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  • 1
    Electronic Resource
    Electronic Resource
    Production of insulin-like growth factor I (IGF-I) and IGF-binding proteins by rat intestinal stromal cells in vitro (1998)
    Springer
    Cellular and molecular life sciences 54 (1998), S. 158-166 
    Details
    ISSN: 1420-9071
    Keywords: Key words. Insulin-like growth factors; IGFs; IGFBP; stroma; epithelium; stromal-epithelial interactions.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. To determine if intestinal stromal cells secrete diffusible factors such as insulin-like growth factors (IGFs) capable of regulating epithelial cell growth in vitro, stromal cells were isolated by enzymatic digestion of rat intestine. Incorporation of [3H]thymidine into DNA and [14C]leucine into protein of IEC-6 cells, a model intestinal epithelial cell line, was significantly increased (two- to threefold) when the IEC-6 cells were co-cultured with stromal cells, relative to IEC-6 cells grown alone. Medium conditioned by stromal cells stimulated DNA synthesis of IEC-6 cells in a dose-dependent manner. Analysis of the conditioned medium revealed that intestinal stromal cells secreted IGF-I, but little IGF-II, in addition to an M r 32,000 IGF-binding protein (IGFBP-2) and an IGFBP having M r∼ 24,000. We conclude that rat intestinal stromal cells secrete one or more diffusible factors, which may include IGF-I and IGFBPs, capable of stimulating proliferation of IEC-6 cells in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000180050137
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  • 2
    Electronic Resource
    Electronic Resource
    Combined hepatocellular and cholangiocarcinoma of the liver: Sonography, CT, Angiography, and Iodized-Oil CT with pathologic correlation (1994)
    Springer
    Abdominal imaging 19 (1994), S. 43-46 
    Details
    ISSN: 1432-0509
    Keywords: Liver, neoplasms ; Sonography ; Angiography ; Computed tomography ; Oily contrast media
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the characteristics of combined hepatocellular and cholangiocarcinoma of the liver by imaging techniques, six patients (five male and one female), aged 46–60 years, with proved combined tumors were selected for this study from the review of 500 resected specimens of liver tumors. Images obtained from sonography, computed tomography (CT), angiography, and CT after intraarterial injection of iodized oil (iodized-oil CT) were retrospectively reviewed and correlated with the appearance of pathologic specimens. Sonographic findings were round or ovoid hypoechoic masses with central hyperechoic area (target appearance) in all patients. On CT scans, tumors were relatively well-defined low- and/or iso-attenuation masses in all patients. Angiography showed hypovascular masses in five patients. In one patient, the tumor appeared as a hypovascular mass with a central hypervascular area. On iodized-oil CT scans, all patients showed partial retention of iodized oil in tumors. Echogenicity in tumors at sonography or attenuation in tumors at CT could not be correlated with histologic difference in tumors at pathologic specimens. However, the hypervascular area at angiography and the compact retention areas of iodized oil at iodized-oil CT corresponded to portions of hepatocellular carcinoma within the combined tumor. On the basis of our results, imaging features, including target appearance at sonography, hypovascular mass with central hypervascular portions at angiography, and partial retention of iodized oil in tumors at iodized-oil CT, might be helpful in making accurate diagnosis of these rare tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02165860
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  • 3
    Electronic Resource
    Electronic Resource
    Focal hepatic nodules after transcatheter oily chemoembolization; detection with spiral CT versus conventional CT (1996)
    Springer
    Abdominal imaging 21 (1996), S. 33-36 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Liver〈+〉—〈+〉CT〈+〉—〈+〉Neoplasms〈+〉—〈+〉Diagnosis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: The objective of this study was to determine if spiral computed tomography (CT) results in increased rate of detection of focal hepatic nodules containing iodized oil after transcatheter oily chemoembolization when compared with conventional CT. Methods: Spiral CT with single 24-s breath-hold technique was compared with conventional sequential CT in 42 patients with suspected hepatocellular carcinomas. Two sets of CT scans obtained after transcatheter oily chemoembolization were independently reviewed by two radiologists. The slice thickness was 10 mm for both data sets. The number and sizes of focal hepatic nodules containing iodized oil were documented. All 42 patients had at least one hepatic nodule. The lesion size varied from 2 mm to 12 cm. Results: In six of the 42 patients, more hepatic nodules could be identified on spiral CT compared with conventional CT. When scans with spiral CT were used, 107 nodules were detected, whereas 98 nodules were detected with conventional CT. Overall, nine (9%) more nodules were detected with spiral CT (〈+〉p= .002). If lesions larger than 2 cm are excluded, nine (15%) more lesions were detected with spiral CT (〈+〉p= .002). Conclusion: Spiral CT results in increased rate of detection of focal hepatic nodules after transcatheter oily chemoembolization, particularly in lesions smaller than 2 cm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900005
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  • 4
    Electronic Resource
    Electronic Resource
    Iodized-oil retention within hepatic hemangioma:characteristics on iodized-oil CT (1996)
    Springer
    Abdominal imaging 21 (1996), S. 420-426 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Angioma, gastrointestinal tract—Contrast media, fatty acid—Computed tomography.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective: The purpose of this study was to describe the characteristic computed tomographic (CT) appearance of iodized-oil retention in hepatic hemangioma and to evaluate the duration of the retention of iodized oil on follow-up CT. Methods: Seventeen hepatic hemangiomas of 14 patients were studied with CT performed 1–3 weeks after injection of 2–9 ml of iodized oil (iodized-oil CT) for the characterization of focal hepatic lesions, which needed differential diagnosis with hepatocellular carcinoma in 10 patients, for therapy in two patients, and for chemoembolization therapy of accompanying hepatocellular carcinomas in two. Twelve patients had 1–7 follow-up CT scans within an interval of 1–38 months. Results: In all cases, iodized-oil CT showed iodized-oil retention within the tumor, regardless of tumor size, shape, location, and amount of injected iodized oil. The distribution was incomplete and predominantly peripheral in all cases. Central retention was also seen in seven cases, in which a relatively large amount of iodized oil was injected, but retention of iodized oil in the tumor was incomplete even in two cases in which a large amount of iodized oil was injected to relieve symptoms and in three cases in which prominent uptake of surrounding liver parenchyma was seen. Patterns of retention were predominantly spotty in five, predominantly nodular in four, and mixed in eight patients. Retention materials slowly washed out but persisted for at least 3 months and up to 38 months (mean = 18.1 months), and complete washout was not seen in any cases at follow-up CT. Conclusion: In all cases of hepatic hemangiomas, iodized oil was retained, and retention persisted over several months. Distribution and patterns of retention were characteristically peripheral, spotty, and nodular at iodized-oil CT. Knowledge of the iodized-oil CT appearance of hepatic hemangioma would be helpful to interpret follow-up CT studies of patients who have undergone iodized-oil chemoembolization procedures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900096
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  • 5
    Electronic Resource
    Electronic Resource
    Helical CT anatomy of pancreatic arteries (1996)
    Springer
    Abdominal imaging 21 (1996), S. 517-521 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Pancreas, anatomy—Pancreas, computed tomography—Computed tomography, helical technology.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: To assess the frequency of visualization of pancreatic arteries in the arterial phase of helical computed tomography (CT). Methods: The visibility of pancreatic and peripancreatic arteries in helical CT images was evaluated in 20 consecutive patients who had no evidence of pancreatic disease. CT examinations were performed by using a continuously rotating CT scanner and intravenous injection of contrast media. The scans were taken 35 s after the start of injection and with a table speed of 3 mm/s. Images were reconstructed in 3-mm section increments. Results: Frequently visualized arteries were the gastroduodenal, anterior and posterior superior pancreaticoduodenal, and right gastroepiploic arteries. Infrequently visualized arteries were the dorsal pancreatic, pancreatica magna, caudal pancreatic, transverse pancreatic, and common, anterior, and posterior inferior pancreaticoduodenal arteries. Conclusion: Helical CT enabled us to recognize small pancreatic arteries, and the evaluation of these arteries should be considered in the staging of pancreatic carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900117
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  • 6
    Electronic Resource
    Electronic Resource
    MR findings of hepatic cavernous hemangioma after intraarterial infusion of iodized oil (1994)
    Springer
    Abdominal imaging 19 (1994), S. 507-511 
    Details
    ISSN: 1432-0509
    Keywords: Liver, diseases-Liver, neoplasms Liver, MR studies ; Magnetic resonance (MR) ; Contrast media, iodized oil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Magnetic resonance (MR) imaging was performed on five tumors of three patients who had hepatic hemangiomas. Four tumors were given an intraarterial infusion of 3–8 ml of iodized oil, while one tumor was not. MR images were obtained at 2.0 or 0.5 T. A single spin echo sequence with TE of 30 ms and TR of 500 ms and a double echo sequence with TEs of 60 and 150 ms and TR of 2000 ms, were used to produce relatively T1-, T2-weighted, and heavily T2-weighted images, respectively. Follow-up MR imaging was done 1–5 months after infusion of iodized oil. On relatively T1 weighted images, hemangiomas showed iso or hypointensity. On T2-weighted images, all tumors showed hyperintensity. However, on heavily T2-weighted images, tumors with iodized oil showed heterogeneous, slight hyperintensity, while tumors without iodized oil showed characteristic appearance of marked hyperintensity in hemangiomas. In hepatic cavernous hemangiomas with intraarterial infusion of iodized oil, familiarity with this unusual MR intensity of tumors on heavily T2-weighted images is useful to avoid the incorrect diagnosis and to reduce the frequency of inappropriate hepatic resection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00198251
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  • 7
    Electronic Resource
    Electronic Resource
    Analysis of cracks in aging aircraft structures, with and without composite-patch repairs (1992)
    Springer
    Computational mechanics 10 (1992), S. 169-201 
    Details
    ISSN: 1432-0924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract In this paper, the problems of composite-patch repair of (i) center and edge-cracked panels loaded in the far-field; and (ii) cracks emanating from pin-loaded fastener holes, are examined in thorough detail. The effects of various non-dimensional design parameters on the reduction in the stress-intensity factors near the crack-tip are determined, and are presented in the form of design charts. Both analytical and numerical methods are employed in this study. In the analytical method, the cracked metallic plate was considered to be infinitely large, and the composite patch was modeled as a long orthotropic strip of finite height (in the direction perpendicular to the crack axis). Next, by using the Finite Element Alternating Method (FEAM), a more general analysis capability that can treat arbitrary shapes of the cracked metallic sheet, as well as of the composite patches, is developed. This general FEAM is applied to: (i) composite patch repairs of cracks emanating from loaded fastener holes (the MSD problem); (ii) composite patch repairs of semi-elliptical surface flaws in thick plates; and (iii) composite patch repairs of quarter-elliptical surface flaws emanating from fastener holes. Problem (i) is two-dimensional in nature while problems (ii) and (iii) are fully three-dimensional. In all these cases, the effects of various design parameters on the crack-tip (front) stress-intensity factors are fully discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00370088
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  • 8
    Electronic Resource
    Electronic Resource
    Crystallization and preliminary X-ray crystallographic analysis of DNA polymerase from Thermus aquaticus (1995)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 51 (1995), S. 1086-1088 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Two crystal forms of DNA polymerase from Thermus aquaticus have been grown at room temperature. Rhombohedral crystals (form I) grown from ammonium sulfate solution diffracted poorly to 10 Å only and thus are not suitable for X-ray structure determination. Trigonal crystals (form II) grown from polyethylene glycol solution are more suitable for structure determination since their diffraction pattern extends to 2.5 Å at cryogenic temperature upon exposure to synchrotron X-rays. They belong to space group P3121 (or its enantiomorph P3221) and their unit-cell dimensions are a = 106.7 and c = 169.7 Å,̃ for flash-frozen crystals. The presence of one molecule per asymmetric unit gives a crystal volume per protein mass (VM) of 3.0 Å3 Da−l and a solvent content of 58% by volume. X-ray data have been collected to 2.7 Å Bragg spacing from native crystals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444995003386
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Characteristics of thermostable pullulanase from Bacillus stearothermophilus and the nucleotide sequence of the gene
    Amsterdam : Elsevier
    Journal of Fermentation and Bioengineering 69 (1990), S. 204-210 
    Details
    ISSN: 0922-338X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0922-338X(90)90213-G
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  • 10
    Electronic Resource
    Electronic Resource
    Raman studies on single-phasic HgBa"2CuO"4"+"δ superconductors
    Amsterdam : Elsevier
    Physica C: Superconductivity and its applications 218 (1993), S. 365-368 
    Details
    ISSN: 0921-4534
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0921-4534(93)90037-Q
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