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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Women's Studies International Quarterly 4 (1981), S. 283 
    ISSN: 0148-0685
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Sociology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Copenhagen : Munksgaard International Publishers
    Journal of periodontal research 36 (2001), S. 0 
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The pattern of cytokeratin expression has been extensively described in the normal and inflamed periodontium. However, there is no information regarding the pattern of cytokeratin expression in the periodontium which has been reformed following regenerative periodontal surgery. The aim of the present investigation was to evaluate the pattern of cytokeratin expression in the reformed human and monkey periodontium following regenerative and conventional periodontal surgery. In 3 monkeys, acute fenestration-type and chronic intrabony defects were treated with guided tissue regeneration (GTR), enamel matrix proteins (EMD), or coronally repositioned flap surgery (control). After a healing period of 5 months, the animals were sacrificed and perfused with 10% buffered formalin for fixation. Specimens containing the defects and surrounding tissues were dissected free, decalcified in EDTA and embedded in paraffin. Histological sections were cut with the microtome set at 3 μm. The sections were alternatively stained either with hematoxylin and eosin, or immunohistochemically by using one of the broad range monoclonal antibodies 34βE12 (for cytokeratins 1, 5, 10 and 14) or KL1 (for cytokeratins 1, 2, 5, 6, 7, 8, 10, 11, 16 and 19), or one of the individual monoclonal antibodies LL025 (for cytokeratin 16), DC 10 (for cytokeratin 18), A53-B/A2 (for cytokeratin 19). Twelve patients, each displaying one deep intrabony defect scheduled for extraction due to advanced periodontitis or prosthetic reasons, were treated as described above. Following a healing period of 6 months, the teeth were extracted together with some of their surrounding soft and hard tissues. The histological and immunohistochemical processing of the human biopsies was identical to that described in monkeys. The results revealed that both the normal non-treated (original) monkey and human junctional epithelium stained strongly with all of the monoclonal antibodies used. The reformed junctional epithelium displayed the same cytokeratin expression pattern as the non-treated junctional epithelium. No differences regarding the cytokeratin expression pattern of the junctional epithelium were found between the treatments and types of healing (i.e. regenerative, through a new periodontal ligament, or reparative through a long junctional epithelium). In the intact periodontal ligament, the epithelial rests of Malassez displayed a comparable cytokeratin expression pattern to that of the junctional epithelium. However, no expression of cytokeratins was seen in the newly formed periodontal ligament. In such specimens, cytokeratin expression was observed only until the
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    HNO 47 (1999), S. 202-203 
    ISSN: 1433-0458
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1433-0458
    Keywords: Schlüsselwörter ; Nasenrachenkarzinom ; Epstein-Barr-Virus ; Immunhistologie ; Polymerasekettenreaktion ; Keywords ; Nasopharyngeal carcinoma ; Epstein-Barr virus ; Immunohistochemistry ; Polymerase chain reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract We report the case of a 36-year-old women who was found to have a malignant tumor extending from the side of her right nasal cavity to the nasopharynx. Magnetic resonance imaging and computed tomography were not able to define the primary site of the tumor. Histologic evaluation demonstrated an undifferentiated squamous cell carcinoma. Because of the different treatment concepts for carcinomas of the nasal cavity and nasopharynx, we tried to identify the primary site by diagnosing Epstein-Barr virus (EBV) infection, which is associated with carcinoma of the nasopharynx. By using immunohistochemistry and polymerase chain reaction EBV could be identified in the cells of the carcinoma. This showed that the primary site of the tumor was located in the nasopharynx and resulted in the patient being treated with simultaneous radiochemotherapy.
    Notes: Zusammenfassung Eine 36 Jahre alte Patientin stellte sich mit einem ausgedehnten Tumor der rechten Nasenhöhle und des rechten Nasenrachens vor. Die histologische Untersuchung ergab ein undifferenziertes Plattenepithelkarzinom. Sowohl mit Hilfe der computertomographischen, als auch der kernspintomographischen Befunde, war keine eindeutige Bestimmung der Primärtumorregion möglich. Anhand der bekannten Assoziation zwischen Karzinomen des Nasenrachens und Epstein-Barr Virus (EBV) wurde versucht, die Primärlokalisation des Tumors zu klären. Immunhistologisch und durch „polymerase chain reaction” war es möglich, eine EBV-Infektion im Tumor nachzuweisen. Die Primärlokalisation des Tumors wurde damit dem Nasenrachen zugeordnet und die entsprechende Therapie für diese Lokalisation in Form einer simultanen Radiochemotherapie eingeleitet.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    HNO 46 (1998), S. 993-997 
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Pseudotumor ; Orbita ; Kalzifikation ; Therapie ; Key words Orbital calcification ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Orbital pseudotumor can be divided histopathologically into three basic types: lymphoid, granulomatous and sclerosing. Chronic lymphoid and granulomatous types may eventually transform into the sclerosing type. The calcifying orbital pseudotumor is a very rare disorder due to a chronic, idiopathic inflammatory process of the orbit. The granulomatous type shows a good response to steroids while radiotherapy is the method of choice for lymphoid lesions. In general, calcifying pseudotumors can be treated only by operative exploration and tumor removal. We report a patient with a calcifying pseudotumor of the orbital apex that was removed through an endonasal approach. Preoperative diagnostic procedures and differential diagnosis are discussed.
    Notes: Zusammenfassung Die Pseudotumoren der Orbita werden histologisch in 3 Gruppen unterteilt: der lymphoide, granulomatöse und sklerosierende Typ. Es ist bekannt, daß lymphoide und granulomatöse Differenzierungsformen bei chronischem Verlauf in die sklerosierende Form übergehen können. Der kalzifizierende Pseudotumor orbitae ist ein sehr seltenes Krankheitsbild, das eine besondere Form chronischer, idiopathischer und entzündlicher Prozesse der Augenhöhle darstellt. Die Diagnose und Abgrenzung von echten Tumoren der Oribita kann nur durch eine Probeexzision erreicht werden. Therapeutisch spricht die granulomatöse Tumorform gut auf die Gabe von Kortikosteroiden an, wohingegen bei der lymphoiden Differenzierung die Radiatio als Therapie der Wahl gilt. Die kalzifizierenden Pseudotumoren können demgegenüber nur operativ im Sinne einer Tumorentfernung therapiert werden, da sie auf eine Radiatio und Kortikosteroidgabe nicht ansprechen. Es wird von einem Patienten mit einem kalzifizierenden Pseudotumor der Orbitaspitze berichtet, der über einen endonasalen Zugang entfernt werden konnte. Präoperative diagnostische Maßnahmen und die Differentialdiagnose werden diskutiert.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Hyper-IgE-Syndrom ; Hiob-Syndrom ; Buckley-Syndrom ; Intravenöse Immunglobulintherapie ; Zungengrundhyperplasie ; Key words Hyper immunoglobulin E syndrome ; Job’s syndrome ; Buckley syndrome ; Intravenous immunoglobuline therapy ; Lymphatic hyperplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Hyperimmunoglobulin E syndrome (Hiob syndrome or Buckley syndrome) is a rare disorder of the immune system that can show characteristic manifestations in the head and neck. Typical symptoms are fever, recurrent urticarial rashes, lymphadenitis, and bacterial infections of the skin and various parenchymatous organs. Diagnosis is established by elevated serum IgE concentrations with the absence of any signs of allergy or parasitic disease. We present our clinical experiences in managing of a 29-year old woman whose hyper IgE syndrome was diagnosed initially during of the treatment of lymphatic hyperplasia of the base of the tongue although she had typical symptoms of hyper IgE syndrome for some years. High-dose intravenous immunoglobulin therapy (IVIG) was found to be well-tolerated and effective. More than one year after a single course of immunoglobin therapy symptoms markedly improved. Current knowledge and therapeutic options in hyper IgE syndrome are discussed. We recommend that IVIG be considered as one of the first choices in the treatment of hyper IgE syndrome.
    Notes: Zusammenfassung Das Hyperimmunglobulin-E-Syndrom (Job’s Syndrom, Hiob-Syndrom, Buckley-Syndrom) ist eine seltene Erkrankung des Immunsystems, die im HNO-Bereich charakteristische Manifestationen zeigen kann. Das Krankheitsbild ist gekennzeichnet durch rezidivierende urtikarielle Exantheme, Fieber, Lymphadenitis, Hyperplasie lymphatischer Organe und bakteriellen Haut- und Organinfektionen. Diagnostisch richtungsweisend sind stark erhöhte IgE-Konzentrationen im Serum beim gleichzeitigem Fehlen von Hinweisen auf allergische und parasitäre Erkrankungen. In der vorgestellten Kasuistik konnte die Diagnose eines Hyper-IgE-Syndroms trotz mehrjährigen Krankheitsverlaufs erst bei einer HNO-ärztlichen Behandlung wegen einer Zungengrundhyperplasie gestellt werden. Therapeutisch erwies sich eine Behandlung mit hochdosiertem intravenösem Immunglobulin (IVIG) als ausgezeichnet verträglich und gut wirksam. Mehr als ein Jahr nach der einmaligen Therapie ist die Symptomatik anhaltend gebessert. Der derzeitige Kenntnisstand und die zur Verfügung stehenden Therapieoptionen beim Hyper-IgE-Syndrom werden dargestellt und diskutiert. Beim Hyper-IgE-Syndrom sollte ein Therapieversuch mit IVIG eine Option der ersten Wahl darstellen.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Pseudotumor orbitae ; Histopathologie ; Therapie ; Rhinochirurgische Zugänge ; Keywords Pseudotumor orbitae ; Histopathology ; Therapy ; Rhinosurgical approaches
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Orbital pseudotumor is a nonspecific inflammatory process of unknown etiology that can be divided histopathologically into three basic types: granulomatous, lymphoid, and sclerosing. Between 1995 and 1998, 12 patients with pseudotumor orbitae were treated in the ENT Department of the University of Saarland. Histopathological examination showed granulomatous type of pseudotumor in six, lymphoid in three, and sclerosing in three patients. In seven cases the pseudotumor orbitae were medially located and in four cases laterally. In one patient nearly all orbital structures were infiltrated. Diagnostic biopsy was taken endonasally in six cases, via medial orbitotomy in two cases, and via lateral orbitotomy in four cases. Due to their good delimitation lymphoid and sclerosing tumors were extracted completely during diagnostic biopsy and patients were free of complaints after a few weeks. The six patients with granulomatous pseudotumor were treated primarily with steroids after the diagnosis had been definitely confirmed by histology. In three of those six cases a second course of steroid therapy had to be given, with positive results in two cases. Follow-up was between 6 and 28 months (mean 16 months). There were no postoperative complications. The clinical and radiographic presentation of the pseudotumors can vary greatly. Therefore, the differential diagnosis of specific infections or neoplasms can only be established through diagnostic biopsy. Different rhinosurgical approaches provide clear biopsy results and in some cases the pseudotumor is even completely removed.
    Notes: Zusammenfassung Der Pseudotumor der Orbita ist ein unspezifischer entzündlicher Prozess dessen Genese unbekannt ist und der histologisch in 3 Gruppen unterteilt wird: der granulomatöse, lymphoide und sklerosierende Typ. Zwischen 1995 und 1998 haben wir 12 Patienten mit einem Pseudotumor der Orbita behandelt. Es handelte sich dabei um Fälle vom granulomatösen (n=6), lymphoiden (n=3) und sklerosierenden (n=3) Typ. Bei 7 Patienten war der Pseudotumor im medialen Bereich der Orbita und in 4 Fällen im lateralen Bereich lokalisiert. Bei einer Patientin lag eine diffuse Infiltration annähernd aller orbitalen Strukturen vor. Die Probebiopsie wurde in 6 Fällen endonasal, in 2 Fällen über eine mediale Orbitotomie und bei 4 Patienten über eine laterale Orbitotomie durchgeführt. Die gut abgrenzbaren lymphoiden (n=3) und sklerosierenden (n=3) Pseudotumoren konnten im Rahmen der Probebiopsie komplett entfernt werden, so dass die Patienten nach wenigen Wochen beschwerdefrei waren. Bei den 6 Patienten mit einem granulomatösen Pseudotumor wurde nach der definitiven Histologie eine primäre Kortikosteroidtherapie durchgeführt. In 3 der 6 Fälle kam es dadurch zu einem Rückgang der Beschwerden mit kompletter Ausheilung. Bei den restlichen 3 Patienten war eine erneute Kortisontherapie erforderlich wobei diese nur in 2 Fällen erfolgreich war. Der Nachbeobachtungszeitraum betrug 6–28 (Mittel 16) Monate. Postoperative Komplikationen traten nicht auf. Die klinische Symptomatik und die radiologische Darstellung der Pseudotumoren kann sehr variabel sein, so dass nur durch eine Probebiopsie eine genaue Differenzierung von spezifischen Infektionen und malignen Raumforderungen möglich ist. Die rhinochirurgischen Zugänge erlauben eine sichere Biopsie und in einigen Fällen auch eine komplette Entfernung des Pseudotumors.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-0662
    Keywords: Gas-liquid partitioning ; Henry's law ; formic acid ; acetic acid ; ammonia ; S(IV)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences
    Notes: Abstract Experimental data from two field experiments on ground based clouds were used to study the distribution of formic acid, acetic acid, ammonia and S(IV) species between liquid and gas phase. The ratio of the concentrations of these compounds between the phases during concurrent measurements was compared to ratios expected according to Henry's law (considering the pH influence). Large discrepancies of several orders of magnitude were seen. Three hypotheses have been investigated to explain the observed discrepancies: The existence of a microscale equilibrium which does not persist in a bulk sample, a thermodynamic shift of the equilibrium due to competing reactions, and nonequilibrium conditions due to mass transfer limitations. Approximate quantitative calculations show that none of these hypotheses is sufficient to explain all of the discrepancies, so a combination of different effects seems to be responsible for this observation. The same theoretical considerations also suggest that mass transfer limitation may be an important factor for highly soluble compounds. The data presented here indicates that it is not possible to simply extrapolate interstitial gas phase composition from measured bulk liquid phase concentrations of a fog or cloud.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-0662
    Keywords: cloud water deposition ; deposition model ; throughfall ; spruce forest ; ionic deposition ; cloud droplet site
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences
    Notes: Abstract A resistance model to calculate the deposition of cloud droplets on a coniferous forest and some improved parameterizations of the indispensable input parameters are described. The deposition model is adapted to the coniferous forest at the Kleiner Feldberg site and verified by the data of a drip water monitoring station below the forest canopy. The measurements of liqud water content, wind speed and trace substance compounds in cloud water of the Ground-based Cloud Experiment (GCE) at Kleiner Feldberg in 1990 are used to calculate the cloud water deposition fluxes and the deposition of trace substances via cloud water interception. The calculated deposition of trace substances via cloud water interceptions is three to six times higher than via rain during the experiment. On a long term data basis the yearly amount of cloud water deposition is 180 mm year−1 at Kleiner Feldberg site (840 m a.s.l.) while the precipitation amount is 1030 mm year−1. Due to higher trace substance concentrations in cloud water compared to rain the ionic deposition via cloud water interception and via precipitation were assessed to be of comparable magnitude.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1573-0662
    Keywords: orographic clouds ; cloud chemistry and microphysics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences
    Notes: Abstract An overview is given of the Kleiner Feldberg cloud experiment performed from 27 October until 13 November 1990. The experiment was carried out by numerous European research groups as a joint effort within the EUROTRAC-GCE project in order to study the interaction of cloud droplets with atmospheric trace constituents. After a description of the observational site and the measurements which were performed, the general cloud formation mechanisms encountered during the experiment are discussed. Special attention is given here to the process of moist adiabatic lifting. Furthermore, an overview is given regarding the pollutant levels in the gas phase, the particulate and the liquid phase, and some major findings are presented with respect to the experimental objectives. Finally, a first comparison attempts to put the results obtained during this campaign into perspective with the previous GCE field campaign in the Po Valley.
    Type of Medium: Electronic Resource
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