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  • 1
    Electronic Resource
    Electronic Resource
    Urinary D-glucaric acid excretion and acetanilide pharmacokinetics before and during diphenylhydantoin administration (1974)
    Springer
    European journal of clinical pharmacology 7 (1974), S. 387-391 
    Details
    ISSN: 1432-1041
    Keywords: Acetanilide ; diphenylhydantoin ; D-glucaric acid ; induction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of a single-dose acetanilide (AA) test, and the urinary D-glucaric acid output (UDGAO) were studied in healthy drug free volunteer subjects before and at the end of a fourteen-day period of medication with 5 mg diphenylhydantoin sodium (DPH) per kg metabolically active mass, thrice daily. The steady state plasma concentration (SSPC) of DPH was also determined. The SSPC of DPH was found to vary from 3.4 to 19.6 µg per ml. The mean UDGAO values increased significantly during DPH medication from 9.5 µmol per g creatinine to 29.5 (p〈0.002). The half-life of plasma AA concentration decreased significantly during DPH medication from a mean of 4.2 h to a mean of 2.8 (p〈0.001). However, the plasma clearance of AA did not change significantly during DPH medication. The increase of UDGAO whilst on treatment with DPH correlated positively with the SSPC of DPH. The evidence from this study suggests that measurement of UDGAO, which is a measure of the activity of the glucuronic pathway does not necessarily indicate the state of induction of oxidizing enzymes in the hepatic endoplasmic reticulum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558212
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  • 2
    Electronic Resource
    Electronic Resource
    The pharmacokinetics of acetanilide and of diphenylhydantoin sodium (1974)
    Springer
    European journal of clinical pharmacology 7 (1974), S. 461-466 
    Details
    ISSN: 1432-1041
    Keywords: Acetanilide ; oxidation ; diphenylhydantoin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Acetanilide and diphenylhydantoin have a similar first stage biotransformation in that both are oxidized in the para position of the benzene ring incorporated in each of the two molecules. The elimination of acetanilide from the plasma was studied in thirty healthy volunteer subjects following a single oral dose of 50 mg per kg metabolically active mass (MAM = weight to the power of 0.7). Plasma clearance values varied from 12.4 to 25.11 per hour. A dose of 5 mg diphenylhydantoin sodium (DPH) per kg MAM was then given thrice daily for 13 days to the same volunteers. The steady state plasma concentrations of DPH varied from 3.4 to 19.6 µg per ml. Statistically significant correlation was demonstrated between plasma acetanilide clearance and DPH clearance (r=+0.4984). This finding suggests either a common enzyme acceptor or a common rate-limiting step in the metabolism of the two drugs. It is possible that the pharmacokinetics of other widely used drugs known to be oxidized, especially phenylbutazone, may also be correlated with the kinetics of acetanilide and of DPH. If this were so, then certain individuals might be at a relatively high risk (due to drug accumulation) of developing adverse effects from drugs metabolized mainly by oxidation, and certain other individuals who metabolize these compounds at a fast rate are likely not to derive therapeutic benefit. A single dose study with simple measurement of acetanilide pharmacokinetics could be used to identify these groups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00560359
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  • 3
    Electronic Resource
    Electronic Resource
    The acetylatin of tryptophan metabolites by rapid and slow acetylators of sulfamethazine (1967)
    Springer
    Cellular and molecular life sciences 23 (1967), S. 959-960 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Es wurden an gesunden Versuchspersonen Belastungsversuche mit Sulfamethazin und Tryptophan ausgeführt und die Ausscheidung der azetylierten Metaboliten im Harn verfolgt. Bei den Tryptophanmetaboliten Kynurenin und Hydroxykynurenin war — im Gegensatz zur Azetylierung von Sulfamethazin — kein Polymorphismus zu beobachten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02136248
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  • 4
    Electronic Resource
    Electronic Resource
    Segregation analysis of α-L-fucosidase activity (1982)
    Springer
    Human genetics 〈Berlin〉 60 (1982), S. 271-273 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Complex segregation analysis of plasma α-L-fucosidase in 45 British families provides evidence for an additive major gene causing low activities of fucosidase. There was no significant evidence of polygenic heritability or common family environment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00303016
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  • 5
    Electronic Resource
    Electronic Resource
    Gas chromatography mass spectrometry studies on biologically important 8-aminoquinoline derivatives (1978)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 5 (1978), S. 76-79 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Several substituted 8-aminoquinolines related to known antimalarial drugs have been studied by gas chromatography mass spectrometry. 5,6-Dihydroxy-8-aminoquinoline, a possible metabolite of Primaquine, can be detected by single ion monitoring after conversion to a trimethylsilyl ether derivative. The mass spectra obtained in this study indicate that there are certain ions which are characteristic of the trimethylsilyl ethers of hydroxylated 8-aminoquinolines and 5,6-dimethoxy-8-aminoquinolines. These compounds should thus be amenable to analysis if they were produced during in vivo metabolism studies. Using selected ion monitoring the derivatized compounds can be detected at submicrogram levels.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200050114
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  • 6
    Electronic Resource
    Electronic Resource
    A selected ion monitoring assay for primaquine in plasma and urine (1979)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 6 (1979), S. 109-112 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The antimalarial drug primaquine was analysed in plasma and urine by gas chromatography mass spectrometry, using a deuterated internal standard. After freeze-drying and extraction with trichloroethylene the sample plus internal standard was reacted with Tri Sil TBT (a) 3:3:2 by volume mixture of trimethylsilylimidazole, N,O,-bis-(trimethylsilylacetamide and trimethylchlorosilane) and an aliquot injected into the gas chromatograph mass spectrometer. The gas chromatographic effluent was monitored at m/z 403 and m/z 406, the molecular ions of the bis-TMS ethers of primaquine and 6-trideuteromethoxy primaquine. Calibration curves were prepared from standards made up in plasma and urine. Data from the analysis of plasma and urine samples from a volunteer who ingested the equivalent of 45 mg primaquine are presented.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200060306
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    Paper (German National Licenses)
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