then centrifuged to equilibrium ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/258756a0
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