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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Langmuir 10 (1994), S. 4265-4269 
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 122 (Jan. 1993), p. 229-236 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 343-346 (May 2000), p. 835-840 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 343-346 (May 2000), p. 97-102 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 191 (May 1995), p. 195-206 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Development genes and evolution 210 (2000), S. 167-179 
    ISSN: 1432-041X
    Keywords: Key words Scanning electron microscopy ; Cell shape dynamics ; Gastrulation ; Amnion ; Serosa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Embryogenesis in the beetle Tribolium is of increasing interest to both molecular and evolutionary biology because it differs from the Drosophila paradigm by its type of segment specification (short- vs. long-germ) and by the extensive epithelial envelopes – amnion and serosa – that are typical of most insects but not of higher dipterans. Using scanning electron microscopy of DAPI staged embryos we document development in Tribolium castaneum from blastoderm to completion of the envelopes, recording many details not otherwise accessible; we also provide a time table of the respective stages at 30°C. The nascent blastoderm cells remain basally confluent with the yolksac until after the 13th (=last synchronous) mitotic cycle. The cells in the prospective serosa – the first domain to segregate visibly from the uniform blastoderm – carry surface protrusions likely to contact the overlying vitelline envelope. The embryonic rudiment, the other (and larger) blastodermal domain, gives rise to amnion and germ anlage. In the latter, visible differentiation begins with a ”primitive pit” reminiscent of the posterior midgut rudiment of Drosophila. The subsequent invagination of the mesoderm resembles Drosophila gastrulation, except in the head region where the median groove extends through the entire preoral region. The prospective amnion starts differing visibly from the germ anlage during early gastrulation. It then folds underneath the spreading serosa and, advancing with the latter, closes the amniotic cavity at the ventral face of the germband. The largest (=posterior) amniotic fold covers a crestlike protrusion of the yolksac. Together with marked changes in the shape and arrangement of the amnion cells, this protrusion may contribute to the fold’s elevation and early progress.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Oxymetrie ; zerebrovenös ; Clark-Sonde ; polarographisch ; intrazerebrales Aneurysma ; Key words Jugular bulb ; Paratrend 7 ; cerebrovenous ; polarographic ; Clark electrode ; Oxygen ; Oximetry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Introduction: Recently, a compact multisensor device 0.5 mm in diameter has become available with a miniaturised Clark electrode for measuring blood oxygen tension and two optical fibres for measuring CO2 tension, pH, and temperature (Paratrend 7, Biomedical Sensors, High Wycombe, UK). We used this new probe for continuous blood gas monitoring in the jugular bulb as an alternative to the commonly used fiberoptic spectrophotometric oximetric measurement of haemoglobin saturation. Results: A 64-year-old patient was admitted for surgery of a right-sided intracranial aneurysm. During surgery, with no artefacts or evidence of catheter drift, a normal jugular venous pO2 (pjvO2) of 39±3 mmHg was measured. Over the period of weaning, two declines in pjvO2 occured (22.5 and 18.7 mm Hg) associated with a decline in CO2 tension and a rise in pH. We treated these events successfully by analgosedation, controlled ventilation with an inspired oxygen fraction of 70%, and elevation of the mean arterial blood pressure to over 100 mmHg. Extubation was possible about 24 h later. Furthermore, 3 h after extubation pjvO2 values could be monitored without difficulty despite movement of the patient. Discussion: The technique of polarographically measuring pjvO2 with a Clark-type probe appears superior to fibreoptic jugular venous oximetry due to the clearly lower incidence of faulty measurements, especially in the intensive care unit, where patients undergo frequent nursing interventions and tend to awaken. We did not even observe artefacts due to patient movement after extubation. A limitation of the new multisensor system might be the distance of 4 cm between the sensor tip and the end of the insertion catheter, which makes samples drawn for in vitro blood gas analyses to control the continuous monitoring less comparable. Improvements in the construction of the probe are recommended.
    Notes: Zusammenfassung Es wird erstmalig über den Einsatz einer neuen Multisensorsonde zur kontinuierlichen Messung der Parameter Sauerstoffpartialdruck (pjvO2), Kohlendioxidpartialdruck (pjvCO2), pH und Temperatur im Bulbus venae jugularis bei einer Patientin mit einem Aneurysma im Abgangsbereich des Ramus communicans posterior berichtet. Ergebnisse: Intra- und postoperativ war es möglich, kontinuierlich und nahezu artefaktfrei die jugularvenösen Blutgase zu erfassen. Die gemessenen Werte lagen innerhalb der Referenzbereiche (pjvO2 39±3 mm Hg). In der postoperativen Weaningphase kam es zweimal zu einem Abfall des jugularvenösen Sauerstoffpartialdrucks auf Werte von 22,5 bzw. 18,7 mm Hg. Durch Anhebung der inspiratorischen Sauerstoffkonzentration (FiO2) und des mittleren arteriellen Blutdrucks (MAP) normalisierte sich der pjvO2. Auch nach der Extubation arbeitete die Sonde störungsfrei (pjvO2 33±2,3 mm Hg). Diskussion: Unsere Ergebnisse zeigen, daß der Einsatz der polarographischen Sauerstoffpartialdruckmessung im Bulbus venae jugularis möglicherweise eine praktikable Alternative zu der bisher routinemäßig eingesetzten spektrophotometrischen jugularvenösen Katheteroxymetrie darstellt. Das Verfahren überzeugte durch seinen geringen Betreuungsaufwand. Problematisch erscheint bei der derzeitigen Konstruktion des Meßsystems die in vivo-Kalibration. Bei einer Distanz von ca. 4 cm zwischen der Sensorspitze und dem Lumen des Plastikkatheters, aus welchem die Blutprobe entnommen wird, beeinträchtigen extrakranielle Zuflüsse die Vergleichbarkeit der Sondenmeßwerte mit den in vitro-Meßergebnissen einer Blutgasanalyse.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-055X
    Keywords: Key words Venous air embolism ; Neurosurgery ; Doppler sensor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: The aim of this study was to compare the sensitivity of a newly applied transoesophageal ultrasonic Doppler sensor for detection of air with the traditional precordial ultrasonic Doppler sensor in clinical use. Methods: We studied 16 patients undergoing neurosurgical procedures in a sitting position. Two ultrasonic Doppler devices were compared as to their ability to detect venous air embolisms (VAE): transoesophageal (ODM II, co. Abbott) versus a precordial ultrasonic Doppler sensor (Parks Medical Electronics Inc.). After establishing general anaesthesia and endotracheal intubation, we applied an ultrasonic Doppler sensor to the right sternal border of the patient’s chest and inserted an ultrasonic Doppler probe into the oesophagus. With the patient in the sitting position, microparticularly d-galactose was injected to verify the efficacy of both ultrasonic Doppler devices. Results: Using ODM II by positioning the probe toward the azygos vein, a dosage of 1 ml microparticularly d-galactose was dedected in every patient. When adjusting the ODM II-probe on the right myocardial wall or using the precordial ultrasonic Doppler sensor, the administration of microparticularly d-galactose was detected by the devices in only 11 patients. Conclusions: This study demonstrates that a transoesophageal ultrasonic Doppler sensor (ODM II) is more efficient than the precordial ultrasonic Doppler sensor for monitoring patients who are at risk of VAE by sonification of the azygos vein.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Zerebrovenöse Oxymetrie ; Bulbus venae jugularis ; Zerebraler Perfusionsdruck ; Zerebraler Blutfluß ; Key words Brain ; Intracranial pressure ; Oxygen ; Saturation ; Fibreoptic oximetry ; Cerebral blood-flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The reliability of continuous fibreoptic oximetry in cerebral venous blood and its correlation with intracranial and cerebral perfusion pressures (pressure-volume curve) were examined in an experimental porcine study. Methods: The pressure in the infratentorial compartment of 13 domestic pigs (18–24 kg) was gradually increased by inflating a Fogarty balloon catheter placed on the surface of the right cerebellar hemisphere and below the tentorium. Single volumes of 0.4 ml saline were injected into the inflatable balloon at 1-min intervals up to a total volume of 7 ml. Intracranial pressure (ICP), arterial blood pressure, cerebral perfusion pressure (CPP), and cerebral venous saturation measured continuously by fibreoptic oximetry and intermittent blood-gas analyses (SjO2 superior sagittal sinus) were monitored during balloon inflation. All data were downloaded onto a PC and evaluated off-line by a commercial statistical software package. Results: Over the whole pressure-volume curve, two phases of SjO2 behaviour were registered by continuous fibreoptic oximetry (Oximetrix 3, Abbott) (Fig. 1). CPP ranges of less than 50% reduction from the initial value showed a linear correlation (r mittl. =0.712, P〈0,01) between both parameters (CPP−SjO2). In CPP ranges below a crucial point of about 50 mmHg no such correlation was found (r mittl =0.176, P〉0.5). In contrast, in 3 pigs a very good correlation was found between CPP and SjO2 over the whole pressure-volume curve as measured by blood-gas analyses of samples from the cerebrovenous catheter (r mittl. =0.84, P〈0.05). Discussion: We conclude that in physiological CPP ranges down to 50 mmHg, SjO2 measurement is a reliable method of detecting oxygen desaturation in cerebrovenous blood. Below that CPP value, the fibreoptic catheter showed repeated false-high oxygen saturation values. The accuracy of SjO2 measurement seems to depend on sufficient cerebral blood flow (CBF): with decreasing CBF the amount of cerebral venous outflow is diminished. We believe this is why we could not find a correlation in low CPP ranges with the oximetry catheter. This flow-dependency is a new aspect of fibreoptic cerebrovenous oximetry. The authors recommend that rising SjO2 values after desaturation events be confirmed by blood-gas analyses.
    Notes: Zusammenfassung Die Beziehung zwischen dem zerebralen Perfusionsdruck (CPP) und der zerebrovenösen Sauerstoffsättigung des Hämoglobins (SjO2) oberhalb eines Perfusionsdrucks von 50 mm Hg (Versuchsabschnitt A) und unterhalb eines Perfusionsdrucks von 50 mm Hg (Versuchsabschnitt B) wurde an einem standardisierten Tiermodell bei 13 Schweinen (18–24 kg) untersucht. Methode: Eine schrittweise Hirndrucksteigerung erfolgte durch einen infratentoriell plazierten Fogarty-Ballonkatheter. Die SjO2 wurde kontinuierlich mit einem im Sinus sagittalis superior befindlichen fiberoptischen Oxymetriekatheter gemessen. Punktuelle Blutgasanalysen (10 Messungen/Tier) sind bei 3 Tieren über den gesamten Hirndruckverlauf durchgeführt worden. Ergebnisse: Für den Versuchsabschnitt A konnte ein mittlerer Korrelationskoeffizient für den Zusammenhang CPP mit SjO2 von rmittl.=0,712 (p〈0,01) und für den Versuchsabschnitt B ein rmittl.=0,176 (p〉0,5) gefunden werden. Die Korrelation der durch punktuelle Blutgasanalysen über die gesamte Druck-Volumenkurve erhaltene Hämoglobinsättigung zum CPP betrug im Mittel rmittl=0,84 (p〈0,05). Schlußfolgerung: Die Ergebnisse der Blutgasanalysemessungen bestätigen den engen Zusammenhang zwischen CPP und SjO2. Im Versuchsabschnitt A ließ sich dieser Zusammenhang auch durch die kontinuierliche Katheteroxymetrie darstellen. Unterhalb eines kritischen CPP von 50 mm Hg im Versuchsabschnitt B drückt die fehlende Korrelation der Beziehung CPP – SjO2 eine Einschränkung der Meßmethodik mittels spektroskopischer Katheteroxymetrie aus.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 45 (1996), S. 745-749 
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Zeugen Jehovas ; Erythropoetin ; Key words Jehova's witness ; Erythropoietin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Erythropoietin, the hematopoietic growth factor, is synthesised in the kidneys and liver and regulates red blood cell production. Within the last few years, recombinant DNA technology has produced synthetic erythropoietin (rhEPO). Some patients, especially Jehova's Witnesses, will not accept blood transfusion. The perioperative administration of rhEPO increases the patients' hematocrit (HCt) to a higher than physiological level. Methods and results. We report a case of a 66-year-old female Jehova's Witness who refused blood transfusions and responded favourably to rhEPO treatment. A total hip arthroplasty was planned. A pre-treatment hemoglobin level (Hb) of 13.7 g/dl and HCt of 43% were documented. After preoperative subcutaneous application of 5000 I.E. rhEPO three times per week and daily oral substitution of 300 mg ferrous sulfate over a period of 3 weeks, the Hb increased to 15.5 g/dl and the HCt to 49%. The operation was carried out after the ninth application of rhEPO. Postoperatively, the Hb concentration was 11.8 g/dl and the HCt 35%. Therefore, postoperative administration of rhEPO was not considered indicated. No side effects of rhEPO application were noted. The patient left hospital on the 10th postoperative day. Conclusions. The case report describes perioperative management using human rhEPO in Jehova's Witnesses. Treatment with rhEPO increases preoperative Hb levels to a point making it possible to compensate for operative blood loss. RhEPO combined with daily iron substitution may be useful in patients who refuse transfusion based on religious convictions.
    Notes: Zusammenfassung Der perioperative Einsatz von rekombinantem Erythropoetin (rhEPO) zeigt neue Perspektiven in der Behandlung der postoperativen nichtrenalen Anämie im Rahmen fremdblutsparender Maßnahmen. Anhand des vorliegenden Fallbeispiels einer 66jährigen Patientin, die der Glaubensgemeinschaft „Zeugen Jehovas“ angehört und von uns auf die anstehende Implantation einer Hüfttotalendoprothese präoperativ mit dreimal wöchentlich 5000 I.E. sc. rekombinantem Erythropoetin behandelt wurde, soll die Möglichkeit des perioperativen Einsatzes dieser Substanz besprochen werden. Zu Beginn der Behandlung betrugen Hämoglobin 13,7 g/dl und Hämatokrit 43 Vol.-%. Die stationäre Aufnahme erfolgte mit einem Hämoglobin von 15,5 g/dl und einem Hämatokrit von 49 Vol.-%. Die Zahl der Retikulozyten stieg präoperativ von 5‰ auf 21‰ und postoperativ auf 31‰ und kann zur Beurteilung des Therapieeffekts herangezogen werden. Postoperativ war keine weitere Erythropoetingabe erforderlich. Die präoperative Gabe von rhEPO ist eine Bereicherung im perioperativen Management fremdblutsparender Maßnahmen. Die Indikation zur homologen Transfusion von Erythrozytenkonzentraten kann somit strenger gestellt werden.
    Type of Medium: Electronic Resource
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