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  • 1
    Electronic Resource
    Electronic Resource
    Optimization theory in linear spaces. I (1969)
    Springer
    Mathematische Annalen 182 (1969), S. 189-206 
    Details
    ISSN: 1432-1807
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01350322
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  • 2
    Electronic Resource
    Electronic Resource
    Cationic glycoproteins in sera of patients with acute infections identified as kappa light chain glycosylated IgG (1993)
    Springer
    Medical microbiology and immunology 182 (1993), S. 107-117 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In half of the sera from patients with acute bacterial infections and 15% of the sera from patients with acute viral infections glycoproteins were found that form a scalariform pattern in the cationic range upon isoelectric focusing. The cationic glycoproteins appeared with the clinical illness. After subsidence of the symptoms they disappeared within 4 to 6 weeks. The proteins were identified as immunoglobulin G (IgG) by determination of the NH2-terminal amino acid sequence. Remarkably, these IgG only contained light chains of the kappa type with high proportions of carbohydrates. Both, N-glycosidic- and O-glycosidic-bound glycans were present. The glycosylated light chains may render the cationic IgG multireactive. Thus, it may be part of an early nonspecific immune defense mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190263
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  • 3
    Electronic Resource
    Electronic Resource
    Enhanced transcription of the s-adenosylhomocysteine hydrolase gene precedes Epstein-Barr virus lytic gene activation in ganglioside-stimulated lymphoma cells (2000)
    Springer
    Medical microbiology and immunology 189 (2000), S. 13-18 
    Details
    ISSN: 1432-1831
    Keywords: Key words Differential display ; Gene expression ; Virus reactivation ; Epstein-Barr virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Stimulation of Epstein-Barr virus (EBV) genome-positive Burkitt lymphoma cells with the ganglioside IV3NeuAc-nLcOse4Cer leads to the induction of cell differentiation processes and activates the EBV lytic viral cycle. In cells of the Burkitt lymphoma line Raji differential expression of host cell genes was analysed in the early phase (150 min) post stimulation with the ganglioside to display the cell activities that precede the activation of the EBV lytic cycle using the differential display reverse transcription-polymerase chain reaction technique. Multiple fragment cDNAs derived from control cells and ganglioside-stimulated cells were amplified using random primers and displayed via polyacrylamide gel electrophoresis. The expression pattern of 8,400 bands was analysed. Eleven differentially expressed fragment cDNAs were reamplified and identified by nucleotide sequencing. Six of these could be identified as coding for proteins that may take part in virus reactivation and differentiation. The most striking finding was the induction of s-adenosylhomocysteine hydrolase (AHCY) expression. The cellular enzyme AHCY plays an important role in transmethylation reactions controlling the replication of several viruses. Thus, an involvement in EBV replication can be suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00008252
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  • 4
    Electronic Resource
    Electronic Resource
    A membrane-located glycosphingolipid of monocyte/granulocyte lineage cells induces growth arrest and triggers the lytic viral cycle in Epstein-Barr virus genome-positive Burkitt lymphoma lines (1999)
    Springer
    Medical microbiology and immunology 188 (1999), S. 23-29 
    Details
    ISSN: 1432-1831
    Keywords: Key words Epstein-Barr virus ; Lytic cycle ; Growth arrest ; Gangliosides ; Monocyte/granulocyte lineage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Gangliosides are known to influence cell growth and differentiation. The neolacto series ganglioside IV3NeuAc-nLc4 (2→3-sialosylparagloboside) is present in members of the monocyte/granulocyte lineage, but is not found in cells that belong to the lymphocyte lineage. In this study we demonstrated that IV3NeuAc-nLc4 inhibits the proliferation of Epstein-Barr virus (EBV) genome-positive Burkitt lymphoma cells of the lines Raji and P3HR-1K. IV3NeuAc-nLc4-induced growth inhibition is associated with an increase in G0/G1 phase cells and a reduced expression of CD21 and HLA-DR antigens on Raji cells. These data suggest that IV3NeuAc-nLc4 may affect differentiation of lymphoma cells. Additionally, the increased expression of viral mRNA species which are characteristic for the lytic viral cycle in the non-producer line Raji and the enhanced release of virions from the producer line P3HR-1K demonstrate that IV3NeuAc-nLc4 activates the replication of EBV. Growth inhibition and termination of the viral latency suggest that IV3NeuAc-nLc4 present in monocyte/granulocyte lineage cells may be an effector of the natural defense against EBV persistency and transformation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004300050101
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  • 5
    Electronic Resource
    Electronic Resource
    High dimensional integration of smooth functions over cubes (1996)
    Springer
    Numerische Mathematik 75 (1996), S. 79-97 
    Details
    ISSN: 0945-3245
    Keywords: Mathematics Subject Classification (1991): 41A55, 41A63, 65D30, 65Y20
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary. We construct a new algorithm for the numerical integration of functions that are defined on a $d$ -dimensional cube. It is based on the Clenshaw-Curtis rule for $d=1$ and on Smolyak's construction. This way we make the best use of the smoothness properties of any (nonperiodic) function. We prove error bounds showing that our algorithm is almost optimal (up to logarithmic factors) for different classes of functions with bounded mixed derivative. Numerical results show that the new method is very competitive, in particular for smooth integrands and $d \ge 8$ .
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002110050231
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  • 6
    Electronic Resource
    Electronic Resource
    On the rate of superlinear convergence of a class of variable metric methods (1980)
    Springer
    Numerische Mathematik 35 (1980), S. 293-313 
    Details
    ISSN: 0945-3245
    Keywords: AMS (MOS) ; 90C30 ; CR: 5.15
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary This paper considers a class of variable metric methods for unconstrained minimization. Without requiring exact line searches each algorithm in this class converges globally and superlinearly on convex functions. Various results on the rate of the superlinear convergence are obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01396414
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  • 7
    Electronic Resource
    Electronic Resource
    Über das Verhalten des Organismus bei Einwirkung verschiedener Weichmacher (1956)
    Springer
    European food research and technology 103 (1956), S. 413-424 
    Details
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Zusammenfassung Umfangreiche akute, subakute und chronische Versuche über die Toxieität der Weichmacher Benzyloctyladipinat, Dibutylphthalat, Mesamoll, Dicyclohexylphthalat und Polymerweichmacher PW 63/51 ergaben, daß alle geprüften Substanzen wenig giftig sind. Es spricht aber manches dafür, daß Mesamoll und PW 63/51 eine besonders günstige Beurteilung hinsichtlich der Unbedenklichkeit ihrer Verwendung auch in Folien, die zur Verpackung von Lebensmitteln gebraucht werden sollen, verdienen. Vor dem Einsatz von Dibutylphthalat zu dem genannten Zweck werden weitere Versuche für nötig gehalten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01683646
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  • 8
    Electronic Resource
    Electronic Resource
    Methods of conjugate directions versus quasi-Newton methods (1972)
    Springer
    Mathematical programming 3 (1972), S. 101-116 
    Details
    ISSN: 1436-4646
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract It is shown that algorithms for minimizing an unconstrained functionF(x), x ∈ E n , which are solely methods of conjugate directions can be expected to exhibit only ann or (n−1) step superlinear rate of convergence to an isolated local minimizer. This is contrasted with quasi-Newton methods which can be expected to exhibit every step superlinear convergence. Similar statements about a quadratic rate of convergence hold when a Lipschitz condition is placed on the second derivatives ofF(x).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01584978
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  • 9
    Electronic Resource
    Electronic Resource
    A superlinearly convergent method for minimization problems with linear inequality constraints (1973)
    Springer
    Mathematical programming 4 (1973), S. 44-71 
    Details
    ISSN: 1436-4646
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract A method is described for minimizing a continuously differentiable functionF(x) ofn variables subject to linear inequality constraints. It can be applied under the same general assumptions as any method of feasible directions. IfF(x) is twice continuously differentiable and the Hessian matrix ofF(x) has certain properties, then the algorithm generates a sequence of points which converges superlinearly to the unique minimizer ofF(x). No computation of secondorder derivatives is required.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01584646
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Average errors for zero finding: Lower bounds for smooth or monotone functions (1994)
    Springer
    Aequationes mathematicae 47 (1994), S. 120-120 
    Details
    ISSN: 1420-8903
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01838149
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    Paper (German National Licenses)
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