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  • 1
    ISSN: 1435-1803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 29 (1973), S. 987-988 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Die Gewebskonzentrationen an ATP, ADP, ATP+ADP, Kreatinphosphat, Kreatin und Kreatinphosphat + Kreatin sind unter vergleichbaren Bedingungen im linken Ventrikel von Mini-pig-Herzen kleiner als im Hundeherzen. Die Unterschiede in den Koeffizienten (ATP/ADP und Kreatinphosphat/Kreatin) dürfen narkosebedingt sein. Sämtliche Messgrössen sind nicht mit dem Entnahmeort der Biopsien (apikal, basal) korreliert.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Die deutliche Erhöhung des peripheren Widerstandes unter Infusion von Hypertensin bei nur mäßigem Anstieg des Lungengefäßwiderstandes führt einerseits zu einer Zunahme der Regurgitation in Fällen mit Mitralinsuffizienz und andererseits zu einer Vergrößerung des Links-rechts-Shunts bei kongenitalen Vitien. Diese Kreislaufveränderungen können mit der Farbstoffverdünnungsmethode leicht erfaßt und diagnostisch verwertet werden.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2013
    Keywords: Coronary Sinus Blood Flow ; Thermodilution Technique ; Mixing of Indicator and Blood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In hydraulic non-occlusive models, mixing effects were studied with slug-injection and constant-infusion techniques. Measurements were accomplished by means of catheters specially constructed with thermistors. Constant-rate infusion of 5 ml/min of saline at room temperature showed homogeneity of mixing. Good correlation (r=0.936) was found between metered flow ranging from 50–450 ml/min and reciprocal temperature changes. In anesthetized open chest dogs reciprocal temperature changes during constant-infusion thermodilution was compared with coronary sinus flow metered by graduated cylinder and stop-watch. For this purpose all the coronary sinus blood was directed through a tubing system with a Y-connector into the jugular vein. In the range of 50–450 ml/min the metered coronary sinus blood flow and the reciprocal of the observed changes in temperature showed a linear correlation (r=0.949). The reproducibility of the thermodilution method is fairly good. Therefore it is believed that this technique will allow accurate measurement of coronary sinus blood flow.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Clinical and experimental medicine 144 (1967), S. 67-72 
    ISSN: 1591-9528
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary An apparatus for coupled electrical stimulation of the heart is presented. The stimulator is triggered by the R-wave of the electrocardiogram. The construction of this devise is described, and the functions of the single parts are discussed. The definitive model has been tested in six canine experiments. It was found to be very reliable in producing 1∶1, 2∶1, or 3∶1 coupled stimulation. The electrocardiograms as obtained in these experiments are presented.
    Notes: Zusammenfassung Es wird über ein Gerät für die gekoppelte elektrische Stimulierung des Herzens berichtet. Sein Aufbau und seine Wirkungsweise werden beschrieben, und die einzelnen Stufen werden nach ihrer Punktion diskutiert. Das definitive Modell des Stimulators wurde in sechs Experimenten an Hunden getestet; die dabei erzielten Resultate, nämlich beliebig wählbare und reproduzierbare gekoppelte Stimulierung im Verhältnis 1∶1, 2∶1 oder 3∶1, werden dokumentiert.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Cardiovascular drugs and therapy 2 (1988), S. 61-65 
    ISSN: 1573-7241
    Keywords: silent ischemia ; methods for detection ; prognosis ; pain perception ; postinfarction ischemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Awareness of silent myocardial ischemia has greatly increased during the last few years in the medical community. Methods for its detection include exercise testing, Holter monitoring, and, more specifically, Thallium-201 scintigraphy, 2D-echocardiography, and multigated radionuclide ventriculography with phase analysis, all during rest and exercise. Cohn's classification of silent ischemia has proven very useful in highlighting the magnitude of the problem. It can be estimated that about 2% to 4% of apparently healthy middle aged males in industrialized European countries are prone to asymptomatic ischemic episodes. Prognosis of silent myocardial ischemia has been evaluated in prospective and retrospective studies. Most authors come to the conclusion that ischemia is the key finding, whether painful of asymptomatic. Even present understanding of pain perception from the ischemic myocardium is incomplete; the high prevalence and the relation with myocardial infarction and sudden cardiac death make silent myocardial ischemia one of today's most relevant problems.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Basic research in cardiology 68 (1973), S. 545-550 
    ISSN: 1435-1803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The principle of a new method to measure valvular regurgitation by means of indicator-dilution is formulated and some possible applications are described. A practical project about to be realised is presented.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1435-1803
    Keywords: Magnesium ; metabolism ; fatty acid ; glucose ; reperfusion ; rat heart
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To determine the effect of magnesium on myocardial function and oxidative metabolism after reperfusion, isolated rat hearts perfused retrogradely with erythrocyte-enriched medium (0.4 mM palmitate bound to 0.4 mM albumin, 11 mM glucose) were subjected to 60 minutes of no-flow ischemia followed by 60 minutes of reperfusion. Untreated postischemic hearts exhibited after 15 minutes of reperfusion recovery of myocardial oxygen consumption to 65% of the preischemic value despite persistent depression of left ventricular isovolumic pressure development to 21%. Magnesium (15 mM) administered during the initial 30 minutes of reperfusion reduced myocardial oxygen consumption of reperfuse myocardium by 35%. Oxidation of [1-14C]palmitate was slightly more reduced (−55%) than oxidation of [U-14C]glucose(−42%). Magnesium did not influence ultimate recovery of contractile function and cumulative myocardial release of creatine kinase. Thus, 15 mM magnesium administered during reperfusion elicited a reduction of oxidative metabolism. However, magnesium did not modify myocardial injury.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Basic research in cardiology 46 (1965), S. 59-74 
    ISSN: 1435-1803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thermistors (NTC-Resistors) open the possibility to registrate under a low velotage the accurate temperature of the surrounding blood (Thermodilution method: thermodilution curves for the estimation of cardiac output, regurgitation and enddiastolic ventricular volume) as well as under an increased voltage a qualitative measurement of the volocity of the blood. The blood velocity measurement in the mean pulmonary artery is easy to carry out. A catheter tip, on which a thermistor has been fixed, has to be placed in a free moving position 2–3 cm distal to the pulmonary valves. Under competent valve conditions the over heated thermistor shows a systolic cooling (increased blood velocity) and a diastolic warming up (standstill of the blood stream close to the valves). Under incompetent conditions a systolic forward and diastolic backward stream occur, that means the overheated thermistor shows as systolic and diastolic cooling. If this last mentionned curve was found on a patient, the regurgitation of a cold injectate form the pulmonary artery into the right ventricel has been checked and proved that in all cases a real regurgitation existed. With help of this technique 447 cardiac patients have been checked and 40 (9%) times incompetent pulmonary valves were found. 23 incompetences existed under 246 acquired valve defects (9,5%), 13 under 201 congenital heart defects (6,5%) and 4 cases were previously operated (pul'monary commissurotomy). A classification in organic and relative pulmonary incompetences has been tried. Angiocardiography, direct observation under cardiac surgery, postoperativ follow up and behaving under conservative therapy as well as autopsies were used for this classification. For this 31 cases could be used: 5 had an organic valve disease (3 acquired, 2 congential), 3 a idiopathic dilatation of the pulmonary artery, 16 a relative incompetence by pulmonary hypertension and 7 could not be classified.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Basic research in cardiology 60 (1969), S. 240-261 
    ISSN: 1435-1803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The factors contributing to the special form of the primary curve after injection of indicator into the circulation are analyzed. The needle to needle volume is subdivided into a progression volume and a dilution volume. The relationship of several parameters of the curve to cardiac output and to the chamber volumes are analyzed theoretically. Circulation models show that degree of asymmetry of the curve depends on the distribution of the dilution volumes: The more numerous and the more equal in volume the dilution chambers, the more symmetric the form of the curve. The easily measurable parameters of the curve (as build up time, peak concentration) are directly proportional to the mean dilution time and the „mixing concentration” in a given system. Measurements in central circulation in mean show a good agreement with a 4–5 chamber model. An explanation for the special form of the curve depending on the site of injection and registration and on pathologie influence of valvular incompetence is given. Statistical methods allow simplified calculation of parameters of clinical significance.
    Notes: Zusammenfassung Die Faktoren, die die besondere Form der Primärkurve nach Indikatorinjektion in den Kreislauf bestimmen, werden analysiert. Grundlegend ist die Unterscheidung zwischen einem Progressions- und einem Dilutionsvolumen. Die Beziehungen der verschiedenen Parameter der Kurve zum Herzminutenvolumen und zu bestimmten Volumina werden bei linear angeordneten Mehrkammermodellen untersucht. In diesen Modellen ist der Grad der Asymmetrie der Kurve von der Verteilung des Dilutionsvolumens abhängig: die Kurve ist um so symmetrischer, je zahlreicher und je ähnlicher im Volumen die Kammern sind. Bei konstanter Verteilung sind die einfach meßbaren Parameter der Kurve (die Konzentrationszeit, die Verdünnungszeit und die maximale Konzentration) zu der mittleren Dilutionszeit bzw. zu der Mischkonzentration direkt proportional. Statistische Messungen beim Menschen zeigen eine weitgehende Übereinstimmung zwischen dem zentralen Kreislauf und diesen Modellen. Sie beiten eine theoretische Erklärung für die besondere Form der Kurve, für ihre Abhängigkeit vom Injektions- und Registricrort sowie für ihre Variationen in pathologischen Situationen (z. B. bei Klappeninsufizienz). Sie erlauben vereinfachte approximative Berechnungen von Parametern. die klinisch bedeutsam sind.
    Type of Medium: Electronic Resource
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