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  • 1
    Electronic Resource
    Electronic Resource
    Eisenionen als essentieler Faktor für die Antigen-Antikörper-Reaktion an der Basalmembran beim bullösen Pemphigoid (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 346-347 
    Details
    ISSN: 1432-1440
    Keywords: Bullous pemphigoid ; indirect IF staining ; metal ions ; antigen-antibody reaction ; Bullöses Pemphigoid ; indirekte Immunfluorescenz ; Metallionen ; Antigen-Antikörper-Reaktion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die beim bullösen Pemphigoid an der Basalmembran ablaufende Antigen-Antikörper-Reaktion kann durch EDTA aufgehoben werden. Dieser Effekt ist durch Zusatz von zweiwertigen Eisen-Ionen reversibel, während eine Reihe sonstiger zweiwertiger Kationen in diesem Zusammenhang unwirksam bleibt. Eine Variation der Fe2+-Zusätze im zeitlichen Ablauf des Reaktionsschemas ergibt, daß das Eisen für die Antigen-Antikörper-Reaktion zwischen den Anti-Basalmembran-Antikörpern und dem antigenen Substrat an der Basalmembran erforderlich ist.
    Notes: Summary When treated with EDTA, the immunofluorescent staining on the basement-membrane with a bullous pemphigoid serum disappears. This effect is reverted by means of Fe2+-ions. A series of other cations is without effect. Iron was added at different stages of the reaction. The result showed that the iron is necessary for the reaction between the antibasement-membrane antibodies and the antigens on the basement-membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468834
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  • 2
    Electronic Resource
    Electronic Resource
    Nachweis von TyrosinasemRNA mittels Reverser Transkription/Polymerasekettenreaktion an Feinnadelpunktaten von Melanommetastasen (1996)
    Springer
    Der Hautarzt 47 (1996), S. 197-199 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Metastasierendes malignes Melanom ; Tyrosinase-mRNA ; Polymerasekettenreaktion ; Feinnadelpunktion ; Key words Metastatic malignant melanoma ; Tyrosinase-mRNA ; Polymerase chain reaction ; Fine-needle punctures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Tyrosinase mRNA produced by melanoma cells can be detected by reverse transcriptase-polymerase chain reaction (rt-pcr) with fine-needle tissue punctures. Fine-needle punctures from six suspected skin and lymph node metastases in three patients with malignant melanoma were analysed via rt-pcr for tyrosinase mRNA. All the suspected metastases were surgically removed and histologically examined separately. In each case the rt-pcr results and the histological diagnosis corresponded. This less invasive and highly sensitive method could prove to be a useful alternative in the diagnosis of melanoma metastasis.
    Notes: Zusammenfassung Melanozytäre Zellen unterscheiden sich in ihrem Metabolismus von anderen Zellen durch die Expression des Enzyms Tyrosinase. Bei 3 Patienten mit malignem Melanom konnte an 6 Feinnadelpunktaten von fraglichen Haut- und Lymphknotenmetastasen die Tyrosinase-mRNA mittels Reverser Transkription/Polymerasekettenreaktion (RT/PCR) nachgewiesen werden. Die Veränderungen wurden im Folgenden operativ entfernt und histologisch aufgearbeitet. Die Ergebnisse der RT/PCR korrespondierten jeweils mit der histologischen Diagnose. Diese wenig invasive und sehr sensitive Methode der Feinnadelpunktion mit anschließender molekularbiologischer Untersuchung könnte für die Diagnostik von Melanommetastasen als Alternative zur diagnostischen Exzision bzw. Aspirationszytologie bedeutsam werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050402
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of selective ultraviolet phototherapy on DNA and antinuclear antibody titers in psoriatic patients (1984)
    Springer
    Archives of dermatological research 276 (1984), S. 297-302 
    Details
    ISSN: 1432-069X
    Keywords: Psoriasis ; Selective ultraviolet phototherapy ; DNA antibodies ; Antinuclear antibodies ; ELISA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The sera of 21 psoriatics treated by selective ultraviolet phototherapy (SUP) for 1–7 months were screened for IgG- and IgM-anti-DNA antibodies and antinuclear antibodies (ANAs) by standardized ELISA and the indirect immunofluorescence technique. No patients developed IgG-antibodies against native DNA under SUP, but two patients increased their IgM-antibody titers five- and tenfold, respectively. The IgG- and IgM-anti-single-stranded-(ss)DNA antibody titers remained unaltered in 38% and 57% of the patients. In 43% and 24%, respectively, they rose to a maximum of three times their original; and in 20% they decreased to a minimum of 40% of their pretherapeutic titers. After 1 month therapy no patient had produced ANAs, but all three patients showing ANAs before therapy had increased titers (one titer step). These remained on the elevated level or were even further increased by one-titer step during progressive therapy. Two patients out of 14 developed low titers of IgM-(1:20) or IgA-(1:40)ANAs against deoxyribonucleoprotein (DNP), initially after 3 months of irradiation; in one of them IgG-ANAs (titer 1:10) against DNP were additionally formed after 6 months of therapy. Our results suggest that lesions in DNA and DNP generated by SUP trigger an immune response to nuclear antigens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404621
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  • 4
    Electronic Resource
    Electronic Resource
    Prostaglandin E2 Gel Improvement of Psoriatic Lesions (1986)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 25 (1986), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: : Proslaglandin (PC) E2 gel and gel alone were topically applied to the psoriatic lesions of ten patients. After a few days, all PG E2 treated lesions improved, but a complete clearing, could not be achieved. Together with results from the literature, our findings strengthen the hypothesis that cyclo-oxygenase activity is endogeneously inhibited in the psoriatic plaque, thus preventing formation of PG E2 and other metabolites. Replenishing of one of these substances (E2) improved the treated lesion, thus demonstrating that a decrease of PG E2 level might be one important factor in the pathogenesis of the psoriatic lesion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1986.tb02240.x
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  • 5
    Electronic Resource
    Electronic Resource
    The oldest fossil lichen (1995)
    [s.l.] : Nature Publishing Group
    Nature 378 (1995), S. 244-244 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - We describe here the oldest unequivocal fossil lichen, from thin sections of Early Devonian (400 million years old) Rhynie chert. Lichens are symbiotic associations between a fungus (mycobiont) and a green alga or cyanobac-terium (photobiont) which range from mutualism to controlled ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/378244a0
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  • 6
    Electronic Resource
    Electronic Resource
    Allomyces in the Devonian (1994)
    [s.l.] : Nature Publishing Group
    Nature 367 (1994), S. 601-601 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - We have found fossil fungi morpho-logically similar to Allomyces, the modern experimental fungus, in thin sections of early Devonian (400 million-year-old) megaplants. The fungus exhibits an iso-morphic alternation of generations in which sporothalli that produce zoosporan-gia and resting ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/367601a0
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  • 7
    Electronic Resource
    Electronic Resource
    Parasitism in a 400-million-year-old green alga (1992)
    [s.l.] : Nature Publishing Group
    Nature 357 (1992), S. 493-494 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] One of the most remarkable fossil assemblages is from the Lower Devonian (Siegenian) Rhynie Chert in Aberdeenshire, Scotland1. This site, now known to have been a freshwater palaeoecosystem, has provided detailed reports of permineral-ized macroplants of Devonian age, and has contributed ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/357493a0
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  • 8
    Electronic Resource
    Electronic Resource
    Der Einfluß von Nettoladung und pH-Milieu auf die Präparation von Anti-Basalmembran-Antikörpern und auf ihre Bindungskapazität beim bullösen Pemphigoid (1974)
    Springer
    Research in experimental medicine 163 (1974), S. 211-217 
    Details
    ISSN: 1433-8580
    Keywords: Bullous pemphigoid ; Indirect IF staining ; Anti basement antibodies ; Chromatography on ion exchanger ; Binding capacity of anti basement antibodies in basement membrane ; Bullöses Pemphigoid ; Indirekte Immunfluorescenz ; Anti-Basalmembran-Antikörper ; Ionenaustauscherchromatographie ; Bindungskapazität von Anti-Basalmembran-Antikörpern an der Basalmembran
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Durch Präcipitation mit Rivanol-Ammoniumsulfat gewonnene Rohpräparationen von Immunglobulin G aus dem Serum eines Patienten mit bullösem Pemphigoid wurden an Ionenaustauschersäulen bei verschiedenen pH-Werten aufgetrennt. 2. Die Anti-Basalmembran-Antikörper waren weitgehend mit mehr negativ geladenen Ig G-Fraktionen assoziiert. 3. Bei Verwendung eines sauren Ionenaustauschers fanden sich im Extremfall die Antikörper ausschließlich in der zweiten und bei alkalischem Ionenaustauscher vollständig in der ersten Fraktion. 4. Die Bindung der Antikörper an das antigene Substrat erfolgte über den gesamten pH-Bereich mit einem deutlichen Maximum bei pH 8,5. 5. Daneben wurden antinucleäre Antikörper beobachtet, deren Reagibilität mit steigender Wasserstoffionenkonzentration zunahm.
    Notes: Summary 1. By precipitation with ethacridine lactate-ammonium sulfate a preparation from a bullous pemphigoid serum is obtained and separated by means of chromatography on ion exchanger employing various ranges of pH. 2. The anti basement antibodies are associated by far with the negative fraction of Ig G. 3. With a acid ion exchanger the antibodies are in the second fraction for the most part and with a basic one they are in the first fraction totally. 4. Binding the antibodies to antigen is observed over the whole range of pH pertaining a maximum of degree at 8.5. 5. Antinuclear antibodies are observed too which react at low degrees of pH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851668
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  • 9
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1970)
    Springer
    Naturwissenschaften 57 (1970), S. 48-52 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00593575
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  • 10
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1966)
    Springer
    Theoretical and applied genetics 36 (1966), S. 195-200 
    Details
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00000009
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