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  • 1
    Electronic Resource
    Electronic Resource
    OPTIMAL STAGING PROCEDURES, INCLUDING IMAGING, TO DEFINE PROGNOSIS OF BLADDER CANCER (1995)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of urology 2 (1995), S. 0 
    Details
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1442-2042.1995.tb00474.x
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  • 2
    Electronic Resource
    Electronic Resource
    Immunolocalization of oestrogen and progesterone receptors in prostatic hyperplasia and carcinoma (1996)
    Oxford, U.K. and Cambridge, USA : Blackwell Science
    Histopathology 28 (1996), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Oestrogen receptors and progesterone receptors were immunolocalized in 19 patients with benign prostatic hyperplasia and in 26 patients with prostatic carcinoma. Immunohistochemistry was performed on tissue that had been fixed in 8% paraformaldehyde and then paraffin-embedded, using microwave irradiation for antigen retrieval. Oestrogen receptor expression was observed exclusively in the stromal cells of six out of 26 (23%) patients with prostatic carcinoma, but in none of the cells of patients with benign prostatic hyperplasia. Progesterone receptor expression was detected in 16 of 19 (84%) and 17 of 19 (89%) of the epithelial cells and stromal cells of patients with benign prostatic hyperplasia, respectively. In patients with prostatic carcinoma, progesterone receptor immunoreactivity was observed in 12 of 20 (46%) and 20 of 26 (77%) of the carcinoma and stromal cells of prostatic carcinoma, respectively. The ratio of epithelial cells with progesterone receptor immunoreactivity corresponded well with that of stromal cells with immunoreactivity in patients with benign prostatic hyperplasia. However, the ratio of stromal cells with progesterone receptor immunoreactivity was much higher than that in carcinoma cells in patients with prostatic carcinoma. Immunolocalization patterns or the ratio of the cells with progesterone receptor immunoreactivity did not significantly correlate with histological differentiation or patient’s age in carcinoma cases. However, patients with advanced surgical stages of disease demonstrated a significantly smaller number of carcinoma and stromal cells with progesterone immunoreactivity in patients with prostatic carcinoma. These results suggest that oestrogens do not have a direct effect on the biological behaviour of benign prostatic hyperplasia and prostatic carcinoma, but that progesterone appears to play a role in the pathogenesis of benign prostatic hyperplasia and prostatic carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.1996.280326.x
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  • 3
    Electronic Resource
    Electronic Resource
    Expression of the SART1 tumor rejection antigen in renal cell carcinoma (2000)
    Springer
    Urological research 28 (2000), S. 178-184 
    Details
    ISSN: 1434-0879
    Keywords: Key words SART1 antigen ; Renal cell carcinoma ; Cytotoxic T lymphocyte ; Immunotherapy ; Cancer vaccine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have previously described the SART1 gene, which encodes both the SART1259 antigen expressed in the cytosol of the majority of squamous cell carcinomas and some adenocarcinomas and the SART1800 antigen expressed in the nucleus of the majority of proliferating cells. The SART1259 antigen is recognized by HLA-A24 and A26-restricted cytotoxic T lymphocytes (CTLs). The present study investigated the expression of these two antigens in renal cell carcinomas (RCCs) in order to identify an appropriate molecule for use in specific immunotherapy for RCC patients. These two antigens were detected in all RCC cell lines and cells of the primary cultures of the RCCs tested. Further, they were detectable in cells of the primary cultures of non-tumorous kidney tissues. In contrast to these cultured cells, SART1259 was detectable in only a few uncultured RCC tissues (5/20, 25%) and was undetectable in non-tumorous kidney tissues. SART1800 was also scarcely detectable in uncultured RCC tissues (3/20, 15%) and non-tumorous kidney tissues (4/20, 20%). HLA-A2402-restricted and tumor-specific CTL (KE4-CTL) used for the cloning of the SART1 gene showed significant levels of cytotoxicity to both the cells from the RCC cell line and the cells from the primary cultures of RCC tissues, but did not lyse any normal cells, including cells from the primary cultures of non-tumorous kidney tissues. The SART1-derived peptide at positions 690–698 induced HLA-A24 restricted CTLs cytotoxic to RCC cells from peripheral blood mononuclear cells (PBMCs) of RCC patients. Therefore, the SART1 peptide could be an appropriate molecule for use in peptide-based specific immunotherapy for RCC patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002400000103
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  • 4
    Electronic Resource
    Electronic Resource
    Bacterial infection and acid mucopolysaccharides in epithelium of rat urinary bladder (1982)
    Springer
    Urological research 10 (1982), S. 93-96 
    Details
    ISSN: 1434-0879
    Keywords: Acid mucopolysaccharides ; Bacterial cystitis ; Glycosaminoglycans ; Rat urinary bladder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distribution of acid mucopolysaccharides in bladder epithelium was studied by colloidal iron staining in experimental cystitis of rats. In normal bladders the staining was mainly confined to the superficial (luminal) layer, but observed uniformly in all layers of epithelium in cystitis. Enzyme digestion (hyaluronidase, heparitinase, chondroitinase AC, chondroitinase ABC) disclosed the existence of hyaluronic acid, heparan sulphate and dermatan sulphate in the bladder epithelium. The possible roles of these mucopolysaccharides glycosaminogycans) were discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262410
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  • 5
    Electronic Resource
    Electronic Resource
    Computed tomography and composition of renal calculi (1984)
    Springer
    Urological research 12 (1984), S. 111-113 
    Details
    ISSN: 1434-0879
    Keywords: Computed tomography ; Attenuation value ; Composition of renal calculi ; In vitro
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The attenuation values of computed tomography were studied in 50 recovered renal calculi of more than 10 mm in diameter, in the hope of determining the composition of calculi in situ. The attenuation value of various calculi (mean±s.d.) in a 5 mm slice with a maximal rectangular region of interest was as follow (Hounsfield units); mixed calcium oxalate and phosphate 1,555±193 (n=22), magnesium ammonium phosphate 1,285±284 (n=18), calcium oxalate 1,690 (n=1), calcium phosphate 1,400 (n=2), cystine 757±114 (n=5) and uric acid 480 (n=2). Attenuation values ranging from 500 to 1,600 overlapped for various calculi, except those composed of uric acid calculi. There was no correlation between the attenuation value and the mineral content such as calcium or magnesium per unit weight of calculus. The mineral content per unit volume seemed to be attributable to the attenuation value. From the present results we conclude that the determination of calculous composition by the attenuation value is possible only for oxalate calculi of more than 1,600 and uric acid calculi of less than 500 attenuation value, provided that the proper CT slice location, the region of interest and the appropriate calculus size can be determined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257175
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  • 6
    Electronic Resource
    Electronic Resource
    Endoscopic observation for detection and monitoring ofN-butyl-N-(4-hydroxybutyl)nitrosamine — induced bladder tumor in rats (1997)
    Springer
    Urological research 25 (1997), S. 183-186 
    Details
    ISSN: 1434-0879
    Keywords: BBN ; Bladder tumor ; Rat ; Endoscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recent advances in tumor carbohydrate biochemistry have demonstrated antitumor effects of locally administered GM3 ganglioside on mouse MBT-2 tumor. When intravesical therapy inN-butyl-N(4-hydroxybu-tyl)nitrosamine (BBN)-induced rat bladder tumor is attempted, it is essential to identify the tumor, to classify its size before therapy and to monitor the effect of the therapy. To establish a more reliable experimental therapeutic system, we assessed the development of BBN-induced rat bladder tumor by endoscopic observation. BBN-induced bladder tumors in rats were observed serially using a 4.2-F flexible fiberscope. The endoscopic findings were compared with the histopathological findings. Intravesical tumor growth varied greatly between individual rats. The smallest change detected by endoscopy was a small edematous lesion histologically proved to be papilloma. The largest nodular lesion was determined to be a papillary, transitional cell carcinoma. This noninvasive method makes the BBN rat experimental system more reliable by allowing confirmation of tumor formation and classification of the tumor volume prior to therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00941980
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  • 7
    Electronic Resource
    Electronic Resource
    Anti-miss-shot control device for selective stone disintegration in extracorporeal shock wave lithotripsy (1991)
    Springer
    Shock waves 1 (1991), S. 145-148 
    Details
    ISSN: 1432-2153
    Keywords: ESWL ; Shock wave ; Anti-miss-shot device ; Tissue injury
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics , Technology
    Notes: Abstract A new device to prevent erroneously focused shock waves to the renal parenchyma during extracorporeal shock wave lithotripsy (ESWL) has been developed; an anti-miss-shot control device (AMCD) and experiments have been conducted to evaluate its effectiveness. For shock wave generation and stone localization, piezoceramic elements (PSE) and ultrasound localization, respectively were used. After stone localization, probing ultrasounds (PU) were emmitted from the PSE towards the focal region and the reflected sound levels (RSL) were monitored by the PSE which also functioned as a microphone. A direct hit by the PU to the stone or a miss was judged from the RSL, i.e. a high RSL indicates a direct hit and a low RSL indicates a miss. Shock waves were generated only when the RSL exceeded the level which indicated a direct hit. The experimental results showed that the injury to the renal parenchyma was decreased by using the AMCD. Clinical application of the AMCD is expected to increase the safety of ESWL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01414909
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  • 8
    Electronic Resource
    Electronic Resource
    Bilateral single ectopic ureter: Report of a case (1977)
    Springer
    International urology and nephrology 9 (1977), S. 123-127 
    Details
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An additional case of bilateral single ectopic ureter is described. Embryology, pathological anatomy, clinical features, treatment and prognosis are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02082013
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