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  • 1
    Digitale Medien
    Digitale Medien
    THE EFFECT OF NORADRENALINE INFUSION ON THE RELATION BETWEEN PULMONARY VENTILATION AND THE ALVEOLAR Po2 AND Pco2, IN MAN (1963)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 109 (1963), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1963.tb13504.x
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  • 2
    Digitale Medien
    Digitale Medien
    A previously unidentified MECP2 open reading frame defines a new protein isoform relevant to Rett syndrome (2004)
    [s.l.] : Nature Publishing Group
    Nature genetics 36 (2004), S. 339-341 
    Details
    ISSN: 1546-1718
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Medizin
    Notizen: [Auszug] Rett syndrome is caused by mutations in the gene MECP2 in ∼80% of affected individuals. We describe a previously unknown MeCP2 isoform. Mutations unique to this isoform and the absence, until now, of identified mutations specific to the previously recognized protein indicate an important role ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/ng1327
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  • 3
    facet.materialart.
    Unbekannt
    A Reconsideration of the Fall of Eve (1975)
    Paris : Periodicals Archive Online (PAO)
    Etudes anglaises. 28:1 (1975:janv./mars) 15 
    Details
    ISSN: 0014-195X
    Thema: Anglistik, Amerikanistik
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0132-1975-028-01-000002
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  • 4
    Digitale Medien
    Digitale Medien
    Effects of the polychlorinated biphenyl Aroclor® 1254 on the American oyster Crassostrea virginica (1972)
    Springer
    Marine biology 17 (1972), S. 209-214 
    Details
    ISSN: 1432-1793
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Young oysters (Crassostrea virginica) were continuously exposed to Aroclor® 1254, a polychlorinated biphenyl (PCB), in flowing, unfiltered seawater. Growth rate (height and in-water weight) was significantly reduced (α=0.05) in oysters exposed to 5 μg/l (ppb) for 24 weeks. Growth rate was not affected in oysters exposed to 1 ppb for 30 weeks. Mortality was not significant in exposed and control groups. In oysters exposed to 5 ppb, greatest PCB residue (whole body) was 425 mg/kg (ppm), 85,000x the concentration in the water, and less than 0.3 ppm was retained after 28 weeks depuration in PCB-free water. In oysters exposed to 1 ppb, greatest residue was 101 ppm, 101,000x the concentration in the water, and less than 0.2 ppm was retained after 12 weeks depuration. Examination of oysters exposed to 5 ppb of this PCB for pathogenesis revealed atrophy of digestive diverticular epithelium and degeneration of vesicular connective tissues concomitant with leukocytic infiltration, but tissue recovery seemed excellent after 12 weeks depuration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00366295
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  • 5
    Digitale Medien
    Digitale Medien
    Changes in body fat and muscle in manual workers at and after retirement (1982)
    Springer
    European journal of applied physiology 49 (1982), S. 187-196 
    Details
    ISSN: 1439-6327
    Schlagwort(e): Anthropometry ; Retirement ; Muscles ; Adipose tissue ; Aged
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The changes in body fat and muscle in 73 men retiring from manual work have been measured in a longitudinal anthropometric study. Body fat increased by about 3% and body muscle decreased by about 1% between measurements made just before retirement and again 1 year later. The decline in muscle was even greater in a subgroup of 22 men who reported that their activity was less after retirement: but a subgroup of 11 whose activity was said to have been greater after retirement showed an increase in body muscle. A sub-sample of 26 men were measured on five further annual occasions (Fig. 1). The initial increase in body fat was reversed, and fat measurements fell back significantly to or below the pre-retirement values. Body muscle, however, continued to decline steadily at the initial rate, and the ratio of thigh muscle area to body mass fell significantly in retirement in the group as a whole. The possible contributions of ageing and of changes in energy balance and physical activity to these findings are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02334067
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  • 6
    Digitale Medien
    Digitale Medien
    An unsupervised “Aerobics” physical training programme in middle-aged factory workers: Feasibility, validation and response (1983)
    Springer
    European journal of applied physiology 52 (1983), S. 120-125 
    Details
    ISSN: 1439-6327
    Schlagwort(e): Activities of daily living ; Work ; Physical fitness ; Heart-rate ; Age factors
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary This paper describes a controlled study of the effects of an unsupervised walking-programme in 108 volunteers from among 580 middle-aged employees in a Nottingham light industrial company. Objective measurements of physical condition and of customary activity were made on four occasions at 12-week intervals. The subjects were randomly allocated to three groups and encouraged to follow a walking-programme in the first, second or third periods of the study: no activity was prescribed in the other periods. Compliance with the programme was estimated from log-cards and from a week's pedometer record. Although there were no significant differences between the changes seen in subjects following the walking-programme and those in control subjects, there were significant small improvements in physical condition and modest increases in customary activity in a) those subjects actually completing the programme, and b) the subjects measured before and after their programme, pooled without regard to the period of measurement. At least some of the increased activity is maintained for 12 weeks after the programme. The marginal changes suggest that the intensity of the training-programme as experienced by the subjects was close to the threshold for maintenance of physical condition in this age-group of workers.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00429038
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  • 7
    Digitale Medien
    Digitale Medien
    Factors affecting the heart rate during self-paced walking (1982)
    Springer
    European journal of applied physiology 48 (1982), S. 105-115 
    Details
    ISSN: 1439-6327
    Schlagwort(e): Age ; Body composition ; Exercise test ; Heart rate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The results of 277 self-paced walking tests have been analysed for the effects of body composition, sex and age using step-up multiple regression analysis. Equations are given for the influence of the significant factors on chosen walking speeds and on heart rate (fc) (standardised at 4.8 km·h−1 by interpolation from points recorded at three walking speeds). The basic equations are: Normal speed (km·h−1)=1.72+2.13 stature (m)−0.008 age (years) Fast speed (km·h−1)=0.54+3.69 stature (m)−0.016 age (years) For men: fc4.8 (beat·min−1)=161−50.7 stature (m)+0.223 body weight (kg) For women: fc4.8 (beat·min−1)=161−50.7 stature (m)+0.223 body weight (kg)+4.43 The significant factors affecting freely chosen walking speeds are stature and age. When estimates of body composition are available, percentage fat is found to be the most influential single factor affecting fc, while sex no longer has a significant effect, and age now has a negative influence. When allowance is made for these factors the effects of customary physical activity can be seen more clearly.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00421170
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  • 8
    Digitale Medien
    Digitale Medien
    Validation of a simple mechanical accelerometer (pedometer) for the estimation of walking activity (1987)
    Springer
    European journal of applied physiology 56 (1987), S. 323-330 
    Details
    ISSN: 1439-6327
    Schlagwort(e): Pedometer ; Walking activity ; Accelerometer ; Activities of daily living ; Exertion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A small (28 g) mechanical accelerometer has been tested by subjecting it to controlled bench tests consisting of repetitive vertical oscillations on two designs of test rig. The accelerometer's 3-digit display provided a cumulated score with a maximum of 99.9 units. This score was compared with an independent count of the imposed oscillations and found to be linear with time (r=0.996) and reproducible on retest (coefficient of variation=± 1.5%). The sensitivity ranged from 6.2 to 7.4 units/10,000 oscillations. The response was related to the maximal applied acceleration (calculated from the amplitude and frequency of the oscillations on the assumption that they were sinusoidal) and independent of the amplitude and frequency used. The threshold maximal acceleration was less than 2 m s−2 and the response had reached a plateau at 4 ms−2. During field studies the accelerometer was firmly attached over the hip in a waistband where it responded to the vertical accelerations produced by walking. When compared with an independent count of footsteps from a heel-mounted resistance pad the accelerometer score (after calibration) was not significantly different. The mean difference was (0.29±0.67, S.D.) 103 “steps” in a younger group (n=8, mean age 39 years) and (0.46±1.08, S.D.) 103 “steps” in an older group of women (n=6, mean age 65 years). Scores of around 10×103 “steps” can be expected in a day in moderately active young subjects and 40 × 103 “steps” in a week in the elderly. Simultaneously recorded scores from both right and left hips were not significantly different. In young subjects the mean difference was typically (1.08±0.8) 103 steps in a daily score of 10 × 103 steps and for old subjects (3.5±10.4) 103 steps in a cumulated 6 day score of 40×103 steps. The accelerometer can therefore be used as a pedometer to give an estimate of the number of footsteps taken over long periods.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00690900
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  • 9
    Digitale Medien
    Digitale Medien
    Bronchoconstriction: a component of the ‘diving response’ in man (1984)
    Springer
    European journal of applied physiology 53 (1984), S. 155-158 
    Details
    ISSN: 1439-6327
    Schlagwort(e): Diving ; Apnoea ; Face immersion ; Bronchoconstriction ; Ipratropium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We have investigated the possibility that a bronchoconstriction accompanies the vagally-mediated bradycardia induced in man by immersion of the face in cold water. Forced expiratory flows (FEF) at 40% and 25% of vital capacity (VC) have been measured from partial flow-volume curves obtained during forced expirations starting at 70% VC. These were performed immediately after 15 s apnoea with or without face immersion, and compared with control expirations having the same volume history but without the preceding apnoea. Five of the 10 subjects showed evidence of a greater than 10% reduction in FEF, which averaged 17% (Fig. 2). Half the response was attributable to the apnoea alone and the other half, which was abolished by ipratropium, to cold face immersion (Fig. 3). This bronchoconstriction appears to be a new component of the ‘diving response’ in man, mediated, like the bradycardia, by vagal efferents.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00422579
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