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  • 1
    ISSN: 1435-1463
    Keywords: 5-hydroxytryptamine ; pharmacokinetic analysis ; in vivo ; cats ; half-life ; elimination rate constant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The kinetics of 5-hydroxytryptamine (5-HT) release into the portal system after efferent electrical vagal stimulation were studied in anin vivo model. Blood samples were drawn from cats before, during and after vagal nerve stimulation, and portal plasma levels of 5-HT were measured. Portal plasma concentration of 5-HT rose during stimulation. After termination of stimulation, the plasma levels returned to steady state values and were used to calculate half-life and elimination rate constant. When pharmacokinetic principles were applied, the plasma half-life (T1/2) was determined to be 1.32 min and the elimination rate constant (kE), 0.5246 min−1. Pharmacokinetic principles also were applied to data from earlierin vitro studies using exogenously administered 5-HT, and a half-life of 1.03 min and a kE of 0.67 min−1 were calculated. Therefore, it appears that exogenously administered 5-HT and neurogenically released endogenous 5-HT are metabolized at a similar rate, both having a short half-life.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dog gastric mucosa was incubated with histamine, IMX and db-cAMP, and the tissue was analyzed for cAMP content and cAMP-dependent protein kinase activity. Results show that in the absence of IMX, histamine does not produce measurable changes in either cAMP content or protein kinase activity ratios. In the presence of 5×10−5 mol/I IMX histamine elicits a dose-dependent accumulation of cAMP, and this accumulation is reflected in elevated protein kinase activity ratios. When IMX concentration is increased to 5×10−4 mol/l, the histamine effect is more pronounced. Incubation of gastric mucosa with 10−6 mol/l db-cAMP results in elevated cAMP tissue levels both in the absence and presence of IMX, but protein kinase activity ratio is significantly elevated only in the presence of 5×10−4 mol/l IMX. It is concluded that histamlen stimulates cAMP formation and protein kinase activation in dog gastric mucosa, but elevations are detectable only when the phosphodiesterase enzyme is inhibited.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Hernia 4 (2000), S. 184-186 
    ISSN: 1248-9204
    Keywords: Hernia ; Prosthetic mesh ; Foreign body tumorigenesis ; Prolonged postoperative wound pain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The omnipresence of prosthetic materials (mesh) used in hernia repairs throughout the world deserves careful review. The propensity to develop operative techniques wherein prosthetic mesh is used routinely, regardless of type hernia, has reached an unacceptable level of practice. Being foreign bodies, postoperative complications occur which directly can be traced to the implanted meshes. Recent interest in mesh complications, i.e., infection, mesh shrinkage, migration and fistula formation, has escalated. Although mesh foreign body tumorigenesis has not been seen in humans following hernia repair, there is sufficient animal data to cause concern. Similarly, neural complications following use of mesh, particularly after the open anterior notension repair methods, are being reported at alarming rates. Many types of inguinal hernias do not need mesh repairs. It is our premise that these hernias must be identified preoperatively. Certainly, type I, II and III C inguinal hernias of our classification, should not receive a prosthetic mesh repair. If prosthetic mesh is to be used, it should be placed to buttress the inguinal wall posteriorly so that advantage of Pascal's law may be assured.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Hernia 2 (1998), S. 1-5 
    ISSN: 1248-9204
    Keywords: Hernia ; Prosthetic mesh ; Posterior inguinal wall ; Hernia types
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A historical review is presented of progress in the approach to the diagnosis and treatment of groin hernias during the years 1948–1998. This time frame includes many advances important to the improvement of our patient care for this very common entity. Four areas of especial interest were selected for review, including: 1. Importance of the posterior inguinal wall; 2. Fundamental changes in our use of prosthetic mesh, type and technique; 3. Individualization of hernia repair and 4. An appraisal of operative approaches and techniques extant at the end of the second millennium.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Surgical endoscopy and other interventional techniques 7 (1993), S. 524-528 
    ISSN: 1432-2218
    Keywords: Gastroesophageal reflux ; Endoscopic ; Sclerosis ; Ultrasound ; Fibrosis ; Cardia ; Therapeutic endoscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have previously reported that endoscopic sclerosis of the gastric cardia is an effective treatment for experimental gastroesophageal reflux in dogs. The histologic effect of endoscopic sclerosis is limited to the proximal stomach; mucosal deformity provides endoscopic evidence of sclerosis, and the intramural effects are shown by ultrasonographic technique. This report describes histologic and ultrasonographic results in the dogs at the completion of endoscopic sclerosis. This report also describes the endoscopic ultrasound results in the first two patients who have completed endoscopic treatment for reflux by means of endoscopic sclerosis of the gastric cardia. All canine and human subjects had sonodense lesions involving all layers of the proximal stomach at the injection site at the conclusion of treatment. Histologic examination of canine tissues showed dense submucosal and muscularis fibrosis in the stomach; the esophagus was normal. Endoscopic ultrasound demonstrates the effect of endoscopic sclerosis; this technique may be useful in the evaluation of symptomatic responses after this treatment.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2218
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 334 (1973), S. 31-32 
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 308 (1964), S. 756-760 
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Eine kontrollierbare Fistel wurde beim Hund angelegt. Diese Fistel eignet sich sehr gut, um funktionelle oder organische Vorgänge in den extrahepatischen Gallengängen verfolgen zu können. Es wurden rostfreie Stahlkugeln in die Gallenblase gesetzt und von den Tieren in wöchentlichen Abständen Röntgenaufnahmen (Cholangiographie) verfertigt. Alle Fremdkörper (imitierte Steine) sind spontan abgegangen. Die Gallengänge haben sich deutlich erweitert. Obzwar dieses Experiment ein “subakutes” war und die experimentellen Erfahrungen nur mit Einschränkung auf den Menschen bezogen werden können, glauben wir, daß sich doch einige Erkenntnisse übertragen lassen.
    Type of Medium: Electronic Resource
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